SLC8A3 (solute carrier family 8 member A3)

Gene

• Entrez ID: 6547
• Gene name: Solute carrier family 8 member A3
• Gene symbol: SLC8A3
• Synonyms: NCX3
• Chromosome: 14
• Chromosome location: 14q24.2
• Summary: This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions an

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT525957	hsa-miR-6769a-3p	PAR-CLIP	20371350
MIRT525956	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT525955	hsa-miR-6847-5p	PAR-CLIP	20371350
MIRT525954	hsa-miR-4257	PAR-CLIP	20371350
MIRT525953	hsa-miR-759	PAR-CLIP	20371350
MIRT525952	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT525948	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT525946	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT525945	hsa-miR-874-5p	PAR-CLIP	20371350
MIRT525957	hsa-miR-6769a-3p	PAR-CLIP	20371350
MIRT525956	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT525955	hsa-miR-6847-5p	PAR-CLIP	20371350
MIRT525954	hsa-miR-4257	PAR-CLIP	20371350
MIRT525953	hsa-miR-759	PAR-CLIP	20371350
MIRT525952	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT525949	hsa-miR-6868-5p	PAR-CLIP	20371350
MIRT525948	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT525947	hsa-miR-298	PAR-CLIP	20371350
MIRT525946	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT525945	hsa-miR-874-5p	PAR-CLIP	20371350
MIRT525957	hsa-miR-6769a-3p	PAR-CLIP	20371350
MIRT525956	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT525955	hsa-miR-6847-5p	PAR-CLIP	20371350
MIRT525954	hsa-miR-4257	PAR-CLIP	20371350
MIRT525953	hsa-miR-759	PAR-CLIP	20371350
MIRT525952	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT525948	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT525947	hsa-miR-298	PAR-CLIP	20371350
MIRT525946	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT525945	hsa-miR-874-5p	PAR-CLIP	20371350
MIRT525957	hsa-miR-6769a-3p	PAR-CLIP	22012620
MIRT525956	hsa-miR-5000-5p	PAR-CLIP	22012620
MIRT525955	hsa-miR-6847-5p	PAR-CLIP	22012620
MIRT525954	hsa-miR-4257	PAR-CLIP	22012620
MIRT525953	hsa-miR-759	PAR-CLIP	22012620
MIRT525952	hsa-miR-186-3p	PAR-CLIP	22012620
MIRT525951	hsa-miR-221-5p	PAR-CLIP	22012620
MIRT525950	hsa-miR-8073	PAR-CLIP	22012620
MIRT525949	hsa-miR-6868-5p	PAR-CLIP	22012620
MIRT525948	hsa-miR-5008-5p	PAR-CLIP	22012620
MIRT525947	hsa-miR-298	PAR-CLIP	22012620
MIRT525946	hsa-miR-5699-5p	PAR-CLIP	22012620
MIRT525945	hsa-miR-874-5p	PAR-CLIP	22012620
MIRT734620	hsa-miR-125a-3p	Luciferase reporter assay, Microarray, Immunofluorescence, Immunocytochemistry (ICC)	32163190
MIRT525957	hsa-miR-6769a-3p	PAR-CLIP	20371350
MIRT525956	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT525955	hsa-miR-6847-5p	PAR-CLIP	20371350
MIRT525954	hsa-miR-4257	PAR-CLIP	20371350
MIRT525953	hsa-miR-759	PAR-CLIP	20371350
MIRT525952	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT525948	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT525946	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT525945	hsa-miR-874-5p	PAR-CLIP	20371350
