SOCS3 (suppressor of cytokine signaling 3)

Gene

• Entrez ID: 9021
• Gene name: Suppressor of cytokine signaling 3
• Gene symbol: SOCS3
• Synonyms: ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3
• Chromosome: 17
• Chromosome location: 17q25.3
• Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005062	hsa-miR-203a-3p	Immunohistochemistry, In situ hybridization, Microarray, Western blot	17622355
MIRT005062	hsa-miR-203a-3p	Luciferase reporter assay, qRT-PCR, Western blot	22207897
MIRT005062	hsa-miR-203a-3p	Luciferase reporter assay, qRT-PCR, Western blot	22207897
MIRT007129	hsa-miR-30c-5p	qRT-PCR	23418453
MIRT054389	hsa-let-7f-5p	Luciferase reporter assay	22894925
MIRT005062	hsa-miR-203a-3p	ELISA, qRT-PCR	23775225
MIRT438883	hsa-miR-155-5p	qRT-PCR	23428672
MIRT438546	hsa-miR-221-3p	Luciferase reporter assay, Western blot	25019494
MIRT438546	hsa-miR-221-3p	Luciferase reporter assay, Western blot	25019494
MIRT438094	hsa-miR-19a-3p	Luciferase reporter assay	23894411
MIRT438094	hsa-miR-19a-3p	Luciferase reporter assay	23894411
MIRT438883	hsa-miR-155-5p	qRT-PCR	23428672
MIRT438546	hsa-miR-221-3p	Luciferase reporter assay, Western blot	25019494
MIRT438546	hsa-miR-221-3p	Luciferase reporter assay, Western blot	25019494
MIRT438094	hsa-miR-19a-3p	Luciferase reporter assay	23894411
MIRT438094	hsa-miR-19a-3p	Luciferase reporter assay	23894411
MIRT534120	hsa-miR-340-5p	PAR-CLIP	22012620
MIRT534119	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT534118	hsa-miR-520f-3p	PAR-CLIP	22012620
MIRT534117	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT534116	hsa-miR-512-3p	PAR-CLIP	22012620
MIRT534115	hsa-miR-4473	PAR-CLIP	22012620
MIRT534114	hsa-miR-4795-3p	PAR-CLIP	22012620
MIRT534113	hsa-miR-335-3p	PAR-CLIP	22012620
MIRT467411	hsa-miR-30b-5p	PAR-CLIP	23592263
MIRT467410	hsa-miR-30a-5p	PAR-CLIP	23592263
MIRT007129	hsa-miR-30c-5p	PAR-CLIP	23592263
MIRT467409	hsa-miR-30d-5p	PAR-CLIP	23592263
MIRT467408	hsa-miR-30e-5p	PAR-CLIP	23592263
MIRT467407	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT467406	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT467405	hsa-miR-8062	PAR-CLIP	23592263
MIRT467404	hsa-miR-126-5p	PAR-CLIP	23592263
MIRT467403	hsa-miR-759	PAR-CLIP	23592263
MIRT467401	hsa-miR-4765	PAR-CLIP	23592263
MIRT467402	hsa-miR-508-3p	PAR-CLIP	23592263
MIRT467400	hsa-miR-4477a	PAR-CLIP	23592263
MIRT467399	hsa-miR-6765-5p	PAR-CLIP	23592263
MIRT467398	hsa-miR-1304-5p	PAR-CLIP	23592263
