UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
7311 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Ubiquitin A-52 residue ribosomal protein fusion product 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
UBA52 |
SynonymsGene synonyms aliases
|
CEP52, HUBCEP52, L40, RPL40 |
ChromosomeChromosome number
|
19 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
19p13.11 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, a |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000122 |
Process |
Negative regulation of transcription by RNA polymerase II |
TAS |
|
GO:0000184 |
Process |
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS |
|
GO:0000187 |
Process |
Activation of MAPK activity |
TAS |
|
GO:0000209 |
Process |
Protein polyubiquitination |
TAS |
|
GO:0000715 |
Process |
Nucleotide-excision repair, DNA damage recognition |
TAS |
|
GO:0000717 |
Process |
Nucleotide-excision repair, DNA duplex unwinding |
TAS |
|
GO:0002755 |
Process |
MyD88-dependent toll-like receptor signaling pathway |
TAS |
|
GO:0002756 |
Process |
MyD88-independent toll-like receptor signaling pathway |
TAS |
|
GO:0003735 |
Function |
Structural constituent of ribosome |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
15147878, 15231748, 15936278, 21900206, 32296183, 32814053 |
GO:0005615 |
Component |
Extracellular space |
HDA |
16502470 |
GO:0005634 |
Component |
Nucleus |
HDA |
21630459 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005741 |
Component |
Mitochondrial outer membrane |
TAS |
|
GO:0005765 |
Component |
Lysosomal membrane |
HDA |
17897319 |
GO:0005783 |
Component |
Endoplasmic reticulum |
IDA |
|
GO:0005789 |
Component |
Endoplasmic reticulum membrane |
TAS |
|
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005886 |
Component |
Plasma membrane |
IDA |
|
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0006283 |
Process |
Transcription-coupled nucleotide-excision repair |
TAS |
|
GO:0006294 |
Process |
Nucleotide-excision repair, preincision complex assembly |
TAS |
|
GO:0006296 |
Process |
Nucleotide-excision repair, DNA incision, 5'-to lesion |
TAS |
|
GO:0006297 |
Process |
Nucleotide-excision repair, DNA gap filling |
TAS |
|
GO:0006413 |
Process |
Translational initiation |
TAS |
|
GO:0006464 |
Process |
Cellular protein modification process |
TAS |
|
GO:0006614 |
Process |
SRP-dependent cotranslational protein targeting to membrane |
TAS |
|
GO:0006625 |
Process |
Protein targeting to peroxisome |
TAS |
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
TAS |
|
GO:0007249 |
Process |
I-kappaB kinase/NF-kappaB signaling |
TAS |
|
GO:0007254 |
Process |
JNK cascade |
TAS |
|
GO:0010008 |
Component |
Endosome membrane |
TAS |
|
GO:0016055 |
Process |
Wnt signaling pathway |
TAS |
|
GO:0016197 |
Process |
Endosomal transport |
TAS |
|
GO:0016567 |
Process |
Protein ubiquitination |
IBA |
21873635 |
GO:0016567 |
Process |
Protein ubiquitination |
TAS |
|
GO:0016579 |
Process |
Protein deubiquitination |
TAS |
|
GO:0019058 |
Process |
Viral life cycle |
TAS |
|
GO:0019068 |
Process |
Virion assembly |
TAS |
|
GO:0019083 |
Process |
Viral transcription |
TAS |
|
GO:0019221 |
Process |
Cytokine-mediated signaling pathway |
TAS |
|
GO:0019941 |
Process |
Modification-dependent protein catabolic process |
IBA |
21873635 |
GO:0019985 |
Process |
Translesion synthesis |
TAS |
|
GO:0022627 |
Component |
Cytosolic small ribosomal subunit |
IBA |
21873635 |
GO:0030512 |
Process |
Negative regulation of transforming growth factor beta receptor signaling pathway |
TAS |
|
GO:0030666 |
Component |
Endocytic vesicle membrane |
TAS |
|
GO:0031145 |
Process |
Anaphase-promoting complex-dependent catabolic process |
TAS |
|
GO:0031386 |
Function |
Protein tag |
IBA |
21873635 |
GO:0031625 |
Function |
Ubiquitin protein ligase binding |
IBA |
21873635 |
GO:0031982 |
Component |
Vesicle |
HDA |
19190083 |
GO:0033683 |
Process |
Nucleotide-excision repair, DNA incision |
TAS |
|
GO:0035666 |
Process |
TRIF-dependent toll-like receptor signaling pathway |
TAS |
|
GO:0036297 |
Process |
Interstrand cross-link repair |
TAS |
|
GO:0042276 |
Process |
Error-prone translesion synthesis |
TAS |
|
GO:0042769 |
Process |
DNA damage response, detection of DNA damage |
TAS |
|
GO:0043065 |
Process |
Positive regulation of apoptotic process |
TAS |
|
GO:0043066 |
Process |
Negative regulation of apoptotic process |
TAS |
|
GO:0043488 |
Process |
Regulation of mRNA stability |
TAS |
|
GO:0043657 |
Component |
Host cell |
IEA |
|
GO:0044267 |
Process |
Cellular protein metabolic process |
TAS |
|
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
TAS |
|
GO:0051092 |
Process |
Positive regulation of NF-kappaB transcription factor activity |
TAS |
|
GO:0051403 |
Process |
Stress-activated MAPK cascade |
TAS |
|
GO:0055085 |
Process |
Transmembrane transport |
TAS |
|
GO:0061024 |
Process |
Membrane organization |
TAS |
|
GO:0061418 |
Process |
Regulation of transcription from RNA polymerase II promoter in response to hypoxia |
TAS |
|
GO:0070062 |
Component |
Extracellular exosome |
HDA |
23533145 |
GO:0070423 |
Process |
Nucleotide-binding oligomerization domain containing signaling pathway |
TAS |
|
GO:0070498 |
Process |
Interleukin-1-mediated signaling pathway |
TAS |
|
GO:0070911 |
Process |
Global genome nucleotide-excision repair |
TAS |
|
GO:0070987 |
Process |
Error-free translesion synthesis |
TAS |
|
GO:0075733 |
Process |
Intracellular transport of virus |
TAS |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P62987 |
Protein name |
Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] |
Protein function |
[Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys re |
PDB |
2LJ5
,
2MBH
,
2MJB
,
2MUR
,
2N3U
,
2N3V
,
2N3W
,
2NBD
,
2NBE
,
2RSU
,
4HJK
,
4JIO
,
4P4H
,
4PIG
,
4PIH
,
4PIJ
,
4RF0
,
4RF1
,
4S1Z
,
4UG0
,
4V6X
,
4XKL
,
5AJ0
,
5GO7
,
5GO8
,
5GOB
,
5GOC
,
5GOD
,
5GOG
,
5GOH
,
5GOI
,
5GOJ
,
5GOK
,
5HPK
,
5HPL
,
5HPS
,
5HPT
,
5J26
,
5J8P
,
5JBV
,
5JBY
,
5LKS
,
5T2C
,
6IP5
,
6IP6
,
6IP8
,
6LQM
,
6OLE
,
6OLF
,
6OLG
,
6OLI
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00240 |
ubiquitin |
3 → 74 |
Ubiquitin family |
Domain |
PF01020 |
Ribosomal_L40e |
78 → 127 |
Ribosomal L40e family |
Family |
|
Sequence |
|
Sequence length |
128 |
Interactions |
View interactions |
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