GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

Home
Browse
- Genes
- Diseases
- Pathways
  - Reactome
  - KEGG
Analysis
Help
Links
FAQ
Contact us

RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)

Gene

5894

Raf-1 proto-oncogene, serine/threonine kinase

RAF1

CMD1NN, CRAF, NS5, Raf-1, c-Raf

3p25.2

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RA

Show/Hide all(45)

SNP ID	Visualize variation	Clinical significance	Consequence
rs3730271	A>C,G,T	Pathogenic, likely-pathogenic, uncertain-significance	Non coding transcript variant, coding sequence variant, missense variant
rs11549992	G>A	Likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	Non coding transcript variant, 5 prime UTR variant, missense variant, coding sequence variant
rs80338796	G>A,C	Pathogenic, likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant
rs80338797	G>C,T	Pathogenic, likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant, genic downstream transcript variant
rs80338798	C>T	Pathogenic	Non coding transcript variant, missense variant, coding sequence variant, genic downstream transcript variant
rs80338799	G>A,C	Pathogenic, likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant, genic downstream transcript variant
rs121434594	G>A,C,T	Pathogenic, likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant
rs145611571	C>A,T	Uncertain-significance, likely-benign, conflicting-interpretations-of-pathogenicity	Missense variant, 5 prime UTR variant, coding sequence variant, non coding transcript variant
rs200856000	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, non coding transcript variant, missense variant, 5 prime UTR variant
rs368796800	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, non coding transcript variant, missense variant
rs370243307	A>G	Conflicting-interpretations-of-pathogenicity, likely-benign, uncertain-significance	Coding sequence variant, non coding transcript variant, missense variant
rs397516813	C>G	Likely-pathogenic, pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs397516815	T>C	Likely-pathogenic, pathogenic	Genic downstream transcript variant, non coding transcript variant, coding sequence variant, missense variant
rs397516822	T>C	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs397516823	A>G	Conflicting-interpretations-of-pathogenicity, likely-benign, benign-likely-benign	Non coding transcript variant, coding sequence variant, intron variant, synonymous variant
rs397516825	T>C	Likely-pathogenic, pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs397516826	C>A,G	Likely-pathogenic, pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs397516827	G>A,C,T	Likely-pathogenic, uncertain-significance, pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs397516828	G>A,C	Pathogenic-likely-pathogenic, not-provided, pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs397516829	A>T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs397516830	A>C,G,T	Likely-pathogenic, pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs587777586	A>G	Pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant, non coding transcript variant
rs587777587	G>A,C	Pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant, non coding transcript variant
rs587777588	C>T	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs587782971	A>G	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs587782972	C>A	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs727503384	G>C	Likely-pathogenic	Missense variant, intron variant, coding sequence variant, non coding transcript variant
rs727505017	A>G,T	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs730881002	T>C,G	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant, downstream transcript variant, genic downstream transcript variant
rs730881003	A>G	Pathogenic, likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant, non coding transcript variant
rs730881009	T>G	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs730881010	T>A,C	Pathogenic-likely-pathogenic, likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs771344560	T>C	Benign, conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, intron variant
rs869025501	G>A,T	Uncertain-significance, likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs876657965	GC>AT	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, non coding transcript variant, coding sequence variant, 5 prime UTR variant
rs886039607	C>G	Pathogenic, likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1057517813	A>C	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1057518155	T>G	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1057519815	C>G	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1057524239	G>C	Conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, missense variant, non coding transcript variant, coding sequence variant
rs1085307553	T>C,G	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1553609795	T>C	Uncertain-significance, pathogenic	Genic downstream transcript variant, non coding transcript variant, missense variant, coding sequence variant
rs1553609996	A>C,G	Uncertain-significance, likely-pathogenic	Genic downstream transcript variant, non coding transcript variant, missense variant, coding sequence variant
rs1553610155	C>A,G	Uncertain-significance, likely-pathogenic	Genic downstream transcript variant, non coding transcript variant, missense variant, coding sequence variant
rs1575573330	G>C	Likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant

