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RPS6KA5 (ribosomal protein S6 kinase A5)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9252
Gene nameGene Name - the full gene name approved by the HGNC.
Ribosomal protein S6 kinase A5
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
RPS6KA5
SynonymsGene synonyms aliases
MSK1, MSPK1, RLPK
ChromosomeChromosome number
14
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.11
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004504 hsa-miR-148a-3p qRT-PCR, Luciferase reporter assay, Western blot 20406806
MIRT004504 hsa-miR-148a-3p qRT-PCR, Luciferase reporter assay, Western blot 20406806
MIRT004504 hsa-miR-148a-3p qRT-PCR, Luciferase reporter assay, Western blot 20406806
MIRT022082 hsa-miR-128-3p Sequencing 20371350
MIRT004504 hsa-miR-148a-3p Reporter assay 20406806
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IEA
GO:0001818 Process Negative regulation of cytokine production TAS 18508628
GO:0002223 Process Stimulatory C-type lectin receptor signaling pathway TAS
GO:0004672 Function Protein kinase activity IDA 9873047
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O75582
Protein name Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)
Protein function Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to
PDB 1VZO , 3KN5 , 3KN6 , 7UP4 , 7UP5 , 7UP6 , 7UP7 , 7UP8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
49 318
Protein kinase domain
Domain
PF00433 Pkinase_C
339 377
Protein kinase C terminal domain
Family
PF00069 Pkinase
427 687
Protein kinase domain
Domain
Sequence
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY
GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA
FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL
ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS
LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK
RLGCGPRDADEIKEHLFF
QKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS
PAALPQSSEKLFQGYSF
VAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY
QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN
IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV
VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD
ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA
KDLIQGLLTVDPNKRLKMSGLRYNEWL
QDGSQLSSNPLMTPDILGSSGAAVHTCVKATFH
AFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTL
QPSNPADSNNPETLFQFSDSVA
Sequence length 802
Interactions View interactions

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