MIRT438094	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT726475	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT007129	hsa-miR-30c-5p	ELISA, Luciferase reporter assay, qRT-PCR, Western blot	26707189
MIRT732459	hsa-miR-4449	Luciferase reporter assay, qRT-PCR, Western blotting	33854373
MIRT467408	hsa-miR-30e-5p	Luciferase reporter assay, Immunoprecipitaion (IP), ELISA	32688283
MIRT735666	hsa-miR-324-5p	Luciferase reporter assay, Western blotting, qRT-PCR, ELISA	33191336
MIRT726475	hsa-miR-19b-3p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR	31667786
MIRT534120	hsa-miR-340-5p	PAR-CLIP	22012620
MIRT534119	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT534118	hsa-miR-520f-3p	PAR-CLIP	22012620
MIRT534117	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT534116	hsa-miR-512-3p	PAR-CLIP	22012620
MIRT534115	hsa-miR-4473	PAR-CLIP	22012620
MIRT534114	hsa-miR-4795-3p	PAR-CLIP	22012620
MIRT534113	hsa-miR-335-3p	PAR-CLIP	22012620
MIRT467411	hsa-miR-30b-5p	PAR-CLIP	23592263
MIRT467410	hsa-miR-30a-5p	PAR-CLIP	23592263
MIRT007129	hsa-miR-30c-5p	PAR-CLIP	23592263
MIRT467409	hsa-miR-30d-5p	PAR-CLIP	23592263
MIRT467408	hsa-miR-30e-5p	PAR-CLIP	23592263
MIRT467407	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT467406	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT467405	hsa-miR-8062	PAR-CLIP	23592263
MIRT467404	hsa-miR-126-5p	PAR-CLIP	23592263
MIRT467403	hsa-miR-759	PAR-CLIP	23592263
MIRT467401	hsa-miR-4765	PAR-CLIP	23592263
MIRT467402	hsa-miR-508-3p	PAR-CLIP	23592263
MIRT467400	hsa-miR-4477a	PAR-CLIP	23592263
MIRT467399	hsa-miR-6765-5p	PAR-CLIP	23592263
MIRT467398	hsa-miR-1304-5p	PAR-CLIP	23592263
MIRT755584	hsa-miR-181a	Luciferase reporter assay, Western blotting, qRT-PCR	34873301
MIRT755584	hsa-miR-181a	Luciferase reporter assay, Western blotting, qRT-PCR	34873301
MIRT726475	hsa-miR-19b-3p	Luciferase reporter assay, Western blotting, qRT-PCR	36484970
MIRT1378519	hsa-miR-1266	CLIP-seq
MIRT1378520	hsa-miR-1290	CLIP-seq
MIRT1378521	hsa-miR-1291	CLIP-seq
MIRT1378522	hsa-miR-148a	CLIP-seq
MIRT1378523	hsa-miR-148b	CLIP-seq
MIRT1378524	hsa-miR-152	CLIP-seq
MIRT1378525	hsa-miR-1827	CLIP-seq
MIRT1378526	hsa-miR-183	CLIP-seq
MIRT1378527	hsa-miR-1908	CLIP-seq
MIRT1378528	hsa-miR-19a	CLIP-seq
MIRT1378529	hsa-miR-19b	CLIP-seq
MIRT1378530	hsa-miR-203	CLIP-seq
MIRT1378531	hsa-miR-216b	CLIP-seq
MIRT1378532	hsa-miR-2467-3p	CLIP-seq
MIRT1378533	hsa-miR-2861	CLIP-seq
MIRT1378534	hsa-miR-3202	CLIP-seq
MIRT1378535	hsa-miR-3529	CLIP-seq
MIRT1378536	hsa-miR-3612	CLIP-seq
MIRT1378537	hsa-miR-3663-3p	CLIP-seq
MIRT1378538	hsa-miR-3664-3p	CLIP-seq
MIRT1378539	hsa-miR-378g	CLIP-seq
