STAT5A (signal transducer and activator of transcription 5A)

Gene

• Entrez ID: 6776
• Gene name: Signal transducer and activator of transcription 5A
• Gene symbol: STAT5A
• Synonyms: MGF, STAT5
• Chromosome: 17
• Chromosome location: 17q21.2
• Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000018	hsa-miR-222-3p	qRT-PCR, Luciferase reporter assay, Western blot	20489169
MIRT000018	hsa-miR-222-3p	Luciferase reporter assay	24736554
MIRT023082	hsa-miR-124-3p	Microarray	18668037
MIRT437995	hsa-miR-223-3p	Luciferase reporter assay, qRT-PCR	24400121
MIRT438254	hsa-miR-221-3p	Luciferase reporter assay	24736554
MIRT610924	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT610924	hsa-miR-5589-3p	HITS-CLIP	23313552
MIRT610924	hsa-miR-5589-3p	HITS-CLIP	27418678
MIRT610925	hsa-miR-1197	HITS-CLIP	23824327
MIRT610925	hsa-miR-1197	HITS-CLIP	23313552
MIRT610925	hsa-miR-1197	HITS-CLIP	27418678
MIRT610926	hsa-miR-8485	HITS-CLIP	23824327
MIRT610926	hsa-miR-8485	HITS-CLIP	23313552
MIRT610926	hsa-miR-8485	HITS-CLIP	27418678
MIRT610927	hsa-miR-4801	HITS-CLIP	23824327
MIRT610927	hsa-miR-4801	HITS-CLIP	23313552
MIRT610927	hsa-miR-4801	HITS-CLIP	27418678
MIRT610928	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT610928	hsa-miR-4731-3p	HITS-CLIP	23313552
MIRT610928	hsa-miR-4731-3p	HITS-CLIP	27418678
MIRT610929	hsa-miR-8080	HITS-CLIP	23824327
MIRT610929	hsa-miR-8080	HITS-CLIP	23313552
MIRT610929	hsa-miR-8080	HITS-CLIP	27418678
MIRT614732	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT614732	hsa-miR-6894-3p	HITS-CLIP	27418678
MIRT614733	hsa-miR-527	HITS-CLIP	23824327
MIRT614734	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT614735	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT614735	hsa-miR-4763-5p	HITS-CLIP	27418678
MIRT622022	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT622023	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT622024	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT622025	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT622026	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT622027	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT622028	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT622029	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT622030	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT622031	hsa-miR-7114-3p	HITS-CLIP	23824327
MIRT622032	hsa-miR-1180-5p	HITS-CLIP	23824327
MIRT622033	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT622034	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT622035	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT622036	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT622037	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT622038	hsa-miR-603	HITS-CLIP	23824327
MIRT693837	hsa-miR-4457	HITS-CLIP	23313552
MIRT693837	hsa-miR-4457	HITS-CLIP	27418678
MIRT731071	hsa-miR-141-3p	Immunocytochemistry, Western blot, Luciferase reporter assay	25241899
MIRT734490	hsa-miR-296-3p	Immunoprecipitaion, Luciferase reporter assay	26923924

Transcription factors

Transcription factor	Regulation	Reference
PPARA	Unknown	21542777

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001938	Process	Positive regulation of endothelial cell proliferation	IMP	20489169
GO:0003700	Function	DNA-binding transcription factor activity	TAS	7719937, 8631883
GO:0005515	Function	Protein binding	IPI	12237455, 16819511, 20075866, 24658140, 25416956, 31980649
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006952	Process	Defense response	IBA	21873635
GO:0007259	Process	Receptor signaling pathway via JAK-STAT	IBA	21873635
GO:0007595	Process	Lactation	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019530	Process	Taurine metabolic process	ISS
GO:0035723	Process	Interleukin-15-mediated signaling pathway	TAS
GO:0038026	Process	Reelin-mediated signaling pathway	IDA	29581031
GO:0038110	Process	Interleukin-2-mediated signaling pathway	TAS
GO:0038111	Process	Interleukin-7-mediated signaling pathway	TAS
GO:0038113	Process	Interleukin-9-mediated signaling pathway	TAS
GO:0040014	Process	Regulation of multicellular organism growth	ISS
GO:0042127	Process	Regulation of cell population proliferation	IBA	21873635
GO:0043434	Process	Response to peptide hormone	IBA	21873635
GO:0043536	Process	Positive regulation of blood vessel endothelial cell migration	IMP	20489169
GO:0060397	Process	Growth hormone receptor signaling pathway via JAK-STAT	IBA	21873635
GO:0060397	Process	Growth hormone receptor signaling pathway via JAK-STAT	TAS

Other IDs

• MIM: 601511
• HGNC: 11366
• e!Ensembl: ENSG00000126561

Protein

• UniProt ID: P42229
• Protein name: Signal transducer and activator of transcription 5A
• Protein function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02865	STAT_int	2 → 124	STAT protein, protein interaction domain	Domain
  PF01017	STAT_alpha	141 → 324	STAT protein, all-alpha domain	Family
  PF02864	STAT_bind	336 → 469	STAT protein, DNA binding domain	Domain
  PF00017	SH2	589 → 670	SH2 domain	Domain

• Sequence:

  MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
  REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
  RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
  RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
  QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
  NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
  LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
  TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
  SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
  QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
  GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY
  MDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLS
  PPAGLFTSARGSLS

• Sequence length: 794