SREBF1 (sterol regulatory element binding transcription factor 1)

Gene

• Entrez ID: 6720
• Gene name: Sterol regulatory element binding transcription factor 1
• Gene symbol: SREBF1
• Synonyms: HMD, IFAP2, SREBP1, bHLHd1
• Chromosome: 17
• Chromosome location: 17p11.2
• Summary: This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes inv

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018325	hsa-miR-335-5p	Microarray	18185580
MIRT051418	hsa-let-7e-5p	CLASH	23622248
MIRT050226	hsa-miR-25-3p	CLASH	23622248
MIRT047574	hsa-miR-10a-5p	CLASH	23622248
MIRT045315	hsa-miR-185-5p	CLASH	23622248
MIRT043859	hsa-miR-378a-3p	CLASH	23622248
MIRT041670	hsa-miR-484	CLASH	23622248
MIRT038739	hsa-miR-93-3p	CLASH	23622248
MIRT037474	hsa-miR-744-5p	CLASH	23622248
MIRT054225	hsa-miR-128-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23990020
MIRT054225	hsa-miR-128-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23990020
MIRT054666	hsa-miR-33a-5p	qRT-PCR, Western blot	24300912
MIRT045315	hsa-miR-185-5p	Luciferase reporter assay, qRT-PCR, Western blot	23951060
MIRT438066	hsa-miR-342-3p	Luciferase reporter assay, qRT-PCR, Western blot	23951060
MIRT045315	hsa-miR-185-5p	Luciferase reporter assay, qRT-PCR, Western blot	23951060
MIRT438066	hsa-miR-342-3p	Luciferase reporter assay, qRT-PCR, Western blot	23951060
MIRT721601	hsa-miR-495-3p	HITS-CLIP	19536157
MIRT721600	hsa-miR-5688	HITS-CLIP	19536157
MIRT721599	hsa-miR-7-1-3p	HITS-CLIP	19536157
MIRT721598	hsa-miR-7-2-3p	HITS-CLIP	19536157
MIRT721597	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT721597	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT721596	hsa-miR-4301	HITS-CLIP	19536157
MIRT721595	hsa-miR-4286	HITS-CLIP	19536157
MIRT721594	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT721593	hsa-miR-4290	HITS-CLIP	19536157
MIRT721592	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT721591	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT487335	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT487333	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487329	hsa-miR-4271	PAR-CLIP	20371350
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT487326	hsa-miR-663b	PAR-CLIP	20371350
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	20371350
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	20371350
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT487335	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT487333	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487329	hsa-miR-4271	PAR-CLIP	20371350
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT487326	hsa-miR-663b	PAR-CLIP	20371350
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	20371350
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	20371350
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT487335	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT487333	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487329	hsa-miR-4271	PAR-CLIP	20371350
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT487326	hsa-miR-663b	PAR-CLIP	20371350
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	20371350
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	20371350
MIRT527532	hsa-miR-95-5p	PAR-CLIP	22012620
MIRT527531	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT487335	hsa-miR-671-5p	PAR-CLIP	23592263
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	23592263
MIRT487333	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT487329	hsa-miR-4271	PAR-CLIP	23592263
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT487326	hsa-miR-663b	PAR-CLIP	23592263
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	23592263
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	23592263
MIRT439142	hsa-let-7c-5p	3'LIFE	25074381
MIRT439117	hsa-miR-10b-5p	3'LIFE	25074381
MIRT439142	hsa-let-7c-5p	3'LIFE	25074381
MIRT439117	hsa-miR-10b-5p	3'LIFE	25074381
MIRT721601	hsa-miR-495-3p	HITS-CLIP	19536157
MIRT721600	hsa-miR-5688	HITS-CLIP	19536157
MIRT721599	hsa-miR-7-1-3p	HITS-CLIP	19536157