MIRT1378540	hsa-miR-379	CLIP-seq
MIRT1378541	hsa-miR-383	CLIP-seq
MIRT1378542	hsa-miR-3927	CLIP-seq
MIRT1378543	hsa-miR-4269	CLIP-seq
MIRT1378544	hsa-miR-4270	CLIP-seq
MIRT1378545	hsa-miR-4271	CLIP-seq
MIRT1378546	hsa-miR-4278	CLIP-seq
MIRT1378547	hsa-miR-4292	CLIP-seq
MIRT1378548	hsa-miR-4313	CLIP-seq
MIRT1378549	hsa-miR-4420	CLIP-seq
MIRT1378550	hsa-miR-4427	CLIP-seq
MIRT1378551	hsa-miR-4437	CLIP-seq
MIRT1378552	hsa-miR-4441	CLIP-seq
MIRT1378553	hsa-miR-4443	CLIP-seq
MIRT1378554	hsa-miR-4455	CLIP-seq
MIRT1378555	hsa-miR-4476	CLIP-seq
MIRT1378556	hsa-miR-4477b	CLIP-seq
MIRT1378557	hsa-miR-450b-3p	CLIP-seq
MIRT1378558	hsa-miR-4512	CLIP-seq
MIRT1378559	hsa-miR-4514	CLIP-seq
MIRT1378560	hsa-miR-4518	CLIP-seq
MIRT1378561	hsa-miR-4674	CLIP-seq
MIRT1378562	hsa-miR-4680-3p	CLIP-seq
MIRT1378563	hsa-miR-4692	CLIP-seq
MIRT1378564	hsa-miR-4716-3p	CLIP-seq
MIRT1378565	hsa-miR-4723-5p	CLIP-seq
MIRT1378566	hsa-miR-4725-3p	CLIP-seq
MIRT1378567	hsa-miR-4733-3p	CLIP-seq
MIRT1378568	hsa-miR-4742-5p	CLIP-seq
MIRT1378569	hsa-miR-4762-3p	CLIP-seq
MIRT1378570	hsa-miR-4772-5p	CLIP-seq
MIRT1378571	hsa-miR-498	CLIP-seq
MIRT1378572	hsa-miR-518a-5p	CLIP-seq
MIRT1378573	hsa-miR-524-3p	CLIP-seq
MIRT1378574	hsa-miR-525-3p	CLIP-seq
MIRT1378575	hsa-miR-527	CLIP-seq
MIRT1378576	hsa-miR-561	CLIP-seq
MIRT1378577	hsa-miR-591	CLIP-seq
MIRT1378578	hsa-miR-649	CLIP-seq
MIRT1378579	hsa-miR-650	CLIP-seq
MIRT1378580	hsa-miR-653	CLIP-seq
MIRT1378581	hsa-miR-663	CLIP-seq
MIRT1378582	hsa-miR-668	CLIP-seq
MIRT1378583	hsa-miR-769-3p	CLIP-seq
MIRT1378584	hsa-miR-890	CLIP-seq
MIRT2112968	hsa-miR-1203	CLIP-seq
MIRT1378522	hsa-miR-148a	CLIP-seq
MIRT1378523	hsa-miR-148b	CLIP-seq
MIRT1378524	hsa-miR-152	CLIP-seq
MIRT1378526	hsa-miR-183	CLIP-seq
MIRT2112969	hsa-miR-34a	CLIP-seq
MIRT2112970	hsa-miR-34c-5p	CLIP-seq
MIRT1378541	hsa-miR-383	CLIP-seq
MIRT2112971	hsa-miR-3938	CLIP-seq
MIRT1378544	hsa-miR-4270	CLIP-seq
MIRT1378547	hsa-miR-4292	CLIP-seq
MIRT2112972	hsa-miR-4308	CLIP-seq
MIRT1378549	hsa-miR-4420	CLIP-seq
MIRT1378552	hsa-miR-4441	CLIP-seq
MIRT2112973	hsa-miR-449a	CLIP-seq
MIRT2112974	hsa-miR-449b	CLIP-seq
MIRT1378559	hsa-miR-4514	CLIP-seq
MIRT2112975	hsa-miR-4691-5p	CLIP-seq
MIRT1378563	hsa-miR-4692	CLIP-seq
MIRT2112976	hsa-miR-4699-5p	CLIP-seq
MIRT2112977	hsa-miR-4709-3p	CLIP-seq
MIRT1378570	hsa-miR-4772-5p	CLIP-seq
MIRT1378576	hsa-miR-561	CLIP-seq
MIRT1378582	hsa-miR-668	CLIP-seq
MIRT2112978	hsa-miR-670	CLIP-seq
MIRT2335851	hsa-miR-1184	CLIP-seq
MIRT2335852	hsa-miR-1205	CLIP-seq
MIRT2335853	hsa-miR-1909	CLIP-seq
