Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
7133 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
TNF receptor superfamily member 1B |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
TNFRSF1B |
SynonymsGene synonyms aliases
|
CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR |
ChromosomeChromosome number
|
1 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
1p36.22 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
JUN |
Activation |
9743209 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P20333 |
Protein name |
Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis fac |
Protein function |
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor media |
PDB |
1CA9
,
3ALQ
,
8HLB
,
9CU8
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00020 |
TNFR_c6 |
40 → 75 |
TNFR/NGFR cysteine-rich region |
Domain |
PF00020 |
TNFR_c6 |
78 → 118 |
TNFR/NGFR cysteine-rich region |
Domain |
PF00020 |
TNFR_c6 |
120 → 161 |
TNFR/NGFR cysteine-rich region |
Domain |
|
Sequence |
|
Sequence length |
461 |
Interactions |
View interactions |