Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
6257 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Retinoid X receptor beta |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
RXRB |
SynonymsGene synonyms aliases
|
DAUDI6, H-2RIIBP, NR2B2, RCoR-1, RXR-beta, RXRbeta |
ChromosomeChromosome number
|
6 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
6p21.32 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptor |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000785 |
Component |
Chromatin |
ISA |
|
GO:0000977 |
Function |
RNA polymerase II transcription regulatory region sequence-specific DNA binding |
IDA |
12767074 |
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IBA |
21873635 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISA |
|
GO:0001228 |
Function |
DNA-binding transcription activator activity, RNA polymerase II-specific |
IDA |
12767074 |
GO:0003707 |
Function |
Steroid hormone receptor activity |
IEA |
|
GO:0004879 |
Function |
Nuclear receptor activity |
IBA |
21873635 |
GO:0004879 |
Function |
Nuclear receptor activity |
IDA |
1662118, 7990953 |
GO:0005515 |
Function |
Protein binding |
IPI |
16189514, 20195357, 21988832, 25303530, 25416956, 26871637, 28514442, 29892012, 31515488, 32296183 |
GO:0005634 |
Component |
Nucleus |
IDA |
7990953 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IEA |
|
GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0006367 |
Process |
Transcription initiation from RNA polymerase II promoter |
TAS |
|
GO:0008270 |
Function |
Zinc ion binding |
IEA |
|
GO:0030154 |
Process |
Cell differentiation |
IBA |
21873635 |
GO:0032526 |
Process |
Response to retinoic acid |
IBA |
21873635 |
GO:0043401 |
Process |
Steroid hormone mediated signaling pathway |
IEA |
|
GO:0044323 |
Function |
Retinoic acid-responsive element binding |
IBA |
21873635 |
GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
IDA |
1662118 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IDA |
12767074 |
GO:0048384 |
Process |
Retinoic acid receptor signaling pathway |
IBA |
21873635 |
GO:0048856 |
Process |
Anatomical structure development |
IBA |
21873635 |
GO:0090575 |
Component |
RNA polymerase II transcription regulator complex |
IBA |
21873635 |
GO:1990837 |
Function |
Sequence-specific double-stranded DNA binding |
IDA |
28473536 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P28702 |
Protein name |
Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta) |
Protein function |
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR |
PDB |
1H9U
,
1UHL
,
5HJP
,
5I4V
,
5KYA
,
5KYJ
,
7A78
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00105 |
zf-C4 |
203 → 272 |
Zinc finger, C4 type (two domains) |
Domain |
PF00104 |
Hormone_recep |
331 → 513 |
Ligand-binding domain of nuclear hormone receptor |
Domain |
|
Sequence |
|
Sequence length |
533 |
Interactions |
View interactions |