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SLC8A1 (solute carrier family 8 member A1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6546
Gene nameGene Name - the full gene name approved by the HGNC.
Solute carrier family 8 member A1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SLC8A1
SynonymsGene synonyms aliases
NCX1
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p22.1
SummarySummary of gene provided in NCBI Entrez Gene.
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However,
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006819 hsa-miR-1-3p Luciferase reporter assay, Western blot 22362515
MIRT510749 hsa-miR-410-3p HITS-CLIP 21572407
MIRT510745 hsa-miR-5011-5p HITS-CLIP 21572407
MIRT510744 hsa-miR-190a-3p HITS-CLIP 21572407
MIRT510742 hsa-miR-3924 HITS-CLIP 21572407
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002026 Process Regulation of the force of heart contraction IC 19481548
GO:0002026 Process Regulation of the force of heart contraction ISS
GO:0002027 Process Regulation of heart rate ISS
GO:0002028 Process Regulation of sodium ion transport IEA
GO:0005432 Function Calcium:sodium antiporter activity IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P32418
Protein name Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1)
Protein function Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:11241183, PubMed:1374913, P
PDB 8JP0 , 8SGI , 8SGJ , 8SGT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01699 Na_Ca_ex
80 251
Sodium/calcium exchanger protein
Family
PF16494 Na_Ca_ex_C
254 390
C-terminal extension of sodium/calcium exchanger domain
Family
PF03160 Calx-beta
396 496
Calx-beta domain
Domain
PF03160 Calx-beta
527 627
Calx-beta domain
Domain
PF01699 Na_Ca_ex
799 964
Sodium/calcium exchanger protein
Family
Sequence
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI
LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG
ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF
IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
FFPICVVFAWV
ADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS
RAFYRIQATRLMTGAGNILKRHAADQARKA
VSMHEVNTEVTENDPVSKIFFEQGTYQCLE
NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII
DDDIFEEDENFLVHLS
NVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF
TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
EIVKTISVKVIDDEEYEKNKTFFLEIG
EPRLVEMSEKKALLLNELGGFTITGKYLFGQPV
FRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESY
EFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHF
LTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVF
VALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF
KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIF
FSSL
EAYCHIKGF
Sequence length 973
Interactions View interactions

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