Show/Hide all(310)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004418	hsa-miR-125b-5p	Western blot	19825990
MIRT004026	hsa-miR-7-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	19073608
MIRT004026	hsa-miR-7-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	19073608
MIRT004026	hsa-miR-7-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	19073608
MIRT004026	hsa-miR-7-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	19073608
MIRT006077	hsa-miR-195-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21350001
MIRT006078	hsa-miR-497-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21350001
MIRT006077	hsa-miR-195-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21350001
MIRT006078	hsa-miR-497-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21350001
MIRT006077	hsa-miR-195-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21350001
MIRT006078	hsa-miR-497-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21350001
MIRT004418	hsa-miR-125b-5p	Western blot;Other	19825990
MIRT004026	hsa-miR-7-5p	Reporter assay;qRT-PCR;Microarray;Other	19073608
MIRT046343	hsa-miR-23b-3p	CLASH	23622248
MIRT044977	hsa-miR-186-5p	CLASH	23622248
MIRT053089	hsa-miR-16-5p	Luciferase reporter assay, Western blot	23507142
MIRT053089	hsa-miR-16-5p	Luciferase reporter assay, Western blot	23507142
MIRT006077	hsa-miR-195-5p	Flow, Immunofluorescence, qRT-PCR, Western blot	23760062
MIRT004026	hsa-miR-7-5p	Luciferase reporter assay, Western blot	24603851
MIRT004026	hsa-miR-7-5p	Luciferase reporter assay, Western blot	24603851
MIRT004026	hsa-miR-7-5p	Luciferase reporter assay, Western blot	24603851
MIRT004026	hsa-miR-7-5p	Luciferase reporter assay, Western blot	24603851
MIRT004026	hsa-miR-7-5p	PAR-CLIP	21572407
MIRT004026	hsa-miR-7-5p	PAR-CLIP	21572407
MIRT541112	hsa-miR-4688	PAR-CLIP	21572407
MIRT541111	hsa-miR-6743-5p	PAR-CLIP	21572407
MIRT541110	hsa-miR-6085	PAR-CLIP	21572407
MIRT541109	hsa-miR-6813-5p	PAR-CLIP	21572407
MIRT541108	hsa-miR-4310	PAR-CLIP	21572407
MIRT541107	hsa-miR-7157-5p	PAR-CLIP	21572407
MIRT541106	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT541105	hsa-miR-3690	PAR-CLIP	21572407
MIRT541103	hsa-miR-4254	PAR-CLIP	21572407
MIRT542738	hsa-miR-4534	PAR-CLIP	21572407
MIRT542737	hsa-miR-8082	PAR-CLIP	21572407
MIRT542736	hsa-miR-3134	PAR-CLIP	21572407
MIRT541104	hsa-miR-4660	PAR-CLIP	21572407
MIRT541101	hsa-miR-6077	PAR-CLIP	21572407
MIRT541102	hsa-miR-486-3p	PAR-CLIP	21572407
MIRT541100	hsa-miR-6789-5p	PAR-CLIP	21572407
MIRT541099	hsa-miR-4291	PAR-CLIP	21572407
MIRT004026	hsa-miR-7-5p	PAR-CLIP	21572407
