RPS27A (ribosomal protein S27a)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
6233 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Ribosomal protein S27a |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
RPS27A |
SynonymsGene synonyms aliases
|
CEP80, HEL112, S27A, UBA80, UBC, UBCEP1, UBCEP80 |
ChromosomeChromosome number
|
2 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
2p16.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008] |
miRNAmiRNA information provided by mirtarbase database.
|
miRTarBase ID |
miRNA |
Experiments |
Reference |
MIRT046153 |
hsa-miR-30b-5p |
CLASH |
23622248 |
MIRT046242 |
hsa-miR-23b-3p |
CLASH |
23622248 |
MIRT047980 |
hsa-miR-30c-5p |
CLASH |
23622248 |
MIRT050094 |
hsa-miR-26a-5p |
CLASH |
23622248 |
MIRT050798 |
hsa-miR-17-5p |
CLASH |
23622248 |
MIRT050798 |
hsa-miR-17-5p |
PAR-CLIP |
23592263 |
MIRT050798 |
hsa-miR-17-5p |
PAR-CLIP |
24398324 |
MIRT050798 |
hsa-miR-17-5p |
PAR-CLIP |
23446348 |
MIRT050798 |
hsa-miR-17-5p |
PAR-CLIP |
22012620 |
MIRT050798 |
hsa-miR-17-5p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT050798 |
hsa-miR-17-5p |
PAR-CLIP |
20371350 |
MIRT448338 |
hsa-miR-578 |
PAR-CLIP |
22100165 |
MIRT448339 |
hsa-miR-643 |
PAR-CLIP |
22100165 |
MIRT464836 |
hsa-miR-510-3p |
PAR-CLIP |
23592263 |
MIRT464836 |
hsa-miR-510-3p |
PAR-CLIP |
24398324 |
MIRT464836 |
hsa-miR-510-3p |
PAR-CLIP |
23446348 |
MIRT464836 |
hsa-miR-510-3p |
PAR-CLIP |
22012620 |
MIRT464836 |
hsa-miR-510-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464836 |
hsa-miR-510-3p |
PAR-CLIP |
20371350 |
MIRT464837 |
hsa-miR-653-5p |
PAR-CLIP |
23592263 |
MIRT464837 |
hsa-miR-653-5p |
PAR-CLIP |
24398324 |
MIRT464837 |
hsa-miR-653-5p |
PAR-CLIP |
23446348 |
MIRT464837 |
hsa-miR-653-5p |
PAR-CLIP |
22012620 |
MIRT464837 |
hsa-miR-653-5p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464837 |
hsa-miR-653-5p |
PAR-CLIP |
20371350 |
MIRT464838 |
hsa-miR-106a-3p |
PAR-CLIP |
23592263 |
MIRT464838 |
hsa-miR-106a-3p |
PAR-CLIP |
24398324 |
MIRT464838 |
hsa-miR-106a-3p |
PAR-CLIP |
23446348 |
MIRT464838 |
hsa-miR-106a-3p |
PAR-CLIP |
22012620 |
MIRT464838 |
hsa-miR-106a-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464838 |
hsa-miR-106a-3p |
PAR-CLIP |
20371350 |
MIRT464839 |
hsa-miR-488-3p |
PAR-CLIP |
23592263 |
MIRT464839 |
hsa-miR-488-3p |
PAR-CLIP |
24398324 |
MIRT464839 |
hsa-miR-488-3p |
PAR-CLIP |
23446348 |
MIRT464839 |
hsa-miR-488-3p |
PAR-CLIP |
22012620 |
MIRT464839 |
hsa-miR-488-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464839 |
hsa-miR-488-3p |
PAR-CLIP |
20371350 |
MIRT464840 |
hsa-miR-6730-5p |
PAR-CLIP |
23592263 |
MIRT464840 |
hsa-miR-6730-5p |
PAR-CLIP |
24398324 |
MIRT464840 |
hsa-miR-6730-5p |
PAR-CLIP |
23446348 |
MIRT464840 |
hsa-miR-6730-5p |
PAR-CLIP |
22012620 |
MIRT464840 |
