GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

Home
Browse
- Genes
- Diseases
- Pathways
  - Reactome
  - KEGG
Analysis
Help
Links
FAQ
Contact us

VCAM1 (vascular cell adhesion molecule 1)

Gene

7412

Vascular cell adhesion molecule 1

VCAM1

CD106, INCAM-100

1p21.2

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

Show/Hide all(113)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004007	hsa-miR-200a-3p	Microarray	17875710
MIRT004081	hsa-miR-126-3p	Luciferase reporter assay, Western blot, Reporter assay;Other	18227515
MIRT020917	hsa-miR-155-5p	qRT-PCR	21310411
MIRT504350	hsa-miR-23c	PAR-CLIP	23446348
MIRT504350	hsa-miR-23c	PAR-CLIP, HITS-CLIP	21572407
MIRT504350	hsa-miR-23c	HITS-CLIP	23824327
MIRT504350	hsa-miR-23c	HITS-CLIP	23313552
MIRT504351	hsa-miR-23b-3p	PAR-CLIP	23446348
MIRT504351	hsa-miR-23b-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT504351	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT504351	hsa-miR-23b-3p	HITS-CLIP	23313552
MIRT504352	hsa-miR-23a-3p	PAR-CLIP	23446348
MIRT504352	hsa-miR-23a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT504352	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT504352	hsa-miR-23a-3p	HITS-CLIP	23313552
MIRT504353	hsa-miR-130a-5p	PAR-CLIP	23446348
MIRT504353	hsa-miR-130a-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT504353	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT504353	hsa-miR-130a-5p	HITS-CLIP	23313552
MIRT504354	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504354	hsa-miR-190a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT504354	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT504354	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT504355	hsa-miR-6074	PAR-CLIP	23446348
MIRT504355	hsa-miR-6074	PAR-CLIP, HITS-CLIP	21572407
MIRT504355	hsa-miR-6074	HITS-CLIP	23824327
MIRT504355	hsa-miR-6074	HITS-CLIP	23313552
MIRT504356	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504356	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT504356	hsa-miR-5011-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT504356	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT504357	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504357	hsa-miR-1277-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT504357	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT504357	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT533248	hsa-miR-6516-5p	PAR-CLIP	22012620
MIRT533248	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT533249	hsa-miR-4677-5p	PAR-CLIP	22012620
MIRT533250	hsa-miR-3678-3p	PAR-CLIP	22012620
MIRT533251	hsa-miR-1273h-3p	PAR-CLIP	22012620
MIRT533252	hsa-miR-6844	PAR-CLIP	22012620
MIRT533253	hsa-miR-22-5p	PAR-CLIP	22012620
MIRT533254	hsa-miR-2116-5p	PAR-CLIP	22012620
MIRT533255	hsa-miR-2467-3p	PAR-CLIP	22012620
MIRT533255	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT533256	hsa-miR-96-3p	PAR-CLIP	22012620
MIRT533257	hsa-miR-5694	PAR-CLIP	22012620
MIRT533257	hsa-miR-5694	PAR-CLIP	27292025
MIRT533258	hsa-miR-6856-3p	PAR-CLIP	22012620