MIRT541112	hsa-miR-4688	PAR-CLIP	21572407
MIRT541111	hsa-miR-6743-5p	PAR-CLIP	21572407
MIRT541110	hsa-miR-6085	PAR-CLIP	21572407
MIRT541109	hsa-miR-6813-5p	PAR-CLIP	21572407
MIRT541108	hsa-miR-4310	PAR-CLIP	21572407
MIRT541107	hsa-miR-7157-5p	PAR-CLIP	21572407
MIRT541106	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT541105	hsa-miR-3690	PAR-CLIP	21572407
MIRT541103	hsa-miR-4254	PAR-CLIP	21572407
MIRT541104	hsa-miR-4660	PAR-CLIP	21572407
MIRT541101	hsa-miR-6077	PAR-CLIP	21572407
MIRT541102	hsa-miR-486-3p	PAR-CLIP	21572407
MIRT541100	hsa-miR-6789-5p	PAR-CLIP	21572407
MIRT541099	hsa-miR-4291	PAR-CLIP	21572407
MIRT532160	hsa-miR-520f-5p	PAR-CLIP	22012620
MIRT532159	hsa-miR-3682-5p	PAR-CLIP	22012620
MIRT532157	hsa-miR-6516-3p	PAR-CLIP	22012620
MIRT532158	hsa-miR-7111-3p	PAR-CLIP	22012620
MIRT532156	hsa-miR-6780a-3p	PAR-CLIP	22012620
MIRT532155	hsa-miR-6881-3p	PAR-CLIP	22012620
MIRT532154	hsa-miR-4799-5p	PAR-CLIP	22012620
MIRT726795	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT726794	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT731714	hsa-miR-132-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26452132
MIRT731714	hsa-miR-132-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26452132
MIRT731714	hsa-miR-132-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26452132
MIRT731714	hsa-miR-132-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26452132
MIRT732809	hsa-miR-455-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blotting	33505218
MIRT735287	hsa-miR-28-3p	qRT-PCR	32425976
MIRT735370	hsa-miR-370-3p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR, In situ hybridization, Flow cytometry	31703640
MIRT004026	hsa-miR-7-5p	PAR-CLIP	21572407
MIRT004026	hsa-miR-7-5p	PAR-CLIP	21572407
MIRT541112	hsa-miR-4688	PAR-CLIP	21572407
MIRT541111	hsa-miR-6743-5p	PAR-CLIP	21572407
MIRT541110	hsa-miR-6085	PAR-CLIP	21572407
MIRT541109	hsa-miR-6813-5p	PAR-CLIP	21572407
MIRT541108	hsa-miR-4310	PAR-CLIP	21572407
MIRT541107	hsa-miR-7157-5p	PAR-CLIP	21572407
MIRT541106	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT541105	hsa-miR-3690	PAR-CLIP	21572407
MIRT541103	hsa-miR-4254	PAR-CLIP	21572407
MIRT542738	hsa-miR-4534	PAR-CLIP	21572407
MIRT542737	hsa-miR-8082	PAR-CLIP	21572407
MIRT542736	hsa-miR-3134	PAR-CLIP	21572407
MIRT541104	hsa-miR-4660	PAR-CLIP	21572407
MIRT541101	hsa-miR-6077	PAR-CLIP	21572407
MIRT541102	hsa-miR-486-3p	PAR-CLIP	21572407
MIRT541100	hsa-miR-6789-5p	PAR-CLIP	21572407
MIRT541099	hsa-miR-4291	PAR-CLIP	21572407
MIRT004026	hsa-miR-7-5p	PAR-CLIP	21572407
MIRT541112	hsa-miR-4688	PAR-CLIP	21572407