hsa-miR-6730-5p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464840 |
hsa-miR-6730-5p |
PAR-CLIP |
20371350 |
MIRT464841 |
hsa-miR-5681a |
PAR-CLIP |
23592263 |
MIRT464841 |
hsa-miR-5681a |
PAR-CLIP |
24398324 |
MIRT464841 |
hsa-miR-5681a |
PAR-CLIP |
23446348 |
MIRT464841 |
hsa-miR-5681a |
PAR-CLIP |
22012620 |
MIRT464841 |
hsa-miR-5681a |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464841 |
hsa-miR-5681a |
PAR-CLIP |
20371350 |
MIRT464842 |
hsa-miR-519c-3p |
PAR-CLIP |
23592263 |
MIRT464842 |
hsa-miR-519c-3p |
PAR-CLIP |
24398324 |
MIRT464842 |
hsa-miR-519c-3p |
PAR-CLIP |
23446348 |
MIRT464842 |
hsa-miR-519c-3p |
PAR-CLIP |
22012620 |
MIRT464842 |
hsa-miR-519c-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464842 |
hsa-miR-519c-3p |
PAR-CLIP |
20371350 |
MIRT464843 |
hsa-miR-519b-3p |
PAR-CLIP |
23592263 |
MIRT464843 |
hsa-miR-519b-3p |
PAR-CLIP |
24398324 |
MIRT464843 |
hsa-miR-519b-3p |
PAR-CLIP |
23446348 |
MIRT464843 |
hsa-miR-519b-3p |
PAR-CLIP |
22012620 |
MIRT464843 |
hsa-miR-519b-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464843 |
hsa-miR-519b-3p |
PAR-CLIP |
20371350 |
MIRT464844 |
hsa-miR-519a-3p |
PAR-CLIP |
23592263 |
MIRT464844 |
hsa-miR-519a-3p |
PAR-CLIP |
24398324 |
MIRT464844 |
hsa-miR-519a-3p |
PAR-CLIP |
23446348 |
MIRT464844 |
hsa-miR-519a-3p |
PAR-CLIP |
22012620 |
MIRT464844 |
hsa-miR-519a-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464844 |
hsa-miR-519a-3p |
PAR-CLIP |
20371350 |
MIRT464845 |
hsa-miR-651-3p |
PAR-CLIP |
23592263 |
MIRT464845 |
hsa-miR-651-3p |
PAR-CLIP |
24398324 |
MIRT464845 |
hsa-miR-651-3p |
PAR-CLIP |
23446348 |
MIRT464845 |
hsa-miR-651-3p |
PAR-CLIP |
22012620 |
MIRT464845 |
hsa-miR-651-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464845 |
hsa-miR-651-3p |
PAR-CLIP |
20371350 |
MIRT464846 |
hsa-miR-526b-3p |
PAR-CLIP |
23592263 |
MIRT464846 |
hsa-miR-526b-3p |
PAR-CLIP |
24398324 |
MIRT464846 |
hsa-miR-526b-3p |
PAR-CLIP |
23446348 |
MIRT464846 |
hsa-miR-526b-3p |
PAR-CLIP |
22012620 |
MIRT464846 |
hsa-miR-526b-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464846 |
hsa-miR-526b-3p |
PAR-CLIP |
20371350 |
MIRT464847 |
hsa-miR-20a-5p |
PAR-CLIP |
23592263 |
MIRT464847 |
hsa-miR-20a-5p |
PAR-CLIP |
24398324 |
MIRT464847 |
hsa-miR-20a-5p |
PAR-CLIP |
23446348 |
MIRT464847 |
hsa-miR-20a-5p |
PAR-CLIP |
22012620 |
MIRT464847 |
hsa-miR-20a-5p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464847 |
hsa-miR-20a-5p |
PAR-CLIP |
20371350 |
MIRT464848 |
hsa-miR-519d-3p |
PAR-CLIP |
23592263 |
MIRT464848 |
hsa-miR-519d-3p |
PAR-CLIP |
24398324 |
MIRT464848 |
hsa-miR-519d-3p |
PAR-CLIP |
23446348 |
MIRT464848 |
hsa-miR-519d-3p |
PAR-CLIP |
22012620 |
MIRT464848 |
hsa-miR-519d-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464848 |
hsa-miR-519d-3p |
PAR-CLIP |
20371350 |
MIRT464849 |
hsa-miR-20b-5p |