MIRT525957	hsa-miR-6769a-3p	PAR-CLIP	20371350
MIRT525956	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT525955	hsa-miR-6847-5p	PAR-CLIP	20371350
MIRT525954	hsa-miR-4257	PAR-CLIP	20371350
MIRT525953	hsa-miR-759	PAR-CLIP	20371350
MIRT525952	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT525949	hsa-miR-6868-5p	PAR-CLIP	20371350
MIRT525948	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT525947	hsa-miR-298	PAR-CLIP	20371350
MIRT525946	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT525945	hsa-miR-874-5p	PAR-CLIP	20371350
MIRT525957	hsa-miR-6769a-3p	PAR-CLIP	20371350
MIRT525956	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT525955	hsa-miR-6847-5p	PAR-CLIP	20371350
MIRT525954	hsa-miR-4257	PAR-CLIP	20371350
MIRT525953	hsa-miR-759	PAR-CLIP	20371350
MIRT525952	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT525948	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT525947	hsa-miR-298	PAR-CLIP	20371350
MIRT525946	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT525945	hsa-miR-874-5p	PAR-CLIP	20371350
MIRT525957	hsa-miR-6769a-3p	PAR-CLIP	22012620
MIRT525956	hsa-miR-5000-5p	PAR-CLIP	22012620
MIRT525955	hsa-miR-6847-5p	PAR-CLIP	22012620
MIRT525954	hsa-miR-4257	PAR-CLIP	22012620
MIRT525953	hsa-miR-759	PAR-CLIP	22012620
MIRT525952	hsa-miR-186-3p	PAR-CLIP	22012620
MIRT525951	hsa-miR-221-5p	PAR-CLIP	22012620
MIRT525950	hsa-miR-8073	PAR-CLIP	22012620
MIRT525949	hsa-miR-6868-5p	PAR-CLIP	22012620
MIRT525948	hsa-miR-5008-5p	PAR-CLIP	22012620
MIRT525947	hsa-miR-298	PAR-CLIP	22012620
MIRT525946	hsa-miR-5699-5p	PAR-CLIP	22012620
MIRT525945	hsa-miR-874-5p	PAR-CLIP	22012620
MIRT1368462	hsa-miR-3148	CLIP-seq
MIRT1368463	hsa-miR-3652	CLIP-seq
MIRT1368464	hsa-miR-433	CLIP-seq
MIRT1368465	hsa-miR-4430	CLIP-seq
MIRT1368466	hsa-miR-4670-3p	CLIP-seq
MIRT1368467	hsa-miR-875-3p	CLIP-seq
MIRT1368468	hsa-miR-371b-3p	CLIP-seq
MIRT1368469	hsa-miR-4266	CLIP-seq
MIRT1368470	hsa-miR-4434	CLIP-seq
MIRT1368471	hsa-miR-4516	CLIP-seq
MIRT1368472	hsa-miR-4753-3p	CLIP-seq
MIRT1368473	hsa-miR-938	CLIP-seq
MIRT1368474	hsa-miR-942	CLIP-seq
MIRT2332626	hsa-miR-1273e	CLIP-seq
MIRT2332627	hsa-miR-1273f	CLIP-seq
MIRT2332628	hsa-miR-3126-5p	CLIP-seq
MIRT2332629	hsa-miR-3149	CLIP-seq
MIRT2332630	hsa-miR-3175	CLIP-seq
MIRT2332631	hsa-miR-3184	CLIP-seq
MIRT2332632	hsa-miR-342-5p	CLIP-seq
MIRT2332633	hsa-miR-345	CLIP-seq
MIRT2332634	hsa-miR-3679-3p	CLIP-seq
MIRT2332635	hsa-miR-3689d	CLIP-seq
MIRT2332636	hsa-miR-3978	CLIP-seq
MIRT2332637	hsa-miR-421	CLIP-seq
MIRT2332638	hsa-miR-423-5p	CLIP-seq
MIRT2332639	hsa-miR-4272	CLIP-seq
MIRT2332640	hsa-miR-4651	CLIP-seq
MIRT2332641	hsa-miR-4659a-3p	CLIP-seq
MIRT2332642	hsa-miR-4659b-3p	CLIP-seq
MIRT2332643	hsa-miR-4664-5p	CLIP-seq
MIRT2332644	hsa-miR-4716-3p	CLIP-seq
MIRT2332645	hsa-miR-4723-5p	CLIP-seq
MIRT2332646	hsa-miR-4775	CLIP-seq
MIRT2332647	hsa-miR-4803	CLIP-seq
MIRT2332648	hsa-miR-583	CLIP-seq
MIRT2332649	hsa-miR-608	CLIP-seq
MIRT2332650	hsa-miR-635	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
KCNIP3	Repression	16306395