MIRT533259	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT610905	hsa-miR-5092	HITS-CLIP	23824327
MIRT619598	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT619599	hsa-miR-3145-5p	HITS-CLIP	23824327
MIRT635473	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT635474	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT635475	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT635476	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT635477	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT635478	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT635479	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT707380	hsa-miR-7110-3p	HITS-CLIP	21572407
MIRT707381	hsa-miR-6845-3p	HITS-CLIP	21572407
MIRT707382	hsa-miR-136-5p	HITS-CLIP	21572407
MIRT707383	hsa-miR-6769b-3p	HITS-CLIP	21572407
MIRT707384	hsa-miR-4723-3p	HITS-CLIP	21572407
MIRT707385	hsa-miR-3183	HITS-CLIP	21572407
MIRT715352	hsa-miR-3127-5p	HITS-CLIP	19536157
MIRT715353	hsa-miR-3691-3p	HITS-CLIP	19536157
MIRT715354	hsa-miR-6754-5p	HITS-CLIP	19536157
MIRT715355	hsa-miR-4441	HITS-CLIP	19536157
MIRT715356	hsa-miR-4270	HITS-CLIP	19536157
MIRT715357	hsa-miR-211-3p	HITS-CLIP	19536157
MIRT715358	hsa-miR-506-5p	HITS-CLIP	19536157
MIRT715359	hsa-miR-181b-5p	HITS-CLIP	19536157
MIRT715360	hsa-miR-4262	HITS-CLIP	19536157
MIRT715361	hsa-miR-181d-5p	HITS-CLIP	19536157
MIRT715362	hsa-miR-181c-5p	HITS-CLIP	19536157
MIRT715363	hsa-miR-181a-5p	HITS-CLIP	19536157
MIRT761590	hsa-miR-1247-3p	PAR-CLIP	27292025
MIRT761880	hsa-miR-1273e	PAR-CLIP	27292025
MIRT762922	hsa-miR-15a-3p	PAR-CLIP	27292025
MIRT763148	hsa-miR-1827	PAR-CLIP	27292025
MIRT763364	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT763927	hsa-miR-219b-3p	PAR-CLIP	27292025
MIRT764534	hsa-miR-302f	PAR-CLIP	27292025
MIRT765966	hsa-miR-3612	PAR-CLIP	27292025
MIRT767499	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT767821	hsa-miR-3929	PAR-CLIP	27292025
MIRT768066	hsa-miR-4252	PAR-CLIP	27292025
MIRT768187	hsa-miR-4257	PAR-CLIP	27292025
MIRT768817	hsa-miR-4419b	PAR-CLIP	27292025
MIRT769055	hsa-miR-4433a-3p	PAR-CLIP	27292025
MIRT769374	hsa-miR-4459	PAR-CLIP	27292025
MIRT769568	hsa-miR-4478	PAR-CLIP	27292025
MIRT770060	hsa-miR-4529-5p	PAR-CLIP	27292025
MIRT770463	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT770691	hsa-miR-4649-3p	PAR-CLIP	27292025
MIRT770963	hsa-miR-4683	PAR-CLIP	27292025
MIRT771604	hsa-miR-4722-5p	PAR-CLIP	27292025
MIRT772159	hsa-miR-4768-3p	PAR-CLIP	27292025
MIRT772661	hsa-miR-485-5p	PAR-CLIP	27292025
MIRT775629	hsa-miR-6086	PAR-CLIP	27292025
MIRT776408	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT776724	hsa-miR-650	PAR-CLIP	27292025
MIRT776863	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT777643	hsa-miR-665	PAR-CLIP	27292025
MIRT779629	hsa-miR-6807-5p	PAR-CLIP	27292025
MIRT779734	hsa-miR-6808-5p	PAR-CLIP	27292025
MIRT781049	hsa-miR-6884-5p	PAR-CLIP	27292025
MIRT781114	hsa-miR-6888-5p	PAR-CLIP	27292025
MIRT781266	hsa-miR-6893-5p	PAR-CLIP	27292025
MIRT781654	hsa-miR-7160-5p	PAR-CLIP	27292025
MIRT782959	hsa-miR-940	PAR-CLIP	27292025