PAR-CLIP |
23592263 |
MIRT464849 |
hsa-miR-20b-5p |
PAR-CLIP |
24398324 |
MIRT464849 |
hsa-miR-20b-5p |
PAR-CLIP |
23446348 |
MIRT464849 |
hsa-miR-20b-5p |
PAR-CLIP |
22012620 |
MIRT464849 |
hsa-miR-20b-5p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464849 |
hsa-miR-20b-5p |
PAR-CLIP |
20371350 |
MIRT464850 |
hsa-miR-93-5p |
PAR-CLIP |
23592263 |
MIRT464850 |
hsa-miR-93-5p |
PAR-CLIP |
24398324 |
MIRT464850 |
hsa-miR-93-5p |
PAR-CLIP |
23446348 |
MIRT464850 |
hsa-miR-93-5p |
PAR-CLIP |
22012620 |
MIRT464850 |
hsa-miR-93-5p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464850 |
hsa-miR-93-5p |
PAR-CLIP |
20371350 |
MIRT464851 |
hsa-miR-106a-5p |
PAR-CLIP |
23592263 |
MIRT464851 |
hsa-miR-106a-5p |
PAR-CLIP |
24398324 |
MIRT464851 |
hsa-miR-106a-5p |
PAR-CLIP |
23446348 |
MIRT464851 |
hsa-miR-106a-5p |
PAR-CLIP |
22012620 |
MIRT464851 |
hsa-miR-106a-5p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464851 |
hsa-miR-106a-5p |
PAR-CLIP |
20371350 |
MIRT464852 |
hsa-miR-106b-5p |
PAR-CLIP |
23592263 |
MIRT464852 |
hsa-miR-106b-5p |
PAR-CLIP |
24398324 |
MIRT464852 |
hsa-miR-106b-5p |
PAR-CLIP |
23446348 |
MIRT464852 |
hsa-miR-106b-5p |
PAR-CLIP |
22012620 |
MIRT464852 |
hsa-miR-106b-5p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464852 |
hsa-miR-106b-5p |
PAR-CLIP |
20371350 |
MIRT464853 |
hsa-miR-454-3p |
PAR-CLIP |
23592263 |
MIRT464853 |
hsa-miR-454-3p |
PAR-CLIP |
24398324 |
MIRT464853 |
hsa-miR-454-3p |
PAR-CLIP |
23446348 |
MIRT464853 |
hsa-miR-454-3p |
PAR-CLIP |
22012620 |
MIRT464853 |
hsa-miR-454-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464853 |
hsa-miR-454-3p |
PAR-CLIP |
20371350 |
MIRT464854 |
hsa-miR-4295 |
PAR-CLIP |
23592263 |
MIRT464854 |
hsa-miR-4295 |
PAR-CLIP |
24398324 |
MIRT464854 |
hsa-miR-4295 |
PAR-CLIP |
23446348 |
MIRT464854 |
hsa-miR-4295 |
PAR-CLIP |
22012620 |
MIRT464854 |
hsa-miR-4295 |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464854 |
hsa-miR-4295 |
PAR-CLIP |
20371350 |
MIRT464855 |
hsa-miR-301a-3p |
PAR-CLIP |
23592263 |
MIRT464855 |
hsa-miR-301a-3p |
PAR-CLIP |
24398324 |
MIRT464855 |
hsa-miR-301a-3p |
PAR-CLIP |
23446348 |
MIRT464855 |
hsa-miR-301a-3p |
PAR-CLIP |
22012620 |
MIRT464855 |
hsa-miR-301a-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464855 |
hsa-miR-301a-3p |
PAR-CLIP |
20371350 |
MIRT464856 |
hsa-miR-3666 |
PAR-CLIP |
23592263 |
MIRT464856 |
hsa-miR-3666 |
PAR-CLIP |
24398324 |
MIRT464856 |
hsa-miR-3666 |
PAR-CLIP |
23446348 |
MIRT464856 |
hsa-miR-3666 |
PAR-CLIP |
22012620 |
MIRT464856 |
hsa-miR-3666 |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464856 |
hsa-miR-3666 |
PAR-CLIP |
20371350 |
MIRT464857 |
hsa-miR-301b-3p |
PAR-CLIP |
23592263 |
MIRT464857 |
hsa-miR-301b-3p |
PAR-CLIP |
24398324 |
MIRT464857 |
hsa-miR-301b-3p |
PAR-CLIP |
23446348 |
MIRT464857 |
hsa-miR-301b-3p |
