TCF7L1 (transcription factor 7 like 1)

Gene

• Entrez ID: 83439
• Gene name: Transcription factor 7 like 1
• Gene symbol: TCF7L1
• Synonyms: -
• Chromosome: 2
• Chromosome location: 2p11.2
• Summary: This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor be

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016640	hsa-miR-429	Reporter assay	20005803
MIRT020351	hsa-miR-200a-3p	Reporter assay	20005803
MIRT021073	hsa-miR-200c-3p	Reporter assay	20005803
MIRT021652	hsa-miR-141-3p	Reporter assay	20005803
MIRT024127	hsa-miR-200b-3p	Reporter assay	20005803
MIRT755664	hsa-miR-185-3p	Luciferase reporter assay	36271413
MIRT1416450	hsa-miR-1207-5p	CLIP-seq
MIRT1416451	hsa-miR-3915	CLIP-seq
MIRT1416452	hsa-miR-3928	CLIP-seq
MIRT1416453	hsa-miR-4269	CLIP-seq
MIRT1416454	hsa-miR-4736	CLIP-seq
MIRT1416455	hsa-miR-4763-3p	CLIP-seq
MIRT1416456	hsa-miR-4795-5p	CLIP-seq
MIRT1554521	hsa-miR-3160-5p	CLIP-seq
MIRT1554522	hsa-miR-3942-3p	CLIP-seq
MIRT1554523	hsa-miR-4257	CLIP-seq
MIRT1554524	hsa-miR-4315	CLIP-seq
MIRT1554525	hsa-miR-4751	CLIP-seq
MIRT1554526	hsa-miR-515-5p	CLIP-seq
MIRT2124881	hsa-miR-125a-3p	CLIP-seq
MIRT2124882	hsa-miR-1289	CLIP-seq
MIRT2124883	hsa-miR-132	CLIP-seq
MIRT2124884	hsa-miR-198	CLIP-seq
MIRT2124885	hsa-miR-212	CLIP-seq
MIRT2124886	hsa-miR-3158-5p	CLIP-seq
MIRT2124887	hsa-miR-3185	CLIP-seq
MIRT2124888	hsa-miR-3198	CLIP-seq
MIRT2124889	hsa-miR-4271	CLIP-seq
MIRT2124890	hsa-miR-4294	CLIP-seq
MIRT2124891	hsa-miR-4309	CLIP-seq
MIRT2124892	hsa-miR-4534	CLIP-seq
MIRT2124893	hsa-miR-455-3p	CLIP-seq
MIRT2124894	hsa-miR-4725-3p	CLIP-seq
MIRT2124895	hsa-miR-4726-3p	CLIP-seq
MIRT2124896	hsa-miR-4773	CLIP-seq
MIRT2124897	hsa-miR-4785	CLIP-seq
MIRT2124898	hsa-miR-520a-5p	CLIP-seq
MIRT2124899	hsa-miR-525-5p	CLIP-seq
MIRT2124900	hsa-miR-542-3p	CLIP-seq
MIRT2124901	hsa-miR-542-5p	CLIP-seq
MIRT2124902	hsa-miR-558	CLIP-seq
MIRT2124903	hsa-miR-564	CLIP-seq
MIRT2124904	hsa-miR-711	CLIP-seq
MIRT2124905	hsa-miR-759	CLIP-seq
MIRT1416450	hsa-miR-1207-5p	CLIP-seq
MIRT2124881	hsa-miR-125a-3p	CLIP-seq
MIRT2347291	hsa-miR-1285	CLIP-seq
MIRT2124882	hsa-miR-1289	CLIP-seq
MIRT2347292	hsa-miR-1909	CLIP-seq
MIRT2347293	hsa-miR-2467-3p	CLIP-seq
MIRT2347294	hsa-miR-31	CLIP-seq
MIRT2347295	hsa-miR-3128	CLIP-seq
MIRT2124886	hsa-miR-3158-5p	CLIP-seq
MIRT2347296	hsa-miR-3179	CLIP-seq
MIRT2124887	hsa-miR-3185	CLIP-seq
MIRT2347297	hsa-miR-3187-5p	CLIP-seq
MIRT2347298	hsa-miR-3192	CLIP-seq
MIRT2124888	hsa-miR-3198	CLIP-seq
MIRT2347299	hsa-miR-320e	CLIP-seq
MIRT2347300	hsa-miR-326	CLIP-seq
MIRT2347301	hsa-miR-330-5p	CLIP-seq
MIRT2347302	hsa-miR-342-3p	CLIP-seq
