RARA (retinoic acid receptor alpha)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5914 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Retinoic acid receptor alpha |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
RARA |
SynonymsGene synonyms aliases
|
NR1B1, RAR, RARalpha |
ChromosomeChromosome number
|
17 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
17q21.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulo |
SNPsSNP information provided by dbSNP.
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miRNAmiRNA information provided by mirtarbase database.
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Transcription factors
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000122 |
Process |
Negative regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0000785 |
Component |
Chromatin |
IDA |
17363140, 21131358 |
GO:0000785 |
Component |
Chromatin |
ISA |
|
GO:0000977 |
Function |
RNA polymerase II transcription regulatory region sequence-specific DNA binding |
IDA |
19917671, 21131358 |
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IBA |
21873635 |
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IDA |
20080953 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISA |
|
GO:0001972 |
Function |
Retinoic acid binding |
IDA |
2825025 |
GO:0003682 |
Function |
Chromatin binding |
IDA |
20080953 |
GO:0003700 |
Function |
DNA-binding transcription factor activity |
IDA |
18922886, 20413580 |
GO:0004879 |
Function |
Nuclear receptor activity |
IBA |
21873635 |
GO:0004879 |
Function |
Nuclear receptor activity |
IDA |
2825025, 21131358 |
GO:0005102 |
Function |
Signaling receptor binding |
IDA |
19628791 |
GO:0005515 |
Function |
Protein binding |
IPI |
9653119, 16189514, 16456540, 16606617, 16769902, 17363140, 17560333, 17641689, 18048326, 19345331, 19850744, 19917671, 19934264, 20080953, 20133701, 20543827, 21478865, 21516116, 21988832, 22056876, 22351778, 23518351, 24819975, 25036637, 25241761, 25303530, 25416956, 26871637, 2989 |
GO:0005634 |
Component |
Nucleus |
IDA |
18845237, 19917671, 20080953 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005730 |
Component |
Nucleolus |
IDA |
|
GO:0005737 |
Component |
Cytoplasm |
IDA |
19850744 |
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0006367 |
Process |
Transcription initiation from RNA polymerase II promoter |
TAS |
|
GO:0006468 |
Process |
Protein phosphorylation |
IMP |
16456540 |
GO:0007165 |
Process |
Signal transduction |
IDA |
2825025 |
GO:0008134 |
Function |
Transcription factor binding |
IPI |
17641689 |
GO:0008270 |
Function |
Zinc ion binding |
IEA |
|
GO:0008284 |
Process |
Positive regulation of cell population proliferation |
IMP |
20080953 |
GO:0009755 |
Process |
Hormone-mediated signaling pathway |
IBA |
21873635 |
GO:0009986 |
Component |
Cell surface |
IC |
2825025 |
GO:0015629 |
Component |
Actin cytoskeleton |
IDA |
|
GO:0019899 |
Function |
Enzyme binding |
IPI |
9628876, 12039952 |
GO:0019904 |
Function |
Protein domain specific binding |
IPI |
20413580 |
GO:0030154 |
Process |
Cell differentiation |
IBA |
21873635 |
GO:0030853 |
Process |
Negative regulation of granulocyte differentiation |
IDA |
19917671 |
GO:0031490 |
Function |
Chromatin DNA binding |
IDA |
19917671 |
GO:0032526 |
Process |
Response to retinoic acid |
IMP |
17538076 |
GO:0032689 |
Process |
Negative regulation of interferon-gamma production |
IDA |
18416830 |
GO:0032720 |
Process |
Negative regulation of tumor necrosis factor production |
IDA |
18416830 |
GO:0032736 |
Process |
Positive regulation of interleukin-13 production |
IDA |
18416830 |
GO:0032753 |
Process |
Positive regulation of interleukin-4 production |
IDA |
18416830 |
GO:0032754 |
Process |
Positive regulation of interleukin-5 production |
IDA |
18416830 |
GO:0032991 |
Component |
Protein-containing complex |
IDA |
19917671, 20080953 |
GO:0043277 |
Process |
Apoptotic cell clearance |
IMP |
19628791 |
GO:0043422 |
Function |
Protein kinase B binding |
IPI |
16417524 |
GO:0044323 |
Function |
Retinoic acid-responsive element binding |
IDA |
19917671 |
GO:0045630 |
Process |
Positive regulation of T-helper 2 cell differentiation |
IDA |
18416830 |
GO:0045787 |
Process |
Positive regulation of cell cycle |
IMP |
20080953 |
GO:0045892 |
Process |
Negative regulation of transcription, DNA-templated |
IDA |
20080953 |
GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
IDA |
18845237, 19850744, 20080953 |
GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
IMP |
19628791 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IDA |
19850744, 19917671, 21131358 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IMP |
20080953 |
GO:0048384 |
Process |
Retinoic acid receptor signaling pathway |
IBA |
21873635 |
GO:0048384 |
Process |
Retinoic acid receptor signaling pathway |
IDA |
19917671 |
GO:0048384 |
Process |
Retinoic acid receptor signaling pathway |
IMP |
17538076 |
GO:0051018 |
Function |
Protein kinase A binding |
IDA |
20215566 |
GO:0051099 |
Process |
Positive regulation of binding |
IMP |
20080953 |
GO:0051393 |
Function |
Alpha-actinin binding |
IPI |
22351778 |
GO:0071391 |
Process |
Cellular response to estrogen stimulus |
IDA |
20080953 |
GO:1990837 |
Function |
Sequence-specific double-stranded DNA binding |
IDA |
28473536 |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P10276 |
Protein name |
Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) |
Protein function |
Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis ret |
PDB |
1DKF
,
1DSZ
,
3A9E
,
3KMR
,
3KMZ
,
4DQM
,
5K13
,
6XWG
,
7AOS
,
7APO
,
7QAA
,
7WQQ
,
9GFE
,
9GFI
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00105 |
zf-C4 |
86 → 155 |
Zinc finger, C4 type (two domains) |
Domain |
PF00104 |
Hormone_recep |
224 → 401 |
Ligand-binding domain of nuclear hormone receptor |
Domain |
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Sequence |
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Sequence length |
462 |
Interactions |
View interactions |
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