PAR-CLIP |
22012620 |
MIRT464857 |
hsa-miR-301b-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464857 |
hsa-miR-301b-3p |
PAR-CLIP |
20371350 |
MIRT464858 |
hsa-miR-130b-3p |
PAR-CLIP |
23592263 |
MIRT464858 |
hsa-miR-130b-3p |
PAR-CLIP |
24398324 |
MIRT464858 |
hsa-miR-130b-3p |
PAR-CLIP |
23446348 |
MIRT464858 |
hsa-miR-130b-3p |
PAR-CLIP |
22012620 |
MIRT464858 |
hsa-miR-130b-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464858 |
hsa-miR-130b-3p |
PAR-CLIP |
20371350 |
MIRT464859 |
hsa-miR-130a-3p |
PAR-CLIP |
23592263 |
MIRT464859 |
hsa-miR-130a-3p |
PAR-CLIP |
24398324 |
MIRT464859 |
hsa-miR-130a-3p |
PAR-CLIP |
23446348 |
MIRT464859 |
hsa-miR-130a-3p |
PAR-CLIP |
22012620 |
MIRT464859 |
hsa-miR-130a-3p |
PAR-CLIP, HITS-CLIP |
21572407 |
MIRT464859 |
hsa-miR-130a-3p |
PAR-CLIP |
20371350 |
MIRT505257 |
hsa-miR-190a-3p |
PAR-CLIP |
23446348 |
MIRT505257 |
hsa-miR-190a-3p |
PAR-CLIP |
21572407 |
MIRT505257 |
hsa-miR-190a-3p |
PAR-CLIP |
20371350 |
MIRT505258 |
hsa-miR-5011-5p |
PAR-CLIP |
23446348 |
MIRT505258 |
hsa-miR-5011-5p |
PAR-CLIP |
21572407 |
MIRT505258 |
hsa-miR-5011-5p |
PAR-CLIP |
20371350 |
MIRT505259 |
hsa-miR-1277-5p |
PAR-CLIP |
23446348 |
MIRT505259 |
hsa-miR-1277-5p |
PAR-CLIP |
21572407 |
MIRT505259 |
hsa-miR-1277-5p |
PAR-CLIP |
20371350 |
MIRT533380 |
hsa-miR-450a-1-3p |
PAR-CLIP |
22012620 |
MIRT533380 |
hsa-miR-450a-1-3p |
PAR-CLIP |
21572407 |
MIRT533380 |
hsa-miR-450a-1-3p |
PAR-CLIP |
20371350 |
MIRT533381 |
hsa-miR-6716-5p |
PAR-CLIP |
22012620 |
MIRT533381 |
hsa-miR-6716-5p |
PAR-CLIP |
21572407 |
MIRT533381 |
hsa-miR-6716-5p |
PAR-CLIP |
20371350 |
MIRT553209 |
hsa-miR-6885-3p |
PAR-CLIP |
21572407 |
MIRT697903 |
hsa-miR-7160-5p |
HITS-CLIP |
23313552 |
MIRT697904 |
hsa-miR-4722-5p |
HITS-CLIP |
23313552 |
MIRT697905 |
hsa-miR-4649-3p |
HITS-CLIP |
23313552 |
MIRT697906 |
hsa-miR-4768-3p |
HITS-CLIP |
23313552 |
MIRT697907 |
hsa-miR-665 |
HITS-CLIP |
23313552 |
MIRT783317 |
hsa-miR-1273f |
HITS-CLIP |
27418678 |
MIRT784347 |
hsa-miR-2681-5p |
HITS-CLIP |
27418678 |
MIRT786631 |
hsa-miR-4756-3p |
HITS-CLIP |
27418678 |
MIRT786840 |
hsa-miR-4797-5p |
HITS-CLIP |
27418678 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000122 |
Process |
Negative regulation of transcription by RNA polymerase II |
TAS |
|
GO:0000184 |
Process |
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS |
|
GO:0000187 |
Process |
Activation of MAPK activity |
TAS |
|
GO:0000209 |
Process |
Protein polyubiquitination |
TAS |
|
GO:0000715 |
Process |
Nucleotide-excision repair, DNA damage recognition |
TAS |
|
GO:0000717 |
Process |
Nucleotide-excision repair, DNA duplex unwinding |
TAS |
|
GO:0002755 |
Process |
MyD88-dependent toll-like receptor signaling pathway |
TAS |
|
GO:0002756 |
Process |
MyD88-independent toll-like receptor signaling pathway |
TAS |
