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STK11 (serine/threonine kinase 11)

Gene

6794

Serine/threonine kinase 11

STK11

LKB1, PJS, hLKB1

19p13.3

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by

Show/Hide all(211)

SNP ID	Visualize variation	Clinical significance	Consequence
rs2075607	G>A,C,T	Likely-benign, conflicting-interpretations-of-pathogenicity, benign	Intron variant
rs9282859	C>G,T	Likely-benign, benign, pathogenic	Synonymous variant, stop gained, coding sequence variant
rs112675807	G>A,C,T	Pathogenic	Splice acceptor variant
rs121913315	G>A,T	Pathogenic-likely-pathogenic, pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs121913316	A>T	Likely-pathogenic	Coding sequence variant, missense variant
rs121913317	G>A,T	Uncertain-significance, likely-pathogenic	Stop gained, coding sequence variant, missense variant
rs121913319	G>-,GG	Pathogenic	Coding sequence variant, frameshift variant
rs121913320	TTTG>-	Pathogenic	Coding sequence variant, frameshift variant
rs121913321	CC>-,C,CCC	Pathogenic	Coding sequence variant, frameshift variant
rs121913322	C>A,G,T	Likely-benign, benign-likely-benign, likely-pathogenic, conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs121913323	C>G,T	Likely-pathogenic, pathogenic, uncertain-significance	Stop gained, coding sequence variant, missense variant
rs121913324	C>T	Pathogenic, likely-pathogenic	Coding sequence variant, stop gained
rs121913325	G>A	Likely-pathogenic	Coding sequence variant, stop gained
rs137853075	C>A,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs137853076	A>G,T	Pathogenic	Stop gained, coding sequence variant, missense variant
rs137853077	T>C	Pathogenic-likely-pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs137853078	G>A	Pathogenic	Coding sequence variant, missense variant
rs137853079	C>A,G,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs137853080	T>G	Pathogenic	Coding sequence variant, missense variant
rs137853081	G>C,T	Pathogenic	Coding sequence variant, missense variant
rs137853082	G>A,C,T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant, stop gained
rs137853083	C>G,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs137854584	G>T	Pathogenic	Coding sequence variant, stop gained
rs148830698	G>A,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs199681533	C>A,G,T	Likely-benign, conflicting-interpretations-of-pathogenicity	Missense variant, synonymous variant, coding sequence variant
rs200078204	C>A,T	Likely-benign, conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs200824447	C>A,T	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs202011521	G>A	Conflicting-interpretations-of-pathogenicity, benign-likely-benign, benign	Synonymous variant, coding sequence variant
rs368466538	C>A,G,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, synonymous variant, coding sequence variant
rs370222210	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs370976710	G>A,C,T	Likely-benign, benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs371264852	G>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs372329880	C>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs372511774	C>T	Likely-benign, benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs373167735	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs376069854	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs376280361	G>A,C	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs397518440	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs397518441	->T	Pathogenic	Coding sequence variant, frameshift variant
rs397518442	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs397518443	AA>-,A	Pathogenic	Coding sequence variant, frameshift variant
rs398123405	G>A,T	Uncertain-significance, pathogenic	Stop gained, coding sequence variant, missense variant
rs398123406	G>C,T	Pathogenic	Splice acceptor variant
rs532889728	G>A	Benign, conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs552610464	G>A	Conflicting-interpretations-of-pathogenicity	5 prime UTR variant
rs553752236	G>A	Likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs556651007	G>A,T	Likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	Synonymous variant, missense variant, coding sequence variant
rs558040549	C>A,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs565993396	A>G	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs567202367	C>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Intron variant
rs587776656	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs587776657	TCGG>-	Pathogenic	Frameshift variant, coding sequence variant
rs587776658	G>A	Pathogenic	Splice acceptor variant
rs587776659	TG>-	Pathogenic	Frameshift variant, coding sequence variant
rs587776660	TCCGGCAGC>-	Pathogenic	Inframe indel, coding sequence variant
rs587776661	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs587778695	C>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance, not-provided	Coding sequence variant, missense variant
rs587780009	G>A,C	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Intron variant
rs587780013	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs587781537	C>A,G,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Stop gained, coding sequence variant, missense variant
rs587781633	A>G	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs587781856	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs587782018	G>C,T	Pathogenic	Splice donor variant