MIRT2347303	hsa-miR-3611	CLIP-seq
MIRT2347304	hsa-miR-3675-5p	CLIP-seq
MIRT2347305	hsa-miR-3937	CLIP-seq
MIRT2347306	hsa-miR-4252	CLIP-seq
MIRT2124889	hsa-miR-4271	CLIP-seq
MIRT2124890	hsa-miR-4294	CLIP-seq
MIRT2124891	hsa-miR-4309	CLIP-seq
MIRT2347307	hsa-miR-4314	CLIP-seq
MIRT2347308	hsa-miR-4461	CLIP-seq
MIRT2347309	hsa-miR-4468	CLIP-seq
MIRT2124892	hsa-miR-4534	CLIP-seq
MIRT2347310	hsa-miR-4646-5p	CLIP-seq
MIRT2124894	hsa-miR-4725-3p	CLIP-seq
MIRT2124895	hsa-miR-4726-3p	CLIP-seq
MIRT2347311	hsa-miR-4731-5p	CLIP-seq
MIRT2347312	hsa-miR-4757-5p	CLIP-seq
MIRT1416455	hsa-miR-4763-3p	CLIP-seq
MIRT2124897	hsa-miR-4785	CLIP-seq
MIRT2347313	hsa-miR-486-3p	CLIP-seq
MIRT2124900	hsa-miR-542-3p	CLIP-seq
MIRT2124901	hsa-miR-542-5p	CLIP-seq
MIRT2347314	hsa-miR-548b-3p	CLIP-seq
MIRT2124902	hsa-miR-558	CLIP-seq
MIRT2124903	hsa-miR-564	CLIP-seq
MIRT2347315	hsa-miR-591	CLIP-seq
MIRT2347316	hsa-miR-612	CLIP-seq
MIRT2124904	hsa-miR-711	CLIP-seq
MIRT2461240	hsa-miR-329	CLIP-seq
MIRT2461241	hsa-miR-362-3p	CLIP-seq
MIRT2461242	hsa-miR-3941	CLIP-seq
MIRT2461243	hsa-miR-548ac	CLIP-seq
MIRT2461244	hsa-miR-548ae	CLIP-seq
MIRT2461245	hsa-miR-548aj	CLIP-seq
MIRT2461246	hsa-miR-548am	CLIP-seq
MIRT2461247	hsa-miR-548d-3p	CLIP-seq
MIRT2461248	hsa-miR-548x	CLIP-seq
MIRT2461249	hsa-miR-548z	CLIP-seq
MIRT2461250	hsa-miR-603	CLIP-seq
MIRT1416450	hsa-miR-1207-5p	CLIP-seq
MIRT2124881	hsa-miR-125a-3p	CLIP-seq
MIRT2347291	hsa-miR-1285	CLIP-seq
MIRT2124882	hsa-miR-1289	CLIP-seq
MIRT2640266	hsa-miR-1321	CLIP-seq
MIRT2640267	hsa-miR-138	CLIP-seq
MIRT2640268	hsa-miR-1587	CLIP-seq
MIRT2347292	hsa-miR-1909	CLIP-seq
MIRT2640269	hsa-miR-194	CLIP-seq
MIRT2640270	hsa-miR-204	CLIP-seq
MIRT2640271	hsa-miR-211	CLIP-seq
MIRT2640272	hsa-miR-2114	CLIP-seq
MIRT2347293	hsa-miR-2467-3p	CLIP-seq
MIRT2347294	hsa-miR-31	CLIP-seq
MIRT2640273	hsa-miR-3126-5p	CLIP-seq
MIRT2347295	hsa-miR-3128	CLIP-seq
MIRT2124886	hsa-miR-3158-5p	CLIP-seq
MIRT1554521	hsa-miR-3160-5p	CLIP-seq
MIRT2347296	hsa-miR-3179	CLIP-seq
MIRT2640274	hsa-miR-3181	CLIP-seq
MIRT2124887	hsa-miR-3185	CLIP-seq
MIRT2347297	hsa-miR-3187-5p	CLIP-seq
MIRT2640275	hsa-miR-3191	CLIP-seq
MIRT2347298	hsa-miR-3192	CLIP-seq
MIRT2124888	hsa-miR-3198	CLIP-seq
MIRT2640276	hsa-miR-320a	CLIP-seq
MIRT2640277	hsa-miR-320b	CLIP-seq
MIRT2640278	hsa-miR-320c	CLIP-seq
MIRT2640279	hsa-miR-320d	CLIP-seq
MIRT2347299	hsa-miR-320e	CLIP-seq
MIRT2347300	hsa-miR-326	CLIP-seq
MIRT2347301	hsa-miR-330-5p	CLIP-seq
MIRT2347303	hsa-miR-3611	CLIP-seq
MIRT2640280	hsa-miR-3689a-3p	CLIP-seq
MIRT2640281	hsa-miR-3689c	CLIP-seq
MIRT1416452	hsa-miR-3928	CLIP-seq
MIRT2347305	hsa-miR-3937	CLIP-seq
