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TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1)

Gene

10454

TGF-beta activated kinase 1 (MAP3K7) binding protein 1

TAB1

3'-Tab1, MAP3K7IP1

22q13.1

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein inter

Show/Hide all(323)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047792	hsa-miR-30d-5p	CLASH	23622248
MIRT054555	hsa-miR-26b-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	24565101
MIRT054555	hsa-miR-26b-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	24565101
MIRT652878	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT652878	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT652877	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT652876	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT652875	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT652874	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT652873	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT652872	hsa-miR-4798-3p	HITS-CLIP	23824327
MIRT652871	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT652870	hsa-miR-935	HITS-CLIP	23824327
MIRT652869	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT652868	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT621912	hsa-miR-3615	HITS-CLIP	23824327
MIRT621911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT621910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT621906	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT621905	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT621904	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621902	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT652867	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT532650	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT532649	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT532648	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT532647	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT652866	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT652865	hsa-miR-1281	HITS-CLIP	23824327
MIRT652864	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT652863	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT652862	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT532646	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT652861	hsa-miR-4284	HITS-CLIP	23824327
MIRT652860	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT652859	hsa-miR-4279	HITS-CLIP	23824327
MIRT652858	hsa-miR-8057	HITS-CLIP	23824327
MIRT621912	hsa-miR-3615	HITS-CLIP	23824327
MIRT621911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT621910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT621909	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT621908	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT621907	hsa-miR-4736	HITS-CLIP	23824327
MIRT621906	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT621905	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT621904	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621903	hsa-miR-7150	HITS-CLIP	23824327
MIRT621902	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT532654	hsa-miR-4318	PAR-CLIP	22012620
MIRT532653	hsa-miR-892a	PAR-CLIP	22012620
MIRT532652	hsa-miR-6841-5p	PAR-CLIP	22012620
MIRT532651	hsa-miR-532-5p	PAR-CLIP	22012620
MIRT532650	hsa-miR-6840-3p	PAR-CLIP	22012620
MIRT532649	hsa-miR-1915-3p	PAR-CLIP	22012620
MIRT532648	hsa-miR-6764-5p	PAR-CLIP	22012620
MIRT532647	hsa-miR-4726-3p	PAR-CLIP	22012620
MIRT532646	hsa-miR-6778-3p	PAR-CLIP	22012620