rs587782259	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign, benign	3 prime UTR variant
rs587782364	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs587782424	TG>-	Pathogenic	Frameshift variant, coding sequence variant
rs727504171	T>G	Likely-pathogenic	Coding sequence variant, missense variant
rs727504172	A>C,T	Pathogenic	Splice acceptor variant
rs730881958	TCATCGGCAAGT>-	Pathogenic	Inframe indel, coding sequence variant
rs730881959	GCAGGAGGGCCGT>-	Pathogenic	Frameshift variant, coding sequence variant
rs730881961	C>A,T	Benign, conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs730881963	G>A,C	Benign, conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant, missense variant
rs730881969	C>A,T	Likely-benign, pathogenic	Synonymous variant, stop gained, coding sequence variant
rs730881970	C>A,T	Uncertain-significance, pathogenic	Stop gained, coding sequence variant, missense variant
rs730881972	G>C,T	Likely-pathogenic	Coding sequence variant, missense variant
rs730881973	C>A,G	Uncertain-significance, pathogenic	Coding sequence variant, missense variant
rs730881976	C>A,G	Likely-pathogenic, pathogenic	Stop gained, coding sequence variant, missense variant
rs730881979	G>A	Pathogenic	Coding sequence variant, missense variant
rs755126393	A>G	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs755746417	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs759090799	ATGAA>-	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Splice acceptor variant, intron variant
rs759284466	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	5 prime UTR variant
rs760399253	C>G,T	Pathogenic	Coding sequence variant, synonymous variant, stop gained
rs764244639	C>G,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs764449808	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs767565606	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant
rs768058962	C>G,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs774072752	G>T	Benign-likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	5 prime UTR variant
rs774100153	C>G,T	Conflicting-interpretations-of-pathogenicity, likely-benign	Missense variant, coding sequence variant, synonymous variant
rs775595174	G>A,C,T	Uncertain-significance, pathogenic	Missense variant, coding sequence variant, stop gained
rs778376925	C>A,G,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs786200991	->G	Pathogenic	Frameshift variant, coding sequence variant
rs786201090	C>T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs786201213	C>A,T	Likely-pathogenic, likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs786201349	C>G,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs786202134	C>A,G,T	Likely-pathogenic	Missense variant, synonymous variant, coding sequence variant
rs786203624	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs786205864	->C	Pathogenic	Frameshift variant, coding sequence variant
rs863224448	G>A	Likely-pathogenic	Splice acceptor variant
rs863224669	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Intron variant
rs864622488	G>A,T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant, stop gained
rs864622707	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs876658584	A>G	Pathogenic	Splice acceptor variant
rs876661012	->A	Pathogenic	Coding sequence variant, stop gained
rs878853247	G>C,T	Likely-pathogenic	Missense variant, coding sequence variant
rs878853984	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs878853985	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Synonymous variant, coding sequence variant
rs886037859	A>G	Conflicting-interpretations-of-pathogenicity, pathogenic-likely-pathogenic	Missense variant, coding sequence variant
rs886037926	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs886039554	G>T	Likely-pathogenic, pathogenic	Splice donor variant
rs886041996	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs927999961	T>-,TT	Conflicting-interpretations-of-pathogenicity	5 prime UTR variant
rs1057517830	G>A	Pathogenic	Splice acceptor variant
rs1057518830	CTG>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1057519858	G>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520017	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520018	T>C	Likely-pathogenic, likely-benign	Coding sequence variant, missense variant
rs1057520038	G>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520039	C>G,T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant, stop gained
rs1057520040	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520041	T>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520042	G>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520379	C>A,G	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520606	G>T	Pathogenic	Coding sequence variant, stop gained
rs1057524439	T>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1060499956	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs1060499958	T>C	Pathogenic, likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1060499960	ACCGGTGG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1060499961	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1060503786	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant
rs1064793427	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1064794805	A>C,G	Likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1085307466	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690916	ATGGGGGACCTG>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1131690917	GGG>-,G,GGGG	Pathogenic, likely-pathogenic, uncertain-significance	Coding sequence variant, frameshift variant, inframe deletion
