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THBD (thrombomodulin)

Gene

7056

Thrombomodulin

THBD

AHUS6, BDCA-3, BDCA3, CD141, THPH12, THRM, TM

20p11.21

The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin gener

Show/Hide all(10)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1800576	C>T	Conflicting-interpretations-of-pathogenicity, risk-factor, likely-benign	Missense variant, coding sequence variant
rs1800578	G>A,T	Risk-factor, likely-benign	Missense variant, coding sequence variant
rs1800579	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign	Missense variant, coding sequence variant
rs16984852	C>A	Pathogenic	5 prime UTR variant
rs121918667	T>C	Risk-factor	Coding sequence variant, missense variant
rs398122807	C>A	Pathogenic	Coding sequence variant, missense variant
rs1347587434	G>A,T	Likely-pathogenic	Synonymous variant, stop gained, coding sequence variant
rs1600409143	G>T	Likely-pathogenic	Stop gained, coding sequence variant
rs1600409323	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1600410451	C>-	Likely-pathogenic	Coding sequence variant, frameshift variant

Show/Hide all(174)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017044	hsa-miR-335-5p	Microarray	18185580
MIRT024294	hsa-miR-215-5p	Microarray	19074876
MIRT026159	hsa-miR-192-5p	Microarray	19074876
MIRT636182	hsa-miR-4436b-3p	HITS-CLIP	23824327
MIRT636181	hsa-miR-4632-5p	HITS-CLIP	23824327
MIRT636180	hsa-miR-6735-5p	HITS-CLIP	23824327
MIRT636178	hsa-miR-6879-5p	HITS-CLIP	23824327
MIRT636179	hsa-miR-7843-5p	HITS-CLIP	23824327
MIRT636177	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT636176	hsa-miR-3127-5p	HITS-CLIP	23824327
MIRT639318	hsa-miR-578	HITS-CLIP	23824327
MIRT636182	hsa-miR-4436b-3p	HITS-CLIP	23824327
MIRT636181	hsa-miR-4632-5p	HITS-CLIP	23824327
MIRT636180	hsa-miR-6735-5p	HITS-CLIP	23824327
MIRT636178	hsa-miR-6879-5p	HITS-CLIP	23824327
MIRT636179	hsa-miR-7843-5p	HITS-CLIP	23824327
MIRT639322	hsa-miR-6132	HITS-CLIP	23824327
MIRT639321	hsa-miR-6836-5p	HITS-CLIP	23824327
MIRT636177	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT639320	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT639319	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT636176	hsa-miR-3127-5p	HITS-CLIP	23824327
MIRT639318	hsa-miR-578	HITS-CLIP	23824327
MIRT636182	hsa-miR-4436b-3p	HITS-CLIP	23824327
MIRT636181	hsa-miR-4632-5p	HITS-CLIP	23824327
MIRT636180	hsa-miR-6735-5p	HITS-CLIP	23824327
MIRT636178	hsa-miR-6879-5p	HITS-CLIP	23824327
MIRT636179	hsa-miR-7843-5p	HITS-CLIP	23824327
MIRT636177	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT636176	hsa-miR-3127-5p	HITS-CLIP	23824327
MIRT636182	hsa-miR-4436b-3p	HITS-CLIP	23824327
MIRT636181	hsa-miR-4632-5p	HITS-CLIP	23824327
MIRT636180	hsa-miR-6735-5p	HITS-CLIP	23824327
MIRT636178	hsa-miR-6879-5p	HITS-CLIP	23824327
MIRT636179	hsa-miR-7843-5p	HITS-CLIP	23824327
MIRT636177	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT636176	hsa-miR-3127-5p	HITS-CLIP	23824327
MIRT639318	hsa-miR-578	HITS-CLIP	23824327
MIRT636182	hsa-miR-4436b-3p	HITS-CLIP	23824327
MIRT636181	hsa-miR-4632-5p	HITS-CLIP	23824327
MIRT636180	hsa-miR-6735-5p	HITS-CLIP	23824327
MIRT636178	hsa-miR-6879-5p	HITS-CLIP	23824327
MIRT636179	hsa-miR-7843-5p	HITS-CLIP	23824327
MIRT639322	hsa-miR-6132	HITS-CLIP	23824327
MIRT639321	hsa-miR-6836-5p	HITS-CLIP	23824327
MIRT636177	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT639320	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT639319	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT636176	hsa-miR-3127-5p	HITS-CLIP	23824327
MIRT639318	hsa-miR-578	HITS-CLIP	23824327
MIRT636182	hsa-miR-4436b-3p	HITS-CLIP	23824327
MIRT636181	hsa-miR-4632-5p	HITS-CLIP	23824327
MIRT636180	hsa-miR-6735-5p	HITS-CLIP	23824327
MIRT636178	hsa-miR-6879-5p	HITS-CLIP	23824327
MIRT636179	hsa-miR-7843-5p	HITS-CLIP	23824327
MIRT636177	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT636176	hsa-miR-3127-5p	HITS-CLIP	23824327
MIRT1422762	hsa-miR-1182	CLIP-seq
MIRT1422763	hsa-miR-1193	CLIP-seq
