TPM4 (tropomyosin 4)

Gene

• Entrez ID: 7171
• Gene name: Tropomyosin 4
• Gene symbol: TPM4
• Synonyms: HEL-S-108
• Chromosome: 19
• Chromosome location: 19p13.12-p13.11
• Summary: This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002782	hsa-miR-1-3p	Microarray	15685193
MIRT002782	hsa-miR-1-3p	pSILAC, Proteomics	18668040
MIRT002782	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT024410	hsa-miR-215-5p	Microarray	19074876
MIRT026576	hsa-miR-192-5p	Microarray	19074876
MIRT036591	hsa-miR-940	CLASH	23622248
MIRT036591	hsa-miR-940	PAR-CLIP	22012620
MIRT045744	hsa-miR-125a-5p	CLASH	23622248
MIRT049990	hsa-miR-28-5p	CLASH	23622248
MIRT052131	hsa-let-7b-5p	CLASH	23622248
MIRT242678	hsa-miR-651-3p	PAR-CLIP	22012620
MIRT242679	hsa-miR-4477b	PAR-CLIP	22012620
MIRT242680	hsa-miR-5089-3p	PAR-CLIP	22012620
MIRT242680	hsa-miR-5089-3p	PAR-CLIP	20371350
MIRT242680	hsa-miR-5089-3p	HITS-CLIP	21572407
MIRT291907	hsa-miR-3148	PAR-CLIP	22012620
MIRT291915	hsa-miR-4496	PAR-CLIP	20371350
MIRT291915	hsa-miR-4496	HITS-CLIP	21572407
MIRT291926	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT291926	hsa-miR-6747-3p	HITS-CLIP	21572407
MIRT291927	hsa-miR-6752-3p	PAR-CLIP	20371350
MIRT291927	hsa-miR-6752-3p	HITS-CLIP	21572407
MIRT291930	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT291931	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT291932	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT291933	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT291934	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT291935	hsa-miR-376c-5p	PAR-CLIP	23592263
MIRT291936	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT291937	hsa-miR-376b-5p	PAR-CLIP	23592263
MIRT291938	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT291939	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT291941	hsa-miR-876-5p	PAR-CLIP	23592263
MIRT291942	hsa-miR-1290	PAR-CLIP	23592263
MIRT291943	hsa-miR-3167	PAR-CLIP	23592263
MIRT291944	hsa-miR-3609	PAR-CLIP	23592263
MIRT291945	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT291946	hsa-miR-3911	PAR-CLIP	23592263
MIRT291947	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT291948	hsa-miR-4509	PAR-CLIP	23592263
MIRT291949	hsa-miR-4684-3p	PAR-CLIP	23592263
MIRT291950	hsa-miR-4744	PAR-CLIP	23592263
MIRT291951	hsa-miR-4752	PAR-CLIP	23592263
MIRT291952	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT291954	hsa-miR-8056	PAR-CLIP	23592263
MIRT465321	hsa-miR-6790-5p	PAR-CLIP	23592263
MIRT465322	hsa-miR-582-5p	PAR-CLIP	23592263
MIRT465323	hsa-miR-4696	PAR-CLIP	23592263
MIRT533547	hsa-miR-7151-3p	PAR-CLIP	22012620
MIRT533548	hsa-miR-5095	PAR-CLIP	22012620
MIRT533549	hsa-miR-4692	PAR-CLIP	22012620
MIRT533550	hsa-miR-4514	PAR-CLIP	22012620
MIRT533551	hsa-miR-3186-5p	PAR-CLIP	22012620
MIRT533552	hsa-miR-6893-5p	PAR-CLIP	22012620
MIRT533553	hsa-miR-4438	PAR-CLIP	22012620
MIRT533554	hsa-miR-6808-5p	PAR-CLIP	22012620
MIRT533555	hsa-miR-3160-3p	PAR-CLIP	22012620
MIRT560942	hsa-miR-24-2-5p	PAR-CLIP	20371350
MIRT560942	hsa-miR-24-2-5p	HITS-CLIP	21572407
MIRT560943	hsa-miR-24-1-5p	PAR-CLIP	20371350
MIRT560943	hsa-miR-24-1-5p	HITS-CLIP	21572407
MIRT560944	hsa-miR-10b-5p	PAR-CLIP	20371350
MIRT560944	hsa-miR-10b-5p	HITS-CLIP	21572407
MIRT560945	hsa-miR-10a-5p	PAR-CLIP	20371350
MIRT560945	hsa-miR-10a-5p	HITS-CLIP	21572407
MIRT560946	hsa-miR-504-5p	PAR-CLIP	20371350
MIRT560946	hsa-miR-504-5p	HITS-CLIP	21572407
MIRT753100	hsa-miR-6510-5p	PAR-CLIP	26701625

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0001725	Component	Stress fiber	IDA	16236705
GO:0005509	Function	Calcium ion binding	NAS	1836432
GO:0005515	Function	Protein binding	IPI	24407287, 28330616, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	TAS	16130169
GO:0005862	Component	Muscle thin filament tropomyosin	TAS	8641132
GO:0005884	Component	Actin filament	IBA	21873635
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006936	Process	Muscle contraction	IBA	21873635
GO:0006936	Process	Muscle contraction	TAS
GO:0007015	Process	Actin filament organization	IBA	21873635
GO:0008307	Function	Structural constituent of muscle	TAS	8641132
GO:0016020	Component	Membrane	HDA	16210410
GO:0030049	Process	Muscle filament sliding	TAS
GO:0042802	Function	Identical protein binding	ISS
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0046982	Function	Protein heterodimerization activity	ISS
GO:0051015	Function	Actin filament binding	IBA	21873635
GO:0051015	Function	Actin filament binding	ISS
GO:0070062	Component	Extracellular exosome	HDA	20458337

Other IDs

• MIM: 600317
• HGNC: 12013
• e!Ensembl: ENSG00000167460

Protein

• UniProt ID: P67936
• Protein name: Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)
• Protein function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00261	Tropomyosin	12 → 248	Tropomyosin	Coiled-coil

• Sequence:

  MAGLNSLEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVE
  EELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAE
  EADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSE
  KEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQ
  TLNELNCI

• Sequence length: 248