MIRT1554522	hsa-miR-3942-3p	CLIP-seq
MIRT2640282	hsa-miR-3944-3p	CLIP-seq
MIRT2347306	hsa-miR-4252	CLIP-seq
MIRT1554523	hsa-miR-4257	CLIP-seq
MIRT2124889	hsa-miR-4271	CLIP-seq
MIRT2640283	hsa-miR-4283	CLIP-seq
MIRT2124890	hsa-miR-4294	CLIP-seq
MIRT2124891	hsa-miR-4309	CLIP-seq
MIRT2347307	hsa-miR-4314	CLIP-seq
MIRT1554524	hsa-miR-4315	CLIP-seq
MIRT2640284	hsa-miR-4419a	CLIP-seq
MIRT2640285	hsa-miR-4425	CLIP-seq
MIRT2640286	hsa-miR-4429	CLIP-seq
MIRT2640287	hsa-miR-4456	CLIP-seq
MIRT2347308	hsa-miR-4461	CLIP-seq
MIRT2347309	hsa-miR-4468	CLIP-seq
MIRT2640288	hsa-miR-4489	CLIP-seq
MIRT2640289	hsa-miR-4492	CLIP-seq
MIRT2640290	hsa-miR-4496	CLIP-seq
MIRT2640291	hsa-miR-4498	CLIP-seq
MIRT2640292	hsa-miR-4505	CLIP-seq
MIRT2640293	hsa-miR-4510	CLIP-seq
MIRT2124892	hsa-miR-4534	CLIP-seq
MIRT2347310	hsa-miR-4646-5p	CLIP-seq
MIRT2640294	hsa-miR-4649-5p	CLIP-seq
MIRT2640295	hsa-miR-4656	CLIP-seq
MIRT2640296	hsa-miR-4674	CLIP-seq
MIRT2640297	hsa-miR-4675	CLIP-seq
MIRT2640298	hsa-miR-4706	CLIP-seq
MIRT2124894	hsa-miR-4725-3p	CLIP-seq
MIRT2124895	hsa-miR-4726-3p	CLIP-seq
MIRT2640299	hsa-miR-4728-5p	CLIP-seq
MIRT2347311	hsa-miR-4731-5p	CLIP-seq
MIRT2640300	hsa-miR-4739	CLIP-seq
MIRT2640301	hsa-miR-4741	CLIP-seq
MIRT2640302	hsa-miR-4749-5p	CLIP-seq
MIRT2640303	hsa-miR-4750	CLIP-seq
MIRT1554525	hsa-miR-4751	CLIP-seq
MIRT2640304	hsa-miR-4756-5p	CLIP-seq
MIRT1416455	hsa-miR-4763-3p	CLIP-seq
MIRT2640305	hsa-miR-4766-5p	CLIP-seq
MIRT2124897	hsa-miR-4785	CLIP-seq
MIRT2640306	hsa-miR-4787-5p	CLIP-seq
MIRT2347313	hsa-miR-486-3p	CLIP-seq
MIRT1554526	hsa-miR-515-5p	CLIP-seq
MIRT2124900	hsa-miR-542-3p	CLIP-seq
MIRT2124901	hsa-miR-542-5p	CLIP-seq
MIRT2347314	hsa-miR-548b-3p	CLIP-seq
MIRT2640307	hsa-miR-555	CLIP-seq
MIRT2124902	hsa-miR-558	CLIP-seq
MIRT2124903	hsa-miR-564	CLIP-seq
MIRT2640308	hsa-miR-570	CLIP-seq
MIRT2347316	hsa-miR-612	CLIP-seq
MIRT2640309	hsa-miR-627	CLIP-seq
MIRT2640310	hsa-miR-635	CLIP-seq
MIRT2124904	hsa-miR-711	CLIP-seq
MIRT2640311	hsa-miR-744	CLIP-seq
MIRT2640312	hsa-miR-762	CLIP-seq
MIRT1416450	hsa-miR-1207-5p	CLIP-seq
MIRT2692839	hsa-miR-1253	CLIP-seq
MIRT2347291	hsa-miR-1285	CLIP-seq
MIRT2124882	hsa-miR-1289	CLIP-seq
MIRT2640268	hsa-miR-1587	CLIP-seq
MIRT2347292	hsa-miR-1909	CLIP-seq
MIRT2640269	hsa-miR-194	CLIP-seq
MIRT2640270	hsa-miR-204	CLIP-seq
MIRT2640271	hsa-miR-211	CLIP-seq
MIRT2640272	hsa-miR-2114	CLIP-seq
MIRT2347293	hsa-miR-2467-3p	CLIP-seq
MIRT2124886	hsa-miR-3158-5p	CLIP-seq
MIRT1554521	hsa-miR-3160-5p	CLIP-seq
MIRT2124887	hsa-miR-3185	CLIP-seq
MIRT2347297	hsa-miR-3187-5p	CLIP-seq
MIRT2124888	hsa-miR-3198	CLIP-seq