Transcription factors

Show/Hide all(11)

Transcription factor	Regulation	Reference
EP300	Activation	19281832
HDAC4	Activation	19281832
HOXA9	Unknown	22269951
IKBKB	Repression	18600306
IRF1	Unknown	15265939;22182512
JUN	Activation	16271621
NFKB1	Activation	10329958;10946302;11359843;16271621;16317091;16385502;19281832;19422386;22708120
NFKB1	Unknown	10553096;10833420;16453001
POU2F1	Repression	9694713
RELA	Activation	10329958;10946302;11359843;16317091;16385502;19281832;19422386;22708120
RELA	Unknown	10553096;10833420;16453001;23042817

Show/Hide all(55)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IEA
GO:0002102	Component	Podosome	IDA	15220135
GO:0002526	Process	Acute inflammatory response	IEA
GO:0002544	Process	Chronic inflammatory response	IEA
GO:0005178	Function	Integrin binding	IBA	21873635
GO:0005178	Function	Integrin binding	IDA	1377228, 15220135, 23620790
GO:0005178	Function	Integrin binding	IMP	19738201
GO:0005615	Component	Extracellular space	IDA	9290466
GO:0005769	Component	Early endosome	IDA	23474851
GO:0005783	Component	Endoplasmic reticulum	IDA	23474851
GO:0005794	Component	Golgi apparatus	IDA	23474851
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005902	Component	Microvillus	IDA	12082081
GO:0007155	Process	Cell adhesion	IBA	21873635
GO:0007155	Process	Cell adhesion	IDA	16809613
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA	1715889
GO:0007159	Process	Leukocyte cell-cell adhesion	IDA	1381355, 1715889, 2688898
GO:0007160	Process	Cell-matrix adhesion	IDA	18308860
GO:0007568	Process	Aging	IEA
GO:0007584	Process	Response to nutrient	IEA
GO:0008131	Function	Primary amine oxidase activity	IDA	23474851
GO:0009308	Process	Amine metabolic process	IDA	23474851
GO:0009897	Component	External side of plasma membrane	IDA	1377228
GO:0009986	Component	Cell surface	IDA	1715889, 23474851
GO:0010043	Process	Response to zinc ion	IEA
GO:0010212	Process	Response to ionizing radiation	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0022614	Process	Membrane to membrane docking	IEP	12082081
GO:0030175	Component	Filopodium	IDA	12082081
GO:0030183	Process	B cell differentiation	IC	1715889
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0034113	Process	Heterotypic cell-cell adhesion	IGI	11078691
GO:0035094	Process	Response to nicotine	IEA
GO:0035584	Process	Calcium-mediated signaling using intracellular calcium source	IGI	15879141
GO:0035924	Process	Cellular response to vascular endothelial growth factor stimulus	IEA
GO:0042102	Process	Positive regulation of T cell proliferation	IDA	1381355
GO:0042383	Component	Sarcolemma	IEA
GO:0045177	Component	Apical part of cell	IDA	12082081
GO:0045471	Process	Response to ethanol	IEA
GO:0050776	Process	Regulation of immune response	TAS
GO:0050839	Function	Cell adhesion molecule binding	IDA	1377228
GO:0050839	Function	Cell adhesion molecule binding	IPI	12082081
GO:0050901	Process	Leukocyte tethering or rolling	IDA	18308860
GO:0050901	Process	Leukocyte tethering or rolling	IEP	2688898
GO:0060326	Process	Cell chemotaxis	IEA
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:0060384	Process	Innervation	IEA
GO:0060945	Process	Cardiac neuron differentiation	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0071065	Component	Alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex	IDA	15220135
GO:0071356	Process	Cellular response to tumor necrosis factor	IEA
GO:0140039	Process	Cell-cell adhesion in response to extracellular stimulus	IGI	11078691
GO:1904646	Process	Cellular response to amyloid-beta	IGI	11078691

MIM	HGNC	e!Ensembl
192225	12663	ENSG00000162692

Protein

UniProt ID

P19320

Protein name

Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106)

Protein function

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

PDB

1IJ9 , 1VCA , 1VSC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07679	I-set	25 → 112	Immunoglobulin I-set domain	Domain
PF05790	C2-set	133 → 221	Immunoglobulin C2-set domain	Domain
PF00047	ig	229 → 306	Immunoglobulin domain	Domain
PF07679	I-set	314 → 400	Immunoglobulin I-set domain	Domain
PF05790	C2-set	421 → 509	Immunoglobulin C2-set domain	Domain
PF13927	Ig_3	515 → 583		Domain
PF07679	I-set	605 → 685	Immunoglobulin I-set domain	Domain

Sequence

MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR
TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE
IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV
TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG
SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN
RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR
SEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSS
VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA
LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP
APKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP
KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQL
KDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFA
RKANMKGSYSLVEAQKSKV

Sequence length

739

Interactions

View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412