rs1131690920	G>A	Pathogenic, likely-pathogenic	Splice donor variant
rs1131690921	G>T	Pathogenic	Splice donor variant
rs1131690922	->ACCT	Pathogenic	Coding sequence variant, frameshift variant
rs1131690923	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690924	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131690925	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690926	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131690929	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1131690930	->C	Pathogenic	Coding sequence variant, frameshift variant
rs1131690931	A>C	Likely-pathogenic	Splice acceptor variant
rs1131690933	->GAAGC	Pathogenic	Coding sequence variant, frameshift variant
rs1131690934	A>G	Pathogenic	Splice acceptor variant
rs1131690935	GGTTCTCCATCCGGCAGA>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1131690936	GGTG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131690938	A>T	Likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1131690939	G>-,GG	Pathogenic	Coding sequence variant, frameshift variant
rs1131690940	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690941	T>C	Likely-pathogenic	Splice donor variant
rs1131690944	A>G	Likely-pathogenic	Splice acceptor variant
rs1131690945	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690946	->C	Pathogenic	Coding sequence variant, frameshift variant
rs1131690947	C>-	Pathogenic	Coding sequence variant, stop gained
rs1131690948	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131690949	->G	Pathogenic	Coding sequence variant, frameshift variant
rs1131690950	G>A,C	Pathogenic	Splice donor variant
rs1131690951	A>G	Pathogenic	Splice donor variant
rs1131690952	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1131690953	CCTGCTGGGGGA>-	Likely-pathogenic, uncertain-significance	Coding sequence variant, inframe deletion
rs1407794756	C>T	Conflicting-interpretations-of-pathogenicity	Intron variant
rs1471868090	C>A,T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant
rs1555734904	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555735001	->AC	Pathogenic	Frameshift variant, coding sequence variant
rs1555735008	C>-	Pathogenic	Coding sequence variant, stop gained
rs1555735014	C>-	Pathogenic, likely-pathogenic	Frameshift variant, coding sequence variant
rs1555735080	GTAAGTA>-	Likely-pathogenic	Intron variant, coding sequence variant, splice donor variant
rs1555737444	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555737480	T>C	Likely-pathogenic	Splice donor variant
rs1555737814	GT>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555737830	G>A	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs1555738205	C>G,T	Pathogenic, likely-benign	Coding sequence variant, stop gained, synonymous variant
rs1555738219	->GGACATCA	Pathogenic	Frameshift variant, coding sequence variant
rs1555738319	G>A	Likely-pathogenic	Splice acceptor variant
rs1555738475	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555738656	->GA	Pathogenic	Frameshift variant, coding sequence variant
rs1555738667	C>-	Pathogenic	Coding sequence variant, stop gained
rs1555738683	T>AC	Pathogenic	Frameshift variant, coding sequence variant
rs1555738723	A>-	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1555738863	CCAAG>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555738874	->TCCATCC	Pathogenic	Frameshift variant, coding sequence variant
rs1555738899	CA>TCC	Pathogenic	Frameshift variant, coding sequence variant
rs1568689930	->C	Pathogenic	Frameshift variant, coding sequence variant
rs1568689994	CT>-	Pathogenic	Frameshift variant, coding sequence variant
rs1568690161	->T	Pathogenic	Frameshift variant, coding sequence variant
rs1568690546	TAA>-	Likely-pathogenic	Intron variant, splice donor variant
rs1568708275	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs1568708382	G>A	Uncertain-significance, likely-pathogenic	Coding sequence variant, missense variant
rs1568709203	->TACAAGTT	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1568710381	G>A	Uncertain-significance, pathogenic	Coding sequence variant, missense variant
rs1599915131	TGCTGGACTCGGAGACGCTGTGCAGGAGG>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599915235	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599924500	TCCTCTCTGTCCCAGGG>-	Likely-pathogenic	Intron variant, coding sequence variant, splice acceptor variant
rs1599925303	G>T	Pathogenic	Coding sequence variant, stop gained
rs1599926521	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599927564	->TGTA	Pathogenic	Frameshift variant, coding sequence variant
rs1599927573	->C	Pathogenic	Frameshift variant, coding sequence variant
rs1599927589	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599927622	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599927645	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599927689	->ACTGTGG	Pathogenic	Frameshift variant, coding sequence variant
rs1599928360	G>-	Likely-pathogenic	Coding sequence variant, splice donor variant
rs1599929258	TGGTTCCGGA>CC	Pathogenic	Frameshift variant, coding sequence variant
rs1599929264	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599929328	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599929335	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599929339	->T	Pathogenic	Frameshift variant, coding sequence variant
rs1599929369	AC>-	Likely-pathogenic	Frameshift variant, coding sequence variant

