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TPM1 (tropomyosin 1)

Gene

7168

Tropomyosin 1

TPM1

C15orf13, CMD1Y, CMH3, HEL-S-265, HTM-alpha, LVNC9, TMSA

15q22.2

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha

Show/Hide all(55)

SNP ID	Visualize variation	Clinical significance	Consequence
rs104894501	G>A,C,T	Uncertain-significance, pathogenic	Coding sequence variant, stop gained, missense variant, genic upstream transcript variant, 5 prime UTR variant, intron variant
rs104894502	A>G,T	Not-provided, pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs104894503	G>A	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs104894504	T>C	Likely-pathogenic, pathogenic	Non coding transcript variant, coding sequence variant, missense variant, 5 prime UTR variant
rs104894505	G>A	Pathogenic-likely-pathogenic, pathogenic	Coding sequence variant, missense variant, genic upstream transcript variant, 5 prime UTR variant, intron variant
rs144045691	A>G	Uncertain-significance, conflicting-interpretations-of-pathogenicity	3 prime UTR variant, coding sequence variant, missense variant, non coding transcript variant, genic downstream transcript variant
rs199476305	G>C	Likely-pathogenic, not-provided	Genic upstream transcript variant, missense variant, intron variant, coding sequence variant, 5 prime UTR variant
rs199476306	C>T	Likely-pathogenic, uncertain-significance	Genic upstream transcript variant, missense variant, intron variant, coding sequence variant, 5 prime UTR variant
rs199476310	T>C	Likely-pathogenic, not-provided	Coding sequence variant, non coding transcript variant, 5 prime UTR variant, missense variant
rs199476311	G>A	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs199476312	T>C	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant, non coding transcript variant
rs199476315	G>A	Pathogenic-likely-pathogenic, pathogenic	Coding sequence variant, non coding transcript variant, intron variant, missense variant
rs199476316	C>T	Likely-pathogenic, uncertain-significance, pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs199476317	G>A	Pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs199476319	A>G	Pathogenic, not-provided	Coding sequence variant, missense variant, non coding transcript variant
rs199476321	T>C	Conflicting-interpretations-of-pathogenicity, likely-pathogenic, uncertain-significance, pathogenic	Coding sequence variant, genic downstream transcript variant, intron variant, missense variant
rs397516363	G>A,T	Likely-pathogenic	Genic upstream transcript variant, missense variant, intron variant, coding sequence variant, 5 prime UTR variant
rs397516364	T>G	Likely-pathogenic	Coding sequence variant, missense variant, 5 prime UTR variant, genic upstream transcript variant
rs397516369	C>G	Likely-pathogenic, pathogenic	Coding sequence variant, non coding transcript variant, 5 prime UTR variant, missense variant
rs397516370	A>G	Likely-pathogenic	Coding sequence variant, non coding transcript variant, 5 prime UTR variant, missense variant
rs397516371	G>C	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs397516372	C>G,T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant, non coding transcript variant
rs397516373	G>A	Likely-pathogenic, uncertain-significance, pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs397516376	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant, non coding transcript variant
rs397516386	C>T	Likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant, non coding transcript variant
rs397516391	G>A,C,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant, 5 prime UTR variant, genic upstream transcript variant
rs397516486	C>G,T	Likely-pathogenic	Missense variant, intron variant, synonymous variant, coding sequence variant, non coding transcript variant
rs532254032	G>A	Likely-benign, conflicting-interpretations-of-pathogenicity, uncertain-significance	Non coding transcript variant, intron variant
rs727503518	G>A	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs727504264	G>C	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs727504290	G>C	Likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant, 5 prime UTR variant
rs727504389	A>T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs730881128	G>A	Conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, coding sequence variant, missense variant, intron variant
rs730881134	A>G,T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs730881136	T>A,G	Pathogenic, uncertain-significance	Non coding transcript variant, coding sequence variant, missense variant
rs730881140	A>G	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant, intron variant
rs730881146	G>A	Pathogenic, uncertain-significance	Splice donor variant, intron variant, genic upstream transcript variant
rs730881151	G>T	Uncertain-significance, likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant, 5 prime UTR variant
rs730881157	C>G	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant, 5 prime UTR variant
rs730881159	G>A,T	Uncertain-significance, likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant, intron variant
rs730881160	A>C	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs754664923	G>A	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant, 5 prime UTR variant
rs757577112	C>G,T	Likely-pathogenic, uncertain-significance	Missense variant, non coding transcript variant, 5 prime UTR variant, coding sequence variant
rs876657662	G>A	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs879253758	G>A	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs886037905	G>A,C	Likely-pathogenic	Synonymous variant, missense variant, coding sequence variant, non coding transcript variant
rs886039444	A>C	Uncertain-significance, likely-pathogenic	5 prime UTR variant, genic upstream transcript variant, coding sequence variant, missense variant
rs1064793284	G>C	Likely-pathogenic	Non coding transcript variant, 5 prime UTR variant, coding sequence variant, missense variant
rs1114167355	A>G	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs1114167356	C>T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs1114167357	T>C	Likely-pathogenic	Splice donor variant, genic upstream transcript variant
rs1555408679	A>G	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs1555409659	TACTCG>-	Likely-pathogenic	Splice acceptor variant, coding sequence variant, non coding transcript variant
rs1596303148	A>G	Likely-pathogenic	5 prime UTR variant, genic upstream transcript variant, missense variant, intron variant, coding sequence variant
rs1596386673	A>T	Likely-pathogenic	Coding sequence variant, non coding transcript variant, missense variant

