SLC8A2 (solute carrier family 8 member A2)

Gene

• Entrez ID: 6543
• Gene name: Solute carrier family 8 member A2
• Gene symbol: SLC8A2
• Synonyms: NCX2
• Chromosome: 19
• Chromosome location: 19q13.32

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002931	Process	Response to ischemia	ISS
GO:0005432	Function	Calcium:sodium antiporter activity	IBA	21873635
GO:0005432	Function	Calcium:sodium antiporter activity	ISS
GO:0005516	Function	Calmodulin binding	IEA
GO:0005886	Component	Plasma membrane	IC
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	ISS
GO:0006811	Process	Ion transport	TAS
GO:0006874	Process	Cellular calcium ion homeostasis	ISS
GO:0007154	Process	Cell communication	IEA
GO:0007611	Process	Learning or memory	ISS
GO:0007612	Process	Learning	ISS
GO:0007613	Process	Memory	ISS
GO:0010468	Process	Regulation of gene expression	ISS
GO:0014069	Component	Postsynaptic density	ISS
GO:0015081	Function	Sodium ion transmembrane transporter activity	ISS	8021246
GO:0015085	Function	Calcium ion transmembrane transporter activity	ISS
GO:0015491	Function	Cation:cation antiporter activity	IBA	21873635
GO:0016020	Component	Membrane	IBA	21873635
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0030001	Process	Metal ion transport	IBA	21873635
GO:0030424	Component	Axon	IBA	21873635
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	ISS
GO:0035725	Process	Sodium ion transmembrane transport	IBA	21873635
GO:0035725	Process	Sodium ion transmembrane transport	ISS	8021246
GO:0042383	Component	Sarcolemma	IBA	21873635
GO:0043025	Component	Neuronal cell body	ISS
GO:0043197	Component	Dendritic spine	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0043679	Component	Axon terminus	ISS
GO:0045202	Component	Synapse	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048172	Process	Regulation of short-term neuronal synaptic plasticity	ISS
GO:0050808	Process	Synapse organization	ISS
GO:0050890	Process	Cognition	ISS
GO:0051480	Process	Regulation of cytosolic calcium ion concentration	ISS
GO:0060291	Process	Long-term synaptic potentiation	ISS
GO:0070050	Process	Neuron cellular homeostasis	ISS
GO:0070588	Process	Calcium ion transmembrane transport	ISS	8021246
GO:0071902	Process	Positive regulation of protein serine/threonine kinase activity	ISS
GO:0098703	Process	Calcium ion import across plasma membrane	IBA	21873635
GO:0098793	Component	Presynapse	IDA	21382638
GO:0098794	Component	Postsynapse	IBA	21873635
GO:0098815	Process	Modulation of excitatory postsynaptic potential	ISS
GO:0099566	Process	Regulation of postsynaptic cytosolic calcium ion concentration	IEA
GO:0099608	Process	Regulation of action potential firing pattern	ISS
GO:0106056	Process	Regulation of calcineurin-mediated signaling	ISS
GO:0150104	Process	Transport across blood-brain barrier	NAS	30280653
GO:1903779	Process	Regulation of cardiac conduction	TAS
GO:1905060	Function	Calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISS
GO:1990034	Process	Calcium ion export across plasma membrane	ISS

Other IDs

• MIM: 601901
• HGNC: 11069
• e!Ensembl: ENSG00000118160

Protein

• UniProt ID: Q9UPR5
• Protein name: Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2)
• Protein function: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01699	Na_Ca_ex	74 → 245	Sodium/calcium exchanger protein	Family
  PF16494	Na_Ca_ex_C	248 → 379	C-terminal extension of sodium/calcium exchanger domain	Family
  PF03160	Calx-beta	384 → 483	Calx-beta domain	Domain
  PF03160	Calx-beta	512 → 612	Calx-beta domain	Domain
  PF01699	Na_Ca_ex	747 → 912	Sodium/calcium exchanger protein	Family

• Sequence:

  MAPLALVGVTLLLAAPPCSGAATPTPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEP
  DDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGT
  VRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVC
  IYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCV
  VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGP
  GPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRL
  MTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQG
  GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFV
  RLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGT
  VDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEE
  YEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLE
  VIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPS
  CFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLK
  DSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVY
  WAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFL
  GLWLLYILFASLEAYCHIRGF

• Sequence length: 921