MIRT1378532	hsa-miR-2467-3p	CLIP-seq
MIRT2335854	hsa-miR-3158-5p	CLIP-seq
MIRT2335855	hsa-miR-3616-3p	CLIP-seq
MIRT1378537	hsa-miR-3663-3p	CLIP-seq
MIRT1378538	hsa-miR-3664-3p	CLIP-seq
MIRT1378544	hsa-miR-4270	CLIP-seq
MIRT2335856	hsa-miR-4274	CLIP-seq
MIRT1378548	hsa-miR-4313	CLIP-seq
MIRT2335857	hsa-miR-4436b-3p	CLIP-seq
MIRT1378552	hsa-miR-4441	CLIP-seq
MIRT1378558	hsa-miR-4512	CLIP-seq
MIRT2335858	hsa-miR-4532	CLIP-seq
MIRT2335859	hsa-miR-455-3p	CLIP-seq
MIRT2335860	hsa-miR-4651	CLIP-seq
MIRT1378571	hsa-miR-498	CLIP-seq
MIRT2335861	hsa-miR-544	CLIP-seq
MIRT2335862	hsa-miR-599	CLIP-seq
MIRT2335863	hsa-miR-608	CLIP-seq
MIRT2335864	hsa-miR-642b	CLIP-seq
MIRT2335865	hsa-miR-885-3p	CLIP-seq
MIRT1378533	hsa-miR-2861	CLIP-seq
MIRT1378536	hsa-miR-3612	CLIP-seq
MIRT1378546	hsa-miR-4278	CLIP-seq
MIRT1378548	hsa-miR-4313	CLIP-seq
MIRT1378558	hsa-miR-4512	CLIP-seq
MIRT1378564	hsa-miR-4716-3p	CLIP-seq
MIRT1378565	hsa-miR-4723-5p	CLIP-seq
MIRT2394948	hsa-miR-4726-3p	CLIP-seq
MIRT2394949	hsa-miR-4728-5p	CLIP-seq
MIRT2335862	hsa-miR-599	CLIP-seq
MIRT2335864	hsa-miR-642b	CLIP-seq
MIRT1378579	hsa-miR-650	CLIP-seq
MIRT1378520	hsa-miR-1290	CLIP-seq
MIRT1378528	hsa-miR-19a	CLIP-seq
MIRT1378529	hsa-miR-19b	CLIP-seq
MIRT1378530	hsa-miR-203	CLIP-seq
MIRT1378533	hsa-miR-2861	CLIP-seq
MIRT2433351	hsa-miR-331-3p	CLIP-seq
MIRT1378536	hsa-miR-3612	CLIP-seq
MIRT1378550	hsa-miR-4427	CLIP-seq
MIRT1378557	hsa-miR-450b-3p	CLIP-seq
MIRT1378558	hsa-miR-4512	CLIP-seq
MIRT1378562	hsa-miR-4680-3p	CLIP-seq
MIRT1378569	hsa-miR-4762-3p	CLIP-seq
MIRT1378571	hsa-miR-498	CLIP-seq
MIRT1378572	hsa-miR-518a-5p	CLIP-seq
MIRT1378575	hsa-miR-527	CLIP-seq
MIRT1378576	hsa-miR-561	CLIP-seq
MIRT1378579	hsa-miR-650	CLIP-seq
MIRT1378580	hsa-miR-653	CLIP-seq
MIRT1378583	hsa-miR-769-3p	CLIP-seq
MIRT1378584	hsa-miR-890	CLIP-seq
MIRT2335851	hsa-miR-1184	CLIP-seq
MIRT2440625	hsa-miR-1193	CLIP-seq
MIRT2335852	hsa-miR-1205	CLIP-seq
MIRT2440626	hsa-miR-1207-3p	CLIP-seq
MIRT2440627	hsa-miR-1226	CLIP-seq
MIRT2440628	hsa-miR-1236	CLIP-seq
MIRT2440629	hsa-miR-1265	CLIP-seq
MIRT2440630	hsa-miR-1321	CLIP-seq
MIRT1378522	hsa-miR-148a	CLIP-seq
MIRT1378523	hsa-miR-148b	CLIP-seq
MIRT1378524	hsa-miR-152	CLIP-seq
MIRT2440631	hsa-miR-1587	CLIP-seq
MIRT2440632	hsa-miR-1825	CLIP-seq
MIRT1378525	hsa-miR-1827	CLIP-seq
MIRT1378526	hsa-miR-183	CLIP-seq
MIRT1378527	hsa-miR-1908	CLIP-seq
MIRT2335853	hsa-miR-1909	CLIP-seq
MIRT2440633	hsa-miR-1915	CLIP-seq
MIRT2440634	hsa-miR-1976	CLIP-seq
MIRT2440635	hsa-miR-2392	CLIP-seq
MIRT1378532	hsa-miR-2467-3p	CLIP-seq
MIRT1378533	hsa-miR-2861	CLIP-seq