Show/Hide all(366)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001980	hsa-miR-21-5p	Luciferase reporter assay, Western blot	17363372
MIRT001980	hsa-miR-21-5p	Review	19935707
MIRT001980	hsa-miR-21-5p	Luciferase reporter assay	18270520
MIRT001980	hsa-miR-21-5p	Luciferase reporter assay	17363372
MIRT001980	hsa-miR-21-5p	Review	20130964
MIRT001980	hsa-miR-21-5p	Review	20026422
MIRT001980	hsa-miR-21-5p	Luciferase reporter assay	19253296
MIRT001327	hsa-miR-1-3p	pSILAC	18668040
MIRT001980	hsa-miR-21-5p	Luciferase reporter assay	21817107
MIRT001980	hsa-miR-21-5p	Luciferase reporter assay	21817107
MIRT021693	hsa-miR-133a-3p	Microarray	21396852
MIRT023135	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT001327	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT001327	hsa-miR-1-3p	Proteomics	18668040
MIRT025560	hsa-miR-34a-5p	Proteomics	21566225
MIRT025560	hsa-miR-34a-5p	Proteomics	21566225
MIRT025560	hsa-miR-34a-5p	Proteomics	21566225
MIRT001980	hsa-miR-21-5p	Microarray	18591254
MIRT001980	hsa-miR-21-5p	Western blot;qRT-PCR	17363372
MIRT053002	hsa-miR-10b-5p	Western blot	22766763
MIRT698095	hsa-miR-892a	HITS-CLIP	23313552
MIRT698094	hsa-miR-3174	HITS-CLIP	23313552
MIRT698093	hsa-miR-6761-3p	HITS-CLIP	23313552
MIRT698092	hsa-miR-6825-3p	HITS-CLIP	23313552
MIRT698091	hsa-miR-6831-3p	HITS-CLIP	23313552
MIRT698090	hsa-miR-1185-5p	HITS-CLIP	23313552
MIRT698089	hsa-miR-3679-5p	HITS-CLIP	23313552
MIRT698088	hsa-miR-3605-5p	HITS-CLIP	23313552
MIRT698087	hsa-miR-145-3p	HITS-CLIP	23313552
MIRT698086	hsa-miR-8064	HITS-CLIP	23313552
MIRT698085	hsa-miR-155-3p	HITS-CLIP	23313552
MIRT698084	hsa-miR-6828-3p	HITS-CLIP	23313552
MIRT698083	hsa-miR-6071	HITS-CLIP	23313552
MIRT698082	hsa-miR-3685	HITS-CLIP	23313552
MIRT698081	hsa-miR-497-5p	HITS-CLIP	23313552
MIRT698095	hsa-miR-892a	HITS-CLIP	23313552
MIRT698094	hsa-miR-3174	HITS-CLIP	23313552
MIRT698093	hsa-miR-6761-3p	HITS-CLIP	23313552
MIRT698092	hsa-miR-6825-3p	HITS-CLIP	23313552
MIRT698091	hsa-miR-6831-3p	HITS-CLIP	23313552
MIRT698090	hsa-miR-1185-5p	HITS-CLIP	23313552
MIRT698089	hsa-miR-3679-5p	HITS-CLIP	23313552
MIRT698088	hsa-miR-3605-5p	HITS-CLIP	23313552
MIRT698087	hsa-miR-145-3p	HITS-CLIP	23313552
MIRT698086	hsa-miR-8064	HITS-CLIP	23313552