MIRT532645	hsa-miR-6791-3p	PAR-CLIP	22012620
MIRT532644	hsa-miR-6829-3p	PAR-CLIP	22012620
MIRT532643	hsa-miR-4711-3p	PAR-CLIP	22012620
MIRT532642	hsa-miR-4693-5p	PAR-CLIP	22012620
MIRT532641	hsa-miR-4633-5p	PAR-CLIP	22012620
MIRT532640	hsa-miR-6836-3p	PAR-CLIP	22012620
MIRT652878	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT652878	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT652877	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT652876	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT652875	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT652874	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT652873	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT652872	hsa-miR-4798-3p	HITS-CLIP	23824327
MIRT652871	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT652870	hsa-miR-935	HITS-CLIP	23824327
MIRT652869	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT652868	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT621912	hsa-miR-3615	HITS-CLIP	23824327
MIRT621911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT621910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT621906	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT621905	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT621904	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621902	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT652867	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT532650	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT532649	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT532648	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT532647	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT652866	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT652865	hsa-miR-1281	HITS-CLIP	23824327
MIRT652864	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT652863	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT652862	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT532646	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT652861	hsa-miR-4284	HITS-CLIP	23824327
MIRT652860	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT652859	hsa-miR-4279	HITS-CLIP	23824327
MIRT652858	hsa-miR-8057	HITS-CLIP	23824327
MIRT621912	hsa-miR-3615	HITS-CLIP	23824327
MIRT621911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT621910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT621909	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT621908	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT621907	hsa-miR-4736	HITS-CLIP	23824327
MIRT621906	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT621905	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT621904	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621903	hsa-miR-7150	HITS-CLIP	23824327
MIRT621902	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT532654	hsa-miR-4318	PAR-CLIP	22012620
MIRT532653	hsa-miR-892a	PAR-CLIP	22012620
MIRT532652	hsa-miR-6841-5p	PAR-CLIP	22012620
MIRT532651	hsa-miR-532-5p	PAR-CLIP	22012620
MIRT532650	hsa-miR-6840-3p	PAR-CLIP	22012620
MIRT532649	hsa-miR-1915-3p	PAR-CLIP	22012620
MIRT532648	hsa-miR-6764-5p	PAR-CLIP	22012620
MIRT532647	hsa-miR-4726-3p	PAR-CLIP	22012620
MIRT532646	hsa-miR-6778-3p	PAR-CLIP	22012620
MIRT532645	hsa-miR-6791-3p	PAR-CLIP	22012620
MIRT532644	hsa-miR-6829-3p	PAR-CLIP	22012620
MIRT532643	hsa-miR-4711-3p	PAR-CLIP	22012620
MIRT532642	hsa-miR-4693-5p	PAR-CLIP	22012620
MIRT532641	hsa-miR-4633-5p	PAR-CLIP	22012620
MIRT532640	hsa-miR-6836-3p	PAR-CLIP	22012620
