SORBS1 (sorbin and SH3 domain containing 1)

Gene

• Entrez ID: 10580
• Gene name: Sorbin and SH3 domain containing 1
• Gene symbol: SORBS1
• Synonyms: CAP, FLAF2, R85FL, SH3D5, SH3P12, SORB1
• Chromosome: 10
• Chromosome location: 10q24.1
• Summary: This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044804	hsa-miR-320a	CLASH	23622248

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	ISS
GO:0003779	Function	Actin binding	TAS	10085297
GO:0005158	Function	Insulin receptor binding	IDA	11374898
GO:0005515	Function	Protein binding	IPI	11371513, 11374898, 12504111, 16374509, 17500595, 19116150, 23892081, 31413325
GO:0005634	Component	Nucleus	IDA	11371513
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	ISS	9447983
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005912	Component	Adherens junction	ISS
GO:0005915	Component	Zonula adherens	TAS	10085297
GO:0005925	Component	Focal adhesion	IDA
GO:0006936	Process	Muscle contraction	TAS
GO:0007160	Process	Cell-matrix adhesion	TAS	10085297
GO:0008092	Function	Cytoskeletal protein binding	TAS	10085297
GO:0008286	Process	Insulin receptor signaling pathway	ISS
GO:0016363	Component	Nuclear matrix	IEA
GO:0030055	Component	Cell-substrate junction	ISS
GO:0030159	Function	Signaling receptor complex adaptor activity	IDA	11374898
GO:0030159	Function	Signaling receptor complex adaptor activity	ISS	9447983
GO:0032869	Process	Cellular response to insulin stimulus	ISS	11001060
GO:0043149	Process	Stress fiber assembly	ISS
GO:0045121	Component	Membrane raft	ISS
GO:0045725	Process	Positive regulation of glycogen biosynthetic process	ISS	11001060
GO:0046326	Process	Positive regulation of glucose import	ISS	11001060
GO:0046628	Process	Positive regulation of insulin receptor signaling pathway	ISS
GO:0046889	Process	Positive regulation of lipid biosynthetic process	ISS	11001060
GO:0048041	Process	Focal adhesion assembly	ISS
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	ISS

Other IDs

• MIM: 605264
• HGNC: 14565
• e!Ensembl: ENSG00000095637

Protein

• UniProt ID: Q9BX66
• Protein name: Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
• Protein function: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).
• PDB: 2DL3, 2ECZ, 2LJ0, 2LJ1, 2MOX, 2O2W, 2O31, 2O9S, 2O9V, 4LN2, 4LNP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02208	Sorb	370 → 411	Sorbin homologous domain	Family
  PF07653	SH3_2	797 → 850	Variant SH3 domain	Domain
  PF00018	SH3_1	873 → 920	SH3 domain	Domain
  PF14604	SH3_9	1238 → 1288	Variant SH3 domain	Domain

• Sequence:

  MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
  LTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
  NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP
  TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS
  FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
  YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
  DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK
  FPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSK
  SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQP
  GKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDR
  KTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHA
  VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA
  DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL
  LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG
  IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV
  DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHS
  KLITPAPSSLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDH
  LALSPRASPSLSLSLPHLSWSDRPTPRSVASPLALPSPHKTYSLAPTSQASLHMNGDGGV
  HTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAGERGP
  GGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGE
  QAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV
  MEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL

• Sequence length: 1292