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TCF7 (transcription factor 7)

Gene

6932

Transcription factor 7

TCF7

TCF-1

5q31.1

This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innat

Show/Hide all(135)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024837	hsa-miR-215-5p	Microarray	19074876
MIRT026207	hsa-miR-192-5p	Microarray	19074876
MIRT731117	hsa-miR-34a-5p	qRT-PCR, Luciferase reporter assay, Immunohistochemistry, Western blot	25436980
MIRT731117	hsa-miR-34a-5p	qRT-PCR, Luciferase reporter assay, Immunohistochemistry, Western blot	25436980
MIRT731389	hsa-miR-22-3p	Luciferase reporter assay, qRT-PCR, Western blot	26193896
MIRT755362	hsa-miR-491-5p	Luciferase reporter assay, Western blotting, qRT-PCR	36988257
MIRT1416377	hsa-miR-127-5p	CLIP-seq
MIRT1416378	hsa-miR-197	CLIP-seq
MIRT1416379	hsa-miR-24	CLIP-seq
MIRT1416380	hsa-miR-296-3p	CLIP-seq
MIRT1416381	hsa-miR-3187-3p	CLIP-seq
MIRT1416382	hsa-miR-3613-3p	CLIP-seq
MIRT1416383	hsa-miR-3663-5p	CLIP-seq
MIRT1416384	hsa-miR-3688-5p	CLIP-seq
MIRT1416385	hsa-miR-371-5p	CLIP-seq
MIRT1416386	hsa-miR-371b-5p	CLIP-seq
MIRT1416387	hsa-miR-4284	CLIP-seq
MIRT1416388	hsa-miR-4435	CLIP-seq
MIRT1416389	hsa-miR-4453	CLIP-seq
MIRT1416390	hsa-miR-4457	CLIP-seq
MIRT1416391	hsa-miR-4470	CLIP-seq
MIRT1416392	hsa-miR-4538	CLIP-seq
MIRT1416393	hsa-miR-4691-3p	CLIP-seq
MIRT1416394	hsa-miR-4701-5p	CLIP-seq
MIRT1416395	hsa-miR-4716-5p	CLIP-seq
MIRT1416396	hsa-miR-4755-3p	CLIP-seq
MIRT1416397	hsa-miR-4761-5p	CLIP-seq
MIRT1416398	hsa-miR-4781-3p	CLIP-seq
MIRT1416399	hsa-miR-5096	CLIP-seq
MIRT1416400	hsa-miR-548s	CLIP-seq
MIRT1416401	hsa-miR-588	CLIP-seq
MIRT1416402	hsa-miR-606	CLIP-seq
MIRT1416403	hsa-miR-624	CLIP-seq
MIRT1416404	hsa-miR-1178	CLIP-seq
MIRT1416405	hsa-miR-125a-3p	CLIP-seq
MIRT1416406	hsa-miR-1273f	CLIP-seq
MIRT1416407	hsa-miR-129-5p	CLIP-seq
MIRT1416408	hsa-miR-143	CLIP-seq
MIRT1416409	hsa-miR-1914	CLIP-seq
MIRT1416378	hsa-miR-197	CLIP-seq
MIRT1416410	hsa-miR-2113	CLIP-seq
MIRT1416411	hsa-miR-218	CLIP-seq
MIRT1416412	hsa-miR-3144-5p	CLIP-seq
MIRT1416413	hsa-miR-3149	CLIP-seq
MIRT1416381	hsa-miR-3187-3p	CLIP-seq
MIRT1416414	hsa-miR-3191	CLIP-seq
MIRT1416415	hsa-miR-339-5p	CLIP-seq
MIRT1416383	hsa-miR-3663-5p	CLIP-seq
MIRT1416385	hsa-miR-371-5p	CLIP-seq
MIRT1416386	hsa-miR-371b-5p	CLIP-seq
MIRT1416416	hsa-miR-3934	CLIP-seq
MIRT1416417	hsa-miR-3935	CLIP-seq
MIRT1416418	hsa-miR-411	CLIP-seq
MIRT1416419	hsa-miR-4287	CLIP-seq
MIRT1416388	hsa-miR-4435	CLIP-seq
MIRT1416420	hsa-miR-4469	CLIP-seq
MIRT1416421	hsa-miR-4487	CLIP-seq
MIRT1416422	hsa-miR-4532	CLIP-seq
MIRT1416423	hsa-miR-4652-5p	CLIP-seq
MIRT1416424	hsa-miR-4667-5p	CLIP-seq
MIRT1416425	hsa-miR-4685-3p	CLIP-seq