MIRT1422764	hsa-miR-1202	CLIP-seq
MIRT1422765	hsa-miR-1208	CLIP-seq
MIRT1422766	hsa-miR-1243	CLIP-seq
MIRT1422767	hsa-miR-1275	CLIP-seq
MIRT1422768	hsa-miR-1298	CLIP-seq
MIRT1422769	hsa-miR-1323	CLIP-seq
MIRT1422770	hsa-miR-18a	CLIP-seq
MIRT1422771	hsa-miR-18b	CLIP-seq
MIRT1422772	hsa-miR-193a-5p	CLIP-seq
MIRT1422773	hsa-miR-19a	CLIP-seq
MIRT1422774	hsa-miR-19b	CLIP-seq
MIRT1422775	hsa-miR-2053	CLIP-seq
MIRT1422776	hsa-miR-21	CLIP-seq
MIRT1422777	hsa-miR-3065-5p	CLIP-seq
MIRT1422778	hsa-miR-3120-3p	CLIP-seq
MIRT1422779	hsa-miR-3155	CLIP-seq
MIRT1422780	hsa-miR-3155b	CLIP-seq
MIRT1422781	hsa-miR-3167	CLIP-seq
MIRT1422782	hsa-miR-3194-5p	CLIP-seq
MIRT1422783	hsa-miR-320a	CLIP-seq
MIRT1422784	hsa-miR-320b	CLIP-seq
MIRT1422785	hsa-miR-320c	CLIP-seq
MIRT1422786	hsa-miR-320d	CLIP-seq
MIRT1422787	hsa-miR-320e	CLIP-seq
MIRT1422788	hsa-miR-342-5p	CLIP-seq
MIRT1422789	hsa-miR-3545-3p	CLIP-seq
MIRT1422790	hsa-miR-365	CLIP-seq
MIRT1422791	hsa-miR-3653	CLIP-seq
MIRT1422792	hsa-miR-3654	CLIP-seq
MIRT1422793	hsa-miR-3681	CLIP-seq
MIRT1422794	hsa-miR-384	CLIP-seq
MIRT1422795	hsa-miR-3925-3p	CLIP-seq
MIRT1422796	hsa-miR-3972	CLIP-seq
MIRT1422797	hsa-miR-4267	CLIP-seq
MIRT1422798	hsa-miR-4275	CLIP-seq
MIRT1422799	hsa-miR-4284	CLIP-seq
MIRT1422800	hsa-miR-4317	CLIP-seq
MIRT1422801	hsa-miR-4429	CLIP-seq
MIRT1422802	hsa-miR-4466	CLIP-seq
MIRT1422803	hsa-miR-452	CLIP-seq
MIRT1422804	hsa-miR-4651	CLIP-seq
MIRT1422805	hsa-miR-4659a-5p	CLIP-seq
MIRT1422806	hsa-miR-4659b-5p	CLIP-seq
MIRT1422807	hsa-miR-4664-5p	CLIP-seq
MIRT1422808	hsa-miR-4665-5p	CLIP-seq
MIRT1422809	hsa-miR-4676-3p	CLIP-seq
MIRT1422810	hsa-miR-4699-5p	CLIP-seq
MIRT1422811	hsa-miR-4706	CLIP-seq
MIRT1422812	hsa-miR-4711-3p	CLIP-seq
MIRT1422813	hsa-miR-4728-5p	CLIP-seq
MIRT1422814	hsa-miR-4731-5p	CLIP-seq
MIRT1422815	hsa-miR-4735-3p	CLIP-seq
MIRT1422816	hsa-miR-4749-5p	CLIP-seq
MIRT1422817	hsa-miR-4766-3p	CLIP-seq
MIRT1422818	hsa-miR-4776-3p	CLIP-seq
MIRT1422819	hsa-miR-4796-3p	CLIP-seq
MIRT1422820	hsa-miR-484	CLIP-seq
MIRT1422821	hsa-miR-515-5p	CLIP-seq
MIRT1422822	hsa-miR-518a-5p	CLIP-seq
MIRT1422823	hsa-miR-520d-5p	CLIP-seq
MIRT1422824	hsa-miR-520g	CLIP-seq
MIRT1422825	hsa-miR-520h	CLIP-seq
MIRT1422826	hsa-miR-524-5p	CLIP-seq
MIRT1422827	hsa-miR-527	CLIP-seq
MIRT1422828	hsa-miR-548o	CLIP-seq
MIRT1422829	hsa-miR-548p	CLIP-seq
MIRT1422830	hsa-miR-552	CLIP-seq
MIRT1422831	hsa-miR-590-5p	CLIP-seq
MIRT1422832	hsa-miR-608	CLIP-seq
MIRT1422833	hsa-miR-622	CLIP-seq
MIRT1422834	hsa-miR-637	CLIP-seq
MIRT1422835	hsa-miR-675	CLIP-seq
MIRT1422836	hsa-miR-744	CLIP-seq
MIRT1422837	hsa-miR-766	CLIP-seq
MIRT1422838	hsa-miR-876-5p	CLIP-seq
MIRT1422839	hsa-miR-9	CLIP-seq
MIRT1422840	hsa-miR-942	CLIP-seq
MIRT1422800	hsa-miR-4317	CLIP-seq
MIRT1422805	hsa-miR-4659a-5p	CLIP-seq
MIRT1422806	hsa-miR-4659b-5p	CLIP-seq
MIRT1920970	hsa-miR-4670-3p	CLIP-seq
MIRT1920971	hsa-miR-4731-3p	CLIP-seq
MIRT1422818	hsa-miR-4776-3p	CLIP-seq
MIRT1920972	hsa-miR-4801	CLIP-seq
MIRT1422800	hsa-miR-4317	CLIP-seq
MIRT1422805	hsa-miR-4659a-5p	CLIP-seq
MIRT1422806	hsa-miR-4659b-5p	CLIP-seq
MIRT1920970	hsa-miR-4670-3p	CLIP-seq
MIRT1920971	hsa-miR-4731-3p	CLIP-seq
MIRT1422818	hsa-miR-4776-3p	CLIP-seq
MIRT1920972	hsa-miR-4801	CLIP-seq
MIRT1920970	hsa-miR-4670-3p	CLIP-seq
MIRT1920971	hsa-miR-4731-3p	CLIP-seq
MIRT1920972	hsa-miR-4801	CLIP-seq
MIRT1422762	hsa-miR-1182	CLIP-seq
MIRT1422790	hsa-miR-365	CLIP-seq
MIRT1422813	hsa-miR-4728-5p	CLIP-seq
MIRT1422821	hsa-miR-515-5p	CLIP-seq
MIRT2348622	hsa-miR-3166	CLIP-seq
MIRT2348623	hsa-miR-3609	CLIP-seq
MIRT2348624	hsa-miR-4468	CLIP-seq
MIRT1422821	hsa-miR-515-5p	CLIP-seq
MIRT2348625	hsa-miR-548ah	CLIP-seq
MIRT2348626	hsa-miR-548t	CLIP-seq
MIRT1422840	hsa-miR-942	CLIP-seq
MIRT2395783	hsa-miR-4661-3p	CLIP-seq
MIRT2395784	hsa-miR-665	CLIP-seq
MIRT1422769	hsa-miR-1323	CLIP-seq
MIRT2641740	hsa-miR-4299	CLIP-seq
MIRT2641741	hsa-miR-4456	CLIP-seq
MIRT2641742	hsa-miR-4762-5p	CLIP-seq
MIRT1422817	hsa-miR-4766-3p	CLIP-seq
MIRT1422828	hsa-miR-548o	CLIP-seq
MIRT1422829	hsa-miR-548p	CLIP-seq
MIRT2641743	hsa-miR-548q	CLIP-seq