MIRT721598	hsa-miR-7-2-3p	HITS-CLIP	19536157
MIRT721597	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT721597	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT721596	hsa-miR-4301	HITS-CLIP	19536157
MIRT721595	hsa-miR-4286	HITS-CLIP	19536157
MIRT721594	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT721593	hsa-miR-4290	HITS-CLIP	19536157
MIRT721592	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT721591	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT487335	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT487333	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487329	hsa-miR-4271	PAR-CLIP	20371350
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT487326	hsa-miR-663b	PAR-CLIP	20371350
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	20371350
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	20371350
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT487335	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT487333	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487329	hsa-miR-4271	PAR-CLIP	20371350
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT487326	hsa-miR-663b	PAR-CLIP	20371350
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	20371350
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	20371350
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT487335	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT487333	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487329	hsa-miR-4271	PAR-CLIP	20371350
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT487326	hsa-miR-663b	PAR-CLIP	20371350
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	20371350
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	20371350
MIRT527532	hsa-miR-95-5p	PAR-CLIP	22012620
MIRT527531	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT487335	hsa-miR-671-5p	PAR-CLIP	23592263
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	23592263
MIRT487333	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT487329	hsa-miR-4271	PAR-CLIP	23592263
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT487326	hsa-miR-663b	PAR-CLIP	23592263
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	23592263
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	23592263
MIRT1387947	hsa-miR-1323	CLIP-seq
MIRT1387948	hsa-miR-142-5p	CLIP-seq
MIRT1387949	hsa-miR-18a	CLIP-seq
MIRT1387950	hsa-miR-18b	CLIP-seq
MIRT1387951	hsa-miR-296-5p	CLIP-seq
MIRT1387952	hsa-miR-3148	CLIP-seq
MIRT1387953	hsa-miR-3173-3p	CLIP-seq
MIRT1387954	hsa-miR-3647-3p	CLIP-seq
MIRT1387955	hsa-miR-4459	CLIP-seq
MIRT1387956	hsa-miR-4698	CLIP-seq
MIRT1387957	hsa-miR-4735-3p	CLIP-seq
MIRT1387958	hsa-miR-4779	CLIP-seq
MIRT1387959	hsa-miR-513c	CLIP-seq
MIRT1387960	hsa-miR-514b-5p	CLIP-seq
MIRT1387961	hsa-miR-548o	CLIP-seq
MIRT1387962	hsa-miR-561	CLIP-seq
MIRT1387963	hsa-miR-1234	CLIP-seq
MIRT1387964	hsa-miR-1275	CLIP-seq
MIRT1387965	hsa-miR-1286	CLIP-seq
MIRT1387947	hsa-miR-1323	CLIP-seq
MIRT1387948	hsa-miR-142-5p	CLIP-seq
MIRT1387949	hsa-miR-18a	CLIP-seq
MIRT1387950	hsa-miR-18b	CLIP-seq
MIRT1387966	hsa-miR-1910	CLIP-seq
MIRT1387967	hsa-miR-2467-3p	CLIP-seq
MIRT1387968	hsa-miR-3158-5p	CLIP-seq
MIRT1387953	hsa-miR-3173-3p	CLIP-seq
MIRT1387969	hsa-miR-330-3p	CLIP-seq
MIRT1387970	hsa-miR-3612	CLIP-seq
MIRT1387954	hsa-miR-3647-3p	CLIP-seq
MIRT1387971	hsa-miR-3678-3p	CLIP-seq
MIRT1387972	hsa-miR-3690	CLIP-seq
MIRT1387973	hsa-miR-377	CLIP-seq
MIRT1387974	hsa-miR-3973	CLIP-seq
MIRT1387975	hsa-miR-4254	CLIP-seq
MIRT1387976	hsa-miR-4297	CLIP-seq
MIRT1387977	hsa-miR-4325	CLIP-seq
MIRT1387978	hsa-miR-4436a	CLIP-seq
MIRT1387979	hsa-miR-4443	CLIP-seq
MIRT1387980	hsa-miR-4446-5p	CLIP-seq
MIRT1387981	hsa-miR-450b-5p	CLIP-seq
MIRT1387982	hsa-miR-4525	CLIP-seq
MIRT1387983	hsa-miR-455-3p	CLIP-seq
MIRT1387984	hsa-miR-4665-3p	CLIP-seq
MIRT1387985	hsa-miR-4665-5p	CLIP-seq
MIRT1387986	hsa-miR-4723-5p	CLIP-seq
MIRT1387987	hsa-miR-4731-5p	CLIP-seq
MIRT1387957	hsa-miR-4735-3p	CLIP-seq
MIRT1387988	hsa-miR-4755-5p	CLIP-seq
MIRT1387989	hsa-miR-4763-5p	CLIP-seq
MIRT1387958	hsa-miR-4779	CLIP-seq