MIRT541111	hsa-miR-6743-5p	PAR-CLIP	21572407
MIRT541110	hsa-miR-6085	PAR-CLIP	21572407
MIRT541109	hsa-miR-6813-5p	PAR-CLIP	21572407
MIRT541108	hsa-miR-4310	PAR-CLIP	21572407
MIRT541107	hsa-miR-7157-5p	PAR-CLIP	21572407
MIRT541106	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT541105	hsa-miR-3690	PAR-CLIP	21572407
MIRT541103	hsa-miR-4254	PAR-CLIP	21572407
MIRT541104	hsa-miR-4660	PAR-CLIP	21572407
MIRT541101	hsa-miR-6077	PAR-CLIP	21572407
MIRT541102	hsa-miR-486-3p	PAR-CLIP	21572407
MIRT541100	hsa-miR-6789-5p	PAR-CLIP	21572407
MIRT541099	hsa-miR-4291	PAR-CLIP	21572407
MIRT532160	hsa-miR-520f-5p	PAR-CLIP	22012620
MIRT532159	hsa-miR-3682-5p	PAR-CLIP	22012620
MIRT532157	hsa-miR-6516-3p	PAR-CLIP	22012620
MIRT532158	hsa-miR-7111-3p	PAR-CLIP	22012620
MIRT532156	hsa-miR-6780a-3p	PAR-CLIP	22012620
MIRT532155	hsa-miR-6881-3p	PAR-CLIP	22012620
MIRT532154	hsa-miR-4799-5p	PAR-CLIP	22012620
MIRT1288352	hsa-miR-125a-3p	CLIP-seq
MIRT1288353	hsa-miR-134	CLIP-seq
MIRT1288354	hsa-miR-1343	CLIP-seq
MIRT1288355	hsa-miR-139-5p	CLIP-seq
MIRT1288356	hsa-miR-2861	CLIP-seq
MIRT1288357	hsa-miR-3118	CLIP-seq
MIRT1288358	hsa-miR-3123	CLIP-seq
MIRT1288359	hsa-miR-3126-5p	CLIP-seq
MIRT1288360	hsa-miR-3140-3p	CLIP-seq
MIRT1288361	hsa-miR-3164	CLIP-seq
MIRT1288362	hsa-miR-3619-3p	CLIP-seq
MIRT1288363	hsa-miR-3925-5p	CLIP-seq
MIRT1288364	hsa-miR-3934	CLIP-seq
MIRT1288365	hsa-miR-4419a	CLIP-seq
MIRT1288366	hsa-miR-4436b-5p	CLIP-seq
MIRT1288367	hsa-miR-4501	CLIP-seq
MIRT1288368	hsa-miR-4505	CLIP-seq
MIRT1288369	hsa-miR-4510	CLIP-seq
MIRT1288370	hsa-miR-4643	CLIP-seq
MIRT1288371	hsa-miR-466	CLIP-seq
MIRT1288372	hsa-miR-4742-3p	CLIP-seq
MIRT1288373	hsa-miR-4789-3p	CLIP-seq
MIRT1288374	hsa-miR-4789-5p	CLIP-seq
MIRT1288375	hsa-miR-502-5p	CLIP-seq
MIRT1288376	hsa-miR-516a-3p	CLIP-seq
MIRT1288377	hsa-miR-548ac	CLIP-seq
MIRT1288378	hsa-miR-548ae	CLIP-seq
MIRT1288379	hsa-miR-548aj	CLIP-seq
MIRT1288380	hsa-miR-548am	CLIP-seq
MIRT1288381	hsa-miR-548d-3p	CLIP-seq
MIRT1288382	hsa-miR-548x	CLIP-seq
MIRT1288383	hsa-miR-548z	CLIP-seq
MIRT1288384	hsa-miR-568	CLIP-seq
MIRT1288385	hsa-miR-587	CLIP-seq
MIRT1288386	hsa-miR-630	CLIP-seq
MIRT1288387	hsa-miR-643	CLIP-seq
MIRT1288388	hsa-miR-764	CLIP-seq
MIRT2085402	hsa-miR-1207-3p	CLIP-seq
MIRT2085403	hsa-miR-1237	CLIP-seq
MIRT2085404	hsa-miR-1248	CLIP-seq
MIRT2085405	hsa-miR-125b	CLIP-seq
MIRT2085406	hsa-miR-1269	CLIP-seq
MIRT2085407	hsa-miR-1269b	CLIP-seq
MIRT2085408	hsa-miR-1273f	CLIP-seq
MIRT2085409	hsa-miR-1288	CLIP-seq
MIRT2085410	hsa-miR-1291	CLIP-seq
MIRT2085411	hsa-miR-1307	CLIP-seq
MIRT1288353	hsa-miR-134	CLIP-seq