MIRT698085	hsa-miR-155-3p	HITS-CLIP	23313552
MIRT698084	hsa-miR-6828-3p	HITS-CLIP	23313552
MIRT698083	hsa-miR-6071	HITS-CLIP	23313552
MIRT698082	hsa-miR-3685	HITS-CLIP	23313552
MIRT698081	hsa-miR-497-5p	HITS-CLIP	23313552
MIRT1449392	hsa-miR-1185	CLIP-seq
MIRT1449393	hsa-miR-1227	CLIP-seq
MIRT1449394	hsa-miR-1228	CLIP-seq
MIRT1449395	hsa-miR-1249	CLIP-seq
MIRT1449396	hsa-miR-1271	CLIP-seq
MIRT1449397	hsa-miR-1283	CLIP-seq
MIRT1449398	hsa-miR-140-3p	CLIP-seq
MIRT1449399	hsa-miR-219-5p	CLIP-seq
MIRT1449400	hsa-miR-2278	CLIP-seq
MIRT1449401	hsa-miR-297	CLIP-seq
MIRT1449402	hsa-miR-299-3p	CLIP-seq
MIRT1449403	hsa-miR-29a	CLIP-seq
MIRT1449404	hsa-miR-29b	CLIP-seq
MIRT1449405	hsa-miR-29c	CLIP-seq
MIRT1449406	hsa-miR-3119	CLIP-seq
MIRT1449407	hsa-miR-3144-5p	CLIP-seq
MIRT1449408	hsa-miR-3149	CLIP-seq
MIRT1449409	hsa-miR-3160-3p	CLIP-seq
MIRT1449410	hsa-miR-3182	CLIP-seq
MIRT1449411	hsa-miR-33a	CLIP-seq
MIRT1449412	hsa-miR-33b	CLIP-seq
MIRT1449413	hsa-miR-3591-5p	CLIP-seq
MIRT1449414	hsa-miR-3606	CLIP-seq
MIRT1449415	hsa-miR-3649	CLIP-seq
MIRT1449416	hsa-miR-375	CLIP-seq
MIRT1449417	hsa-miR-3917	CLIP-seq
MIRT1449418	hsa-miR-3973	CLIP-seq
MIRT1449419	hsa-miR-409-3p	CLIP-seq
MIRT1449420	hsa-miR-4445	CLIP-seq
MIRT1449421	hsa-miR-4477b	CLIP-seq
MIRT1449422	hsa-miR-4487	CLIP-seq
MIRT1449423	hsa-miR-4491	CLIP-seq
MIRT1449424	hsa-miR-4504	CLIP-seq
MIRT1449425	hsa-miR-4639-5p	CLIP-seq
MIRT1449426	hsa-miR-4645-3p	CLIP-seq
MIRT1449427	hsa-miR-4652-3p	CLIP-seq
MIRT1449428	hsa-miR-4657	CLIP-seq
MIRT1449429	hsa-miR-4659a-3p	CLIP-seq
MIRT1449430	hsa-miR-4659b-3p	CLIP-seq
MIRT1449431	hsa-miR-4677-3p	CLIP-seq
MIRT1449432	hsa-miR-4679	CLIP-seq
MIRT1449433	hsa-miR-4684-5p	CLIP-seq
MIRT1449434	hsa-miR-4716-3p	CLIP-seq
MIRT1449435	hsa-miR-4732-3p	CLIP-seq
MIRT1449436	hsa-miR-4778-3p	CLIP-seq
MIRT1449437	hsa-miR-4782-3p	CLIP-seq
MIRT1449438	hsa-miR-4790-3p	CLIP-seq
MIRT1449439	hsa-miR-4799-5p	CLIP-seq
MIRT1449440	hsa-miR-503	CLIP-seq
MIRT1449441	hsa-miR-508-3p	CLIP-seq
MIRT1449442	hsa-miR-513c	CLIP-seq
MIRT1449443	hsa-miR-514b-5p	CLIP-seq
MIRT1449444	hsa-miR-520d-5p	CLIP-seq
MIRT1449445	hsa-miR-520g	CLIP-seq
MIRT1449446	hsa-miR-520h	CLIP-seq
MIRT1449447	hsa-miR-524-5p	CLIP-seq
MIRT1449448	hsa-miR-542-3p	CLIP-seq
MIRT1449449	hsa-miR-548a-3p	CLIP-seq
