SEM1 (SEM1 26S proteasome subunit)

Gene

• Entrez ID: 7979
• Gene name: SEM1 26S proteasome subunit
• Gene symbol: SEM1
• Synonyms: C7orf76, DSS1, ECD, PSMD15, SHFD1, SHFM1, SHSF1, Shfdg1
• Chromosome: 7
• Chromosome location: 7q21.3
• Summary: The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT450571	hsa-miR-548a-5p	PAR-CLIP	22100165
MIRT450570	hsa-miR-548ab	PAR-CLIP	22100165
MIRT450569	hsa-miR-548ad-5p	PAR-CLIP	22100165
MIRT450568	hsa-miR-548ae-5p	PAR-CLIP	22100165
MIRT450567	hsa-miR-548ak	PAR-CLIP	22100165
MIRT450566	hsa-miR-548am-5p	PAR-CLIP	22100165
MIRT450565	hsa-miR-548ap-5p	PAR-CLIP	22100165
MIRT450564	hsa-miR-548aq-5p	PAR-CLIP	22100165
MIRT450563	hsa-miR-548ar-5p	PAR-CLIP	22100165
MIRT450562	hsa-miR-548as-5p	PAR-CLIP	22100165
MIRT450561	hsa-miR-548au-5p	PAR-CLIP	22100165
MIRT450560	hsa-miR-548ay-5p	PAR-CLIP	22100165
MIRT450559	hsa-miR-548b-5p	PAR-CLIP	22100165
MIRT450558	hsa-miR-548bb-5p	PAR-CLIP	22100165
MIRT450557	hsa-miR-548c-5p	PAR-CLIP	22100165
MIRT450556	hsa-miR-548d-5p	PAR-CLIP	22100165
MIRT450555	hsa-miR-548h-5p	PAR-CLIP	22100165
MIRT450554	hsa-miR-548i	PAR-CLIP	22100165
MIRT450553	hsa-miR-548j-5p	PAR-CLIP	22100165
MIRT450552	hsa-miR-548o-5p	PAR-CLIP	22100165
MIRT450551	hsa-miR-548w	PAR-CLIP	22100165
MIRT450550	hsa-miR-548y	PAR-CLIP	22100165
MIRT450549	hsa-miR-559	PAR-CLIP	22100165
MIRT450548	hsa-miR-548av-5p	PAR-CLIP	22100165
MIRT450547	hsa-miR-548k	PAR-CLIP	22100165
MIRT450545	hsa-miR-8054	PAR-CLIP	22100165
MIRT450546	hsa-miR-548l	PAR-CLIP	22100165
MIRT450544	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT450543	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT450542	hsa-miR-1225-3p	PAR-CLIP	22100165
MIRT450541	hsa-miR-1233-3p	PAR-CLIP	22100165
MIRT450540	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450539	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT450538	hsa-miR-3161	PAR-CLIP	22100165
MIRT450537	hsa-miR-653-5p	PAR-CLIP	22100165
MIRT450536	hsa-miR-599	PAR-CLIP	22100165

Other IDs

• MIM: 601285
• HGNC: 10845
• e!Ensembl: ENSG00000127922

Protein

• UniProt ID: P60896
• Protein name: 26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein)
• Protein function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which
• PDB: 1IYJ, 1MIU, 1MJE, 3T5X, 5GJQ, 5GJR, 5L4K, 5LN3, 5M32, 5T0C, 5T0G, 5T0H, 5T0I, 5T0J, 5VFR, 5VFT, 5VGZ, 5VHF, 5VHH, 5VHI, 5VHS, 6MSB, 6MSD, 6MSG, 6MSH, 6MSJ, 6MSK, 6WJD, 6WJN, 7QXN, 7QXP, 7QXU, 7QXW, 7QXX, 7QY7, 7QYA, 7QYB, 7W37, 7W38, 7W39, 7W3A, 7W3B, 7W3C, 7W3F, 7W3G, 7W3H, 7W3I, 7W3J, 7W3K, 7W3M, 8CVT
• UniProt ID: Q6ZVN7
• Protein name: Putative protein SEM1, isoform 2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17697	DUF5543	1 → 128		Family

• Sequence:

  MYCQDSNICAVFAVQGGKVGRKHGIKRGRRPSIRSPAQRARGPWIHESKHPAFAKQQINL
  EMPNSRATTELAWVCSSTSRKKKWARSLTLSTAPLSPPPSLVHCEDCSCLPGCHSGDLYN
  LAPAERTC

• Sequence length: 128