MIRT2085412	hsa-miR-135a	CLIP-seq
MIRT2085413	hsa-miR-135b	CLIP-seq
MIRT2085414	hsa-miR-143	CLIP-seq
MIRT2085415	hsa-miR-150	CLIP-seq
MIRT2085416	hsa-miR-15a	CLIP-seq
MIRT2085417	hsa-miR-15b	CLIP-seq
MIRT2085418	hsa-miR-16	CLIP-seq
MIRT2085419	hsa-miR-1910	CLIP-seq
MIRT2085420	hsa-miR-1915	CLIP-seq
MIRT2085421	hsa-miR-195	CLIP-seq
MIRT2085422	hsa-miR-296-5p	CLIP-seq
MIRT1288357	hsa-miR-3118	CLIP-seq
MIRT1288358	hsa-miR-3123	CLIP-seq
MIRT2085423	hsa-miR-3127-5p	CLIP-seq
MIRT2085424	hsa-miR-3136-3p	CLIP-seq
MIRT1288360	hsa-miR-3140-3p	CLIP-seq
MIRT2085425	hsa-miR-3155	CLIP-seq
MIRT2085426	hsa-miR-3155b	CLIP-seq
MIRT1288361	hsa-miR-3164	CLIP-seq
MIRT2085427	hsa-miR-3173-5p	CLIP-seq
MIRT2085428	hsa-miR-3181	CLIP-seq
MIRT2085429	hsa-miR-330-3p	CLIP-seq
MIRT2085430	hsa-miR-3652	CLIP-seq
MIRT2085431	hsa-miR-378	CLIP-seq
MIRT2085432	hsa-miR-378b	CLIP-seq
MIRT2085433	hsa-miR-378c	CLIP-seq
MIRT2085434	hsa-miR-378d	CLIP-seq
MIRT2085435	hsa-miR-378e	CLIP-seq
MIRT2085436	hsa-miR-378f	CLIP-seq
MIRT2085437	hsa-miR-378h	CLIP-seq
MIRT2085438	hsa-miR-378i	CLIP-seq
MIRT2085439	hsa-miR-3918	CLIP-seq
MIRT2085440	hsa-miR-3921	CLIP-seq
MIRT1288363	hsa-miR-3925-5p	CLIP-seq
MIRT2085441	hsa-miR-3944-3p	CLIP-seq
MIRT2085442	hsa-miR-422a	CLIP-seq
MIRT2085443	hsa-miR-424	CLIP-seq
MIRT2085444	hsa-miR-4283	CLIP-seq
MIRT2085445	hsa-miR-4319	CLIP-seq
MIRT2085446	hsa-miR-4324	CLIP-seq
MIRT2085447	hsa-miR-4430	CLIP-seq
MIRT2085448	hsa-miR-4446-3p	CLIP-seq
MIRT2085449	hsa-miR-4448	CLIP-seq
MIRT2085450	hsa-miR-4489	CLIP-seq
MIRT2085451	hsa-miR-4492	CLIP-seq
MIRT2085452	hsa-miR-4498	CLIP-seq
MIRT1288367	hsa-miR-4501	CLIP-seq
MIRT1288368	hsa-miR-4505	CLIP-seq
MIRT2085453	hsa-miR-4515	CLIP-seq
MIRT2085454	hsa-miR-4524	CLIP-seq
MIRT2085455	hsa-miR-4638-5p	CLIP-seq
MIRT1288370	hsa-miR-4643	CLIP-seq
MIRT2085456	hsa-miR-4653-5p	CLIP-seq
MIRT2085457	hsa-miR-4656	CLIP-seq
MIRT1288371	hsa-miR-466	CLIP-seq
MIRT2085458	hsa-miR-4662a-5p	CLIP-seq
MIRT2085459	hsa-miR-4685-5p	CLIP-seq
MIRT2085460	hsa-miR-4687-3p	CLIP-seq
MIRT2085461	hsa-miR-4690-5p	CLIP-seq
MIRT2085462	hsa-miR-4708-5p	CLIP-seq
MIRT2085463	hsa-miR-4713-5p	CLIP-seq
MIRT2085464	hsa-miR-4721	CLIP-seq
MIRT2085465	hsa-miR-4726-3p	CLIP-seq
MIRT2085466	hsa-miR-4731-5p	CLIP-seq
MIRT2085467	hsa-miR-4732-3p	CLIP-seq
MIRT2085468	hsa-miR-4740-5p	CLIP-seq
MIRT2085469	hsa-miR-4750	CLIP-seq
MIRT2085470	hsa-miR-4763-5p	CLIP-seq
MIRT2085471	hsa-miR-4766-5p	CLIP-seq
MIRT2085472	hsa-miR-4770	CLIP-seq
MIRT1288373	hsa-miR-4789-3p	CLIP-seq
MIRT1288374	hsa-miR-4789-5p	CLIP-seq
MIRT2085473	hsa-miR-484	CLIP-seq
MIRT2085474	hsa-miR-497	CLIP-seq