MIRT1449450	hsa-miR-548a-5p	CLIP-seq
MIRT1449451	hsa-miR-548ab	CLIP-seq
MIRT1449452	hsa-miR-548ak	CLIP-seq
MIRT1449453	hsa-miR-548b-5p	CLIP-seq
MIRT1449454	hsa-miR-548c-5p	CLIP-seq
MIRT1449455	hsa-miR-548d-5p	CLIP-seq
MIRT1449456	hsa-miR-548e	CLIP-seq
MIRT1449457	hsa-miR-548f	CLIP-seq
MIRT1449458	hsa-miR-548h	CLIP-seq
MIRT1449459	hsa-miR-548i	CLIP-seq
MIRT1449460	hsa-miR-548j	CLIP-seq
MIRT1449461	hsa-miR-548n	CLIP-seq
MIRT1449462	hsa-miR-548t	CLIP-seq
MIRT1449463	hsa-miR-548w	CLIP-seq
MIRT1449464	hsa-miR-548y	CLIP-seq
MIRT1449465	hsa-miR-556-5p	CLIP-seq
MIRT1449466	hsa-miR-558	CLIP-seq
MIRT1449467	hsa-miR-559	CLIP-seq
MIRT1449468	hsa-miR-562	CLIP-seq
MIRT1449469	hsa-miR-567	CLIP-seq
MIRT1449470	hsa-miR-600	CLIP-seq
MIRT1449471	hsa-miR-653	CLIP-seq
MIRT1449472	hsa-miR-921	CLIP-seq
MIRT1449473	hsa-miR-96	CLIP-seq
MIRT1449399	hsa-miR-219-5p	CLIP-seq
MIRT1555139	hsa-miR-300	CLIP-seq
MIRT1555140	hsa-miR-381	CLIP-seq
MIRT1449420	hsa-miR-4445	CLIP-seq
MIRT1555141	hsa-miR-4528	CLIP-seq
MIRT1555142	hsa-miR-4666-3p	CLIP-seq
MIRT1449437	hsa-miR-4782-3p	CLIP-seq
MIRT1555143	hsa-miR-4789-5p	CLIP-seq
MIRT1449441	hsa-miR-508-3p	CLIP-seq
MIRT1449442	hsa-miR-513c	CLIP-seq
MIRT1449443	hsa-miR-514b-5p	CLIP-seq
MIRT1449449	hsa-miR-548a-3p	CLIP-seq
MIRT1449456	hsa-miR-548e	CLIP-seq
MIRT1449457	hsa-miR-548f	CLIP-seq
MIRT1555144	hsa-miR-587	CLIP-seq
MIRT1449392	hsa-miR-1185	CLIP-seq
MIRT2134402	hsa-miR-2355-5p	CLIP-seq
MIRT1449401	hsa-miR-297	CLIP-seq
MIRT1555139	hsa-miR-300	CLIP-seq
MIRT1449408	hsa-miR-3149	CLIP-seq
MIRT1449410	hsa-miR-3182	CLIP-seq
MIRT1449413	hsa-miR-3591-5p	CLIP-seq
MIRT1449414	hsa-miR-3606	CLIP-seq
MIRT2134403	hsa-miR-3679-3p	CLIP-seq
MIRT1555140	hsa-miR-381	CLIP-seq
MIRT1449419	hsa-miR-409-3p	CLIP-seq
MIRT2134404	hsa-miR-4286	CLIP-seq
MIRT2134405	hsa-miR-4446-5p	CLIP-seq
MIRT1555141	hsa-miR-4528	CLIP-seq
MIRT1449429	hsa-miR-4659a-3p	CLIP-seq
MIRT1449430	hsa-miR-4659b-3p	CLIP-seq
MIRT1555142	hsa-miR-4666-3p	CLIP-seq
MIRT1449436	hsa-miR-4778-3p	CLIP-seq
MIRT1555143	hsa-miR-4789-5p	CLIP-seq
MIRT1449438	hsa-miR-4790-3p	CLIP-seq
MIRT1449449	hsa-miR-548a-3p	CLIP-seq
MIRT1449456	hsa-miR-548e	CLIP-seq
MIRT1449457	hsa-miR-548f	CLIP-seq
MIRT1449469	hsa-miR-567	CLIP-seq
MIRT1555144	hsa-miR-587	CLIP-seq
