RNF5 (ring finger protein 5)

Gene

• Entrez ID: 6048
• Gene name: Ring finger protein 5
• Gene symbol: RNF5
• Synonyms: RING5, RMA1
• Chromosome: 6
• Chromosome location: 6p21.32
• Summary: The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and alter

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT042288	hsa-miR-484	CLASH	23622248
MIRT1313522	hsa-let-7a	CLIP-seq
MIRT1313523	hsa-let-7b	CLIP-seq
MIRT1313524	hsa-let-7c	CLIP-seq
MIRT1313525	hsa-let-7d	CLIP-seq
MIRT1313526	hsa-let-7e	CLIP-seq
MIRT1313527	hsa-let-7f	CLIP-seq
MIRT1313528	hsa-let-7g	CLIP-seq
MIRT1313529	hsa-let-7i	CLIP-seq
MIRT1313530	hsa-miR-151-3p	CLIP-seq
MIRT1313531	hsa-miR-1915	CLIP-seq
MIRT1313532	hsa-miR-196a	CLIP-seq
MIRT1313533	hsa-miR-196b	CLIP-seq
MIRT1313534	hsa-miR-200b	CLIP-seq
MIRT1313535	hsa-miR-200c	CLIP-seq
MIRT1313536	hsa-miR-214	CLIP-seq
MIRT1313537	hsa-miR-2355-5p	CLIP-seq
MIRT1313538	hsa-miR-298	CLIP-seq
MIRT1313539	hsa-miR-3121-3p	CLIP-seq
MIRT1313540	hsa-miR-3123	CLIP-seq
MIRT1313541	hsa-miR-3149	CLIP-seq
MIRT1313542	hsa-miR-3150a-3p	CLIP-seq
MIRT1313543	hsa-miR-3173-3p	CLIP-seq
MIRT1313544	hsa-miR-3174	CLIP-seq
MIRT1313545	hsa-miR-3175	CLIP-seq
MIRT1313546	hsa-miR-3180	CLIP-seq
MIRT1313547	hsa-miR-3180-3p	CLIP-seq
MIRT1313548	hsa-miR-3184	CLIP-seq
MIRT1313549	hsa-miR-3196	CLIP-seq
MIRT1313550	hsa-miR-3202	CLIP-seq
MIRT1313551	hsa-miR-326	CLIP-seq
MIRT1313552	hsa-miR-330-5p	CLIP-seq
MIRT1313553	hsa-miR-3619-5p	CLIP-seq
MIRT1313554	hsa-miR-3667-3p	CLIP-seq
MIRT1313555	hsa-miR-3919	CLIP-seq
MIRT1313556	hsa-miR-3921	CLIP-seq
MIRT1313557	hsa-miR-423-5p	CLIP-seq
MIRT1313558	hsa-miR-429	CLIP-seq
MIRT1313559	hsa-miR-4291	CLIP-seq
MIRT1313560	hsa-miR-4303	CLIP-seq
MIRT1313561	hsa-miR-4426	CLIP-seq
MIRT1313562	hsa-miR-4433	CLIP-seq
MIRT1313563	hsa-miR-4436b-3p	CLIP-seq
MIRT1313564	hsa-miR-4458	CLIP-seq
MIRT1313565	hsa-miR-4468	CLIP-seq
MIRT1313566	hsa-miR-4488	CLIP-seq
MIRT1313567	hsa-miR-4500	CLIP-seq
MIRT1313568	hsa-miR-4522	CLIP-seq
MIRT1313569	hsa-miR-4647	CLIP-seq
MIRT1313570	hsa-miR-4653-5p	CLIP-seq
MIRT1313571	hsa-miR-4662b	CLIP-seq
MIRT1313572	hsa-miR-4667-5p	CLIP-seq
MIRT1313573	hsa-miR-4685-5p	CLIP-seq
MIRT1313574	hsa-miR-4697-5p	CLIP-seq
MIRT1313575	hsa-miR-4700-5p	CLIP-seq
MIRT1313576	hsa-miR-4765	CLIP-seq
MIRT1313577	hsa-miR-615-5p	CLIP-seq
MIRT1313578	hsa-miR-637	CLIP-seq
MIRT1313579	hsa-miR-665	CLIP-seq
MIRT1313580	hsa-miR-761	CLIP-seq
MIRT1313581	hsa-miR-921	CLIP-seq
MIRT1313582	hsa-miR-922	CLIP-seq
MIRT1313583	hsa-miR-939	CLIP-seq
MIRT1313584	hsa-miR-98	CLIP-seq
MIRT2093361	hsa-miR-149	CLIP-seq
MIRT2093362	hsa-miR-3064-5p	CLIP-seq
MIRT2093363	hsa-miR-3135b	CLIP-seq
MIRT1313542	hsa-miR-3150a-3p	CLIP-seq
MIRT2093364	hsa-miR-3166	CLIP-seq
MIRT1313545	hsa-miR-3175	CLIP-seq
MIRT1313551	hsa-miR-326	CLIP-seq
MIRT1313552	hsa-miR-330-5p	CLIP-seq
MIRT2093365	hsa-miR-3652	CLIP-seq
MIRT2093366	hsa-miR-3689d	CLIP-seq
MIRT2093367	hsa-miR-4257	CLIP-seq
MIRT2093368	hsa-miR-4430	CLIP-seq
MIRT2093369	hsa-miR-4505	CLIP-seq
MIRT2093370	hsa-miR-4659a-3p	CLIP-seq
MIRT2093371	hsa-miR-4659b-3p	CLIP-seq
MIRT2093372	hsa-miR-4794	CLIP-seq
MIRT2093373	hsa-miR-541	CLIP-seq
MIRT2093374	hsa-miR-654-5p	CLIP-seq
MIRT1313583	hsa-miR-939	CLIP-seq
MIRT2093375	hsa-miR-942	CLIP-seq
MIRT2317899	hsa-miR-1224-3p	CLIP-seq
MIRT1313531	hsa-miR-1915	CLIP-seq
MIRT1313534	hsa-miR-200b	CLIP-seq
MIRT1313535	hsa-miR-200c	CLIP-seq
MIRT1313537	hsa-miR-2355-5p	CLIP-seq
MIRT2093362	hsa-miR-3064-5p	CLIP-seq
MIRT1313540	hsa-miR-3123	CLIP-seq
MIRT2093363	hsa-miR-3135b	CLIP-seq
MIRT2317900	hsa-miR-3617	CLIP-seq
MIRT2093365	hsa-miR-3652	CLIP-seq
