PTPRM (protein tyrosine phosphatase receptor type M)

Gene

• Entrez ID: 5797
• Gene name: Protein tyrosine phosphatase receptor type M
• Gene symbol: PTPRM
• Synonyms: PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu
• Chromosome: 18
• Chromosome location: 18p11.23
• Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018602	hsa-miR-335-5p	Microarray	18185580
MIRT054104	hsa-miR-205-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, QRTPCR	23497265
MIRT654607	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT654608	hsa-miR-557	HITS-CLIP	23824327
MIRT654609	hsa-miR-507	HITS-CLIP	23824327
MIRT654610	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT654611	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT654612	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654613	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT654614	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT654615	hsa-miR-1253	HITS-CLIP	23824327
MIRT654616	hsa-miR-1279	HITS-CLIP	23824327
MIRT654617	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654618	hsa-miR-4461	HITS-CLIP	23824327
MIRT654619	hsa-miR-1264	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001937	Process	Negative regulation of endothelial cell proliferation	IMP	18566238
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA	21873635
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	8393854, 17965016, 18566238
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	IDA	10809770
GO:0005515	Function	Protein binding	IPI	9531566, 11278757, 16380380
GO:0005737	Component	Cytoplasm	IDA	16380380
GO:0005886	Component	Plasma membrane	IDA
GO:0005887	Component	Integral component of plasma membrane	NAS	1655529
GO:0005911	Component	Cell-cell junction	IDA	15491993, 16380380
GO:0005912	Component	Adherens junction	IDA	17965016
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0006470	Process	Protein dephosphorylation	IDA	8393854, 10809770
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IDA	8393854
GO:0007165	Process	Signal transduction	IDA	15080886
GO:0010596	Process	Negative regulation of endothelial cell migration	IMP	18566238
GO:0010842	Process	Retina layer formation	IMP	14623235
GO:0016525	Process	Negative regulation of angiogenesis	IMP	18566238
GO:0030027	Component	Lamellipodium	IDA	15706045
GO:0031175	Process	Neuron projection development	IDA	16380380
GO:0031175	Process	Neuron projection development	IMP	17276081
GO:0031290	Process	Retinal ganglion cell axon guidance	IDA	15080886
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	IEA
GO:0042493	Process	Response to drug	IDA	18566238
GO:0042802	Function	Identical protein binding	IPI	10809770
GO:0045296	Function	Cadherin binding	IDA	9531566
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	15491993

Other IDs

• MIM: 176888
• HGNC: 9675
• e!Ensembl: ENSG00000173482

Protein

• UniProt ID: P28827
• Protein name: Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)
• Protein function: Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
• PDB: 1RPM, 2C9A, 2V5Y
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00629	MAM	27 → 183	MAM domain, meprin/A5/mu	Domain
  PF00047	ig	189 → 274	Immunoglobulin domain	Domain
  PF00041	fn3	283 → 366	Fibronectin type III domain	Domain
  PF00041	fn3	488 → 575	Fibronectin type III domain	Domain
  PF18861	PTP_tm	611 → 768	Transmembrane domain of protein tyrosine phosphatase, receptor type J	Family
  PF00102	Y_phosphatase	923 → 1153	Protein-tyrosine phosphatase	Domain
  PF00102	Y_phosphatase	1213 → 1447	Protein-tyrosine phosphatase	Domain

• Sequence:

  MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD
  PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV
  NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH
  PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR
  FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI
  QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE
  GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC
  YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED
  LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS
  KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT
  DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY
  FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA
  TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST
  RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY
  YPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGF
  KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID
  GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK
  DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV
  KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT
  EEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTL
  RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT
  QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLE
  EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG
  GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF
  CYEVALEYLNSG

• Sequence length: 1452