RXRA (retinoid X receptor alpha)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
6256 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Retinoid X receptor alpha |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
RXRA |
SynonymsGene synonyms aliases
|
NR2B1, RXR-alpha, RXRalpha |
ChromosomeChromosome number
|
9 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
9q34.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by bind |
SNPsSNP information provided by dbSNP.
|
SNP ID |
Visualize variation |
Clinical significance |
Consequence |
rs1057519958 |
C>A,T |
Likely-pathogenic |
Coding sequence variant, missense variant |
rs1588299621 |
G>A |
Likely-pathogenic |
Coding sequence variant, missense variant |
|
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
NR1I2 |
Unknown |
21295138 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000122 |
Process |
Negative regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0000122 |
Process |
Negative regulation of transcription by RNA polymerase II |
IDA |
17426122 |
GO:0000785 |
Component |
Chromatin |
IDA |
18511497, 25592151 |
GO:0000785 |
Component |
Chromatin |
ISA |
|
GO:0000976 |
Function |
Transcription regulatory region sequence-specific DNA binding |
IDA |
18511497 |
GO:0000977 |
Function |
RNA polymerase II transcription regulatory region sequence-specific DNA binding |
IDA |
7831303 |
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IBA |
21873635 |
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IDA |
12037571 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISA |
|
GO:0001972 |
Function |
Retinoic acid binding |
IDA |
19043829 |
GO:0003690 |
Function |
Double-stranded DNA binding |
IMP |
19043829 |
GO:0003700 |
Function |
DNA-binding transcription factor activity |
IDA |
12037571, 17426122 |
GO:0003707 |
Function |
Steroid hormone receptor activity |
IEA |
|
GO:0004879 |
Function |
Nuclear receptor activity |
IBA |
21873635 |
GO:0004879 |
Function |
Nuclear receptor activity |
IDA |
1651173, 7990953, 20219900, 25592151 |
GO:0004879 |
Function |
Nuclear receptor activity |
TAS |
19374686 |
GO:0005515 |
Function |
Protein binding |
IPI |
9653119, 10428834, 10866662, 11915042, 12040021, 14701856, 15722453, 16769902, 17363140, 17426122, 17641689, 17673910, 17947383, 19047629, 19345331, 19786558, 19917671, 20219900, 20541701, 20682316, 21220114, 21478865, 21988832, 22179700, 22474364, 23602807, 24561505, 25241761, 2530 |
GO:0005634 |
Component |
Nucleus |
IDA |
7990953, 19917671 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005739 |
Component |
Mitochondrion |
IEA |
|
GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0006367 |
Process |
Transcription initiation from RNA polymerase II promoter |
TAS |
|
GO:0008203 |
Process |
Cholesterol metabolic process |
TAS |
19374686 |
GO:0008270 |
Function |
Zinc ion binding |
IDA |
19043829 |
GO:0015721 |
Process |
Bile acid and bile salt transport |
TAS |
|
GO:0016922 |
Function |
Nuclear receptor binding |
IPI |
19043829 |
GO:0019048 |
Process |
Modulation by virus of host process |
IDA |
11915042 |
GO:0019216 |
Process |
Regulation of lipid metabolic process |
TAS |
|
GO:0019899 |
Function |
Enzyme binding |
IPI |
12039952 |
GO:0030154 |
Process |
Cell differentiation |
IBA |
21873635 |
GO:0032526 |
Process |
Response to retinoic acid |
IBA |
21873635 |
GO:0032526 |
Process |
Response to retinoic acid |
IMP |
17538076 |
GO:0035357 |
Process |
Peroxisome proliferator activated receptor signaling pathway |
IDA |
10195690 |
GO:0042277 |
Function |
Peptide binding |
IDA |
19043829 |
GO:0042802 |
Function |
Identical protein binding |
IPI |
7831303 |
GO:0042809 |
Function |
Vitamin D receptor binding |
IPI |
17426122 |
GO:0043235 |
Component |
Receptor complex |
IDA |
17426122, 19043829 |
GO:0043401 |
Process |
Steroid hormone mediated signaling pathway |
IEA |
|
GO:0043565 |
Function |
Sequence-specific DNA binding |
IDA |
11915042 |
GO:0044323 |
Function |
Retinoic acid-responsive element binding |
IBA |
21873635 |
GO:0044323 |
Function |
Retinoic acid-responsive element binding |
IDA |
19917671, 25592151 |
GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
IDA |
1651173 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IDA |
12037571, 20219900, 25592151 |
GO:0048384 |
Process |
Retinoic acid receptor signaling pathway |
IBA |
21873635 |
GO:0048384 |
Process |
Retinoic acid receptor signaling pathway |
IMP |
17538076 |
GO:0048856 |
Process |
Anatomical structure development |
IBA |
21873635 |
GO:0050692 |
Function |
DNA binding domain binding |
IDA |
19043829 |
GO:0050693 |
Function |
LBD domain binding |
IDA |
19043829 |
GO:0070644 |
Function |
Vitamin D response element binding |
IDA |
17426122 |
GO:0090575 |
Component |
RNA polymerase II transcription regulator complex |
IBA |
21873635 |
GO:0090575 |
Component |
RNA polymerase II transcription regulator complex |
IDA |
17426122, 18511497 |
GO:1990837 |
Function |
Sequence-specific double-stranded DNA binding |
IDA |
28473536 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P19793 |
Protein name |
Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha) |
Protein function |
Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in respons |
PDB |
1BY4
,
1DSZ
,
1FBY
,
1FM6
,
1FM9
,
1G1U
,
1G5Y
,
1K74
,
1MV9
,
1MVC
,
1MZN
,
1R0N
,
1RDT
,
1RXR
,
1XLS
,
1XV9
,
1XVP
,
1YNW
,
2ACL
,
2NLL
,
2P1T
,
2P1U
,
2P1V
,
2ZXZ
,
2ZY0
,
3DZU
,
3DZY
,
3E00
,
3E94
,
3FAL
,
3FC6
,
3FUG
,
3H0A
,
3KWY
,
3NSP
,
3NSQ
,
3OAP
,
3OZJ
,
3PCU
,
3R29
,
3R2A
,
3R5M
,
3UVV
,
4CN2
,
4CN3
,
4CN5
,
4CN7
,
4J5W
,
4J5X
,
4K4J
,
4K6I
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF11825 |
Nuc_recep-AF1 |
17 → 127 |
Nuclear/hormone receptor activator site AF-1 |
Family |
PF00105 |
zf-C4 |
133 → 202 |
Zinc finger, C4 type (two domains) |
Domain |
PF00104 |
Hormone_recep |
257 → 442 |
Ligand-binding domain of nuclear hormone receptor |
Domain |
|
Sequence |
|
Sequence length |
462 |
Interactions |
View interactions |
|
|