|
GO:0003723 |
Function |
RNA binding |
HDA |
22658674, 22681889 |
GO:0003735 |
Function |
Structural constituent of ribosome |
HDA |
15883184 |
GO:0005515 |
Function |
Protein binding |
IPI |
14755250, 15936278, 16189514, 20374249, 25416956, 32296183, 32814053 |
GO:0005615 |
Component |
Extracellular space |
HDA |
16502470 |
GO:0005634 |
Component |
Nucleus |
HDA |
21630459 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005730 |
Component |
Nucleolus |
HDA |
16791210 |
GO:0005737 |
Component |
Cytoplasm |
HDA |
16791210 |
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005741 |
Component |
Mitochondrial outer membrane |
TAS |
|
GO:0005789 |
Component |
Endoplasmic reticulum membrane |
TAS |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0006283 |
Process |
Transcription-coupled nucleotide-excision repair |
TAS |
|
GO:0006294 |
Process |
Nucleotide-excision repair, preincision complex assembly |
TAS |
|
GO:0006296 |
Process |
Nucleotide-excision repair, DNA incision, 5'-to lesion |
TAS |
|
GO:0006297 |
Process |
Nucleotide-excision repair, DNA gap filling |
TAS |
|
GO:0006412 |
Process |
Translation |
IC |
8706699, 15883184 |
GO:0006413 |
Process |
Translational initiation |
TAS |
|
GO:0006614 |
Process |
SRP-dependent cotranslational protein targeting to membrane |
TAS |
|
GO:0006625 |
Process |
Protein targeting to peroxisome |
TAS |
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
TAS |
|
GO:0007249 |
Process |
I-kappaB kinase/NF-kappaB signaling |
TAS |
|
GO:0007254 |
Process |
JNK cascade |
TAS |
|
GO:0010008 |
Component |
Endosome membrane |
TAS |
|
GO:0015935 |
Component |
Small ribosomal subunit |
HDA |
15883184 |
GO:0016020 |
Component |
Membrane |
HDA |
19946888 |
GO:0016055 |
Process |
Wnt signaling pathway |
TAS |
|
GO:0016197 |
Process |
Endosomal transport |
TAS |
|
GO:0016567 |
Process |
Protein ubiquitination |
IBA |
21873635 |
GO:0016567 |
Process |
Protein ubiquitination |
TAS |
|
GO:0016579 |
Process |
Protein deubiquitination |
TAS |
|
GO:0019058 |
Process |
Viral life cycle |
TAS |
|
GO:0019068 |
Process |
Virion assembly |
TAS |
|
GO:0019083 |
Process |
Viral transcription |
TAS |
|
GO:0019221 |
Process |
Cytokine-mediated signaling pathway |
TAS |
|
GO:0019941 |
Process |
Modification-dependent protein catabolic process |
IBA |
21873635 |
GO:0019985 |
Process |
Translesion synthesis |
TAS |
|
GO:0022627 |
Component |
Cytosolic small ribosomal subunit |
HDA |
15883184 |
GO:0022627 |
Component |
Cytosolic small ribosomal subunit |
IBA |
21873635 |
GO:0022627 |
Component |
Cytosolic small ribosomal subunit |
IDA |
8706699 |
GO:0030512 |
Process |
Negative regulation of transforming growth factor beta receptor signaling pathway |
TAS |
|
GO:0030666 |
Component |
Endocytic vesicle membrane |
TAS |
|
GO:0031145 |
Process |
