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STAT5A (signal transducer and activator of transcription 5A)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6776
Gene nameGene Name - the full gene name approved by the HGNC.
Signal transducer and activator of transcription 5A
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
STAT5A
SynonymsGene synonyms aliases
MGF, STAT5
ChromosomeChromosome number
17
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.2
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that tran
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000018 hsa-miR-222-3p qRT-PCR, Luciferase reporter assay, Western blot 20489169
MIRT023082 hsa-miR-124-3p Microarray 18668037
MIRT438254 hsa-miR-221-3p Luciferase reporter assay 24736554
MIRT000018 hsa-miR-222-3p Luciferase reporter assay 24736554
MIRT000018 hsa-miR-222-3p Luciferase reporter assay 24736554
Transcription factors
Transcription factor Regulation Reference
PPARA Unknown 21542777
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001938 Process Positive regulation of endothelial cell proliferation IMP 20489169
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P42229
Protein name Signal transducer and activator of transcription 5A
Protein function Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated F
PDB 7TVA , 7TVB , 7UBT , 7UC6 , 7UC7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02865 STAT_int
2 124
STAT protein, protein interaction domain
Domain
PF01017 STAT_alpha
141 324
STAT protein, all-alpha domain
Family
PF02864 STAT_bind
336 469
STAT protein, DNA binding domain
Domain
PF00017 SH2
589 670
SH2 domain
Domain
Sequence
Sequence length 794
Interactions View interactions

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