MIRT1408119	hsa-miR-10a	CLIP-seq
MIRT1408120	hsa-miR-10b	CLIP-seq
MIRT1408121	hsa-miR-323-3p	CLIP-seq
MIRT1408122	hsa-miR-3609	CLIP-seq
MIRT1408123	hsa-miR-4725-5p	CLIP-seq
MIRT1408124	hsa-miR-504	CLIP-seq
MIRT1408125	hsa-miR-548ah	CLIP-seq
MIRT1408126	hsa-miR-548t	CLIP-seq
MIRT1408127	hsa-miR-1226	CLIP-seq
MIRT1408128	hsa-miR-1233	CLIP-seq
MIRT1408129	hsa-miR-125a-5p	CLIP-seq
MIRT1408130	hsa-miR-125b	CLIP-seq
MIRT1408131	hsa-miR-129-5p	CLIP-seq
MIRT1408132	hsa-miR-298	CLIP-seq
MIRT1408133	hsa-miR-335	CLIP-seq
MIRT1408134	hsa-miR-3670	CLIP-seq
MIRT1408135	hsa-miR-3678-3p	CLIP-seq
MIRT1408136	hsa-miR-4319	CLIP-seq
MIRT1408137	hsa-miR-450b-5p	CLIP-seq
MIRT1408138	hsa-miR-4733-3p	CLIP-seq
MIRT1408139	hsa-miR-4775	CLIP-seq
MIRT1408140	hsa-miR-507	CLIP-seq
MIRT1408141	hsa-miR-557	CLIP-seq
MIRT1408142	hsa-miR-590-3p	CLIP-seq
MIRT2122388	hsa-miR-1587	CLIP-seq
MIRT2122389	hsa-miR-1915	CLIP-seq
MIRT2122390	hsa-miR-1972	CLIP-seq
MIRT2122391	hsa-miR-299-3p	CLIP-seq
MIRT2122392	hsa-miR-3714	CLIP-seq
MIRT2122393	hsa-miR-3919	CLIP-seq
MIRT2122394	hsa-miR-3925-5p	CLIP-seq
MIRT2122395	hsa-miR-4286	CLIP-seq
MIRT2122396	hsa-miR-4456	CLIP-seq
MIRT2122397	hsa-miR-4492	CLIP-seq
MIRT2122398	hsa-miR-4493	CLIP-seq
MIRT2122399	hsa-miR-4498	CLIP-seq
MIRT2122400	hsa-miR-4640-3p	CLIP-seq
MIRT2122401	hsa-miR-4656	CLIP-seq
MIRT2122402	hsa-miR-4675	CLIP-seq
MIRT2122403	hsa-miR-4741	CLIP-seq
MIRT2122404	hsa-miR-4786-5p	CLIP-seq
MIRT2122405	hsa-miR-762	CLIP-seq
MIRT2344668	hsa-miR-1202	CLIP-seq
MIRT2344669	hsa-miR-1207-3p	CLIP-seq
MIRT1408127	hsa-miR-1226	CLIP-seq
MIRT2344670	hsa-miR-1286	CLIP-seq
MIRT2344671	hsa-miR-149	CLIP-seq
MIRT2122390	hsa-miR-1972	CLIP-seq
MIRT2344672	hsa-miR-22	CLIP-seq
MIRT2344673	hsa-miR-24	CLIP-seq
MIRT2344674	hsa-miR-3176	CLIP-seq
MIRT2344675	hsa-miR-3194-5p	CLIP-seq
MIRT2344676	hsa-miR-331-3p	CLIP-seq
MIRT2344677	hsa-miR-3620	CLIP-seq
MIRT2344678	hsa-miR-365	CLIP-seq
MIRT2344679	hsa-miR-3679-3p	CLIP-seq
MIRT2344680	hsa-miR-3684	CLIP-seq
MIRT2344681	hsa-miR-3692	CLIP-seq
MIRT2344682	hsa-miR-3922-3p	CLIP-seq
MIRT2344683	hsa-miR-3972	CLIP-seq
MIRT2344684	hsa-miR-4267	CLIP-seq
MIRT2344685	hsa-miR-4448	CLIP-seq
MIRT2122400	hsa-miR-4640-3p	CLIP-seq
MIRT2344686	hsa-miR-4650-5p	CLIP-seq
MIRT2344687	hsa-miR-4715-3p	CLIP-seq
MIRT2344688	hsa-miR-4722-3p	CLIP-seq
MIRT2344689	hsa-miR-4722-5p	CLIP-seq
MIRT2344690	hsa-miR-4729	CLIP-seq
MIRT2344691	hsa-miR-4763-5p	CLIP-seq
MIRT2344692	hsa-miR-4782-5p	CLIP-seq
MIRT2344693	hsa-miR-556-3p	CLIP-seq
MIRT2637927	hsa-miR-1229	CLIP-seq
MIRT2637928	hsa-miR-1273f	CLIP-seq
MIRT2637929	hsa-miR-1302	CLIP-seq
MIRT2637930	hsa-miR-1307	CLIP-seq
MIRT2637931	hsa-miR-135a	CLIP-seq
MIRT2637932	hsa-miR-135b	CLIP-seq
MIRT2637933	hsa-miR-147	CLIP-seq
MIRT2344671	hsa-miR-149	CLIP-seq
MIRT2637934	hsa-miR-18a	CLIP-seq
MIRT2637935	hsa-miR-18b	CLIP-seq
MIRT2637936	hsa-miR-1913	CLIP-seq
MIRT2637937	hsa-miR-219-5p	CLIP-seq
MIRT2637938	hsa-miR-2392	CLIP-seq
MIRT2344673	hsa-miR-24	CLIP-seq
MIRT2637939	hsa-miR-2467-3p	CLIP-seq
MIRT1408132	hsa-miR-298	CLIP-seq
MIRT2637940	hsa-miR-3064-5p	CLIP-seq
MIRT2637941	hsa-miR-3150a-3p	CLIP-seq
MIRT2637942	hsa-miR-3158-5p	CLIP-seq
MIRT2637943	hsa-miR-3175	CLIP-seq
MIRT2637944	hsa-miR-3183	CLIP-seq
MIRT2637945	hsa-miR-3187-3p	CLIP-seq
MIRT2637946	hsa-miR-3189-5p	CLIP-seq
MIRT2637947	hsa-miR-324-3p	CLIP-seq
MIRT2637948	hsa-miR-3605-5p	CLIP-seq
MIRT2637949	hsa-miR-3622a-3p	CLIP-seq
MIRT2637950	hsa-miR-3622b-3p	CLIP-seq
MIRT1408134	hsa-miR-3670	CLIP-seq
MIRT2637951	hsa-miR-3675-5p	CLIP-seq