Anaphase-promoting complex-dependent catabolic process |
TAS |
|
GO:0031386 |
Function |
Protein tag |
IBA |
21873635 |
GO:0031625 |
Function |
Ubiquitin protein ligase binding |
IBA |
21873635 |
GO:0031982 |
Component |
Vesicle |
HDA |
19190083 |
GO:0033683 |
Process |
Nucleotide-excision repair, DNA incision |
TAS |
|
GO:0035666 |
Process |
TRIF-dependent toll-like receptor signaling pathway |
TAS |
|
GO:0036297 |
Process |
Interstrand cross-link repair |
TAS |
|
GO:0042276 |
Process |
Error-prone translesion synthesis |
TAS |
|
GO:0042769 |
Process |
DNA damage response, detection of DNA damage |
TAS |
|
GO:0043065 |
Process |
Positive regulation of apoptotic process |
TAS |
|
GO:0043066 |
Process |
Negative regulation of apoptotic process |
TAS |
|
GO:0043488 |
Process |
Regulation of mRNA stability |
TAS |
|
GO:0043657 |
Component |
Host cell |
IEA |
|
GO:0044267 |
Process |
Cellular protein metabolic process |
TAS |
|
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
TAS |
|
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
GO:0051092 |
Process |
Positive regulation of NF-kappaB transcription factor activity |
TAS |
|
GO:0051403 |
Process |
Stress-activated MAPK cascade |
TAS |
|
GO:0055085 |
Process |
Transmembrane transport |
TAS |
|
GO:0061024 |
Process |
Membrane organization |
TAS |
|
GO:0061418 |
Process |
Regulation of transcription from RNA polymerase II promoter in response to hypoxia |
TAS |
|
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19199708, 20458337, 23533145 |
GO:0070423 |
Process |
Nucleotide-binding oligomerization domain containing signaling pathway |
TAS |
|
GO:0070498 |
Process |
Interleukin-1-mediated signaling pathway |
TAS |
|
GO:0070911 |
Process |
Global genome nucleotide-excision repair |
TAS |
|
GO:0070987 |
Process |
Error-free translesion synthesis |
TAS |
|
GO:0075733 |
Process |
Intracellular transport of virus |
TAS |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P62979 |
Protein name |
Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a (Small ribosomal subunit protein eS31)] |
Protein function |
[Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.; [40S ribosomal protein S27a]: Component of the 40S subunit of the ribosome. |
PDB |
2KHW
,
2KOX
,
2KTF
,
2KWU
,
2KWV
,
2L0F
,
2L0T
,
2XK5
,
3AXC
,
3I3T
,
3K9P
,
3N30
,
3N32
,
3NHE
,
3NOB
,
3NS8
,
3PHD
,
3PHW
,
3TBL
,
3VDZ
,
4R62
,
4UG0
,
4V6X
,
5A2Q
,
5AJ0
,
5FLX
,
5LKS
,
5T2C
,
5WVO
,
5YDK
,
6DC6
,
6EK0
,
6FEC
,
6G18
,
6G51
,
6G53
,
6G5H
,
6G5I
,
6IP5
,
6IP6
,
6IP8
,
6J99
,
6KFP
,
6KG6
,
6KIU
,
6KIV
,
6KIW
,
6OLE
,
6OLF
,
6OLG
,
6OLI
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00240 |
ubiquitin |
3 → 74 |
Ubiquitin family |
Domain |
PF01599 |
Ribosomal_S27 |
102 → 147 |
Ribosomal protein S27a |
Domain |
|
Sequence |
|
Sequence length |
156 |
Interactions |
View interactions |
|
|