MIRT2440636	hsa-miR-299-3p	CLIP-seq
MIRT2440637	hsa-miR-3064-3p	CLIP-seq
MIRT2440638	hsa-miR-3064-5p	CLIP-seq
MIRT2440639	hsa-miR-30a	CLIP-seq
MIRT2440640	hsa-miR-30b	CLIP-seq
MIRT2440641	hsa-miR-30c	CLIP-seq
MIRT2440642	hsa-miR-30d	CLIP-seq
MIRT2440643	hsa-miR-30e	CLIP-seq
MIRT2440644	hsa-miR-3124-3p	CLIP-seq
MIRT2440645	hsa-miR-3150b-3p	CLIP-seq
MIRT2440646	hsa-miR-3151	CLIP-seq
MIRT2440647	hsa-miR-3155	CLIP-seq
MIRT2440648	hsa-miR-3155b	CLIP-seq
MIRT2335854	hsa-miR-3158-5p	CLIP-seq
MIRT2440649	hsa-miR-3183	CLIP-seq
MIRT2440650	hsa-miR-3184	CLIP-seq
MIRT2440651	hsa-miR-3192	CLIP-seq
MIRT2440652	hsa-miR-3194-5p	CLIP-seq
MIRT2440653	hsa-miR-342-5p	CLIP-seq
MIRT2112969	hsa-miR-34a	CLIP-seq
MIRT2112970	hsa-miR-34c-5p	CLIP-seq
MIRT2440654	hsa-miR-3605-5p	CLIP-seq
MIRT1378536	hsa-miR-3612	CLIP-seq
MIRT2440655	hsa-miR-361-3p	CLIP-seq
MIRT2335855	hsa-miR-3616-3p	CLIP-seq
MIRT2440656	hsa-miR-3622b-5p	CLIP-seq
MIRT2440657	hsa-miR-3649	CLIP-seq
MIRT2440658	hsa-miR-3661	CLIP-seq
MIRT1378537	hsa-miR-3663-3p	CLIP-seq
MIRT1378538	hsa-miR-3664-3p	CLIP-seq
MIRT2440659	hsa-miR-3679-3p	CLIP-seq
MIRT2440660	hsa-miR-3689a-3p	CLIP-seq
MIRT2440661	hsa-miR-3689c	CLIP-seq
MIRT1378541	hsa-miR-383	CLIP-seq
MIRT2440662	hsa-miR-3944-5p	CLIP-seq
MIRT2440663	hsa-miR-423-5p	CLIP-seq
MIRT2440664	hsa-miR-4265	CLIP-seq
MIRT2440665	hsa-miR-4267	CLIP-seq
MIRT1378544	hsa-miR-4270	CLIP-seq
MIRT2335856	hsa-miR-4274	CLIP-seq
MIRT2440666	hsa-miR-4286	CLIP-seq
MIRT1378547	hsa-miR-4292	CLIP-seq
MIRT2440667	hsa-miR-4296	CLIP-seq
MIRT2112972	hsa-miR-4308	CLIP-seq
MIRT2440668	hsa-miR-4322	CLIP-seq
MIRT2440669	hsa-miR-4417	CLIP-seq
MIRT2440670	hsa-miR-4419a	CLIP-seq
MIRT1378549	hsa-miR-4420	CLIP-seq
MIRT2440671	hsa-miR-4436a	CLIP-seq
MIRT2335857	hsa-miR-4436b-3p	CLIP-seq
MIRT1378552	hsa-miR-4441	CLIP-seq
MIRT2440672	hsa-miR-4446-3p	CLIP-seq
MIRT2440673	hsa-miR-4447	CLIP-seq
MIRT1378554	hsa-miR-4455	CLIP-seq
MIRT2440674	hsa-miR-4456	CLIP-seq
MIRT2440675	hsa-miR-4459	CLIP-seq
MIRT2440676	hsa-miR-4472	CLIP-seq
MIRT2440677	hsa-miR-4492	CLIP-seq
MIRT2440678	hsa-miR-4498	CLIP-seq
MIRT2112973	hsa-miR-449a	CLIP-seq
MIRT2112974	hsa-miR-449b	CLIP-seq
MIRT2440679	hsa-miR-4508	CLIP-seq
MIRT2440680	hsa-miR-4510	CLIP-seq
MIRT1378559	hsa-miR-4514	CLIP-seq
MIRT2335858	hsa-miR-4532	CLIP-seq
MIRT2335859	hsa-miR-455-3p	CLIP-seq
MIRT2440681	hsa-miR-4645-5p	CLIP-seq
MIRT2440682	hsa-miR-4648	CLIP-seq
MIRT2335860	hsa-miR-4651	CLIP-seq
MIRT2440683	hsa-miR-4656	CLIP-seq
MIRT2440684	hsa-miR-4661-3p	CLIP-seq
MIRT2440685	hsa-miR-4664-5p	CLIP-seq