MIRT1387959	hsa-miR-513c	CLIP-seq
MIRT1387960	hsa-miR-514b-5p	CLIP-seq
MIRT1387990	hsa-miR-518a-5p	CLIP-seq
MIRT1387991	hsa-miR-527	CLIP-seq
MIRT1387992	hsa-miR-548an	CLIP-seq
MIRT1387961	hsa-miR-548o	CLIP-seq
MIRT1387993	hsa-miR-550a	CLIP-seq
MIRT1387962	hsa-miR-561	CLIP-seq
MIRT1387994	hsa-miR-625	CLIP-seq
MIRT1387995	hsa-miR-637	CLIP-seq
MIRT1387996	hsa-miR-650	CLIP-seq
MIRT1387963	hsa-miR-1234	CLIP-seq
MIRT1387969	hsa-miR-330-3p	CLIP-seq
MIRT1387976	hsa-miR-4297	CLIP-seq
MIRT1387984	hsa-miR-4665-3p	CLIP-seq
MIRT2116230	hsa-miR-1233	CLIP-seq
MIRT2116231	hsa-miR-150	CLIP-seq
MIRT2116232	hsa-miR-185	CLIP-seq
MIRT2116233	hsa-miR-3065-3p	CLIP-seq
MIRT2116234	hsa-miR-3153	CLIP-seq
MIRT2116235	hsa-miR-326	CLIP-seq
MIRT2116236	hsa-miR-330-5p	CLIP-seq
MIRT1387970	hsa-miR-3612	CLIP-seq
MIRT2116237	hsa-miR-4306	CLIP-seq
MIRT1387979	hsa-miR-4443	CLIP-seq
MIRT2116238	hsa-miR-4487	CLIP-seq
MIRT2116239	hsa-miR-4497	CLIP-seq
MIRT2116240	hsa-miR-4644	CLIP-seq
MIRT2116241	hsa-miR-4667-5p	CLIP-seq
MIRT2116242	hsa-miR-4695-5p	CLIP-seq
MIRT2116243	hsa-miR-4700-5p	CLIP-seq
MIRT2116244	hsa-miR-4713-5p	CLIP-seq
MIRT2116245	hsa-miR-4757-5p	CLIP-seq
MIRT2116246	hsa-miR-486-3p	CLIP-seq
MIRT1387995	hsa-miR-637	CLIP-seq
MIRT1387996	hsa-miR-650	CLIP-seq
MIRT2116247	hsa-miR-662	CLIP-seq
MIRT2338765	hsa-miR-1236	CLIP-seq
MIRT1387947	hsa-miR-1323	CLIP-seq
MIRT2116233	hsa-miR-3065-3p	CLIP-seq
MIRT2338766	hsa-miR-3137	CLIP-seq
MIRT1387952	hsa-miR-3148	CLIP-seq
MIRT2338767	hsa-miR-3183	CLIP-seq
MIRT2338768	hsa-miR-339-5p	CLIP-seq
MIRT2338769	hsa-miR-4257	CLIP-seq
MIRT1387976	hsa-miR-4297	CLIP-seq
MIRT2338770	hsa-miR-4421	CLIP-seq
MIRT1387955	hsa-miR-4459	CLIP-seq
MIRT2338771	hsa-miR-4672	CLIP-seq
MIRT2338772	hsa-miR-4723-3p	CLIP-seq
MIRT2338773	hsa-miR-486-5p	CLIP-seq
MIRT1387959	hsa-miR-513c	CLIP-seq
MIRT1387960	hsa-miR-514b-5p	CLIP-seq
MIRT1387961	hsa-miR-548o	CLIP-seq
MIRT2338774	hsa-miR-670	CLIP-seq
MIRT2395152	hsa-miR-4649-3p	CLIP-seq
MIRT2116230	hsa-miR-1233	CLIP-seq
MIRT1387963	hsa-miR-1234	CLIP-seq
MIRT2632205	hsa-miR-1289	CLIP-seq
MIRT2116231	hsa-miR-150	CLIP-seq
MIRT2116232	hsa-miR-185	CLIP-seq
MIRT2116234	hsa-miR-3153	CLIP-seq
MIRT2632206	hsa-miR-3173-5p	CLIP-seq
MIRT2632207	hsa-miR-3198	CLIP-seq
MIRT2116235	hsa-miR-326	CLIP-seq
MIRT2116236	hsa-miR-330-5p	CLIP-seq
MIRT2632208	hsa-miR-4270	CLIP-seq
MIRT2632209	hsa-miR-4294	CLIP-seq
MIRT2116237	hsa-miR-4306	CLIP-seq
MIRT2632210	hsa-miR-4309	CLIP-seq
MIRT2632211	hsa-miR-4327	CLIP-seq
MIRT2632212	hsa-miR-4441	CLIP-seq
MIRT2632213	hsa-miR-4480	CLIP-seq
MIRT2116239	hsa-miR-4497	CLIP-seq
MIRT2116240	hsa-miR-4644	CLIP-seq
MIRT2116241	hsa-miR-4667-5p	CLIP-seq
MIRT2116243	hsa-miR-4700-5p	CLIP-seq
MIRT2632214	hsa-miR-4704-5p	CLIP-seq
MIRT2116244	hsa-miR-4713-5p	CLIP-seq
MIRT2632215	hsa-miR-4715-5p	CLIP-seq
MIRT2116245	hsa-miR-4757-5p	CLIP-seq
MIRT2632216	hsa-miR-4785	CLIP-seq
MIRT2116246	hsa-miR-486-3p	CLIP-seq
MIRT1387995	hsa-miR-637	CLIP-seq
MIRT2116247	hsa-miR-662	CLIP-seq
MIRT2116230	hsa-miR-1233	CLIP-seq
MIRT1387963	hsa-miR-1234	CLIP-seq
MIRT2632205	hsa-miR-1289	CLIP-seq
MIRT2116231	hsa-miR-150	CLIP-seq
MIRT2116232	hsa-miR-185	CLIP-seq
MIRT2116234	hsa-miR-3153	CLIP-seq
MIRT2632206	hsa-miR-3173-5p	CLIP-seq
MIRT2632207	hsa-miR-3198	CLIP-seq
MIRT2116235	hsa-miR-326	CLIP-seq
MIRT2116236	hsa-miR-330-5p	CLIP-seq
MIRT2632208	hsa-miR-4270	CLIP-seq
MIRT2632209	hsa-miR-4294	CLIP-seq
MIRT2116237	hsa-miR-4306	CLIP-seq
MIRT2632210	hsa-miR-4309	CLIP-seq
MIRT2632211	hsa-miR-4327	CLIP-seq
MIRT2632212	hsa-miR-4441	CLIP-seq
MIRT2632213	hsa-miR-4480	CLIP-seq
MIRT2116239	hsa-miR-4497	CLIP-seq
MIRT2116240	hsa-miR-4644	CLIP-seq
MIRT2116241	hsa-miR-4667-5p	CLIP-seq
MIRT2116243	hsa-miR-4700-5p	CLIP-seq
MIRT2632214	hsa-miR-4704-5p	CLIP-seq
MIRT2116244	hsa-miR-4713-5p	CLIP-seq
MIRT2632215	hsa-miR-4715-5p	CLIP-seq
MIRT2116245	hsa-miR-4757-5p	CLIP-seq
MIRT2632216	hsa-miR-4785	CLIP-seq
MIRT2116246	hsa-miR-486-3p	CLIP-seq
MIRT1387995	hsa-miR-637	CLIP-seq
MIRT2116247	hsa-miR-662	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Activation	20179320
SP1	Unknown	15462672

