SDC3 (syndecan 3)

Gene

• Entrez ID: 9672
• Gene name: Syndecan 3
• Gene symbol: SDC3
• Synonyms: SDCN, SYND3
• Chromosome: 1
• Chromosome location: 1p35.2
• Summary: The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018892	hsa-miR-335-5p	Microarray	18185580
MIRT030232	hsa-miR-26b-5p	Microarray	19088304
MIRT439694	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT446627	hsa-miR-124-5p	PAR-CLIP	22100165
MIRT446628	hsa-miR-3689f	PAR-CLIP	22100165
MIRT446629	hsa-miR-3689e	PAR-CLIP	22100165
MIRT446630	hsa-miR-3689b-5p	PAR-CLIP	22100165
MIRT446631	hsa-miR-3689a-5p	PAR-CLIP	22100165
MIRT446632	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT446633	hsa-miR-509-3p	PAR-CLIP	22100165
MIRT446634	hsa-miR-190b	PAR-CLIP	22100165
MIRT446635	hsa-miR-4679	PAR-CLIP	22100165
MIRT446636	hsa-miR-190a-5p	PAR-CLIP	22100165
MIRT446637	hsa-miR-4677-3p	PAR-CLIP	22100165
MIRT446638	hsa-miR-654-3p	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0005515	Function	Protein binding	IPI	18093920
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006024	Process	Glycosaminoglycan biosynthetic process	TAS
GO:0006027	Process	Glycosaminoglycan catabolic process	TAS
GO:0009986	Component	Cell surface	IBA	21873635
GO:0016020	Component	Membrane	ISS
GO:0016021	Component	Integral component of membrane	IEA
GO:0016477	Process	Cell migration	IBA	21873635
GO:0042802	Function	Identical protein binding	IPI	18093920
GO:0043202	Component	Lysosomal lumen	TAS
GO:0044393	Component	Microspike	ISS
GO:0050900	Process	Leukocyte migration	TAS
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	27068509

Other IDs

• MIM: 186357
• HGNC: 10660
• e!Ensembl: ENSG00000162512

Protein

• UniProt ID: O75056
• Protein name: Syndecan-3 (SYND3)
• Protein function: Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01034	Syndecan	378 → 440	Syndecan domain	Family

• Sequence:

  MKPGPPHRAGAAHGAGAGAGAAAGPGARGLLLPPLLLLLLAGRAAGAQRWRSENFERPVD
  LEGSGDDDSFPDDELDDLYSGSGSGYFEQESGIETAMRFSPDVALAVSTTPAVLPTTNIQ
  PVGTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTVSTTMATTAATSTGDPTVATVP
  ATVATATPSTPAAPPFTATTAVIRTTGVRRLLPLPLTTVATARATTPEAPSPPTTAAVLD
  TEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTPETFLTT
  IRDEPEVPVSGGPSGDFELPEEETTQPDTANEVVAVGGAAAKASSPPGTLPKGARPGPGL
  LDNAIDSGSSAAQLPQKSILERKEVLVAVIVGGVVGALFAAFLVTLLIYRMKKKDEGSYT
  LEEPKQASVTYQKPDKQEEFYA

• Sequence length: 442