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TRAF6 (TNF receptor associated factor 6)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7189
Gene nameGene Name - the full gene name approved by the HGNC.
TNF receptor associated factor 6
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TRAF6
SynonymsGene synonyms aliases
MGC:3310, RNF85
ChromosomeChromosome number
11
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p12
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling fro
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000711 hsa-miR-146a-5p Western blot, Northern blot 18504431
MIRT000711 hsa-miR-146a-5p Luciferase reporter assay, Western blot 20061417
MIRT000711 hsa-miR-146a-5p qRT-PCR, flow, Luciferase reporter assay, Western blot 20375304
MIRT000711 hsa-miR-146a-5p qRT-PCR 18759964
MIRT000711 hsa-miR-146a-5p Immunoprecipitaion, Western blot, Communoprecipitaion 19898489
Transcription factors
Transcription factor Regulation Reference
RUNX3 Activation 17956589
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 18093978
GO:0000187 Process Activation of MAPK activity TAS
GO:0000209 Process Protein polyubiquitination IDA 15125833, 19675569
GO:0001503 Process Ossification IEA
GO:0001701 Process In utero embryonic development IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9Y4K3
Protein name TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Protein function E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 (PubMed:11057907, PubMed:18347055, PubMed:19465916, PubMe
PDB 1LB4 , 1LB5 , 1LB6 , 2ECI , 2JMD , 3HCS , 3HCT , 3HCU , 4Z8M , 5ZUJ , 6A33 , 7L3L , 8HZ2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13923 zf-C3HC4_2
69 107
Domain
PF18048 TRAF6_Z2
157 183
TNF receptor-associated factor 6 zinc finger 2
Domain
PF02176 zf-TRAF
204 261
TRAF-type zinc finger
Family
Sequence
MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF
DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD
NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK
DCP
RRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI
PCTFSTFGCHEKMQRNHLARH
LQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH
QLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNF
GMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDS
HLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLE
ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
Sequence length 522
Interactions View interactions

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