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RPS27A (ribosomal protein S27a)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6233
Gene nameGene Name - the full gene name approved by the HGNC.
Ribosomal protein S27a
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
RPS27A
SynonymsGene synonyms aliases
CEP80, HEL112, S27A, UBA80, UBC, UBCEP1, UBCEP80
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p16.1
SummarySummary of gene provided in NCBI Entrez Gene.
Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT046153 hsa-miR-30b-5p CLASH 23622248
MIRT046242 hsa-miR-23b-3p CLASH 23622248
MIRT047980 hsa-miR-30c-5p CLASH 23622248
MIRT050094 hsa-miR-26a-5p CLASH 23622248
MIRT050798 hsa-miR-17-5p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
GO:0000187 Process Activation of MAPK activity TAS
GO:0000209 Process Protein polyubiquitination TAS
GO:0000715 Process Nucleotide-excision repair, DNA damage recognition TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P62979
Protein name Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a (Small ribosomal subunit protein eS31)]
Protein function [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.; [40S ribosomal protein S27a]: Component of the 40S subunit of the ribosome.
PDB 2KHW , 2KOX , 2KTF , 2KWU , 2KWV , 2L0F , 2L0T , 2XK5 , 3AXC , 3I3T , 3K9P , 3N30 , 3N32 , 3NHE , 3NOB , 3NS8 , 3PHD , 3PHW , 3TBL , 3VDZ , 4R62 , 4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5T2C , 5WVO , 5YDK , 6DC6 , 6EK0 , 6FEC , 6G18 , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6J99 , 6KFP , 6KG6 , 6KIU , 6KIV , 6KIW , 6OLE , 6OLF , 6OLG , 6OLI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00240 ubiquitin
3 74
Ubiquitin family
Domain
PF01599 Ribosomal_S27
102 147
Ribosomal protein S27a
Domain
Sequence
Sequence length 156
Interactions View interactions

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