MIRT1416426	hsa-miR-4700-5p	CLIP-seq
MIRT1416394	hsa-miR-4701-5p	CLIP-seq
MIRT1416427	hsa-miR-4708-5p	CLIP-seq
MIRT1416395	hsa-miR-4716-5p	CLIP-seq
MIRT1416428	hsa-miR-4717-5p	CLIP-seq
MIRT1416429	hsa-miR-4731-5p	CLIP-seq
MIRT1416430	hsa-miR-4735-5p	CLIP-seq
MIRT1416396	hsa-miR-4755-3p	CLIP-seq
MIRT1416431	hsa-miR-4763-5p	CLIP-seq
MIRT1416432	hsa-miR-4770	CLIP-seq
MIRT1416433	hsa-miR-4775	CLIP-seq
MIRT1416398	hsa-miR-4781-3p	CLIP-seq
MIRT1416434	hsa-miR-4783-5p	CLIP-seq
MIRT1416435	hsa-miR-486-3p	CLIP-seq
MIRT1416399	hsa-miR-5096	CLIP-seq
MIRT1416400	hsa-miR-548s	CLIP-seq
MIRT1416436	hsa-miR-550a	CLIP-seq
MIRT1416401	hsa-miR-588	CLIP-seq
MIRT1416437	hsa-miR-590-3p	CLIP-seq
MIRT1416438	hsa-miR-591	CLIP-seq
MIRT1416402	hsa-miR-606	CLIP-seq
MIRT1416439	hsa-miR-636	CLIP-seq
MIRT1416440	hsa-miR-640	CLIP-seq
MIRT1416441	hsa-miR-758	CLIP-seq
MIRT1416442	hsa-miR-764	CLIP-seq
MIRT1416443	hsa-miR-3545-3p	CLIP-seq
MIRT1416444	hsa-miR-3921	CLIP-seq
MIRT1416445	hsa-miR-4251	CLIP-seq
MIRT1416446	hsa-miR-4329	CLIP-seq
MIRT1416447	hsa-miR-4421	CLIP-seq
MIRT1416448	hsa-miR-4653-5p	CLIP-seq
MIRT1416428	hsa-miR-4717-5p	CLIP-seq
MIRT1416449	hsa-miR-593	CLIP-seq
MIRT1416424	hsa-miR-4667-5p	CLIP-seq
MIRT1416426	hsa-miR-4700-5p	CLIP-seq
MIRT2640247	hsa-miR-1224-3p	CLIP-seq
MIRT2640248	hsa-miR-1260	CLIP-seq
MIRT2640249	hsa-miR-1260b	CLIP-seq
MIRT2640250	hsa-miR-1280	CLIP-seq
MIRT2640251	hsa-miR-1281	CLIP-seq
MIRT2640252	hsa-miR-1297	CLIP-seq
MIRT2640253	hsa-miR-188-3p	CLIP-seq
MIRT2640254	hsa-miR-26a	CLIP-seq
MIRT2640255	hsa-miR-26b	CLIP-seq
MIRT1416413	hsa-miR-3149	CLIP-seq
MIRT2640256	hsa-miR-3156-3p	CLIP-seq
MIRT2640257	hsa-miR-3614-5p	CLIP-seq
MIRT2640258	hsa-miR-3920	CLIP-seq
MIRT1416417	hsa-miR-3935	CLIP-seq
MIRT1416418	hsa-miR-411	CLIP-seq
MIRT2640259	hsa-miR-432	CLIP-seq
MIRT2640260	hsa-miR-4465	CLIP-seq
MIRT1416422	hsa-miR-4532	CLIP-seq
MIRT2640261	hsa-miR-4666-5p	CLIP-seq
MIRT1416430	hsa-miR-4735-5p	CLIP-seq
MIRT2640262	hsa-miR-4740-3p	CLIP-seq
MIRT1416433	hsa-miR-4775	CLIP-seq
MIRT1416434	hsa-miR-4783-5p	CLIP-seq
MIRT1416437	hsa-miR-590-3p	CLIP-seq
MIRT2640263	hsa-miR-642b	CLIP-seq
MIRT2640264	hsa-miR-718	CLIP-seq
MIRT2640265	hsa-miR-890	CLIP-seq
MIRT2640251	hsa-miR-1281	CLIP-seq
MIRT2640252	hsa-miR-1297	CLIP-seq
MIRT2640254	hsa-miR-26a	CLIP-seq
MIRT2640255	hsa-miR-26b	CLIP-seq
MIRT1416413	hsa-miR-3149	CLIP-seq
MIRT2640260	hsa-miR-4465	CLIP-seq
MIRT1416422	hsa-miR-4532	CLIP-seq
MIRT1416430	hsa-miR-4735-5p	CLIP-seq
MIRT1416433	hsa-miR-4775	CLIP-seq
MIRT1416434	hsa-miR-4783-5p	CLIP-seq
MIRT1416437	hsa-miR-590-3p	CLIP-seq
MIRT2640264	hsa-miR-718	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
CTNNB1	Unknown	17724465