Show/Hide all(88)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020252	hsa-miR-130b-3p	Sequencing	20371350
MIRT028122	hsa-miR-93-5p	Sequencing	20371350
MIRT050817	hsa-miR-17-5p	CLASH	23622248
MIRT052942	hsa-miR-199a-3p	Luciferase reporter assay, Western blot	22265968
MIRT052942	hsa-miR-199a-3p	Luciferase reporter assay, Western blot	22265968
MIRT570514	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT570513	hsa-miR-3141	PAR-CLIP	20371350
MIRT570512	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT570511	hsa-miR-4767	PAR-CLIP	20371350
MIRT492157	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT492156	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT492154	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT492155	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT492161	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT492160	hsa-miR-6890-3p	PAR-CLIP	23592263
MIRT492159	hsa-miR-4721	PAR-CLIP	23592263
MIRT492158	hsa-miR-604	PAR-CLIP	23592263
MIRT492157	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT492156	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT492154	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT492155	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT492153	hsa-miR-6829-5p	PAR-CLIP	23592263
MIRT492152	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT492151	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT492150	hsa-miR-5698	PAR-CLIP	23592263
MIRT492149	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT492148	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT492146	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT492147	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT028122	hsa-miR-93-5p	Luciferase reporter assay	28382150
MIRT028122	hsa-miR-93-5p	Luciferase reporter assay	28382150
MIRT028122	hsa-miR-93-5p	Luciferase reporter assay	28382150
MIRT028122	hsa-miR-93-5p	Luciferase reporter assay	28382150
MIRT570514	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT570513	hsa-miR-3141	PAR-CLIP	20371350
MIRT570512	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT570511	hsa-miR-4767	PAR-CLIP	20371350
MIRT492157	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT492156	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT492154	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT492155	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT492161	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT492160	hsa-miR-6890-3p	PAR-CLIP	23592263
MIRT492159	hsa-miR-4721	PAR-CLIP	23592263
MIRT492158	hsa-miR-604	PAR-CLIP	23592263
MIRT492157	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT492156	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT492154	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT492155	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT492153	hsa-miR-6829-5p	PAR-CLIP	23592263
MIRT492152	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT492151	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT492150	hsa-miR-5698	PAR-CLIP	23592263
MIRT492149	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT492148	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT492146	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT492147	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT1397196	hsa-miR-1255a	CLIP-seq
MIRT1397197	hsa-miR-1255b	CLIP-seq
MIRT1397198	hsa-miR-1299	CLIP-seq
MIRT1397199	hsa-miR-1470	CLIP-seq
MIRT1397200	hsa-miR-1471	CLIP-seq
MIRT1397201	hsa-miR-1908	CLIP-seq
MIRT1397202	hsa-miR-2115	CLIP-seq
MIRT1397203	hsa-miR-3130-3p	CLIP-seq
MIRT1397204	hsa-miR-3177-3p	CLIP-seq
MIRT1397205	hsa-miR-3663-5p	CLIP-seq
MIRT1397206	hsa-miR-3676	CLIP-seq
MIRT1397207	hsa-miR-3682-3p	CLIP-seq
MIRT1397208	hsa-miR-4433	CLIP-seq
MIRT1397209	hsa-miR-4459	CLIP-seq
MIRT1397210	hsa-miR-4479	CLIP-seq
MIRT1397211	hsa-miR-4768-3p	CLIP-seq
MIRT1397212	hsa-miR-4782-5p	CLIP-seq
MIRT1397213	hsa-miR-4793-3p	CLIP-seq
MIRT1397214	hsa-miR-516b	CLIP-seq
MIRT1397215	hsa-miR-663	CLIP-seq
MIRT1397216	hsa-miR-767-5p	CLIP-seq
MIRT2118976	hsa-miR-1205	CLIP-seq
MIRT2118977	hsa-miR-1291	CLIP-seq
MIRT1397199	hsa-miR-1470	CLIP-seq
MIRT2118978	hsa-miR-1909	CLIP-seq
MIRT2118979	hsa-miR-3173-5p	CLIP-seq
MIRT1397199	hsa-miR-1470	CLIP-seq
MIRT2341278	hsa-miR-532-3p	CLIP-seq
MIRT2341279	hsa-miR-662	CLIP-seq
MIRT2692231	hsa-miR-4484	CLIP-seq
MIRT2692232	hsa-miR-4740-3p	CLIP-seq