MIRT2134406	hsa-miR-676	CLIP-seq
MIRT1449472	hsa-miR-921	CLIP-seq
MIRT2355679	hsa-miR-192	CLIP-seq
MIRT2355680	hsa-miR-215	CLIP-seq
MIRT1449399	hsa-miR-219-5p	CLIP-seq
MIRT2134402	hsa-miR-2355-5p	CLIP-seq
MIRT1449401	hsa-miR-297	CLIP-seq
MIRT1449402	hsa-miR-299-3p	CLIP-seq
MIRT1555139	hsa-miR-300	CLIP-seq
MIRT1449406	hsa-miR-3119	CLIP-seq
MIRT1449408	hsa-miR-3149	CLIP-seq
MIRT1449413	hsa-miR-3591-5p	CLIP-seq
MIRT1449414	hsa-miR-3606	CLIP-seq
MIRT2134403	hsa-miR-3679-3p	CLIP-seq
MIRT1555140	hsa-miR-381	CLIP-seq
MIRT2355681	hsa-miR-4269	CLIP-seq
MIRT2134404	hsa-miR-4286	CLIP-seq
MIRT2134405	hsa-miR-4446-5p	CLIP-seq
MIRT2355682	hsa-miR-4452	CLIP-seq
MIRT1449423	hsa-miR-4491	CLIP-seq
MIRT2355683	hsa-miR-4514	CLIP-seq
MIRT1555141	hsa-miR-4528	CLIP-seq
MIRT2355684	hsa-miR-4640-3p	CLIP-seq
MIRT1449428	hsa-miR-4657	CLIP-seq
MIRT1555142	hsa-miR-4666-3p	CLIP-seq
MIRT2355685	hsa-miR-4692	CLIP-seq
MIRT1449435	hsa-miR-4732-3p	CLIP-seq
MIRT2355686	hsa-miR-4742-5p	CLIP-seq
MIRT2355687	hsa-miR-4774-5p	CLIP-seq
MIRT1449437	hsa-miR-4782-3p	CLIP-seq
MIRT1555143	hsa-miR-4789-5p	CLIP-seq
MIRT1449439	hsa-miR-4799-5p	CLIP-seq
MIRT1449469	hsa-miR-567	CLIP-seq
MIRT1555144	hsa-miR-587	CLIP-seq
MIRT1449470	hsa-miR-600	CLIP-seq
MIRT1449472	hsa-miR-921	CLIP-seq
MIRT1449392	hsa-miR-1185	CLIP-seq
MIRT1449394	hsa-miR-1228	CLIP-seq
MIRT1449398	hsa-miR-140-3p	CLIP-seq
MIRT2355679	hsa-miR-192	CLIP-seq
MIRT2355680	hsa-miR-215	CLIP-seq
MIRT1449399	hsa-miR-219-5p	CLIP-seq
MIRT2134402	hsa-miR-2355-5p	CLIP-seq
MIRT1449401	hsa-miR-297	CLIP-seq
MIRT1449402	hsa-miR-299-3p	CLIP-seq
MIRT1449403	hsa-miR-29a	CLIP-seq
MIRT1449404	hsa-miR-29b	CLIP-seq
MIRT1449405	hsa-miR-29c	CLIP-seq
MIRT1555139	hsa-miR-300	CLIP-seq
MIRT1449407	hsa-miR-3144-5p	CLIP-seq
MIRT1449408	hsa-miR-3149	CLIP-seq
MIRT1449410	hsa-miR-3182	CLIP-seq
MIRT1449411	hsa-miR-33a	CLIP-seq
MIRT1449412	hsa-miR-33b	CLIP-seq
MIRT1449413	hsa-miR-3591-5p	CLIP-seq
MIRT1449414	hsa-miR-3606	CLIP-seq
MIRT2434302	hsa-miR-3622a-3p	CLIP-seq
MIRT2434303	hsa-miR-3622b-3p	CLIP-seq
MIRT1449415	hsa-miR-3649	CLIP-seq
MIRT2134403	hsa-miR-3679-3p	CLIP-seq
MIRT2434304	hsa-miR-3691-5p	CLIP-seq
MIRT1449416	hsa-miR-375	CLIP-seq
MIRT1555140	hsa-miR-381	CLIP-seq
MIRT2434305	hsa-miR-3936	CLIP-seq
MIRT1449418	hsa-miR-3973	CLIP-seq