MIRT1288375	hsa-miR-502-5p	CLIP-seq
MIRT2085475	hsa-miR-503	CLIP-seq
MIRT1288376	hsa-miR-516a-3p	CLIP-seq
MIRT2085476	hsa-miR-532-3p	CLIP-seq
MIRT1288384	hsa-miR-568	CLIP-seq
MIRT2085477	hsa-miR-570	CLIP-seq
MIRT2085478	hsa-miR-586	CLIP-seq
MIRT1288385	hsa-miR-587	CLIP-seq
MIRT1288387	hsa-miR-643	CLIP-seq
MIRT2085479	hsa-miR-646	CLIP-seq
MIRT2085480	hsa-miR-670	CLIP-seq
MIRT2085481	hsa-miR-7	CLIP-seq
MIRT2085482	hsa-miR-762	CLIP-seq
MIRT2085483	hsa-miR-942	CLIP-seq
MIRT2310792	hsa-miR-1197	CLIP-seq
MIRT2085402	hsa-miR-1207-3p	CLIP-seq
MIRT2310793	hsa-miR-1226	CLIP-seq
MIRT2085405	hsa-miR-125b	CLIP-seq
MIRT2085408	hsa-miR-1273f	CLIP-seq
MIRT2310794	hsa-miR-1286	CLIP-seq
MIRT2085411	hsa-miR-1307	CLIP-seq
MIRT1288354	hsa-miR-1343	CLIP-seq
MIRT2085414	hsa-miR-143	CLIP-seq
MIRT2310795	hsa-miR-1587	CLIP-seq
MIRT2085416	hsa-miR-15a	CLIP-seq
MIRT2085417	hsa-miR-15b	CLIP-seq
MIRT2085418	hsa-miR-16	CLIP-seq
MIRT2085419	hsa-miR-1910	CLIP-seq
MIRT2085421	hsa-miR-195	CLIP-seq
MIRT1288356	hsa-miR-2861	CLIP-seq
MIRT2085428	hsa-miR-3181	CLIP-seq
MIRT2310796	hsa-miR-329	CLIP-seq
MIRT2310797	hsa-miR-362-3p	CLIP-seq
MIRT2310798	hsa-miR-378g	CLIP-seq
MIRT2085440	hsa-miR-3921	CLIP-seq
MIRT2085441	hsa-miR-3944-3p	CLIP-seq
MIRT2085443	hsa-miR-424	CLIP-seq
MIRT2085445	hsa-miR-4319	CLIP-seq
MIRT2085446	hsa-miR-4324	CLIP-seq
MIRT1288365	hsa-miR-4419a	CLIP-seq
MIRT2310799	hsa-miR-4434	CLIP-seq
MIRT2310800	hsa-miR-4436a	CLIP-seq
MIRT2085448	hsa-miR-4446-3p	CLIP-seq
MIRT2310801	hsa-miR-4468	CLIP-seq
MIRT2085451	hsa-miR-4492	CLIP-seq
MIRT2085452	hsa-miR-4498	CLIP-seq
MIRT1288368	hsa-miR-4505	CLIP-seq
MIRT1288369	hsa-miR-4510	CLIP-seq
MIRT2310802	hsa-miR-4516	CLIP-seq
MIRT2085454	hsa-miR-4524	CLIP-seq
MIRT2310803	hsa-miR-4531	CLIP-seq
MIRT2310804	hsa-miR-455-5p	CLIP-seq
MIRT2085455	hsa-miR-4638-5p	CLIP-seq
MIRT2085456	hsa-miR-4653-5p	CLIP-seq
MIRT2085457	hsa-miR-4656	CLIP-seq
MIRT2085458	hsa-miR-4662a-5p	CLIP-seq
MIRT2310805	hsa-miR-4675	CLIP-seq
MIRT2085460	hsa-miR-4687-3p	CLIP-seq
MIRT2085462	hsa-miR-4708-5p	CLIP-seq
MIRT2085464	hsa-miR-4721	CLIP-seq
MIRT2085467	hsa-miR-4732-3p	CLIP-seq
MIRT2310806	hsa-miR-4741	CLIP-seq
MIRT2085469	hsa-miR-4750	CLIP-seq
MIRT2085471	hsa-miR-4766-5p	CLIP-seq
MIRT2085472	hsa-miR-4770	CLIP-seq
MIRT2085474	hsa-miR-497	CLIP-seq
MIRT2085475	hsa-miR-503	CLIP-seq
MIRT2310807	hsa-miR-634	CLIP-seq
MIRT2085479	hsa-miR-646	CLIP-seq
MIRT2085480	hsa-miR-670	CLIP-seq
MIRT2085481	hsa-miR-7	CLIP-seq
MIRT2085482	hsa-miR-762	CLIP-seq
MIRT2085483	hsa-miR-942	CLIP-seq
MIRT2085440	hsa-miR-3921	CLIP-seq
MIRT2085456	hsa-miR-4653-5p	CLIP-seq