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002244	Process	Hematopoietic progenitor cell differentiation	IEA
GO:0005432	Function	Calcium:sodium antiporter activity	IBA	21873635
GO:0005432	Function	Calcium:sodium antiporter activity	ISS
GO:0005516	Function	Calmodulin binding	IEA
GO:0005741	Component	Mitochondrial outer membrane	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0005874	Component	Microtubule	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	ISS
GO:0006811	Process	Ion transport	TAS
GO:0006851	Process	Mitochondrial calcium ion transmembrane transport	ISS
GO:0006874	Process	Cellular calcium ion homeostasis	ISS
GO:0007154	Process	Cell communication	IEA
GO:0007611	Process	Learning or memory	ISS
GO:0007612	Process	Learning	ISS
GO:0007613	Process	Memory	ISS
GO:0014069	Component	Postsynaptic density	ISS
GO:0014819	Process	Regulation of skeletal muscle contraction	ISS
GO:0015491	Function	Cation:cation antiporter activity	IBA	21873635
GO:0016020	Component	Membrane	IBA	21873635
GO:0016528	Component	Sarcoplasm	IEA
GO:0021537	Process	Telencephalon development	IEA
GO:0030001	Process	Metal ion transport	IBA	21873635
GO:0030424	Component	Axon	IBA	21873635
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	ISS
GO:0031226	Component	Intrinsic component of plasma membrane	IDA	21959935
GO:0031594	Component	Neuromuscular junction	ISS
GO:0035725	Process	Sodium ion transmembrane transport	IBA	21873635
GO:0035725	Process	Sodium ion transmembrane transport	ISS
GO:0042383	Component	Sarcolemma	IBA	21873635
GO:0042383	Component	Sarcolemma	ISS
GO:0042552	Process	Myelination	ISS
GO:0043025	Component	Neuronal cell body	ISS
GO:0043197	Component	Dendritic spine	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0043679	Component	Axon terminus	ISS
GO:0045202	Component	Synapse	IDA	21382638
GO:0045202	Component	Synapse	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	21959935
GO:0048709	Process	Oligodendrocyte differentiation	ISS
GO:0050808	Process	Synapse organization	ISS
GO:0051560	Process	Mitochondrial calcium ion homeostasis	ISS
GO:0060291	Process	Long-term synaptic potentiation	ISS
GO:0070588	Process	Calcium ion transmembrane transport	ISS
GO:0071320	Process	Cellular response to cAMP	IEA
GO:0071456	Process	Cellular response to hypoxia	ISS
GO:0071901	Process	Negative regulation of protein serine/threonine kinase activity	ISS
GO:0098703	Process	Calcium ion import across plasma membrane	IBA	21873635
GO:0098794	Component	Postsynapse	IBA	21873635
GO:0098815	Process	Modulation of excitatory postsynaptic potential	ISS
GO:0099055	Component	Integral component of postsynaptic membrane	IEA
GO:0099566	Process	Regulation of postsynaptic cytosolic calcium ion concentration	IEA
GO:0099580	Function	Ion antiporter activity involved in regulation of postsynaptic membrane potential	IEA
GO:1903779	Process	Regulation of cardiac conduction	TAS
GO:1905060	Function	Calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IEA
GO:1990034	Process	Calcium ion export across plasma membrane	IEA

Other IDs

• MIM: 607991
• HGNC: 11070
• e!Ensembl: ENSG00000100678

Protein

• UniProt ID: P57103
• Protein name: Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3)
• Protein function: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01699	Na_Ca_ex	79 → 250	Sodium/calcium exchanger protein	Family
  PF16494	Na_Ca_ex_C	253 → 380	C-terminal extension of sodium/calcium exchanger domain	Family
  PF03160	Calx-beta	385 → 485	Calx-beta domain	Domain
  PF03160	Calx-beta	519 → 619	Calx-beta domain	Domain
  PF01699	Na_Ca_ex	753 → 918	Sodium/calcium exchanger protein	Family

• Sequence:

  MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
  PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
  TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
  IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
  FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
  LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
  MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
  KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
  FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
  VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV
  KIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVL
  GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG
  EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG
  CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW
  SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA
  TTWLFVSLWLLYILFATLEAYCYIKGF

• Sequence length: 927