MIRT2355681	hsa-miR-4269	CLIP-seq
MIRT2134404	hsa-miR-4286	CLIP-seq
MIRT1449420	hsa-miR-4445	CLIP-seq
MIRT2134405	hsa-miR-4446-5p	CLIP-seq
MIRT2355682	hsa-miR-4452	CLIP-seq
MIRT2434306	hsa-miR-4474-5p	CLIP-seq
MIRT1449421	hsa-miR-4477b	CLIP-seq
MIRT1449423	hsa-miR-4491	CLIP-seq
MIRT1449424	hsa-miR-4504	CLIP-seq
MIRT2355683	hsa-miR-4514	CLIP-seq
MIRT1555141	hsa-miR-4528	CLIP-seq
MIRT1449425	hsa-miR-4639-5p	CLIP-seq
MIRT2355684	hsa-miR-4640-3p	CLIP-seq
MIRT1449426	hsa-miR-4645-3p	CLIP-seq
MIRT1449427	hsa-miR-4652-3p	CLIP-seq
MIRT1449428	hsa-miR-4657	CLIP-seq
MIRT1449429	hsa-miR-4659a-3p	CLIP-seq
MIRT1449430	hsa-miR-4659b-3p	CLIP-seq
MIRT1555142	hsa-miR-4666-3p	CLIP-seq
MIRT1449431	hsa-miR-4677-3p	CLIP-seq
MIRT1449432	hsa-miR-4679	CLIP-seq
MIRT2355685	hsa-miR-4692	CLIP-seq
MIRT2434307	hsa-miR-4713-3p	CLIP-seq
MIRT1449434	hsa-miR-4716-3p	CLIP-seq
MIRT1449435	hsa-miR-4732-3p	CLIP-seq
MIRT2355686	hsa-miR-4742-5p	CLIP-seq
MIRT2434308	hsa-miR-4752	CLIP-seq
MIRT2434309	hsa-miR-4764-5p	CLIP-seq
MIRT2355687	hsa-miR-4774-5p	CLIP-seq
MIRT1449436	hsa-miR-4778-3p	CLIP-seq
MIRT1449437	hsa-miR-4782-3p	CLIP-seq
MIRT1555143	hsa-miR-4789-5p	CLIP-seq
MIRT1449441	hsa-miR-508-3p	CLIP-seq
MIRT1449442	hsa-miR-513c	CLIP-seq
MIRT1449443	hsa-miR-514b-5p	CLIP-seq
MIRT1449445	hsa-miR-520g	CLIP-seq
MIRT1449446	hsa-miR-520h	CLIP-seq
MIRT1449448	hsa-miR-542-3p	CLIP-seq
MIRT1449449	hsa-miR-548a-3p	CLIP-seq
MIRT1449450	hsa-miR-548a-5p	CLIP-seq
MIRT1449451	hsa-miR-548ab	CLIP-seq
MIRT1449452	hsa-miR-548ak	CLIP-seq
MIRT1449453	hsa-miR-548b-5p	CLIP-seq
MIRT1449454	hsa-miR-548c-5p	CLIP-seq
MIRT1449455	hsa-miR-548d-5p	CLIP-seq
MIRT1449456	hsa-miR-548e	CLIP-seq
MIRT1449457	hsa-miR-548f	CLIP-seq
MIRT1449458	hsa-miR-548h	CLIP-seq
MIRT1449459	hsa-miR-548i	CLIP-seq
MIRT1449460	hsa-miR-548j	CLIP-seq
MIRT1449461	hsa-miR-548n	CLIP-seq
MIRT1449462	hsa-miR-548t	CLIP-seq
MIRT1449463	hsa-miR-548w	CLIP-seq
MIRT1449464	hsa-miR-548y	CLIP-seq
MIRT1449467	hsa-miR-559	CLIP-seq
MIRT1449468	hsa-miR-562	CLIP-seq
MIRT1449469	hsa-miR-567	CLIP-seq
MIRT2434310	hsa-miR-581	CLIP-seq
MIRT1555144	hsa-miR-587	CLIP-seq
MIRT2434311	hsa-miR-643	CLIP-seq
MIRT1449471	hsa-miR-653	CLIP-seq
MIRT2134406	hsa-miR-676	CLIP-seq
MIRT1449472	hsa-miR-921	CLIP-seq
MIRT2649236	hsa-miR-105	CLIP-seq