Transcription factors

Show/Hide all(7)

Transcription factor	Regulation	Reference
NFYA	Unknown	22412893
NFYB	Unknown	22412893
NKX2-1	Repression	23995788
NR1H4	Activation	22265968
SP1	Unknown	22412893;23995788
STAT3	Unknown	24913037
STAT5A	Unknown	24913037

Show/Hide all(59)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IDA	12805220
GO:0001558	Process	Regulation of cell growth	ISS
GO:0001894	Process	Tissue homeostasis	IEA
GO:0001944	Process	Vasculature development	ISS
GO:0002039	Function	P53 binding	IDA	11430832
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	11430832, 12805220, 19892943
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	12595760, 12753905, 12805220, 14676191, 17216128, 19274086, 19513107, 19892943, 20562859, 22575644, 22939624, 24362629, 25036637, 25241761, 25329316, 25852190, 26479318, 28514442
GO:0005524	Function	ATP binding	IDA	12805220
GO:0005634	Component	Nucleus	IDA	12805220, 18854309
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	11430832, 12805220, 17216128, 18854309
GO:0005739	Component	Mitochondrion	IDA	11430832
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IDA	12805220, 25329316
GO:0006470	Process	Protein dephosphorylation	IMP	15731909
GO:0006914	Process	Autophagy	IEA
GO:0006974	Process	Cellular response to DNA damage stimulus	IMP	25329316
GO:0007050	Process	Cell cycle arrest	IDA	12805220, 17216128
GO:0007050	Process	Cell cycle arrest	TAS
GO:0007283	Process	Spermatogenesis	IEA
GO:0007409	Process	Axonogenesis	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	17216128, 25329316
GO:0010212	Process	Response to ionizing radiation	ISS
GO:0010508	Process	Positive regulation of autophagy	IMP	23878245
GO:0016020	Component	Membrane	ISS
GO:0030010	Process	Establishment of cell polarity	IMP	24643070
GO:0030010	Process	Establishment of cell polarity	ISS
GO:0030275	Function	LRR domain binding	IEA
GO:0030295	Function	Protein kinase activator activity	IDA	19892943
GO:0030308	Process	Negative regulation of cell growth	ISS
GO:0030511	Process	Positive regulation of transforming growth factor beta receptor signaling pathway	IMP	18311138
GO:0032147	Process	Activation of protein kinase activity	IMP	15731909
GO:0042593	Process	Glucose homeostasis	ISS
GO:0043276	Process	Anoikis	IMP	19622832
GO:0045059	Process	Positive thymic T cell selection	IEA
GO:0046777	Process	Protein autophosphorylation	IDA	11430832
GO:0048814	Process	Regulation of dendrite morphogenesis	IEA
GO:0050772	Process	Positive regulation of axonogenesis	IEA
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0051645	Process	Golgi localization	IEA
GO:0051896	Process	Regulation of protein kinase B signaling	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IEA
GO:0060770	Process	Negative regulation of epithelial cell proliferation involved in prostate gland development	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0071493	Process	Cellular response to UV-B	IDA	25329316
GO:0072332	Process	Intrinsic apoptotic signaling pathway by p53 class mediator	IDA	11430832
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IMP	15731909
GO:0097484	Process	Dendrite extension	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	27461402
GO:1900182	Process	Positive regulation of protein localization to nucleus	IEA
GO:1901610	Process	Positive regulation of vesicle transport along microtubule	IMP	24643070
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS
GO:1904262	Process	Negative regulation of TORC1 signaling	IMP	23878245

MIM	HGNC	e!Ensembl
602216	11389	ENSG00000118046

Protein

UniProt ID

Q15831

Protein name

Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)

Protein function

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage respo

PDB

2WTK , 4ZDR , 5WXN , 8VSU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	49 → 309	Protein kinase domain	Domain

Sequence

MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSY
GKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNE
EKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPG
NLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWS
AGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSI
RQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDI
IYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSA
SSKIRRLSACKQQ

Sequence length

433

Interactions

View interactions

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