RASIP1 (Ras interacting protein 1)

Gene

• Entrez ID: 54922
• Gene name: Ras interacting protein 1
• Gene symbol: RASIP1
• Synonyms: RAIN
• Chromosome: 19
• Chromosome location: 19q13.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018491	hsa-miR-335-5p	Microarray	18185580
MIRT022870	hsa-miR-124-3p	Microarray	18668037
MIRT029847	hsa-miR-26b-5p	Microarray	19088304

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IBA	21873635
GO:0001525	Process	Angiogenesis	ISS
GO:0001570	Process	Vasculogenesis	ISS
GO:0005515	Function	Protein binding	IPI	26780829
GO:0005795	Component	Golgi stack	IEA
GO:0005911	Component	Cell-cell junction	IBA	21873635
GO:0005911	Component	Cell-cell junction	IMP	26780829
GO:0007165	Process	Signal transduction	IEA
GO:0010507	Process	Negative regulation of autophagy	IMP	22354037
GO:0032991	Component	Protein-containing complex	IDA	26780829
GO:0033625	Process	Positive regulation of integrin activation	IMP	26780829
GO:0035024	Process	Negative regulation of Rho protein signal transduction	IBA	21873635
GO:0035024	Process	Negative regulation of Rho protein signal transduction	IMP	26780829
GO:0042803	Function	Protein homodimerization activity	IDA	26780829
GO:0043087	Process	Regulation of GTPase activity	IBA	21873635
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048754	Process	Branching morphogenesis of an epithelial tube	ISS
GO:0051020	Function	GTPase binding	IBA	21873635
GO:0051020	Function	GTPase binding	IPI	26780829
GO:1905709	Process	Negative regulation of membrane permeability	IDA	26780829
GO:2000299	Process	Negative regulation of Rho-dependent protein serine/threonine kinase activity	IBA	21873635
GO:2000299	Process	Negative regulation of Rho-dependent protein serine/threonine kinase activity	IMP	26780829

Other IDs

• MIM: 609623
• HGNC: 24716
• e!Ensembl: ENSG00000105538

Protein

• UniProt ID: Q5U651
• Protein name: Ras-interacting protein 1 (Rain)
• Protein function: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
• PDB: 5KHO, 5KHQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00788	RA	144 → 259	Ras association (RalGDS/AF-6) domain	Domain
  PF01843	DIL	770 → 877	DIL domain	Family

• Sequence:

  MLSGERKEGGSPRFGKLHLPVGLWINSPRKQLAKLGRRWPSAASVKSSSSDTGSRSSEPL
  PPPPPHVELRRVGAVKAAGGASGSRAKRISQLFRGSGTGTTGSSGAGGPGTPGGAQRWAS
  EKKLPELAAGVAPEPPLATRATAPPGVLKIFGAGLASGANYKSVLATARSTARELVAEAL
  ERYGLAGSPGGGPGESSCVDAFALCDALGRPAAAGVGSGEWRAEHLRVLGDSERPLLVQE
  LWRARPGWARRFELRGREEARRLEQEAFGAADSEGTGAPSWRPQKNRSRAASGGAALASP
  GPGTGSGAPAGSGGKERSENLSLRRSVSELSLQGRRRRQQERRQQALSMAPGAADAQIGT
  ADPGDFDQLTQCLIQAPSNRPYFLLLQGYQDAQDFVVYVMTREQHVFGRGGNSSGRGGSP
  APYVDTFLNAPDILPRHCTVRAGPEHPAMVRPSRGAPVTHNGCLLLREAELHPGDLLGLG
  EHFLFMYKDPRTGGSGPARPPWLPARPGATPPGPGWAFSCRLCGRGLQERGEALAAYLDG
  REPVLRFRPREEEALLGEIVRAAAAGSGDLPPLGPATLLALCVQHSARELELGHLPRLLG
  RLARLIKEAVWEKIKEIGDRQPENHPEGVPEVPLTPEAVSVELRPLMLWMANTTELLSFV
  QEKVLEMEKEADQEDPQLCNDLELCDEAMALLDEVIMCTFQQSVYYLTKTLYSTLPALLD
  SNPFTAGAELPGPGAELGAMPPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSN
  ASLLNSLMERGQGRPFYQWSRAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSMAVNLLC
  VPRTSLLKASWSSLRTDHPTLTPAQLHHLLSHYQLGPGRGPPAAWDPPPAEREAVDTGDI
  FESFSSHPPLILPLGSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANYRHGPPVA
  TSP

• Sequence length: 963