MIRT2649237	hsa-miR-1207-3p	CLIP-seq
MIRT2649238	hsa-miR-124	CLIP-seq
MIRT2649239	hsa-miR-1254	CLIP-seq
MIRT2649240	hsa-miR-128	CLIP-seq
MIRT2649241	hsa-miR-149	CLIP-seq
MIRT2649242	hsa-miR-2467-3p	CLIP-seq
MIRT2649243	hsa-miR-3116	CLIP-seq
MIRT2649244	hsa-miR-3135b	CLIP-seq
MIRT1449410	hsa-miR-3182	CLIP-seq
MIRT2649245	hsa-miR-338-5p	CLIP-seq
MIRT2649246	hsa-miR-3670	CLIP-seq
MIRT2649247	hsa-miR-3678-3p	CLIP-seq
MIRT2649248	hsa-miR-3686	CLIP-seq
MIRT2649249	hsa-miR-3714	CLIP-seq
MIRT2649250	hsa-miR-3910	CLIP-seq
MIRT2649251	hsa-miR-3919	CLIP-seq
MIRT2649252	hsa-miR-3925-5p	CLIP-seq
MIRT2649253	hsa-miR-4302	CLIP-seq
MIRT2649254	hsa-miR-4434	CLIP-seq
MIRT2649255	hsa-miR-4516	CLIP-seq
MIRT2649256	hsa-miR-4521	CLIP-seq
MIRT2649257	hsa-miR-4531	CLIP-seq
MIRT1449425	hsa-miR-4639-5p	CLIP-seq
MIRT2649258	hsa-miR-4648	CLIP-seq
MIRT2649259	hsa-miR-4756-3p	CLIP-seq
MIRT2649260	hsa-miR-506	CLIP-seq
MIRT2649261	hsa-miR-550a	CLIP-seq
MIRT2649262	hsa-miR-589	CLIP-seq
MIRT2649263	hsa-miR-661	CLIP-seq
MIRT2649264	hsa-miR-760	CLIP-seq
MIRT2649265	hsa-miR-940	CLIP-seq
MIRT2649236	hsa-miR-105	CLIP-seq
MIRT2649237	hsa-miR-1207-3p	CLIP-seq
MIRT2649238	hsa-miR-124	CLIP-seq
MIRT2649239	hsa-miR-1254	CLIP-seq
MIRT2649240	hsa-miR-128	CLIP-seq
MIRT2693946	hsa-miR-1302	CLIP-seq
MIRT2649241	hsa-miR-149	CLIP-seq
MIRT2649242	hsa-miR-2467-3p	CLIP-seq
MIRT2649243	hsa-miR-3116	CLIP-seq
MIRT2649244	hsa-miR-3135b	CLIP-seq
MIRT1449410	hsa-miR-3182	CLIP-seq
MIRT2649245	hsa-miR-338-5p	CLIP-seq
MIRT2649246	hsa-miR-3670	CLIP-seq
MIRT2649247	hsa-miR-3678-3p	CLIP-seq
MIRT2649248	hsa-miR-3686	CLIP-seq
MIRT2649249	hsa-miR-3714	CLIP-seq
MIRT2649250	hsa-miR-3910	CLIP-seq
MIRT2649251	hsa-miR-3919	CLIP-seq
MIRT2649252	hsa-miR-3925-5p	CLIP-seq
MIRT2693947	hsa-miR-4298	CLIP-seq
MIRT2649253	hsa-miR-4302	CLIP-seq
MIRT2649254	hsa-miR-4434	CLIP-seq
MIRT2649255	hsa-miR-4516	CLIP-seq
MIRT2649256	hsa-miR-4521	CLIP-seq
MIRT2649257	hsa-miR-4531	CLIP-seq
MIRT1449425	hsa-miR-4639-5p	CLIP-seq
MIRT2649258	hsa-miR-4648	CLIP-seq
MIRT2649259	hsa-miR-4756-3p	CLIP-seq
MIRT2649260	hsa-miR-506	CLIP-seq
MIRT2649261	hsa-miR-550a	CLIP-seq
MIRT2649262	hsa-miR-589	CLIP-seq
MIRT2649263	hsa-miR-661	CLIP-seq
MIRT2649264	hsa-miR-760	CLIP-seq
MIRT2649265	hsa-miR-940	CLIP-seq

