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SCN4B (sodium voltage-gated channel beta subunit 4)

Gene

6330

Sodium voltage-gated channel beta subunit 4

SCN4B

ATFB17, LQT10, Navbeta4

11q23.3

The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. De

Show/Hide all(6)

SNP ID	Visualize variation	Clinical significance	Consequence
rs112363898	T>A	Uncertain-significance, likely-benign, conflicting-interpretations-of-pathogenicity	Non coding transcript variant, 5 prime UTR variant, coding sequence variant, missense variant, intron variant
rs121434386	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs149868494	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Missense variant, genic upstream transcript variant, coding sequence variant
rs587777559	A>C	Pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs587777560	T>G	Pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs777894412	C>G,T	Conflicting-interpretations-of-pathogenicity	Missense variant, intron variant, non coding transcript variant, coding sequence variant, 5 prime UTR variant

Show/Hide all(160)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023310	hsa-miR-122-5p	Microarray	17612493
MIRT1330109	hsa-let-7a	CLIP-seq
MIRT1330110	hsa-let-7b	CLIP-seq
MIRT1330111	hsa-let-7c	CLIP-seq
MIRT1330112	hsa-let-7d	CLIP-seq
MIRT1330113	hsa-let-7e	CLIP-seq
MIRT1330114	hsa-let-7f	CLIP-seq
MIRT1330115	hsa-let-7g	CLIP-seq
MIRT1330116	hsa-let-7i	CLIP-seq
MIRT1330117	hsa-miR-1207-3p	CLIP-seq
MIRT1330118	hsa-miR-1252	CLIP-seq
MIRT1330119	hsa-miR-1273f	CLIP-seq
MIRT1330120	hsa-miR-1294	CLIP-seq
MIRT1330121	hsa-miR-132	CLIP-seq
MIRT1330122	hsa-miR-1321	CLIP-seq
MIRT1330123	hsa-miR-143	CLIP-seq
MIRT1330124	hsa-miR-15a	CLIP-seq
MIRT1330125	hsa-miR-15b	CLIP-seq
MIRT1330126	hsa-miR-16	CLIP-seq
MIRT1330127	hsa-miR-1909	CLIP-seq
MIRT1330128	hsa-miR-1910	CLIP-seq
MIRT1330129	hsa-miR-1913	CLIP-seq
MIRT1330130	hsa-miR-1914	CLIP-seq
MIRT1330131	hsa-miR-1915	CLIP-seq
MIRT1330132	hsa-miR-193a-3p	CLIP-seq
MIRT1330133	hsa-miR-193b	CLIP-seq
MIRT1330134	hsa-miR-195	CLIP-seq
MIRT1330135	hsa-miR-202	CLIP-seq
MIRT1330136	hsa-miR-2110	CLIP-seq
MIRT1330137	hsa-miR-212	CLIP-seq
MIRT1330138	hsa-miR-3117-5p	CLIP-seq
MIRT1330139	hsa-miR-3150a-3p	CLIP-seq
MIRT1330140	hsa-miR-3153	CLIP-seq
MIRT1330141	hsa-miR-3162-3p	CLIP-seq
MIRT1330142	hsa-miR-3162-5p	CLIP-seq
MIRT739050	hsa-miR-3188	CLIP-seq
MIRT1330143	hsa-miR-324-3p	CLIP-seq
MIRT1330144	hsa-miR-3614-5p	CLIP-seq
MIRT1330145	hsa-miR-3620	CLIP-seq
MIRT1330146	hsa-miR-3646	CLIP-seq
MIRT1330147	hsa-miR-3944-5p	CLIP-seq
MIRT1330148	hsa-miR-424	CLIP-seq
MIRT1330149	hsa-miR-4265	CLIP-seq
MIRT1330150	hsa-miR-4268	CLIP-seq
MIRT1330151	hsa-miR-4271	CLIP-seq
MIRT1330152	hsa-miR-4287	CLIP-seq
MIRT1330153	hsa-miR-4296	CLIP-seq
MIRT1330154	hsa-miR-4312	CLIP-seq
MIRT1330155	hsa-miR-4316	CLIP-seq
MIRT1330156	hsa-miR-4318	CLIP-seq
MIRT1330157	hsa-miR-4322	CLIP-seq
MIRT1330158	hsa-miR-4417	CLIP-seq
MIRT1330159	hsa-miR-4434	CLIP-seq
