SCN7A (sodium voltage-gated channel alpha subunit 7)

Gene

• Entrez ID: 6332
• Gene name: Sodium voltage-gated channel alpha subunit 7
• Gene symbol: SCN7A
• Synonyms: NaG, Nav2.1, Nav2.2, SCN6A
• Chromosome: 2
• Chromosome location: 2q24.3
• Summary: This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT716723	hsa-miR-6769a-3p	HITS-CLIP	19536157
MIRT716722	hsa-miR-3675-3p	HITS-CLIP	19536157
MIRT716721	hsa-miR-6801-3p	HITS-CLIP	19536157
MIRT716720	hsa-miR-6810-3p	HITS-CLIP	19536157
MIRT716719	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT716718	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT716717	hsa-miR-93-3p	HITS-CLIP	19536157
MIRT716716	hsa-miR-4695-3p	HITS-CLIP	19536157
MIRT716715	hsa-miR-210-5p	HITS-CLIP	19536157
MIRT716714	hsa-miR-8075	HITS-CLIP	19536157
MIRT716713	hsa-miR-7641	HITS-CLIP	19536157
MIRT716723	hsa-miR-6769a-3p	HITS-CLIP	19536157
MIRT716722	hsa-miR-3675-3p	HITS-CLIP	19536157
MIRT716721	hsa-miR-6801-3p	HITS-CLIP	19536157
MIRT716720	hsa-miR-6810-3p	HITS-CLIP	19536157
MIRT716719	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT716718	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT716717	hsa-miR-93-3p	HITS-CLIP	19536157
MIRT716716	hsa-miR-4695-3p	HITS-CLIP	19536157
MIRT716715	hsa-miR-210-5p	HITS-CLIP	19536157
MIRT716714	hsa-miR-8075	HITS-CLIP	19536157
MIRT716713	hsa-miR-7641	HITS-CLIP	19536157
MIRT1330215	hsa-miR-1253	CLIP-seq
MIRT1330216	hsa-miR-1264	CLIP-seq
MIRT1330217	hsa-miR-140-5p	CLIP-seq
MIRT1330218	hsa-miR-2053	CLIP-seq
MIRT1330219	hsa-miR-208a	CLIP-seq
MIRT1330220	hsa-miR-208b	CLIP-seq
MIRT1330221	hsa-miR-3545-5p	CLIP-seq
MIRT1330222	hsa-miR-3646	CLIP-seq
MIRT1330223	hsa-miR-3662	CLIP-seq
MIRT1330224	hsa-miR-4432	CLIP-seq
MIRT1330225	hsa-miR-4460	CLIP-seq
MIRT1330226	hsa-miR-4803	CLIP-seq
MIRT1330227	hsa-miR-499-5p	CLIP-seq
MIRT1330228	hsa-miR-548a-5p	CLIP-seq
MIRT1330229	hsa-miR-548ab	CLIP-seq
MIRT1330230	hsa-miR-548ak	CLIP-seq
MIRT1330231	hsa-miR-548b-5p	CLIP-seq
MIRT1330232	hsa-miR-548c-5p	CLIP-seq
MIRT1330233	hsa-miR-548d-5p	CLIP-seq
MIRT1330234	hsa-miR-548h	CLIP-seq
MIRT1330235	hsa-miR-548i	CLIP-seq
MIRT1330236	hsa-miR-548j	CLIP-seq
MIRT1330237	hsa-miR-548n	CLIP-seq
MIRT1330238	hsa-miR-548w	CLIP-seq
MIRT1330239	hsa-miR-548y	CLIP-seq
MIRT1330240	hsa-miR-559	CLIP-seq
MIRT1330241	hsa-miR-633	CLIP-seq
MIRT1330242	hsa-miR-802	CLIP-seq
MIRT2097838	hsa-miR-370	CLIP-seq
MIRT2097839	hsa-miR-4720-3p	CLIP-seq
MIRT2097840	hsa-miR-4804-3p	CLIP-seq
MIRT2322122	hsa-miR-570	CLIP-seq
MIRT2458957	hsa-miR-1244	CLIP-seq
MIRT2458958	hsa-miR-3184	CLIP-seq
MIRT2458959	hsa-miR-423-5p	CLIP-seq
MIRT2458960	hsa-miR-4688	CLIP-seq
MIRT2458961	hsa-miR-486-3p	CLIP-seq
MIRT2458957	hsa-miR-1244	CLIP-seq
MIRT2458958	hsa-miR-3184	CLIP-seq
MIRT2458959	hsa-miR-423-5p	CLIP-seq
MIRT2458960	hsa-miR-4688	CLIP-seq
MIRT2458961	hsa-miR-486-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001518	Component	Voltage-gated sodium channel complex	IBA	21873635
GO:0005244	Function	Voltage-gated ion channel activity	IEA
GO:0005248	Function	Voltage-gated sodium channel activity	IBA	21873635
GO:0006814	Process	Sodium ion transport	TAS	1317577
GO:0006936	Process	Muscle contraction	IEA
GO:0009617	Process	Response to bacterium	IEA
GO:0019228	Process	Neuronal action potential	IBA	21873635
GO:0030424	Component	Axon	IBA	21873635
GO:0034765	Process	Regulation of ion transmembrane transport	IEA
GO:0035725	Process	Sodium ion transmembrane transport	IBA	21873635
GO:0055078	Process	Sodium ion homeostasis	IEA
GO:0086010	Process	Membrane depolarization during action potential	IBA	21873635
GO:0097386	Component	Glial cell projection	IEA

Other IDs

• MIM: 182392
• HGNC: 10594
• e!Ensembl: ENSG00000136546

Protein

• UniProt ID: Q01118
• Protein name: Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha)
• Protein function: Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMe
• PDB: 7TJ8, 7TJ9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00520	Ion_trans	117 → 405	Ion transport protein	Family
  PF00520	Ion_trans	504 → 738	Ion transport protein	Family
  PF06512	Na_trans_assoc	742 → 929	Sodium ion transport-associated	Family
  PF00520	Ion_trans	933 → 1202	Ion transport protein	Family
  PF00520	Ion_trans	1250 → 1507	Ion transport protein	Family

• Sequence:

  MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQG
  MVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFF
  QLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPW
  NWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGV
  IILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEG
  ERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYH
  QILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGK
  ELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAK
  TFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIG
  NLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRM
  LRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHI
  DKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLV
  LYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDH
  VNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIAS
  GESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNG
  CRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQ
  RKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTR
  EELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLF
  AGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVAT
  FNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHK
  IKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVL
  ICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFM
  VVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPAL
  LNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGML
  DAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLN
  IASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLI
  ALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTL
  KRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQS
  QI

• Sequence length: 1682