RPS27A (ribosomal protein S27a)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
6233 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Ribosomal protein S27a |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
RPS27A |
SynonymsGene synonyms aliases
|
CEP80, HEL112, S27A, UBA80, UBC, UBCEP1, UBCEP80, eS31 |
ChromosomeChromosome number
|
2 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
2p16.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated p |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000122 |
Process |
Negative regulation of transcription by RNA polymerase II |
TAS |
|
GO:0000184 |
Process |
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS |
|
GO:0000187 |
Process |
Activation of MAPK activity |
TAS |
|
GO:0000209 |
Process |
Protein polyubiquitination |
TAS |
|
GO:0000715 |
Process |
Nucleotide-excision repair, DNA damage recognition |
TAS |
|
GO:0000717 |
Process |
Nucleotide-excision repair, DNA duplex unwinding |
TAS |
|
GO:0002755 |
Process |
MyD88-dependent toll-like receptor signaling pathway |
TAS |
|
GO:0002756 |
Process |
MyD88-independent toll-like receptor signaling pathway |
TAS |
|
GO:0003723 |
Function |
RNA binding |
HDA |
22658674, 22681889 |
GO:0003735 |
Function |
Structural constituent of ribosome |
HDA |
15883184 |
GO:0005515 |
Function |
Protein binding |
IPI |
14755250, 15936278, 16189514, 20374249, 25416956, 32296183, 32814053 |
GO:0005615 |
Component |
Extracellular space |
HDA |
16502470 |
GO:0005634 |
Component |
Nucleus |
HDA |
21630459 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005730 |
Component |
Nucleolus |
HDA |
16791210 |
GO:0005737 |
Component |
Cytoplasm |
HDA |
16791210 |
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005741 |
Component |
Mitochondrial outer membrane |
TAS |
|
GO:0005789 |
Component |
Endoplasmic reticulum membrane |
TAS |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0006283 |
Process |
Transcription-coupled nucleotide-excision repair |
TAS |
|
GO:0006294 |
Process |
Nucleotide-excision repair, preincision complex assembly |
TAS |
|
GO:0006296 |
Process |
Nucleotide-excision repair, DNA incision, 5'-to lesion |
TAS |
|
GO:0006297 |
Process |
Nucleotide-excision repair, DNA gap filling |
TAS |
|
GO:0006412 |
Process |
Translation |
IC |
8706699, 15883184 |
GO:0006413 |
Process |
Translational initiation |
TAS |
|
GO:0006614 |
Process |
SRP-dependent cotranslational protein targeting to membrane |
TAS |
|
GO:0006625 |
Process |
Protein targeting to peroxisome |
TAS |
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
TAS |
|
GO:0007249 |
Process |
I-kappaB kinase/NF-kappaB signaling |
TAS |
|
GO:0007254 |
Process |
JNK cascade |
TAS |
|
GO:0010008 |
Component |
Endosome membrane |
TAS |
|
GO:0015935 |
Component |
Small ribosomal subunit |
HDA |
15883184 |
GO:0016020 |
Component |
Membrane |
HDA |
19946888 |
GO:0016055 |
Process |
Wnt signaling pathway |
TAS |
|
GO:0016197 |
Process |
Endosomal transport |
TAS |
|
GO:0016567 |
Process |
Protein ubiquitination |
IBA |
21873635 |
GO:0016567 |
Process |
Protein ubiquitination |
TAS |
|
GO:0016579 |
Process |
Protein deubiquitination |
TAS |
|
GO:0019058 |
Process |
Viral life cycle |
TAS |
|
GO:0019068 |
Process |
Virion assembly |
TAS |
|
GO:0019083 |
Process |
Viral transcription |
TAS |
|
GO:0019221 |
Process |
Cytokine-mediated signaling pathway |
