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STAT3 (signal transducer and activator of transcription 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6774
Gene nameGene Name - the full gene name approved by the HGNC.
Signal transducer and activator of transcription 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
STAT3
SynonymsGene synonyms aliases
ADMIO, ADMIO1, APRF, HIES
ChromosomeChromosome number
17
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.2
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the ce
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs113994135 G>A Pathogenic Coding sequence variant, missense variant
rs113994136 C>A,T Pathogenic Coding sequence variant, missense variant
rs113994137 C>T Pathogenic Coding sequence variant, missense variant
rs113994138 CAC>- Pathogenic Coding sequence variant, inframe deletion
rs113994139 C>T Pathogenic Coding sequence variant, missense variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000497 hsa-miR-20b-5p qRT-PCR, ELISA, ChIP, Western blot 20232316
MIRT005006 hsa-miR-125b-5p Microarray 17891175
MIRT006959 hsa-miR-337-3p Luciferase reporter assay, qRT-PCR, Western blot 22723956
MIRT021003 hsa-miR-155-5p Proteomics 18668040
MIRT028178 hsa-miR-93-5p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
BCL6 Unknown 17951530
BRCA1 Unknown 11163768
CEBPA Unknown 24429361
HDAC1 Unknown 18611949
HIC1 Activation 24067369
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS 8675499
GO:0000785 Component Chromatin IDA 16835372
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 17324931
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P40763
Protein name Signal transducer and activator of transcription 3 (Acute-phase response factor)
Protein function Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed
PDB 5AX3 , 5U5S , 6NJS , 6NUQ , 6QHD , 6TLC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02865 STAT_int
2 120
STAT protein, protein interaction domain
Domain
PF01017 STAT_alpha
141 313
STAT protein, all-alpha domain
Family
PF02864 STAT_bind
325 464
STAT protein, DNA binding domain
Domain
PF00017 SH2
584 674
SH2 domain
Domain
Sequence
Sequence length 770
Interactions View interactions

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