Show/Hide all(62)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0000186	Process	Activation of MAPKK activity	IDA	10644344
GO:0001666	Process	Response to hypoxia	IEA
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0004672	Function	Protein kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	19667065
GO:0004709	Function	MAP kinase kinase kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	7644510, 7760835, 7791872, 7882972, 7935795, 7939632, 8085158, 8332187, 8601312, 8670882, 8756332, 9144171, 9624170, 10433554, 10523642, 11697890, 11909642, 12620389, 14688280, 15778465, 15935327, 16239230, 16306228, 16330544, 16405965, 16837009, 17097642, 17229891, 17724343, 1797917
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	17724343
GO:0005737	Component	Cytoplasm	ISS
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005741	Component	Mitochondrial outer membrane	TAS	8929532
GO:0005794	Component	Golgi apparatus	IPI	17724343
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	16009725
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	17724343
GO:0005886	Component	Plasma membrane	IDA	16009725
GO:0005886	Component	Plasma membrane	TAS
GO:0006468	Process	Protein phosphorylation	IEA
GO:0006915	Process	Apoptotic process	TAS	8929532
GO:0007165	Process	Signal transduction	TAS	8063729
GO:0007190	Process	Activation of adenylate cyclase activity	IDA	15385642
GO:0007507	Process	Heart development	IEA
GO:0008179	Function	Adenylate cyclase binding	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	9765203
GO:0010856	Function	Adenylate cyclase activator activity	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0019899	Function	Enzyme binding	IPI	23509299
GO:0030154	Process	Cell differentiation	IEA
GO:0030168	Process	Platelet activation	TAS
GO:0030878	Process	Thyroid gland development	IEA
GO:0031143	Component	Pseudopodium	IEA
GO:0031267	Function	Small GTPase binding	IPI	12194967
GO:0031333	Process	Negative regulation of protein-containing complex assembly	IDA	19667065
GO:0031434	Function	Mitogen-activated protein kinase kinase binding	IEA
GO:0033138	Process	Positive regulation of peptidyl-serine phosphorylation	IDA	19667065
GO:0034220	Process	Ion transmembrane transport	TAS
GO:0035019	Process	Somatic stem cell population maintenance	IEA
GO:0035023	Process	Regulation of Rho protein signal transduction	TAS	16649144
GO:0035773	Process	Insulin secretion involved in cellular response to glucose stimulus	IEA
GO:0035994	Process	Response to muscle stretch	IEA
GO:0042060	Process	Wound healing	TAS	15943972
GO:0042802	Function	Identical protein binding	IPI	17979178, 20130576, 22169110, 22510884
GO:0042981	Process	Regulation of apoptotic process	TAS	21779496
GO:0043066	Process	Negative regulation of apoptotic process	IDA	19667065
GO:0043154	Process	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	TAS	21779496
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045104	Process	Intermediate filament cytoskeleton organization	IEA
GO:0045595	Process	Regulation of cell differentiation	TAS	21779496
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048011	Process	Neurotrophin TRK receptor signaling pathway	IEA
GO:0048538	Process	Thymus development	IEA
GO:0060324	Process	Face development	IEA
GO:0071550	Process	Death-inducing signaling complex assembly	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:1902042	Process	Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA
GO:2000145	Process	Regulation of cell motility	TAS	21779496

MIM	HGNC	e!Ensembl
164760	9829	ENSG00000132155

Protein

UniProt ID

P04049

Protein name

RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)

Protein function

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation,

PDB

1C1Y , 1FAQ , 1FAR , 1GUA , 1RFA , 3CU8 , 3IQJ , 3IQU , 3IQV , 3KUC , 3KUD , 3NKX , 3O8I , 3OMV , 4FJ3 , 4G0N , 4G3X , 4IEA , 4IHL , 6NTC , 6NTD , 6PTS , 6PTW , 6VJJ , 6XGU , 6XGV , 6XHA , 6XHB , 6XI7 , 7JHP , 7Z37 , 7Z38 , 8A68 , 8A6F , 8A6H , 8ATR , 8ATS , 8AV0 , 8CHF , 8CPD , 8EPW , 8GAE , 8GFT , 8JOF , 8JOG , 8S42 , 8T74 , 8T75 , 8U1L , 9AXA , 9AXC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02196	RBD	57 → 129	Raf-like Ras-binding domain	Domain
PF00130	C1_1	139 → 187	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF07714	PK_Tyr_Ser-Thr	349 → 606	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF

Sequence length

648

Interactions

View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412