Transcription factors

Show/Hide all(14)

Transcription factor	Regulation	Reference
EP300	Repression	15677570
KLF2	Activation	19661484
KLF4	Activation	19661484
NFKB1	Repression	17211835;22406829
PARP1	Activation	21489980
PARP1	Repression	21489980
RARA	Activation	9269772
RARA	Unknown	11036068
RARB	Unknown	11036068
RARG	Unknown	11036068
RELA	Repression	17211835;22406829
RXRA	Unknown	11036068
SP1	Activation	22406829
SP1	Unknown	11036068

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	14691232, 17379830, 32296183
GO:0005615	Component	Extracellular space	IEA
GO:0005774	Component	Vacuolar membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IEA
GO:0007565	Process	Female pregnancy	IEA
GO:0007596	Process	Blood coagulation	TAS
GO:0009897	Component	External side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IDA	17379830
GO:0010165	Process	Response to X-ray	IEA
GO:0010544	Process	Negative regulation of platelet activation	TAS	17379830
GO:0016327	Component	Apicolateral plasma membrane	IEA
GO:0030195	Process	Negative regulation of blood coagulation	TAS	17379830
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0038023	Function	Signaling receptor activity	TAS	2822087
GO:0050900	Process	Leukocyte migration	TAS
GO:0051591	Process	Response to cAMP	IEA
GO:0051918	Process	Negative regulation of fibrinolysis	TAS	17379830

MIM	HGNC	e!Ensembl
188040	11784	ENSG00000178726

Protein

UniProt ID

P07204

Protein name

Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141)

Protein function

Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis (PubMed:10761923). Acts as a cofactor for thrombin activation of p

PDB

1ADX , 1DQB , 1DX5 , 1EGT , 1FGD , 1FGE , 1HLT , 1TMR , 1ZAQ , 2ADX , 3GIS , 5TO3 , 7T4R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00059	Lectin_C	41 → 169	Lectin C-type domain	Domain
PF14670	FXa_inhibition	245 → 280		Domain
PF12662	cEGF	305 → 328	Complement Clr-like EGF-like	Domain

Sequence

MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLM
TVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYS
RWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAV
EPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAP
GAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNP
DQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDG
ECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPN
TQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDC
DSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLR
KKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL

Sequence length

575

Interactions

View interactions

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