GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

Home
Browse
- Genes
- Diseases
- Pathways
  - Reactome
  - KEGG
Analysis
Help
Links
FAQ
Contact us

RAC2 (Rac family small GTPase 2)

Gene

5880

Rac family small GTPase 2

RAC2

EN-7, Gx, HSPC022, IMD73A, IMD73B, IMD73C, p21-Rac2

22q13.1

This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarizati

Show/Hide all(2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs74315507	C>T	Pathogenic	Coding sequence variant, missense variant
rs1555908409	C>T	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant

Show/Hide all(152)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016574	hsa-miR-193b-3p	Microarray	20304954
MIRT755715	hsa-miR-1246	Western blotting, RNA-seq	38287447
MIRT1287073	hsa-miR-103a	CLIP-seq
MIRT1287074	hsa-miR-107	CLIP-seq
MIRT1287075	hsa-miR-122	CLIP-seq
MIRT1287076	hsa-miR-1914	CLIP-seq
MIRT1287077	hsa-miR-3180-5p	CLIP-seq
MIRT1287078	hsa-miR-3199	CLIP-seq
MIRT1287079	hsa-miR-342-5p	CLIP-seq
MIRT1287080	hsa-miR-3664-3p	CLIP-seq
MIRT1287081	hsa-miR-3937	CLIP-seq
MIRT1287082	hsa-miR-3944-5p	CLIP-seq
MIRT1287083	hsa-miR-4515	CLIP-seq
MIRT1287084	hsa-miR-4648	CLIP-seq
MIRT1287085	hsa-miR-4651	CLIP-seq
MIRT1287086	hsa-miR-4661-3p	CLIP-seq
MIRT1287087	hsa-miR-4664-5p	CLIP-seq
MIRT1287088	hsa-miR-4677-3p	CLIP-seq
MIRT1287089	hsa-miR-520a-5p	CLIP-seq
MIRT1287090	hsa-miR-525-5p	CLIP-seq
MIRT1287091	hsa-miR-608	CLIP-seq
MIRT1287092	hsa-miR-887	CLIP-seq
MIRT1287093	hsa-miR-922	CLIP-seq
MIRT1556923	hsa-miR-1286	CLIP-seq
MIRT1556924	hsa-miR-219-1-3p	CLIP-seq
MIRT1556925	hsa-miR-31	CLIP-seq
MIRT1556926	hsa-miR-3125	CLIP-seq
MIRT1556927	hsa-miR-3128	CLIP-seq
MIRT1556928	hsa-miR-3132	CLIP-seq
MIRT1556929	hsa-miR-326	CLIP-seq
MIRT1556930	hsa-miR-330-5p	CLIP-seq
MIRT1556931	hsa-miR-3916	CLIP-seq
MIRT1556932	hsa-miR-3928	CLIP-seq
MIRT1556933	hsa-miR-3940-5p	CLIP-seq
MIRT1556934	hsa-miR-4259	CLIP-seq
MIRT1556935	hsa-miR-4451	CLIP-seq
MIRT1556936	hsa-miR-4503	CLIP-seq
MIRT1556937	hsa-miR-4507	CLIP-seq
MIRT1556938	hsa-miR-4680-5p	CLIP-seq
MIRT1556939	hsa-miR-4720-3p	CLIP-seq
MIRT1556940	hsa-miR-4720-5p	CLIP-seq
MIRT1556941	hsa-miR-4731-5p	CLIP-seq
MIRT1556942	hsa-miR-4799-3p	CLIP-seq
MIRT1556943	hsa-miR-4804-3p	CLIP-seq
MIRT1556944	hsa-miR-544	CLIP-seq
MIRT1556945	hsa-miR-571	CLIP-seq
MIRT1556946	hsa-miR-629	CLIP-seq
MIRT1556947	hsa-miR-657	CLIP-seq
MIRT1556948	hsa-miR-877	CLIP-seq
MIRT2310539	hsa-miR-3126-3p	CLIP-seq
MIRT2310540	hsa-miR-3176	CLIP-seq
MIRT2310541	hsa-miR-3688-5p	CLIP-seq
MIRT2310542	hsa-miR-382	CLIP-seq
MIRT2310543	hsa-miR-3922-3p	CLIP-seq
MIRT2310544	hsa-miR-4474-3p	CLIP-seq
MIRT2310545	hsa-miR-885-3p	CLIP-seq
MIRT1287073	hsa-miR-103a	CLIP-seq
MIRT1287074	hsa-miR-107	CLIP-seq
MIRT2393373	hsa-miR-3065-3p	CLIP-seq
MIRT2393374	hsa-miR-4506	CLIP-seq
MIRT2393375	hsa-miR-450b-3p	CLIP-seq
MIRT1287085	hsa-miR-4651	CLIP-seq
MIRT2393376	hsa-miR-4787-5p	CLIP-seq
MIRT2393377	hsa-miR-602	CLIP-seq
MIRT1287091	hsa-miR-608	CLIP-seq
MIRT2393378	hsa-miR-769-3p	CLIP-seq
