TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1)

Gene

• Entrez ID: 10454
• Gene name: TGF-beta activated kinase 1 (MAP3K7) binding protein 1
• Gene symbol: TAB1
• Synonyms: 3'-Tab1, MAP3K7IP1
• Chromosome: 22
• Chromosome location: 22q13.1
• Summary: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047792	hsa-miR-30d-5p	CLASH	23622248
MIRT054555	hsa-miR-26b-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	24565101
MIRT532640	hsa-miR-6836-3p	PAR-CLIP	22012620
MIRT532641	hsa-miR-4633-5p	PAR-CLIP	22012620
MIRT532642	hsa-miR-4693-5p	PAR-CLIP	22012620
MIRT532643	hsa-miR-4711-3p	PAR-CLIP	22012620
MIRT532644	hsa-miR-6829-3p	PAR-CLIP	22012620
MIRT532645	hsa-miR-6791-3p	PAR-CLIP	22012620
MIRT532646	hsa-miR-6778-3p	PAR-CLIP	22012620
MIRT532646	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT532647	hsa-miR-4726-3p	PAR-CLIP	22012620
MIRT532647	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT532648	hsa-miR-6764-5p	PAR-CLIP	22012620
MIRT532648	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT532649	hsa-miR-1915-3p	PAR-CLIP	22012620
MIRT532649	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT532650	hsa-miR-6840-3p	PAR-CLIP	22012620
MIRT532650	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT532651	hsa-miR-532-5p	PAR-CLIP	22012620
MIRT532652	hsa-miR-6841-5p	PAR-CLIP	22012620
MIRT532653	hsa-miR-892a	PAR-CLIP	22012620
MIRT532654	hsa-miR-4318	PAR-CLIP	22012620
MIRT621902	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT621903	hsa-miR-7150	HITS-CLIP	23824327
MIRT621904	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621905	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT621906	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT621907	hsa-miR-4736	HITS-CLIP	23824327
MIRT621908	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT621909	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT621910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT621911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT621912	hsa-miR-3615	HITS-CLIP	23824327
MIRT652858	hsa-miR-8057	HITS-CLIP	23824327
MIRT652859	hsa-miR-4279	HITS-CLIP	23824327
MIRT652860	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT652861	hsa-miR-4284	HITS-CLIP	23824327
MIRT652862	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT652863	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT652864	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT652865	hsa-miR-1281	HITS-CLIP	23824327
MIRT652866	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT652867	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT652868	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT652869	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT652870	hsa-miR-935	HITS-CLIP	23824327
MIRT652871	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT652872	hsa-miR-4798-3p	HITS-CLIP	23824327
MIRT652873	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT652874	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT652875	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT652876	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT652877	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT652878	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT734746	hsa-miR-29a-5p	ELISA, Luciferase reporter assay, qRT-PCR, Western blot	25549087

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000185	Process	Activation of MAPKKK activity	IEA
GO:0000187	Process	Activation of MAPK activity	TAS
GO:0001701	Process	In utero embryonic development	IEA
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0003007	Process	Heart morphogenesis	IEA
GO:0003279	Process	Cardiac septum development	IEA
GO:0004724	Function	Magnesium-dependent protein serine/threonine phosphatase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10094049, 11460167, 14743216, 16845370, 17620599, 19026643, 21900206, 21903422, 21988832, 22158122, 23818254, 25241761, 25260751, 27107012, 27505673, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006469	Process	Negative regulation of protein kinase activity	IBA	21873635
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IEA
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	TAS
GO:0007254	Process	JNK cascade	TAS
GO:0008047	Function	Enzyme activator activity	TAS	8638164
GO:0010008	Component	Endosome membrane	TAS
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016607	Component	Nuclear speck	IDA
GO:0019209	Function	Kinase activator activity	IEA
GO:0030324	Process	Lung development	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0035904	Process	Aorta development	IEA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0048273	Function	Mitogen-activated protein kinase p38 binding	IEA
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	TAS
GO:0060976	Process	Coronary vasculature development	IEA
GO:0070423	Process	Nucleotide-binding oligomerization domain containing signaling pathway	TAS
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS

Other IDs

• MIM: 602615
• HGNC: 18157
• e!Ensembl: ENSG00000100324

Protein

• UniProt ID: Q15750
• Protein name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)
• Protein function: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
• PDB: 2J4O, 2POM, 2POP, 2YDS, 2YIY, 4AY5, 4AY6, 4GS6, 4KA3, 4L3P, 4L52, 4L53, 4O91, 5DIY, 5E7R, 5GJD, 5GJF, 5GJG, 5J7S, 5J8I, 5J9L, 5JGA, 5JGB, 5JGD, 5JH6, 5JK3, 5NZZ, 5O90, 5V5N, 5VVU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00481	PP2C	69 → 334	Protein phosphatase 2C	Family

• Sequence:

  MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPEDSWLKFRSEN
  NCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLES
  IDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYV
  ANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQEST
  RRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAH
  GPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMTL
  LVRNFGYPLGEMSQPTPSPAPAAGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNG
  AHSASTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGGLFRSRPAHSLPPGEDGRVEP
  YVDFAEFYRLWSVDHGEQSVVTAP

• Sequence length: 504