MIRT1313554	hsa-miR-3667-3p	CLIP-seq
MIRT2093366	hsa-miR-3689d	CLIP-seq
MIRT1313555	hsa-miR-3919	CLIP-seq
MIRT2093367	hsa-miR-4257	CLIP-seq
MIRT2317901	hsa-miR-4271	CLIP-seq
MIRT1313558	hsa-miR-429	CLIP-seq
MIRT2093368	hsa-miR-4430	CLIP-seq
MIRT1313562	hsa-miR-4433	CLIP-seq
MIRT1313563	hsa-miR-4436b-3p	CLIP-seq
MIRT2317902	hsa-miR-4471	CLIP-seq
MIRT2093369	hsa-miR-4505	CLIP-seq
MIRT1313573	hsa-miR-4685-5p	CLIP-seq
MIRT2317903	hsa-miR-4699-5p	CLIP-seq
MIRT2317904	hsa-miR-4709-3p	CLIP-seq
MIRT2317905	hsa-miR-4725-3p	CLIP-seq
MIRT2317906	hsa-miR-4768-5p	CLIP-seq
MIRT2093373	hsa-miR-541	CLIP-seq
MIRT1313577	hsa-miR-615-5p	CLIP-seq
MIRT2317907	hsa-miR-641	CLIP-seq
MIRT2093374	hsa-miR-654-5p	CLIP-seq
MIRT1313579	hsa-miR-665	CLIP-seq
MIRT2093361	hsa-miR-149	CLIP-seq
MIRT2093362	hsa-miR-3064-5p	CLIP-seq
MIRT2093363	hsa-miR-3135b	CLIP-seq
MIRT1313551	hsa-miR-326	CLIP-seq
MIRT1313552	hsa-miR-330-5p	CLIP-seq
MIRT2093365	hsa-miR-3652	CLIP-seq
MIRT2093366	hsa-miR-3689d	CLIP-seq
MIRT2093368	hsa-miR-4430	CLIP-seq
MIRT2093369	hsa-miR-4505	CLIP-seq
MIRT2093370	hsa-miR-4659a-3p	CLIP-seq
MIRT2093371	hsa-miR-4659b-3p	CLIP-seq
MIRT2093372	hsa-miR-4794	CLIP-seq
MIRT2093373	hsa-miR-541	CLIP-seq
MIRT2093374	hsa-miR-654-5p	CLIP-seq
MIRT2093375	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	19269966
GO:0005515	Function	Protein binding	IPI	12861019, 14667819, 16901789, 19269966, 19549727, 20152160, 24019521, 25416956, 25759021, 31515488, 32296183, 32814053
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0008270	Function	Zinc ion binding	TAS	9533025
GO:0009617	Process	Response to bacterium	IEA
GO:0010507	Process	Negative regulation of autophagy	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0030433	Process	Ubiquitin-dependent ERAD pathway	IGI	24019521
GO:0031648	Process	Protein destabilization	IEA
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0036503	Process	ERAD pathway	IMP	24019521
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0044257	Process	Cellular protein catabolic process	IMP	19285439
GO:0044322	Component	Endoplasmic reticulum quality control compartment	IEA
GO:0044390	Function	Ubiquitin-like protein conjugating enzyme binding	IBA	21873635
GO:0044877	Function	Protein-containing complex binding	IPI	24019521
GO:0055085	Process	Transmembrane transport	TAS
GO:0061630	Function	Ubiquitin protein ligase activity	IBA	21873635
GO:0061630	Function	Ubiquitin protein ligase activity	TAS	24019521
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	19269966
GO:0070936	Process	Protein K48-linked ubiquitination	IDA	19285439
GO:0071712	Process	ER-associated misfolded protein catabolic process	IBA	21873635
GO:0071712	Process	ER-associated misfolded protein catabolic process	IMP	19269966
GO:1904380	Process	Endoplasmic reticulum mannose trimming	TAS
GO:2000785	Process	Regulation of autophagosome assembly	IEA

Other IDs

• MIM: 602677
• HGNC: 10068
• e!Ensembl: ENSG00000204308

Protein

• UniProt ID: Q99942
• Protein name: E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)
• Protein function: Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:11329381, PubMed:12861019, PubMed:16176924, PubMed:19269966, PubMed:19285439). May function together with E2 ubiquitin-conjugating enzymes UBE2D1/
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13920	zf-C3HC4_3	23 → 73		Domain

• Sequence:

  MAAAEEEDGGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPE
  RQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPESRGGFQPFGDTGGF
  HFSFGVGAFPFGFFTTVFNAHEPFRRGTGVDLGQGHPASSWQDSLFLFLAIFFFFWLLSI
  

• Sequence length: 180