MIRT2393379	hsa-miR-873	CLIP-seq
MIRT1287073	hsa-miR-103a	CLIP-seq
MIRT1287074	hsa-miR-107	CLIP-seq
MIRT2606939	hsa-miR-1207-5p	CLIP-seq
MIRT2606940	hsa-miR-1264	CLIP-seq
MIRT2606941	hsa-miR-1301	CLIP-seq
MIRT2606942	hsa-miR-1909	CLIP-seq
MIRT1287076	hsa-miR-1914	CLIP-seq
MIRT2606943	hsa-miR-302a	CLIP-seq
MIRT2606944	hsa-miR-302b	CLIP-seq
MIRT2606945	hsa-miR-302c	CLIP-seq
MIRT2606946	hsa-miR-302d	CLIP-seq
MIRT2606947	hsa-miR-302e	CLIP-seq
MIRT1556925	hsa-miR-31	CLIP-seq
MIRT2606948	hsa-miR-342-3p	CLIP-seq
MIRT2606949	hsa-miR-3653	CLIP-seq
MIRT2606950	hsa-miR-3658	CLIP-seq
MIRT1287080	hsa-miR-3664-3p	CLIP-seq
MIRT2606951	hsa-miR-372	CLIP-seq
MIRT2606952	hsa-miR-373	CLIP-seq
MIRT1287082	hsa-miR-3944-5p	CLIP-seq
MIRT2606953	hsa-miR-4432	CLIP-seq
MIRT2606954	hsa-miR-4492	CLIP-seq
MIRT2606955	hsa-miR-4498	CLIP-seq
MIRT2606956	hsa-miR-4660	CLIP-seq
MIRT1287086	hsa-miR-4661-3p	CLIP-seq
MIRT1287088	hsa-miR-4677-3p	CLIP-seq
MIRT2606957	hsa-miR-4709-3p	CLIP-seq
MIRT2606958	hsa-miR-4736	CLIP-seq
MIRT2606959	hsa-miR-4763-3p	CLIP-seq
MIRT2606960	hsa-miR-5047	CLIP-seq
MIRT2606961	hsa-miR-513a-5p	CLIP-seq
MIRT2606962	hsa-miR-519a	CLIP-seq
MIRT2606963	hsa-miR-519b-3p	CLIP-seq
MIRT2606964	hsa-miR-519c-3p	CLIP-seq
MIRT2606965	hsa-miR-520a-3p	CLIP-seq
MIRT2606966	hsa-miR-520b	CLIP-seq
MIRT2606967	hsa-miR-520c-3p	CLIP-seq
MIRT2606968	hsa-miR-520d-3p	CLIP-seq
MIRT2606969	hsa-miR-520e	CLIP-seq
MIRT2606970	hsa-miR-548n	CLIP-seq
MIRT2606971	hsa-miR-548t	CLIP-seq
MIRT2606972	hsa-miR-561	CLIP-seq
MIRT2606973	hsa-miR-563	CLIP-seq
MIRT2606974	hsa-miR-762	CLIP-seq
MIRT1287093	hsa-miR-922	CLIP-seq
MIRT1287073	hsa-miR-103a	CLIP-seq
MIRT1287074	hsa-miR-107	CLIP-seq
MIRT2606939	hsa-miR-1207-5p	CLIP-seq
MIRT2606940	hsa-miR-1264	CLIP-seq
MIRT2606941	hsa-miR-1301	CLIP-seq
MIRT2606942	hsa-miR-1909	CLIP-seq
MIRT2689276	hsa-miR-1912	CLIP-seq
MIRT1287076	hsa-miR-1914	CLIP-seq
MIRT2606943	hsa-miR-302a	CLIP-seq
MIRT2606944	hsa-miR-302b	CLIP-seq
MIRT2606945	hsa-miR-302c	CLIP-seq
MIRT2606946	hsa-miR-302d	CLIP-seq
MIRT2606947	hsa-miR-302e	CLIP-seq
MIRT2606948	hsa-miR-342-3p	CLIP-seq
MIRT2606949	hsa-miR-3653	CLIP-seq
MIRT2606950	hsa-miR-3658	CLIP-seq
MIRT1287080	hsa-miR-3664-3p	CLIP-seq
MIRT2606951	hsa-miR-372	CLIP-seq
MIRT2606952	hsa-miR-373	CLIP-seq
MIRT1287082	hsa-miR-3944-5p	CLIP-seq
MIRT2606954	hsa-miR-4492	CLIP-seq
MIRT2606955	hsa-miR-4498	CLIP-seq
MIRT2606956	hsa-miR-4660	CLIP-seq
MIRT1287086	hsa-miR-4661-3p	CLIP-seq
MIRT1287088	hsa-miR-4677-3p	CLIP-seq
MIRT2606958	hsa-miR-4736	CLIP-seq
MIRT2606959	hsa-miR-4763-3p	CLIP-seq
MIRT2606960	hsa-miR-5047	CLIP-seq
MIRT2606961	hsa-miR-513a-5p	CLIP-seq
MIRT2606962	hsa-miR-519a	CLIP-seq
MIRT2606963	hsa-miR-519b-3p	CLIP-seq
MIRT2606964	hsa-miR-519c-3p	CLIP-seq
MIRT2606965	hsa-miR-520a-3p	CLIP-seq
MIRT2606966	hsa-miR-520b	CLIP-seq
MIRT2606967	hsa-miR-520c-3p	CLIP-seq
MIRT2606968	hsa-miR-520d-3p	CLIP-seq
MIRT2606969	hsa-miR-520e	CLIP-seq
MIRT2606973	hsa-miR-563	CLIP-seq
MIRT2606974	hsa-miR-762	CLIP-seq
MIRT1287093	hsa-miR-922	CLIP-seq