Show/Hide all(43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	IDA	12686598
GO:0003065	Process	Positive regulation of heart rate by epinephrine	ISS	17556658
GO:0003779	Function	Actin binding	TAS	12686598
GO:0005200	Function	Structural constituent of cytoskeleton	TAS	12686598
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 25416956, 26871637
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	TAS	16130169
GO:0005862	Component	Muscle thin filament tropomyosin	TAS	8205619
GO:0005884	Component	Actin filament	IBA	21873635
GO:0006936	Process	Muscle contraction	IBA	21873635
GO:0006936	Process	Muscle contraction	TAS
GO:0006937	Process	Regulation of muscle contraction	TAS	3336363
GO:0007010	Process	Cytoskeleton organization	TAS	12686598
GO:0007015	Process	Actin filament organization	IBA	21873635
GO:0008016	Process	Regulation of heart contraction	TAS	8205619
GO:0008092	Function	Cytoskeletal protein binding	IPI	17987659
GO:0008307	Function	Structural constituent of muscle	TAS	8205619
GO:0008360	Process	Regulation of cell shape	IMP	21817107
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0030017	Component	Sarcomere	TAS	16754800
GO:0030049	Process	Muscle filament sliding	ISS	11136687
GO:0030049	Process	Muscle filament sliding	TAS
GO:0030336	Process	Negative regulation of cell migration	ISS	15897890
GO:0031529	Process	Ruffle organization	ISS	15897890
GO:0032059	Component	Bleb	IMP	12686598
GO:0032587	Component	Ruffle membrane	IDA	12686598
GO:0032781	Process	Positive regulation of ATPase activity	ISS	11136687
GO:0034614	Process	Cellular response to reactive oxygen species	IEP	12686598
GO:0042060	Process	Wound healing	ISS	17721995
GO:0042802	Function	Identical protein binding	ISS
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0045214	Process	Sarcomere organization	IMP	11273725
GO:0045785	Process	Positive regulation of cell adhesion	ISS	17721995
GO:0046982	Function	Protein heterodimerization activity	ISS
GO:0051015	Function	Actin filament binding	IBA	21873635
GO:0051015	Function	Actin filament binding	ISS
GO:0051496	Process	Positive regulation of stress fiber assembly	ISS	15897890
GO:0055010	Process	Ventricular cardiac muscle tissue morphogenesis	IMP	11136687
GO:0060048	Process	Cardiac muscle contraction	IBA	21873635
GO:0060048	Process	Cardiac muscle contraction	IMP	11136687
GO:1904706	Process	Negative regulation of vascular associated smooth muscle cell proliferation	IMP	21817107
GO:1904753	Process	Negative regulation of vascular associated smooth muscle cell migration	IMP	21817107

MIM	HGNC	e!Ensembl
191010	12010	ENSG00000140416

Protein

UniProt ID

P09493

Protein name

Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)

Protein function

Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth mu

PDB

3MUD , 5KHT , 6UT2 , 6X5Z , 7UTI , 7UTL , 8EFH , 8EFI , 8ENC , 8ZB7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00261	Tropomyosin	48 → 284	Tropomyosin	Coiled-coil

Sequence

MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKY
SEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA
DESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAE
ERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAE
FAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI

Sequence length

284

Interactions

View interactions

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