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	23610160
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0003062	Process	Regulation of heart rate by chemical signal	IEA
GO:0003677	Function	DNA binding	ISS
GO:0003682	Function	Chromatin binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	16407292
GO:0004879	Function	Nuclear receptor activity	IDA	23610160
GO:0005515	Function	Protein binding	IPI	14701856, 16713569, 21993218, 23610160, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	15358760
GO:0005635	Component	Nuclear envelope	TAS	8156598
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006629	Process	Lipid metabolic process	TAS	8156598
GO:0007568	Process	Aging	IEA
GO:0007623	Process	Circadian rhythm	TAS
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0008286	Process	Insulin receptor signaling pathway	IEA
GO:0008610	Process	Lipid biosynthetic process	ISS
GO:0009267	Process	Cellular response to starvation	ISS	16407292
GO:0009749	Process	Response to glucose	IEA
GO:0010867	Process	Positive regulation of triglyceride biosynthetic process	ISS
GO:0010876	Process	Lipid localization	IEA
GO:0010883	Process	Regulation of lipid storage	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0019217	Process	Regulation of fatty acid metabolic process	IEA
GO:0019901	Function	Protein kinase binding	IEA
GO:0030324	Process	Lung development	IEA
GO:0030522	Process	Intracellular receptor signaling pathway	IEA
GO:0031065	Process	Positive regulation of histone deacetylation	IEA
GO:0031647	Process	Regulation of protein stability	IMP	24912190
GO:0032094	Process	Response to food	IEA
GO:0032526	Process	Response to retinoic acid	IEA
GO:0032570	Process	Response to progesterone	IEA
GO:0032810	Function	Sterol response element binding	IDA	16407292
GO:0032933	Process	SREBP signaling pathway	IDA	27614840
GO:0032933	Process	SREBP signaling pathway	IMP	27614840
GO:0032991	Component	Protein-containing complex	IEA
GO:0033762	Process	Response to glucagon	IEA
GO:0042493	Process	Response to drug	IEA
GO:0042789	Process	MRNA transcription by RNA polymerase II	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045444	Process	Fat cell differentiation	IEA
GO:0045471	Process	Response to ethanol	IEA
GO:0045540	Process	Regulation of cholesterol biosynthetic process	TAS
GO:0045542	Process	Positive regulation of cholesterol biosynthetic process	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	26437365
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IGI	23610160
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	TAS	23610160
GO:0046676	Process	Negative regulation of insulin secretion	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0051591	Process	Response to cAMP	IEA
GO:0071398	Process	Cellular response to fatty acid	IEA
GO:1903146	Process	Regulation of autophagy of mitochondrion	IMP	24912190
GO:1903214	Process	Regulation of protein targeting to mitochondrion	IMP	24912190
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 184756
• HGNC: 11289
• e!Ensembl: ENSG00000072310

