RASIP1 (Ras interacting protein 1)

Gene

• Entrez ID: 54922
• Gene name: Ras interacting protein 1
• Gene symbol: RASIP1
• Synonyms: RAIN
• Chromosome: 19
• Chromosome location: 19q13.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018491	hsa-miR-335-5p	Microarray	18185580
MIRT022870	hsa-miR-124-3p	Microarray	18668037
MIRT029847	hsa-miR-26b-5p	Microarray	19088304

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IBA	21873635
GO:0001525	Process	Angiogenesis	ISS
GO:0001570	Process	Vasculogenesis	ISS
GO:0005515	Function	Protein binding	IPI	26780829
GO:0005795	Component	Golgi stack	IEA
GO:0005911	Component	Cell-cell junction	IBA	21873635
GO:0005911	Component	Cell-cell junction	IMP	26780829
GO:0007165	Process	Signal transduction	IEA
GO:0010507	Process	Negative regulation of autophagy	IMP	22354037
GO:0032991	Component	Protein-containing complex	IDA	26780829
GO:0033625	Process	Positive regulation of integrin activation	IMP	26780829
GO:0035024	Process	Negative regulation of Rho protein signal transduction	IBA	21873635
GO:0035024	Process	Negative regulation of Rho protein signal transduction	IMP	26780829
GO:0042803	Function	Protein homodimerization activity	IDA	26780829
GO:0043087	Process	Regulation of GTPase activity	IBA	21873635
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048754	Process	Branching morphogenesis of an epithelial tube	ISS
GO:0051020	Function	GTPase binding	IBA	21873635
GO:0051020	Function	GTPase binding	IPI	26780829
GO:1905709	Process	Negative regulation of membrane permeability	IDA	26780829
GO:2000299	Process	Negative regulation of Rho-dependent protein serine/threonine kinase activity	IBA	21873635
GO:2000299	Process	Negative regulation of Rho-dependent protein serine/threonine kinase activity	IMP	26780829

Other IDs

• MIM: 609623
• HGNC: 24716
• e!Ensembl: ENSG00000105538

Protein

• UniProt ID: Q5U651
• Protein name: Ras-interacting protein 1 (Rain)
• Protein function: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endot
• PDB: 5KHO, 5KHQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00788	RA	144 → 259	Ras association (RalGDS/AF-6) domain	Domain
  PF01843	DIL	770 → 877	DIL domain	Family

• Sequence:

  MLSGERKEGGSPRFGKLHLPVGLWINSPRKQLAKLGRRWPSAASVKSSSSDTGSRSSEPL
  PPPPPHVELRRVGAVKAAGGASGSRAKRISQLFRGSGTGTTGSSGAGGPGTPGGAQRWAS
  EKKLPELAAGVAPEPPLATRATAPPGVLKIFGAGLASGANYKSVLATARSTARELVAEAL
  ERYGLAGSPGGGPGESSCVDAFALCDALGRPAAAGVGSGEWRAEHLRVLGDSERPLLVQE
  LWRARPGWARRFELRGREEARRLEQEAFGAADSEGTGAPSWRPQKNRSRAASGGAALASP
  GPGTGSGAPAGSGGKERSENLSLRRSVSELSLQGRRRRQQERRQQALSMAPGAADAQIGT
  ADPGDFDQLTQCLIQAPSNRPYFLLLQGYQDAQDFVVYVMTREQHVFGRGGNSSGRGGSP
  APYVDTFLNAPDILPRHCTVRAGPEHPAMVRPSRGAPVTHNGCLLLREAELHPGDLLGLG
  EHFLFMYKDPRTGGSGPARPPWLPARPGATPPGPGWAFSCRLCGRGLQERGEALAAYLDG
  REPVLRFRPREEEALLGEIVRAAAAGSGDLPPLGPATLLALCVQHSARELELGHLPRLLG
  RLARLIKEAVWEKIKEIGDRQPENHPEGVPEVPLTPEAVSVELRPLMLWMANTTELLSFV
  QEKVLEMEKEADQEDPQLCNDLELCDEAMALLDEVIMCTFQQSVYYLTKTLYSTLPALLD
  SNPFTAGAELPGPGAELGAMPPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSN
  ASLLNSLMERGQGRPFYQWSRAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSMAVNLLC
  VPRTSLLKASWSSLRTDHPTLTPAQLHHLLSHYQLGPGRGPPAAWDPPPAEREAVDTGDI
  FESFSSHPPLILPLGSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANYRHGPPVA
  TSP

• Sequence length: 963