MIRT2637952	hsa-miR-370	CLIP-seq
MIRT2122392	hsa-miR-3714	CLIP-seq
MIRT2637953	hsa-miR-377	CLIP-seq
MIRT2637954	hsa-miR-3911	CLIP-seq
MIRT2637955	hsa-miR-3926	CLIP-seq
MIRT2637956	hsa-miR-3973	CLIP-seq
MIRT2637957	hsa-miR-4265	CLIP-seq
MIRT2122395	hsa-miR-4286	CLIP-seq
MIRT2637958	hsa-miR-4296	CLIP-seq
MIRT2637959	hsa-miR-4298	CLIP-seq
MIRT2637960	hsa-miR-4303	CLIP-seq
MIRT2637961	hsa-miR-4322	CLIP-seq
MIRT2637962	hsa-miR-4327	CLIP-seq
MIRT2637963	hsa-miR-4417	CLIP-seq
MIRT2637964	hsa-miR-4435	CLIP-seq
MIRT2637965	hsa-miR-4445	CLIP-seq
MIRT2637966	hsa-miR-4474-3p	CLIP-seq
MIRT2637967	hsa-miR-4638-5p	CLIP-seq
MIRT2637968	hsa-miR-4651	CLIP-seq
MIRT2637969	hsa-miR-4659a-3p	CLIP-seq
MIRT2637970	hsa-miR-4659b-3p	CLIP-seq
MIRT2637971	hsa-miR-4685-5p	CLIP-seq
MIRT2637972	hsa-miR-4698	CLIP-seq
MIRT2637973	hsa-miR-4701-5p	CLIP-seq
MIRT2637974	hsa-miR-4723-3p	CLIP-seq
MIRT2637975	hsa-miR-4735-3p	CLIP-seq
MIRT2637976	hsa-miR-4749-3p	CLIP-seq
MIRT2637977	hsa-miR-4756-3p	CLIP-seq
MIRT2637978	hsa-miR-4758-3p	CLIP-seq
MIRT2637979	hsa-miR-4761-5p	CLIP-seq
MIRT2637980	hsa-miR-4773	CLIP-seq
MIRT2637981	hsa-miR-4782-3p	CLIP-seq
MIRT2122404	hsa-miR-4786-5p	CLIP-seq
MIRT2637982	hsa-miR-4794	CLIP-seq
MIRT2637983	hsa-miR-4796-3p	CLIP-seq
MIRT2637984	hsa-miR-4797-5p	CLIP-seq
MIRT2637985	hsa-miR-486-3p	CLIP-seq
MIRT2637986	hsa-miR-491-5p	CLIP-seq
MIRT2637987	hsa-miR-494	CLIP-seq
MIRT2637988	hsa-miR-508-3p	CLIP-seq
MIRT2637989	hsa-miR-520g	CLIP-seq
MIRT2637990	hsa-miR-520h	CLIP-seq
MIRT2637991	hsa-miR-544	CLIP-seq
MIRT2637992	hsa-miR-548s	CLIP-seq
MIRT2637993	hsa-miR-588	CLIP-seq
MIRT2637994	hsa-miR-603	CLIP-seq
MIRT2637995	hsa-miR-604	CLIP-seq
MIRT2637996	hsa-miR-605	CLIP-seq
MIRT2637997	hsa-miR-608	CLIP-seq
MIRT2637998	hsa-miR-644	CLIP-seq
MIRT2637999	hsa-miR-647	CLIP-seq
MIRT2638000	hsa-miR-769-5p	CLIP-seq
MIRT2638001	hsa-miR-939	CLIP-seq
MIRT2638002	hsa-miR-940	CLIP-seq
MIRT2692583	hsa-miR-1260	CLIP-seq
MIRT2692584	hsa-miR-1260b	CLIP-seq
MIRT2637933	hsa-miR-147	CLIP-seq
MIRT2344671	hsa-miR-149	CLIP-seq
MIRT2692585	hsa-miR-188-3p	CLIP-seq
MIRT2637934	hsa-miR-18a	CLIP-seq
MIRT2637935	hsa-miR-18b	CLIP-seq
MIRT2637936	hsa-miR-1913	CLIP-seq
MIRT2637937	hsa-miR-219-5p	CLIP-seq
MIRT2344673	hsa-miR-24	CLIP-seq
MIRT2637939	hsa-miR-2467-3p	CLIP-seq
MIRT2637940	hsa-miR-3064-5p	CLIP-seq
MIRT2692586	hsa-miR-3156-3p	CLIP-seq
MIRT2637945	hsa-miR-3187-3p	CLIP-seq
MIRT2637946	hsa-miR-3189-5p	CLIP-seq
MIRT2637947	hsa-miR-324-3p	CLIP-seq
MIRT1408134	hsa-miR-3670	CLIP-seq
MIRT2344681	hsa-miR-3692	CLIP-seq
MIRT2637954	hsa-miR-3911	CLIP-seq
MIRT2637955	hsa-miR-3926	CLIP-seq
MIRT2122395	hsa-miR-4286	CLIP-seq
MIRT2692587	hsa-miR-4292	CLIP-seq
MIRT2637960	hsa-miR-4303	CLIP-seq
MIRT2692588	hsa-miR-4308	CLIP-seq
MIRT2637962	hsa-miR-4327	CLIP-seq
MIRT2637964	hsa-miR-4435	CLIP-seq
MIRT2637965	hsa-miR-4445	CLIP-seq
MIRT2637966	hsa-miR-4474-3p	CLIP-seq
MIRT2637969	hsa-miR-4659a-3p	CLIP-seq
MIRT2637970	hsa-miR-4659b-3p	CLIP-seq
MIRT2637972	hsa-miR-4698	CLIP-seq
MIRT2637973	hsa-miR-4701-5p	CLIP-seq
MIRT2637975	hsa-miR-4735-3p	CLIP-seq
MIRT2637978	hsa-miR-4758-3p	CLIP-seq
MIRT2637979	hsa-miR-4761-5p	CLIP-seq
MIRT2637981	hsa-miR-4782-3p	CLIP-seq
MIRT2122404	hsa-miR-4786-5p	CLIP-seq
MIRT2637982	hsa-miR-4794	CLIP-seq
MIRT2637988	hsa-miR-508-3p	CLIP-seq
MIRT2637991	hsa-miR-544	CLIP-seq
MIRT2637992	hsa-miR-548s	CLIP-seq
MIRT2637993	hsa-miR-588	CLIP-seq
MIRT2637995	hsa-miR-604	CLIP-seq
MIRT2637998	hsa-miR-644	CLIP-seq
MIRT2637999	hsa-miR-647	CLIP-seq
MIRT2638000	hsa-miR-769-5p	CLIP-seq