MIRT1330160	hsa-miR-4436a	CLIP-seq
MIRT1330161	hsa-miR-4436b-5p	CLIP-seq
MIRT1330162	hsa-miR-4446-3p	CLIP-seq
MIRT739049	hsa-miR-4446-5p	CLIP-seq
MIRT1330163	hsa-miR-4448	CLIP-seq
MIRT1330164	hsa-miR-4458	CLIP-seq
MIRT1330165	hsa-miR-4468	CLIP-seq
MIRT1330166	hsa-miR-4469	CLIP-seq
MIRT1330167	hsa-miR-4475	CLIP-seq
MIRT1330168	hsa-miR-4492	CLIP-seq
MIRT1330169	hsa-miR-4498	CLIP-seq
MIRT1330170	hsa-miR-4499	CLIP-seq
MIRT1330171	hsa-miR-4500	CLIP-seq
MIRT1330172	hsa-miR-4503	CLIP-seq
MIRT1330173	hsa-miR-4504	CLIP-seq
MIRT1330174	hsa-miR-4505	CLIP-seq
MIRT1330175	hsa-miR-4516	CLIP-seq
MIRT1330176	hsa-miR-4522	CLIP-seq
MIRT1330177	hsa-miR-4641	CLIP-seq
MIRT1330178	hsa-miR-4646-5p	CLIP-seq
MIRT1330179	hsa-miR-4662a-3p	CLIP-seq
MIRT1330180	hsa-miR-4668-5p	CLIP-seq
MIRT1330181	hsa-miR-4677-3p	CLIP-seq
MIRT1330182	hsa-miR-4679	CLIP-seq
MIRT1330183	hsa-miR-4685-3p	CLIP-seq
MIRT1330184	hsa-miR-4685-5p	CLIP-seq
MIRT1330185	hsa-miR-4691-3p	CLIP-seq
MIRT1330186	hsa-miR-4701-5p	CLIP-seq
MIRT1330187	hsa-miR-4708-5p	CLIP-seq
MIRT1330188	hsa-miR-4709-5p	CLIP-seq
MIRT1330189	hsa-miR-4711-5p	CLIP-seq
MIRT1330190	hsa-miR-4713-5p	CLIP-seq
MIRT1330191	hsa-miR-4725-3p	CLIP-seq
MIRT1330192	hsa-miR-4739	CLIP-seq
MIRT739048	hsa-miR-4755-5p	CLIP-seq
MIRT1330193	hsa-miR-4756-5p	CLIP-seq
MIRT1330194	hsa-miR-4770	CLIP-seq
MIRT1330195	hsa-miR-497	CLIP-seq
MIRT1330196	hsa-miR-542-3p	CLIP-seq
MIRT1330197	hsa-miR-548a-3p	CLIP-seq
MIRT1330198	hsa-miR-548e	CLIP-seq
MIRT1330199	hsa-miR-548f	CLIP-seq
MIRT1330200	hsa-miR-548g	CLIP-seq
MIRT1330201	hsa-miR-588	CLIP-seq
MIRT1330202	hsa-miR-646	CLIP-seq
MIRT739047	hsa-miR-670	CLIP-seq
MIRT1330203	hsa-miR-762	CLIP-seq
MIRT1330204	hsa-miR-922	CLIP-seq
MIRT1330205	hsa-miR-98	CLIP-seq
MIRT739050	hsa-miR-3188	CLIP-seq
MIRT739049	hsa-miR-4446-5p	CLIP-seq
MIRT739048	hsa-miR-4755-5p	CLIP-seq
MIRT739047	hsa-miR-670	CLIP-seq
MIRT739050	hsa-miR-3188	CLIP-seq
MIRT739049	hsa-miR-4446-5p	CLIP-seq
MIRT739048	hsa-miR-4755-5p	CLIP-seq
MIRT739047	hsa-miR-670	CLIP-seq
MIRT739050	hsa-miR-3188	CLIP-seq
MIRT739049	hsa-miR-4446-5p	CLIP-seq
MIRT739048	hsa-miR-4755-5p	CLIP-seq
MIRT739047	hsa-miR-670	CLIP-seq
MIRT739050	hsa-miR-3188	CLIP-seq
MIRT739049	hsa-miR-4446-5p	CLIP-seq
MIRT739048	hsa-miR-4755-5p	CLIP-seq
MIRT739047	hsa-miR-670	CLIP-seq
MIRT739050	hsa-miR-3188	CLIP-seq
MIRT739049	hsa-miR-4446-5p	CLIP-seq
MIRT739048	hsa-miR-4755-5p	CLIP-seq
MIRT739047	hsa-miR-670	CLIP-seq
MIRT739050	hsa-miR-3188	CLIP-seq
MIRT739049	hsa-miR-4446-5p	CLIP-seq
MIRT739048	hsa-miR-4755-5p	CLIP-seq
MIRT739047	hsa-miR-670	CLIP-seq
MIRT2097805	hsa-miR-1233	CLIP-seq
MIRT2097806	hsa-miR-1273d	CLIP-seq
MIRT2097807	hsa-miR-3120-5p	CLIP-seq
MIRT739050	hsa-miR-3188	CLIP-seq
MIRT2097808	hsa-miR-346	CLIP-seq
MIRT2097809	hsa-miR-3663-5p	CLIP-seq
MIRT2097810	hsa-miR-4288	CLIP-seq
MIRT2097811	hsa-miR-4308	CLIP-seq
MIRT739049	hsa-miR-4446-5p	CLIP-seq
MIRT2097812	hsa-miR-4447	CLIP-seq
MIRT2097813	hsa-miR-4472	CLIP-seq
MIRT2097814	hsa-miR-4527	CLIP-seq