MIRT2440686	hsa-miR-4673	CLIP-seq
MIRT2440687	hsa-miR-4675	CLIP-seq
MIRT2440688	hsa-miR-4687-3p	CLIP-seq
MIRT1378563	hsa-miR-4692	CLIP-seq
MIRT2440689	hsa-miR-4700-3p	CLIP-seq
MIRT2440690	hsa-miR-4721	CLIP-seq
MIRT2440691	hsa-miR-4722-5p	CLIP-seq
MIRT2440692	hsa-miR-4723-3p	CLIP-seq
MIRT2394948	hsa-miR-4726-3p	CLIP-seq
MIRT2394949	hsa-miR-4728-5p	CLIP-seq
MIRT1378567	hsa-miR-4733-3p	CLIP-seq
MIRT2440693	hsa-miR-4739	CLIP-seq
MIRT2440694	hsa-miR-4741	CLIP-seq
MIRT2440695	hsa-miR-4756-5p	CLIP-seq
MIRT2440696	hsa-miR-4764-5p	CLIP-seq
MIRT1378570	hsa-miR-4772-5p	CLIP-seq
MIRT2440697	hsa-miR-4779	CLIP-seq
MIRT2440698	hsa-miR-4784	CLIP-seq
MIRT2440699	hsa-miR-484	CLIP-seq
MIRT2440700	hsa-miR-486-3p	CLIP-seq
MIRT2440701	hsa-miR-491-5p	CLIP-seq
MIRT2440702	hsa-miR-492	CLIP-seq
MIRT2440703	hsa-miR-515-5p	CLIP-seq
MIRT2440704	hsa-miR-541	CLIP-seq
MIRT2335861	hsa-miR-544	CLIP-seq
MIRT2440705	hsa-miR-548v	CLIP-seq
MIRT1378577	hsa-miR-591	CLIP-seq
MIRT2335862	hsa-miR-599	CLIP-seq
MIRT2335863	hsa-miR-608	CLIP-seq
MIRT2440706	hsa-miR-629	CLIP-seq
MIRT2440707	hsa-miR-631	CLIP-seq
MIRT2335864	hsa-miR-642b	CLIP-seq
MIRT1378579	hsa-miR-650	CLIP-seq
MIRT2440708	hsa-miR-654-5p	CLIP-seq
MIRT2440709	hsa-miR-661	CLIP-seq
MIRT1378581	hsa-miR-663	CLIP-seq
MIRT1378582	hsa-miR-668	CLIP-seq
MIRT2112978	hsa-miR-670	CLIP-seq
MIRT2440710	hsa-miR-718	CLIP-seq
MIRT2440711	hsa-miR-762	CLIP-seq
MIRT2440712	hsa-miR-765	CLIP-seq
MIRT2440713	hsa-miR-766	CLIP-seq
MIRT2335865	hsa-miR-885-3p	CLIP-seq
MIRT2440714	hsa-miR-940	CLIP-seq
MIRT2440626	hsa-miR-1207-3p	CLIP-seq
MIRT2440632	hsa-miR-1825	CLIP-seq
MIRT1378525	hsa-miR-1827	CLIP-seq
MIRT2440636	hsa-miR-299-3p	CLIP-seq
MIRT2440639	hsa-miR-30a	CLIP-seq
MIRT2440640	hsa-miR-30b	CLIP-seq
MIRT2440641	hsa-miR-30c	CLIP-seq
MIRT2440642	hsa-miR-30d	CLIP-seq
MIRT2440643	hsa-miR-30e	CLIP-seq
MIRT2630125	hsa-miR-3119	CLIP-seq
MIRT2440644	hsa-miR-3124-3p	CLIP-seq
MIRT2440651	hsa-miR-3192	CLIP-seq
MIRT2630126	hsa-miR-337-3p	CLIP-seq
MIRT2630127	hsa-miR-3685	CLIP-seq
MIRT2440660	hsa-miR-3689a-3p	CLIP-seq
MIRT2440661	hsa-miR-3689c	CLIP-seq
MIRT2630128	hsa-miR-384	CLIP-seq
MIRT2630129	hsa-miR-3929	CLIP-seq
MIRT2440666	hsa-miR-4286	CLIP-seq
MIRT1378547	hsa-miR-4292	CLIP-seq
MIRT2112972	hsa-miR-4308	CLIP-seq
MIRT2630130	hsa-miR-4419b	CLIP-seq
MIRT2630131	hsa-miR-4474-3p	CLIP-seq
MIRT2630132	hsa-miR-4478	CLIP-seq
MIRT2630133	hsa-miR-4491	CLIP-seq
MIRT2630134	hsa-miR-4657	CLIP-seq
MIRT2630135	hsa-miR-4728-3p	CLIP-seq
MIRT2394949	hsa-miR-4728-5p	CLIP-seq
MIRT2630136	hsa-miR-495	CLIP-seq