Show/Hide all(51)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	22106281, 22949657, 32296183
GO:0005525	Function	GTP binding	IBA	21873635
GO:0005525	Function	GTP binding	IMP	19625648
GO:0005635	Component	Nuclear envelope	IEA
GO:0005829	Component	Cytosol	IDA	19625648
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA	21873635
GO:0005884	Component	Actin filament	IDA	19625648
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005938	Component	Cell cortex	IBA	21873635
GO:0007015	Process	Actin filament organization	IBA	21873635
GO:0007015	Process	Actin filament organization	IMP	21167572
GO:0007163	Process	Establishment or maintenance of cell polarity	IBA	21873635
GO:0007165	Process	Signal transduction	TAS	2674130
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0008045	Process	Motor neuron axon guidance	IBA	21873635
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008360	Process	Regulation of cell shape	IBA	21873635
GO:0010310	Process	Regulation of hydrogen peroxide metabolic process	TAS	16636067
GO:0010592	Process	Positive regulation of lamellipodium assembly	IMP	19625648
GO:0010810	Process	Regulation of cell-substrate adhesion	IMP	21167572
GO:0016601	Process	Rac protein signal transduction	IBA	21873635
GO:0019887	Function	Protein kinase regulator activity	IEA
GO:0019901	Function	Protein kinase binding	IBA	21873635
GO:0030027	Component	Lamellipodium	IDA	19625648
GO:0030031	Process	Cell projection assembly	IBA	21873635
GO:0030670	Component	Phagocytic vesicle membrane	TAS
GO:0030865	Process	Cortical cytoskeleton organization	IBA	21873635
GO:0031410	Component	Cytoplasmic vesicle	IBA	21873635
GO:0032956	Process	Regulation of actin cytoskeleton organization	IBA	21873635
GO:0042129	Process	Regulation of T cell proliferation	IEA
GO:0042995	Component	Cell projection	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0043304	Process	Regulation of mast cell degranulation	IEA
GO:0043652	Process	Engulfment of apoptotic cell	IBA	21873635
GO:0045453	Process	Bone resorption	IEA
GO:0045454	Process	Cell redox homeostasis	TAS
GO:0045859	Process	Regulation of protein kinase activity	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051897	Process	Positive regulation of protein kinase B signaling	TAS
GO:0060263	Process	Regulation of respiratory burst	IDA	16636067
GO:0060753	Process	Regulation of mast cell chemotaxis	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337, 23533145
GO:0071593	Process	Lymphocyte aggregation	IMP	21167572
GO:0090023	Process	Positive regulation of neutrophil chemotaxis	IMP	19625648
GO:1902622	Process	Regulation of neutrophil migration	IBA	21873635
GO:1902622	Process	Regulation of neutrophil migration	IMP	21167572
GO:1903955	Process	Positive regulation of protein targeting to mitochondrion	HMP	24270810

MIM	HGNC	e!Ensembl
602049	9802	ENSG00000128340

Protein

UniProt ID

P15153

Protein name

Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2)

Protein function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state (PubMed:30723080). In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory proce

PDB

1DS6 , 2W2T , 2W2V , 2W2X

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	5 → 178	Ras family	Domain

Sequence

MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG
QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR
DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ
PTRQQKRACSLL

Sequence length

192

Interactions

View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412