RNF185 (ring finger protein 185)

Gene

• Entrez ID: 91445
• Gene name: Ring finger protein 185
• Gene symbol: RNF185
• Synonyms: -
• Chromosome: 22
• Chromosome location: 22q12.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT040228	hsa-miR-615-3p	CLASH	23622248
MIRT042563	hsa-miR-423-3p	CLASH	23622248
MIRT205528	hsa-miR-21-5p	PAR-CLIP	23592263
MIRT205528	hsa-miR-21-5p	PAR-CLIP	24398324
MIRT205529	hsa-miR-590-5p	PAR-CLIP	23592263
MIRT205529	hsa-miR-590-5p	PAR-CLIP	24398324
MIRT205530	hsa-miR-3125	PAR-CLIP	24398324
MIRT205531	hsa-miR-3185	PAR-CLIP	24398324
MIRT205532	hsa-miR-3916	PAR-CLIP	24398324
MIRT205534	hsa-miR-4738-3p	PAR-CLIP	23592263
MIRT205534	hsa-miR-4738-3p	PAR-CLIP	24398324
MIRT205536	hsa-miR-6859-5p	PAR-CLIP	24398324
MIRT458407	hsa-miR-4468	PAR-CLIP	23592263
MIRT458408	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT458409	hsa-miR-4792	PAR-CLIP	23592263
MIRT458410	hsa-miR-4710	PAR-CLIP	23592263
MIRT458411	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT458412	hsa-miR-1255a	PAR-CLIP	23592263
MIRT458413	hsa-miR-298	PAR-CLIP	23592263
MIRT458414	hsa-miR-6134	PAR-CLIP	23592263
MIRT458415	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT458416	hsa-miR-27b-5p	PAR-CLIP	23592263
MIRT458417	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT458418	hsa-miR-4257	PAR-CLIP	23592263
MIRT458418	hsa-miR-4257	PAR-CLIP	24398324
MIRT458419	hsa-miR-4762-5p	PAR-CLIP	23592263
MIRT458419	hsa-miR-4762-5p	PAR-CLIP	24398324
MIRT458420	hsa-miR-892c-5p	PAR-CLIP	23592263
MIRT458420	hsa-miR-892c-5p	PAR-CLIP	24398324
MIRT499676	hsa-miR-6847-5p	PAR-CLIP	24398324
MIRT499677	hsa-miR-551b-5p	PAR-CLIP	24398324
MIRT740750	hsa-miR-3179	PAR-CLIP	26701625
MIRT741168	hsa-miR-3202	PAR-CLIP	26701625
MIRT743719	hsa-miR-4283	PAR-CLIP	26701625
MIRT748272	hsa-miR-4747-5p	PAR-CLIP	26701625
MIRT750056	hsa-miR-5196-5p	PAR-CLIP	26701625
MIRT750385	hsa-miR-541-3p	PAR-CLIP	26701625
MIRT753456	hsa-miR-654-5p	PAR-CLIP	26701625
MIRT754849	hsa-miR-6757-5p	PAR-CLIP	26701625
MIRT755202	hsa-miR-6769a-5p	PAR-CLIP	26701625
MIRT755249	hsa-miR-6769b-5p	PAR-CLIP	26701625
MIRT756485	hsa-miR-6805-5p	PAR-CLIP	26701625
MIRT757443	hsa-miR-6846-5p	PAR-CLIP	26701625
MIRT757517	hsa-miR-6848-5p	PAR-CLIP	26701625
MIRT758824	hsa-miR-7106-3p	PAR-CLIP	26701625
MIRT760587	hsa-miR-92a-2-5p	PAR-CLIP	26701625

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19549727, 21931693, 24019521, 25416956, 28514442, 31515488, 32296183
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	24019521, 27485036
GO:0005789	Component	Endoplasmic reticulum membrane	NAS	24019521
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0006914	Process	Autophagy	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0030433	Process	Ubiquitin-dependent ERAD pathway	IMP	24019521
GO:0036503	Process	ERAD pathway	IGI	24019521
GO:0043130	Function	Ubiquitin binding	IDA	27485036
GO:0044322	Component	Endoplasmic reticulum quality control compartment	IEA
GO:0044390	Function	Ubiquitin-like protein conjugating enzyme binding	IBA	21873635
GO:0044390	Function	Ubiquitin-like protein conjugating enzyme binding	IPI	24019521
GO:0044877	Function	Protein-containing complex binding	IPI	24019521
GO:0046872	Function	Metal ion binding	IEA
GO:0051865	Process	Protein autoubiquitination	IDA	24019521, 27485036
GO:0055085	Process	Transmembrane transport	TAS
GO:0061630	Function	Ubiquitin protein ligase activity	IBA	21873635
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	24019521, 27485036
GO:0061630	Function	Ubiquitin protein ligase activity	TAS
GO:0071712	Process	ER-associated misfolded protein catabolic process	IBA	21873635
GO:1904294	Process	Positive regulation of ERAD pathway	IMP	27485036
GO:1904380	Process	Endoplasmic reticulum mannose trimming	TAS

Other IDs

• MIM: HGNC

Protein

• UniProt ID: Q96GF1
• Protein name: E3 ubiquitin-protein ligase RNF185 (EC 2.3.2.27) (RING finger protein 185) (RING-type E3 ubiquitin transferase RNF185)
• Protein function: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693). Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036). Protects cells from ER stress-induced apoptosis (PubMed:27485036). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13920	zf-C3HC4_3	35 → 85		Domain

• Sequence:

  MASKGPSASASPENSSAGGPSGSSNGAGESGGQDSTFECNICLDTAKDAVISLCGHLFCW
  PCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENR
  GGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPGTPQYVDEQFLSRLFLF
  VALVIMFWLLIA

• Sequence length: 192