TAS |
|
GO:0019941 |
Process |
Modification-dependent protein catabolic process |
IBA |
21873635 |
GO:0019985 |
Process |
Translesion synthesis |
TAS |
|
GO:0022627 |
Component |
Cytosolic small ribosomal subunit |
HDA |
15883184 |
GO:0022627 |
Component |
Cytosolic small ribosomal subunit |
IBA |
21873635 |
GO:0022627 |
Component |
Cytosolic small ribosomal subunit |
IDA |
8706699 |
GO:0030512 |
Process |
Negative regulation of transforming growth factor beta receptor signaling pathway |
TAS |
|
GO:0030666 |
Component |
Endocytic vesicle membrane |
TAS |
|
GO:0031145 |
Process |
Anaphase-promoting complex-dependent catabolic process |
TAS |
|
GO:0031386 |
Function |
Protein tag |
IBA |
21873635 |
GO:0031625 |
Function |
Ubiquitin protein ligase binding |
IBA |
21873635 |
GO:0031982 |
Component |
Vesicle |
HDA |
19190083 |
GO:0033683 |
Process |
Nucleotide-excision repair, DNA incision |
TAS |
|
GO:0035666 |
Process |
TRIF-dependent toll-like receptor signaling pathway |
TAS |
|
GO:0036297 |
Process |
Interstrand cross-link repair |
TAS |
|
GO:0042276 |
Process |
Error-prone translesion synthesis |
TAS |
|
GO:0042769 |
Process |
DNA damage response, detection of DNA damage |
TAS |
|
GO:0043065 |
Process |
Positive regulation of apoptotic process |
TAS |
|
GO:0043066 |
Process |
Negative regulation of apoptotic process |
TAS |
|
GO:0043488 |
Process |
Regulation of mRNA stability |
TAS |
|
GO:0043657 |
Component |
Host cell |
IEA |
|
GO:0044267 |
Process |
Cellular protein metabolic process |
TAS |
|
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
TAS |
|
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
GO:0051092 |
Process |
Positive regulation of NF-kappaB transcription factor activity |
TAS |
|
GO:0051403 |
Process |
Stress-activated MAPK cascade |
TAS |
|
GO:0055085 |
Process |
Transmembrane transport |
TAS |
|
GO:0061024 |
Process |
Membrane organization |
TAS |
|
GO:0061418 |
Process |
Regulation of transcription from RNA polymerase II promoter in response to hypoxia |
TAS |
|
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19199708, 20458337, 23533145 |
GO:0070423 |
Process |
Nucleotide-binding oligomerization domain containing signaling pathway |
TAS |
|
GO:0070498 |
Process |
Interleukin-1-mediated signaling pathway |
TAS |
|
GO:0070911 |
Process |
Global genome nucleotide-excision repair |
TAS |
|
GO:0070987 |
Process |
Error-free translesion synthesis |
TAS |
|
GO:0075733 |
Process |
Intracellular transport of virus |
TAS |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P62979 |
Protein name |
Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] |
Protein function |
[Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys re |
PDB |
2KHW
,
2KOX
,
2KTF
,
2KWU
,
2KWV
,
2L0F
,
2L0T
,
2XK5
,
3AXC
,
3I3T
,
3K9P
,
3N30
,
3N32
,
3NHE
,
3NOB
,
3NS8
,
3PHD
,
3PHW
,
3TBL
,
3VDZ
,
4R62
,
4UG0
,
4V6X
,
5A2Q
,
5AJ0
,
5FLX
,
5LKS
,
5T2C
,
5WVO
,
5YDK
,
6DC6
,
6FEC
,
6G18
,
6G51
,
6G53
,
6G5H
,
6G5I
,
6IP5
,
6IP6
,
6IP8
,
6J99
,
6KFP
,
6KG6
,
6KIU
,
6KIV
,
6KIW
,
6OLE
,
6OLF
,
6OLG
,
6OLI
,
6OLZ
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00240 |
ubiquitin |
3 → 74 |
Ubiquitin family |
Domain |
PF01599 |
Ribosomal_S27 |
102 → 147 |
Ribosomal protein S27a |
Domain |
|
Sequence |
|
Sequence length |
156 |
Interactions |
View interactions |
|
|
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