MIRT2097815	hsa-miR-4723-5p	CLIP-seq
MIRT739048	hsa-miR-4755-5p	CLIP-seq
MIRT2097816	hsa-miR-4797-3p	CLIP-seq
MIRT2097817	hsa-miR-632	CLIP-seq
MIRT739047	hsa-miR-670	CLIP-seq
MIRT2097818	hsa-miR-767-3p	CLIP-seq
MIRT2097819	hsa-miR-939	CLIP-seq
MIRT2322112	hsa-miR-1202	CLIP-seq
MIRT2322113	hsa-miR-3184	CLIP-seq
MIRT2322114	hsa-miR-3194-5p	CLIP-seq
MIRT2322115	hsa-miR-3926	CLIP-seq
MIRT2322116	hsa-miR-3972	CLIP-seq
MIRT2322117	hsa-miR-423-5p	CLIP-seq
MIRT1330149	hsa-miR-4265	CLIP-seq
MIRT1330153	hsa-miR-4296	CLIP-seq
MIRT1330157	hsa-miR-4322	CLIP-seq
MIRT1330158	hsa-miR-4417	CLIP-seq
MIRT2322118	hsa-miR-4728-5p	CLIP-seq
MIRT2322119	hsa-miR-548s	CLIP-seq
MIRT739047	hsa-miR-670	CLIP-seq
MIRT739049	hsa-miR-4446-5p	CLIP-seq
MIRT2432935	hsa-miR-4740-3p	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001518	Component	Voltage-gated sodium channel complex	IDA	12930796, 17592081
GO:0001518	Component	Voltage-gated sodium channel complex	IMP	24297919
GO:0005244	Function	Voltage-gated ion channel activity	IEA
GO:0005248	Function	Voltage-gated sodium channel activity	IDA	12930796
GO:0005515	Function	Protein binding	IPI	32296183
GO:0006814	Process	Sodium ion transport	IDA	12930796
GO:0010765	Process	Positive regulation of sodium ion transport	IDA	17592081
GO:0014704	Component	Intercalated disc	ISS
GO:0017080	Function	Sodium channel regulator activity	IDA	17592081, 24297919
GO:0031226	Component	Intrinsic component of plasma membrane	IDA	24297919
GO:0035725	Process	Sodium ion transmembrane transport	IDA	20226894
GO:0044325	Function	Ion channel binding	IPI	17592081
GO:0060048	Process	Cardiac muscle contraction	IMP	17592081
GO:0060307	Process	Regulation of ventricular cardiac muscle cell membrane repolarization	IMP	17592081
GO:0086002	Process	Cardiac muscle cell action potential involved in contraction	IMP	17592081
GO:0086006	Function	Voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IMP	17592081
GO:0086012	Process	Membrane depolarization during cardiac muscle cell action potential	IMP	17592081
GO:0086016	Process	AV node cell action potential	IMP	17592081
GO:0086091	Process	Regulation of heart rate by cardiac conduction	IMP	17592081
GO:2000649	Process	Regulation of sodium ion transmembrane transporter activity	IDA	17592081, 24297919

MIM	HGNC	e!Ensembl
608256	10592	ENSG00000177098

Protein

UniProt ID

Q8IWT1

Protein name

Sodium channel regulatory subunit beta-4

Protein function

Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by swi

PDB

4MZ2 , 4MZ3 , 5XAW , 6VSV , 7DTD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	37 → 151	Immunoglobulin V-set domain	Domain

Sequence

MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFG
FEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRD
LEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILI
LLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV

Sequence length

228

Interactions

View interactions

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