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TPM3 (tropomyosin 3)
Gene
Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7170
Gene nameGene Name - the full gene name approved by the HGNC.
Tropomyosin 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TPM3
SynonymsGene synonyms aliases
CAPM1, CFTD, CMYO4A, CMYO4B, CMYP4A, CMYP4B, HEL-189, HEL-S-82p, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPM3nu, TPMsk3, TRK, hscp30
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in
SNPsSNP information provided by dbSNP.
Gene SNPs Other IDs
SNP ID Visualize variation Clinical significance Consequence
rs80358247 A>C Not-provided, pathogenic Non coding transcript variant, missense variant, coding sequence variant, genic upstream transcript variant
rs80358248 G>A Not-provided, pathogenic Non coding transcript variant, coding sequence variant, genic upstream transcript variant, stop gained
rs113605263 C>A,G,T Pathogenic, not-provided, uncertain-significance Genic downstream transcript variant, intron variant, splice acceptor variant
rs121964852 C>T Pathogenic Genic downstream transcript variant, non coding transcript variant, missense variant, coding sequence variant
rs121964853 G>C,T Likely-pathogenic, pathogenic, not-provided Genic downstream transcript variant, missense variant, coding sequence variant, 5 prime UTR variant, intron variant, non coding transcript variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT001403 hsa-miR-16-5p pSILAC 18668040
MIRT001403 hsa-miR-16-5p pSILAC 18668040
MIRT001325 hsa-miR-1-3p pSILAC 18668040
MIRT021512 hsa-miR-145-5p Reporter assay;Microarray 21351259
MIRT001325 hsa-miR-1-3p Proteomics;Microarray 18668037
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Other IDs
GO ID Ontology Definition Evidence Reference
GO:0001725 Component Stress fiber IDA 16236705
GO:0003674 Function Molecular_function ND
GO:0005515 Function Protein binding IPI 16189514, 21516116, 23892143, 25416956, 25910212, 25959826, 27107012, 31515488, 32296183, 32814053
GO:0005829 Component Cytosol IDA
GO:0005829 Component Cytosol TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Other IDs
UniProt ID P06753
Protein name Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)
Protein function Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by int
PDB 6OTN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00261 Tropomyosin
49 → 285
Tropomyosin
 Coiled-coil
Sequence
Sequence length 285
Interactions View interactions

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