RPS6KB2 (ribosomal protein S6 kinase B2)

Gene

• Entrez ID: 6199
• Gene name: Ribosomal protein S6 kinase B2
• Gene symbol: RPS6KB2
• Synonyms: KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, S6KB, S6KI(2), S6Kbeta, SRK, STK14B, p70(S6K)-beta, p70S6Kb
• Chromosome: 11
• Chromosome location: 11q13.2
• Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphoryla

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027691	hsa-miR-98-5p	Microarray	19088304
MIRT029811	hsa-miR-26b-5p	Microarray	19088304
MIRT036102	hsa-miR-1296-5p	CLASH	23622248
MIRT1318846	hsa-miR-1470	CLIP-seq
MIRT1318847	hsa-miR-1908	CLIP-seq
MIRT1318848	hsa-miR-1973	CLIP-seq
MIRT1318849	hsa-miR-3127-5p	CLIP-seq
MIRT1318850	hsa-miR-3605-3p	CLIP-seq
MIRT1318851	hsa-miR-4290	CLIP-seq
MIRT1318852	hsa-miR-4641	CLIP-seq
MIRT1318853	hsa-miR-4688	CLIP-seq
MIRT1318854	hsa-miR-4767	CLIP-seq
MIRT1318855	hsa-miR-663	CLIP-seq
MIRT2094807	hsa-miR-1268	CLIP-seq
MIRT2094808	hsa-miR-1268b	CLIP-seq
MIRT2094809	hsa-miR-129-3p	CLIP-seq
MIRT1318846	hsa-miR-1470	CLIP-seq
MIRT1318847	hsa-miR-1908	CLIP-seq
MIRT1318848	hsa-miR-1973	CLIP-seq
MIRT2094810	hsa-miR-2277-5p	CLIP-seq
MIRT2094811	hsa-miR-3157-5p	CLIP-seq
MIRT2094812	hsa-miR-339-3p	CLIP-seq
MIRT1318850	hsa-miR-3605-3p	CLIP-seq
MIRT1318851	hsa-miR-4290	CLIP-seq
MIRT1318852	hsa-miR-4641	CLIP-seq
MIRT2094813	hsa-miR-4690-3p	CLIP-seq
MIRT1318854	hsa-miR-4767	CLIP-seq
MIRT1318855	hsa-miR-663	CLIP-seq
MIRT2094814	hsa-miR-744	CLIP-seq
MIRT2319213	hsa-miR-1228	CLIP-seq
MIRT2094807	hsa-miR-1268	CLIP-seq
MIRT2094808	hsa-miR-1268b	CLIP-seq
MIRT1318846	hsa-miR-1470	CLIP-seq
MIRT1318847	hsa-miR-1908	CLIP-seq
MIRT2319214	hsa-miR-1913	CLIP-seq
MIRT1318848	hsa-miR-1973	CLIP-seq
MIRT2319215	hsa-miR-22	CLIP-seq
MIRT2094810	hsa-miR-2277-5p	CLIP-seq
MIRT1318849	hsa-miR-3127-5p	CLIP-seq
MIRT2319216	hsa-miR-3166	CLIP-seq
MIRT2319217	hsa-miR-3189-5p	CLIP-seq
MIRT2319218	hsa-miR-324-3p	CLIP-seq
MIRT2319219	hsa-miR-329	CLIP-seq
MIRT2094812	hsa-miR-339-3p	CLIP-seq
MIRT1318850	hsa-miR-3605-3p	CLIP-seq
MIRT2319220	hsa-miR-361-3p	CLIP-seq
MIRT2319221	hsa-miR-362-3p	CLIP-seq
MIRT1318851	hsa-miR-4290	CLIP-seq
MIRT2319222	hsa-miR-4530	CLIP-seq
MIRT1318852	hsa-miR-4641	CLIP-seq
MIRT1318853	hsa-miR-4688	CLIP-seq
MIRT2319223	hsa-miR-4726-3p	CLIP-seq
MIRT2319224	hsa-miR-4758-3p	CLIP-seq
MIRT1318854	hsa-miR-4767	CLIP-seq
MIRT2319225	hsa-miR-603	CLIP-seq
MIRT1318855	hsa-miR-663	CLIP-seq
MIRT2094814	hsa-miR-744	CLIP-seq
MIRT2319226	hsa-miR-922	CLIP-seq
MIRT2319213	hsa-miR-1228	CLIP-seq
MIRT2614787	hsa-miR-1299	CLIP-seq
MIRT2614788	hsa-miR-1915	CLIP-seq
MIRT2614789	hsa-miR-193b	CLIP-seq
MIRT2614790	hsa-miR-3136-3p	CLIP-seq
MIRT2614791	hsa-miR-326	CLIP-seq
MIRT2319219	hsa-miR-329	CLIP-seq
MIRT2614792	hsa-miR-330-5p	CLIP-seq
MIRT2319220	hsa-miR-361-3p	CLIP-seq
MIRT2319221	hsa-miR-362-3p	CLIP-seq
MIRT2319223	hsa-miR-4726-3p	CLIP-seq
MIRT2614793	hsa-miR-593	CLIP-seq
MIRT2614794	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004672	Function	Protein kinase activity	TAS	9804755
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004711	Function	Ribosomal protein S6 kinase activity	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006412	Process	Translation	TAS	9804755
GO:0007165	Process	Signal transduction	TAS	9804755
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0031929	Process	TOR signaling	IBA	21873635
GO:0031929	Process	TOR signaling	IMP	29750193
GO:0042277	Function	Peptide binding	IEA
GO:0043491	Process	Protein kinase B signaling	IEA
GO:0045948	Process	Positive regulation of translational initiation	IMP	16763566
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA

Other IDs

• MIM: 608939
• HGNC: 10437
• e!Ensembl: ENSG00000175634

Protein

• UniProt ID: Q9UBS0
• Protein name: Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kina
• Protein function: Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pat
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	67 → 328	Protein kinase domain	Domain
  PF00433	Pkinase_C	349 → 389	Protein kinase C terminal domain	Family

• Sequence:

  MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPE
  RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAER
  NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL
  ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI
  LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLV
  KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT
  RFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRA
  PVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRP
  GR

• Sequence length: 482