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000976	Function	Transcription regulatory region sequence-specific DNA binding	IDA	18579517, 20128911
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0001217	Function	DNA-binding transcription repressor activity	ISS
GO:0005515	Function	Protein binding	IPI	9783587, 16442529, 17218525, 17510365, 19358846, 20028982, 25678599, 26079538
GO:0005634	Component	Nucleus	IDA	18579517
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of transcription, DNA-templated	ISS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006955	Process	Immune response	TAS	1569101
GO:0008013	Function	Beta-catenin binding	IDA	9488439
GO:0016604	Component	Nuclear body	IDA
GO:0033153	Process	T cell receptor V(D)J recombination	IEA
GO:0042492	Process	Gamma-delta T cell differentiation	ISS
GO:0045586	Process	Regulation of gamma-delta T cell differentiation	ISS
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IBA	21873635
GO:0071353	Process	Cellular response to interleukin-4	IDA	18579517
GO:1904837	Process	Beta-catenin-TCF complex assembly	TAS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:1990907	Component	Beta-catenin-TCF complex	IBA	21873635

MIM	HGNC	e!Ensembl
189908	11639	ENSG00000081059

Protein

UniProt ID

P36402

Protein name

Transcription factor 7 (TCF-7) (T-cell-specific transcription factor 1) (T-cell factor 1) (TCF-1)

Protein function

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-s

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08347	CTNNB1_binding	1 → 212	N-terminal CTNNB1 binding	Family
PF00505	HMG_box	269 → 337	HMG (high mobility group) box	Domain

Sequence

MPQLDSGGGGAGGGDDLGAPDELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSLVNESE
GAAGGAGIPGVPGAGAGARGEAEALGREHAAQRLFPDKLPEPLEDGLKAPECTSGMYKET
VYSAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPHGVPQLSLYEHFNSPHPTPAPADISQ
KQVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWFTHPSLMLGSGVPGHPAAIPHPAIVPPS
GKQELQPFDRNLKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAIN
QILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTET
NWPRELKDGNGQESLSMSSSSSPA

Sequence length

384

Interactions

View interactions

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