Protein

• UniProt ID: P36956
• Protein name: Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor
• Protein function: [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentratio
• PDB: 1AM9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00010	HLH	324 → 374	Helix-loop-helix DNA-binding domain	Domain

• Sequence:

  MDEPPFSEAALEQALGEPCDLDAALLTDIEDMLQLINNQDSDFPGLFDPPYAGSGAGGTD
  PASPDTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPPQPAPTPLKMYPSMPAFSPGP
  GIKEESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPPGGFSTGSPPGN
  TQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQQVPVLL
  QPHFIKADSLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDA
  EKLPINRLAAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKS
  AVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHKSKSLKDLVSACGSGGNTDVLMEGVKTE
  VEDTLTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLHSR
  GMLDRSRLALCTLVFLCLSCNPLASLLGARGLPSPSDTTSVYHSPGRNVLGTESRDGPGW
  AQWLLPPVVWLLNGLLVLVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLARGDFAQ
  AAQQLWLALRALGRPLPTSHLDLACSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRV
  DASASARDAALVYHKLHQLHTMGKHTGGHLTATNLALSALNLAECAGDAVSVATLAEIYV
  AAALRVKTSLPRALHFLTRFFLSSARQACLAQSGSVPPAMQWLCHPVGHRFFVDGDWSVL
  STPWESLYSLAGNPVDPLAQVTQLFREHLLERALNCVTQPNPSPGSADGDKEFSDALGYL
  QLLNSCSDAAGAPAYSFSISSSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPL
  VEHLPRVLQESERPLPRAALHSFKAARALLGCAKAESGPASLTICEKASGYLQDSLATTP
  ASSSIDKAVQLFLCDLLLVVRTSLWRQQQPPAPAPAAQGTSSRPQASALELRGFQRDLSS
  LRRLAQSFRPAMRRVFLHEATARLMAGASPTRTHQLLDRSLRRRAGPGGKGGAVAELEPR
  PTRREHAEALLLASCYLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGG
  GTTVTSS

• Sequence length: 1147