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UBB (ubiquitin B)
Gene
Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7314
Gene nameGene Name - the full gene name approved by the HGNC.
Ubiquitin B
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
UBB
SynonymsGene synonyms aliases
HEL-S-50
ChromosomeChromosome number
17
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p11.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer`s disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT029681 hsa-miR-26b-5p Microarray 19088304
MIRT035905 hsa-miR-1287-5p CLASH 23622248
MIRT036732 hsa-miR-760 CLASH 23622248
MIRT038186 hsa-miR-148b-5p CLASH 23622248
MIRT038925 hsa-miR-92a-1-5p CLASH 23622248
Transcription factors
Gene SNPs Transcription factors Other IDs
Transcription factor Regulation Reference
HSF1 Unknown 20692357
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS
GO:0000187 Process Activation of MAPK activity TAS
GO:0000209 Process Protein polyubiquitination TAS
GO:0000715 Process Nucleotide-excision repair, DNA damage recognition TAS
GO:0000717 Process Nucleotide-excision repair, DNA duplex unwinding TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Transcription factors Other IDs
UniProt ID P0CG47
Protein name Polyubiquitin-B [Cleaved into: Ubiquitin]
Protein function [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
PDB 2KHW , 2MBB , 2MRO , 2MSG , 2N13 , 4UEL , 4UF6 , 4WHV , 4WLR , 4WUR , 4XOF , 4ZFR , 4ZFT , 4ZPZ , 4ZUX , 5BNB , 5CAW , 5CRA , 5CVM , 5CVN , 5CVO , 5D0K , 5D0M , 5DFL , 5DK8 , 5E6J , 5EDV , 5EMZ , 5EYA , 5GJQ , 5GO7 , 5GO8 , 5GOB , 5GOC , 5GOD , 5GOG , 5GOH , 5GOI , 5GOJ , 5GOK , 5H7S , 5IBK , 5IFR , 5JBY , 5JG6 , 5JP3 , 5JTJ , 5JTV , 5K9P , 5KGF , 5KHY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00240 ubiquitin
3 → 74
Ubiquitin family
 Domain
PF00240 ubiquitin
79 → 150
Ubiquitin family
 Domain
PF00240 ubiquitin
155 → 226
Ubiquitin family
 Domain
Sequence
Sequence length 229
Interactions View interactions

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