MIRT2640276	hsa-miR-320a	CLIP-seq
MIRT2640277	hsa-miR-320b	CLIP-seq
MIRT2640278	hsa-miR-320c	CLIP-seq
MIRT2640279	hsa-miR-320d	CLIP-seq
MIRT2347299	hsa-miR-320e	CLIP-seq
MIRT2640280	hsa-miR-3689a-3p	CLIP-seq
MIRT2640281	hsa-miR-3689c	CLIP-seq
MIRT2347305	hsa-miR-3937	CLIP-seq
MIRT1554522	hsa-miR-3942-3p	CLIP-seq
MIRT1554523	hsa-miR-4257	CLIP-seq
MIRT2124889	hsa-miR-4271	CLIP-seq
MIRT2124890	hsa-miR-4294	CLIP-seq
MIRT2124891	hsa-miR-4309	CLIP-seq
MIRT1554524	hsa-miR-4315	CLIP-seq
MIRT2640285	hsa-miR-4425	CLIP-seq
MIRT2640286	hsa-miR-4429	CLIP-seq
MIRT2347308	hsa-miR-4461	CLIP-seq
MIRT2347309	hsa-miR-4468	CLIP-seq
MIRT2640289	hsa-miR-4492	CLIP-seq
MIRT2640290	hsa-miR-4496	CLIP-seq
MIRT2640291	hsa-miR-4498	CLIP-seq
MIRT2640292	hsa-miR-4505	CLIP-seq
MIRT2124892	hsa-miR-4534	CLIP-seq
MIRT2640294	hsa-miR-4649-5p	CLIP-seq
MIRT2640295	hsa-miR-4656	CLIP-seq
MIRT2640296	hsa-miR-4674	CLIP-seq
MIRT2640297	hsa-miR-4675	CLIP-seq
MIRT2640298	hsa-miR-4706	CLIP-seq
MIRT2124894	hsa-miR-4725-3p	CLIP-seq
MIRT2640299	hsa-miR-4728-5p	CLIP-seq
MIRT2347311	hsa-miR-4731-5p	CLIP-seq
MIRT2640301	hsa-miR-4741	CLIP-seq
MIRT2640302	hsa-miR-4749-5p	CLIP-seq
MIRT1554525	hsa-miR-4751	CLIP-seq
MIRT1416455	hsa-miR-4763-3p	CLIP-seq
MIRT2640305	hsa-miR-4766-5p	CLIP-seq
MIRT2692840	hsa-miR-4768-3p	CLIP-seq
MIRT2124897	hsa-miR-4785	CLIP-seq
MIRT2640306	hsa-miR-4787-5p	CLIP-seq
MIRT2347313	hsa-miR-486-3p	CLIP-seq
MIRT1554526	hsa-miR-515-5p	CLIP-seq
MIRT2124901	hsa-miR-542-5p	CLIP-seq
MIRT2347314	hsa-miR-548b-3p	CLIP-seq
MIRT2640307	hsa-miR-555	CLIP-seq
MIRT2124902	hsa-miR-558	CLIP-seq
MIRT2640308	hsa-miR-570	CLIP-seq
MIRT2347316	hsa-miR-612	CLIP-seq
MIRT2640309	hsa-miR-627	CLIP-seq
MIRT2640310	hsa-miR-635	CLIP-seq
MIRT2640311	hsa-miR-744	CLIP-seq
MIRT2640312	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0003677	Function	DNA binding	NAS	1741298, 11085512
GO:0003700	Function	DNA-binding transcription factor activity	NAS	1741298, 11085512
GO:0005634	Component	Nucleus	NAS	1741298, 11085512
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0006325	Process	Chromatin organization	NAS	1741298, 11085512
GO:0006355	Process	Regulation of transcription, DNA-templated	NAS	1741298, 11085512
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0008013	Function	Beta-catenin binding	IEA
GO:0030111	Process	Regulation of Wnt signaling pathway	NAS	1741298, 11085512
GO:0060070	Process	Canonical Wnt signaling pathway	IBA	21873635
GO:1904837	Process	Beta-catenin-TCF complex assembly	TAS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:1990907	Component	Beta-catenin-TCF complex	IBA	21873635