MIRT2630137	hsa-miR-496	CLIP-seq
MIRT2112978	hsa-miR-670	CLIP-seq
MIRT2440710	hsa-miR-718	CLIP-seq
MIRT2440626	hsa-miR-1207-3p	CLIP-seq
MIRT2440631	hsa-miR-1587	CLIP-seq
MIRT2440632	hsa-miR-1825	CLIP-seq
MIRT1378525	hsa-miR-1827	CLIP-seq
MIRT2691727	hsa-miR-199a-5p	CLIP-seq
MIRT2691728	hsa-miR-199b-5p	CLIP-seq
MIRT2691729	hsa-miR-2114	CLIP-seq
MIRT2440636	hsa-miR-299-3p	CLIP-seq
MIRT2440638	hsa-miR-3064-5p	CLIP-seq
MIRT2440639	hsa-miR-30a	CLIP-seq
MIRT2440640	hsa-miR-30b	CLIP-seq
MIRT2440641	hsa-miR-30c	CLIP-seq
MIRT2440642	hsa-miR-30d	CLIP-seq
MIRT2440643	hsa-miR-30e	CLIP-seq
MIRT2630125	hsa-miR-3119	CLIP-seq
MIRT2440644	hsa-miR-3124-3p	CLIP-seq
MIRT2691730	hsa-miR-3174	CLIP-seq
MIRT2440651	hsa-miR-3192	CLIP-seq
MIRT2630126	hsa-miR-337-3p	CLIP-seq
MIRT1378536	hsa-miR-3612	CLIP-seq
MIRT2691731	hsa-miR-3613-3p	CLIP-seq
MIRT2440656	hsa-miR-3622b-5p	CLIP-seq
MIRT2630127	hsa-miR-3685	CLIP-seq
MIRT2440660	hsa-miR-3689a-3p	CLIP-seq
MIRT2440661	hsa-miR-3689c	CLIP-seq
MIRT2630128	hsa-miR-384	CLIP-seq
MIRT2691732	hsa-miR-3925-3p	CLIP-seq
MIRT2630129	hsa-miR-3929	CLIP-seq
MIRT2440664	hsa-miR-4265	CLIP-seq
MIRT2440666	hsa-miR-4286	CLIP-seq
MIRT2691733	hsa-miR-4290	CLIP-seq
MIRT1378547	hsa-miR-4292	CLIP-seq
MIRT2440667	hsa-miR-4296	CLIP-seq
MIRT2112972	hsa-miR-4308	CLIP-seq
MIRT1378548	hsa-miR-4313	CLIP-seq
MIRT2440668	hsa-miR-4322	CLIP-seq
MIRT2440669	hsa-miR-4417	CLIP-seq
MIRT2630130	hsa-miR-4419b	CLIP-seq
MIRT2630131	hsa-miR-4474-3p	CLIP-seq
MIRT2630132	hsa-miR-4478	CLIP-seq
MIRT2630133	hsa-miR-4491	CLIP-seq
MIRT2440677	hsa-miR-4492	CLIP-seq
MIRT2440678	hsa-miR-4498	CLIP-seq
MIRT2440683	hsa-miR-4656	CLIP-seq
MIRT2630134	hsa-miR-4657	CLIP-seq
MIRT2440687	hsa-miR-4675	CLIP-seq
MIRT2440688	hsa-miR-4687-3p	CLIP-seq
MIRT2630135	hsa-miR-4728-3p	CLIP-seq
MIRT2394949	hsa-miR-4728-5p	CLIP-seq
MIRT2440694	hsa-miR-4741	CLIP-seq
MIRT2630137	hsa-miR-496	CLIP-seq
MIRT2691734	hsa-miR-548a-3p	CLIP-seq
MIRT2691735	hsa-miR-548ae	CLIP-seq
MIRT2691736	hsa-miR-548aj	CLIP-seq
MIRT2691737	hsa-miR-548am	CLIP-seq
MIRT2691738	hsa-miR-548e	CLIP-seq
MIRT2691739	hsa-miR-548f	CLIP-seq
MIRT2691740	hsa-miR-548g	CLIP-seq
MIRT2440705	hsa-miR-548v	CLIP-seq
MIRT2691741	hsa-miR-548x	CLIP-seq
MIRT2335862	hsa-miR-599	CLIP-seq
MIRT2440706	hsa-miR-629	CLIP-seq
MIRT2335864	hsa-miR-642b	CLIP-seq
MIRT1378579	hsa-miR-650	CLIP-seq
MIRT2112978	hsa-miR-670	CLIP-seq
MIRT2440710	hsa-miR-718	CLIP-seq
MIRT2440711	hsa-miR-762	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CEBPA	Activation	19332118
NFKB1	Unknown	23335796
RELA	Unknown	23335796