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000185	Process	Activation of MAPKKK activity	IEA
GO:0000187	Process	Activation of MAPK activity	TAS
GO:0001701	Process	In utero embryonic development	IEA
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0003007	Process	Heart morphogenesis	IEA
GO:0003279	Process	Cardiac septum development	IEA
GO:0004724	Function	Magnesium-dependent protein serine/threonine phosphatase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10094049, 11460167, 14743216, 16845370, 17620599, 19026643, 21900206, 21903422, 21988832, 22158122, 23818254, 25241761, 25260751, 27107012, 27505673, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006469	Process	Negative regulation of protein kinase activity	IBA	21873635
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IEA
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	TAS
GO:0007254	Process	JNK cascade	TAS
GO:0008047	Function	Enzyme activator activity	TAS	8638164
GO:0010008	Component	Endosome membrane	TAS
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016607	Component	Nuclear speck	IDA
GO:0019209	Function	Kinase activator activity	IEA
GO:0030324	Process	Lung development	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0035904	Process	Aorta development	IEA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0048273	Function	Mitogen-activated protein kinase p38 binding	IEA
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	TAS
GO:0060976	Process	Coronary vasculature development	IEA
GO:0070423	Process	Nucleotide-binding oligomerization domain containing signaling pathway	TAS
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS

MIM	HGNC	e!Ensembl
602615	18157	ENSG00000100324

Protein

UniProt ID

Q15750

Protein name

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)

Protein function

Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with th

PDB

2J4O , 2POM , 2POP , 2YDS , 2YIY , 4AY5 , 4AY6 , 4GS6 , 4KA3 , 4L3P , 4L52 , 4L53 , 4O91 , 5DIY , 5E7R , 5GJD , 5GJF , 5GJG , 5J7S , 5J8I , 5J9L , 5JGA , 5JGB , 5JGD , 5JH6 , 5JK3 , 5NZZ , 5O90 , 5V5N , 5VVU , 7NTH , 7NTI , 8GW3 , 8XI8 , 9FPD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00481	PP2C	69 → 334	Protein phosphatase 2C	Family

Sequence

MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPEDSWLKFRSEN
NCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLES
IDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYV
ANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQEST
RRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAH
GPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMTL
LVRNFGYPLGEMSQPTPSPAPAAGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNG
AHSASTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGGLFRSRPAHSLPPGEDGRVEP
YVDFAEFYRLWSVDHGEQSVVTAP

Sequence length

504

Interactions

View interactions

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