Other IDs

• MIM: 604652
• HGNC: 11640
• e!Ensembl: ENSG00000152284

Protein

• UniProt ID: Q9HCS4
• Protein name: Transcription factor 7-like 1 (HMG box transcription factor 3) (TCF-3)
• Protein function: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08347	CTNNB1_binding	1 → 250	N-terminal CTNNB1 binding	Family
  PF00505	HMG_box	346 → 414	HMG (high mobility group) box	Domain

• Sequence:

  MPQLGGGGGGGGGGSGGGGGSSAGAAGGGDDLGANDELIPFQDEGGEEQEPSSDSASAQR
  DLDEVKSSLVNESENQSSSSDSEAERRPQPVRDTFQKPRDYFAEVRRPQDSAFFKGPPYP
  GYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLSNKVP
  VVQHPHHMHPLTPLITYSNDHFSPGSPPTHLSPEIDPKTGIPRPPHPSELSPYYPLSPGA
  VGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMNASMSSLVSSRFSPHMVAPAHPGL
  PTSGIPHPAIVSPIVKQEPAPPSLSPAVSVKSPVTVKKEEEKKPHVKKPLNAFMLYMKEM
  RAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHSQLYPTWSARDNYG
  KKKKRKREKQLSQTQSQQQVQEAEGALASKSKKPCVQYLPPEKPCDSPASSHGSMLDSPA
  TPSAALASPAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKAAASSSGQMGSQPP
  LLSRPLPLGSMPTALLASPPSFPATLHAHQALPVLQAQPLSLVTKSAH

• Sequence length: 588