SP3	Unknown	10570957
STAT1	Unknown	19115200
STAT3	Activation	11788008;15184887;19332118;20357037;22179221
STAT3	Unknown	23335796
STAT4	Repression	14559241

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001784	Function	Phosphotyrosine residue binding	IEA
GO:0004860	Function	Protein kinase inhibitor activity	TAS	9266833
GO:0005515	Function	Protein binding	IPI	19027008, 24728074, 25203322, 25416956, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0005942	Component	Phosphatidylinositol 3-kinase complex	IBA	21873635
GO:0006469	Process	Negative regulation of protein kinase activity	IEA
GO:0007259	Process	Receptor signaling pathway via JAK-STAT	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0040008	Process	Regulation of growth	IEA
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	TAS
GO:0042532	Process	Negative regulation of tyrosine phosphorylation of STAT protein	IMP	25019494
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043551	Process	Regulation of phosphatidylinositol 3-kinase activity	IEA
GO:0043687	Process	Post-translational protein modification	TAS
GO:0045597	Process	Positive regulation of cell differentiation	IEA
GO:0046426	Process	Negative regulation of receptor signaling pathway via JAK-STAT	IMP	25019494
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IEA
GO:0046854	Process	Phosphatidylinositol phosphorylation	IBA	21873635
GO:0046935	Function	1-phosphatidylinositol-3-kinase regulator activity	IBA	21873635
GO:0050728	Process	Negative regulation of inflammatory response	IEA
GO:0060334	Process	Regulation of interferon-gamma-mediated signaling pathway	TAS
GO:0060670	Process	Branching involved in labyrinthine layer morphogenesis	IEA
GO:0060674	Process	Placenta blood vessel development	IEA
GO:0060707	Process	Trophoblast giant cell differentiation	IEA
GO:0070102	Process	Interleukin-6-mediated signaling pathway	TAS
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA

Other IDs

• MIM: 604176
• HGNC: 19391
• e!Ensembl: ENSG00000184557

Protein

• UniProt ID: O14543
• Protein name: Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
• Protein function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduc
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00017	SH2	46 → 127	SH2 domain	Domain

• Sequence:

  MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLL
  SAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCV
  LKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSR
  PLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL

• Sequence length: 225