Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
9252 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Ribosomal protein S6 kinase A5 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
RPS6KA5 |
SynonymsGene synonyms aliases
|
MSK1, MSPK1, RLPK |
ChromosomeChromosome number
|
14 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
14q32.11 |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000287 |
Function |
Magnesium ion binding |
IEA |
|
GO:0001818 |
Process |
Negative regulation of cytokine production |
TAS |
18508628 |
GO:0002223 |
Process |
Stimulatory C-type lectin receptor signaling pathway |
TAS |
|
GO:0004672 |
Function |
Protein kinase activity |
IDA |
9873047 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IBA |
21873635 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IDA |
9687510 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IMP |
12773393 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
TAS |
|
GO:0005515 |
Function |
Protein binding |
IPI |
12628924, 21988832, 25241761, 25535969, 32296183 |
GO:0005524 |
Function |
ATP binding |
IDA |
9687510 |
GO:0005634 |
Component |
Nucleus |
IDA |
9687510, 18511904 |
GO:0005634 |
Component |
Nucleus |
IMP |
12628924 |
GO:0005654 |
Component |
Nucleoplasm |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
18511904 |
GO:0006355 |
Process |
Regulation of transcription, DNA-templated |
IBA |
21873635 |
GO:0006355 |
Process |
Regulation of transcription, DNA-templated |
IDA |
9687510 |
GO:0006355 |
Process |
Regulation of transcription, DNA-templated |
IMP |
12763138 |
GO:0006468 |
Process |
Protein phosphorylation |
IDA |
9687510 |
GO:0006954 |
Process |
Inflammatory response |
IEA |
|
GO:0007173 |
Process |
Epidermal growth factor receptor signaling pathway |
TAS |
9873047 |
GO:0007411 |
Process |
Axon guidance |
TAS |
|
GO:0016572 |
Process |
Histone phosphorylation |
IBA |
21873635 |
GO:0016572 |
Process |
Histone phosphorylation |
IDA |
9873047 |
GO:0016572 |
Process |
Histone phosphorylation |
TAS |
20018936 |
GO:0018105 |
Process |
Peptidyl-serine phosphorylation |
IBA |
21873635 |
GO:0032793 |
Process |
Positive regulation of CREB transcription factor activity |
TAS |
18508628 |
GO:0033129 |
Process |
Positive regulation of histone phosphorylation |
IMP |
20018936 |
GO:0035066 |
Process |
Positive regulation of histone acetylation |
IMP |
20018936 |
GO:0035556 |
Process |
Intracellular signal transduction |
IDA |
9687510 |
GO:0043987 |
Process |
Histone H3-S10 phosphorylation |
IMP |
12773393 |
GO:0043988 |
Process |
Histone H3-S28 phosphorylation |
IMP |
12773393 |
GO:0043990 |
Process |
Histone H2A-S1 phosphorylation |
IDA |
15010469 |
GO:0045892 |
Process |
Negative regulation of transcription, DNA-templated |
IDA |
15010469 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IMP |
20018936 |
GO:0051092 |
Process |
Positive regulation of NF-kappaB transcription factor activity |
IMP |
12628924, 18511904 |
GO:0070498 |
Process |
Interleukin-1-mediated signaling pathway |
IMP |
20018936 |
GO:0106310 |
Function |
Protein serine kinase activity |
IEA |
|
GO:0106311 |
Function |
Protein threonine kinase activity |
IEA |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
O75582 |
Protein name |
Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) |
Protein function |
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to |
PDB |
1VZO
,
3KN5
,
3KN6
,
7UP4
,
7UP5
,
7UP6
,
7UP7
,
7UP8
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069 |
Pkinase |
49 → 318 |
Protein kinase domain |
Domain |
PF00433 |
Pkinase_C |
339 → 377 |
Protein kinase C terminal domain |
Family |
PF00069 |
Pkinase |
427 → 687 |
Protein kinase domain |
Domain |
|
Sequence |
|
Sequence length |
802 |
Interactions |
View interactions |