Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5795 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Protein tyrosine phosphatase receptor type J |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PTPRJ |
SynonymsGene synonyms aliases
|
CD148, DEP1, HPTP eta, HPTPeta, R-PTP-ETA, R-PTP-J, SCC1, THC10 |
ChromosomeChromosome number
|
11 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
11p11.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic tra |
SNPsSNP information provided by dbSNP.
|
SNP ID |
Visualize variation |
Clinical significance |
Consequence |
rs1566734 |
A>C |
Pathogenic |
Missense variant, coding sequence variant, non coding transcript variant |
rs121434507 |
C>T |
Pathogenic |
Coding sequence variant, non coding transcript variant, missense variant |
|
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001772 |
Component |
Immunological synapse |
IDA |
12913111 |
GO:0004725 |
Function |
Protein tyrosine phosphatase activity |
IBA |
21873635 |
GO:0004725 |
Function |
Protein tyrosine phosphatase activity |
IDA |
9531590, 10821867, 12913111, 18348712, 18936167, 19332538 |
GO:0004725 |
Function |
Protein tyrosine phosphatase activity |
IMP |
9780142, 12475979 |
GO:0004725 |
Function |
Protein tyrosine phosphatase activity |
TAS |
|
GO:0005161 |
Function |
Platelet-derived growth factor receptor binding |
IPI |
10821867 |
GO:0005515 |
Function |
Protein binding |
IPI |
10821867, 12370829, 12475979, 12771128, 16893970, 18936167, 19167335, 19494114, 23650535 |
GO:0005886 |
Component |
Plasma membrane |
IDA |
9531590, 18348712, 19836242 |
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0005887 |
Component |
Integral component of plasma membrane |
TAS |
7937872 |
GO:0005911 |
Component |
Cell-cell junction |
IDA |
12370829, 19332538 |
GO:0006470 |
Process |
Protein dephosphorylation |
IBA |
21873635 |
GO:0008013 |
Function |
Beta-catenin binding |
IPI |
12370829 |
GO:0008285 |
Process |
Negative regulation of cell population proliferation |
IDA |
14709717, 16682945 |
GO:0009986 |
Component |
Cell surface |
IDA |
12913111 |
GO:0010642 |
Process |
Negative regulation of platelet-derived growth factor receptor signaling pathway |
IDA |
14709717 |
GO:0016791 |
Function |
Phosphatase activity |
IDA |
12062403, 12370829, 19494114 |
GO:0016791 |
Function |
Phosphatase activity |
IMP |
11259588, 19836242 |
GO:0019901 |
Function |
Protein kinase binding |
IPI |
19332538 |
GO:0030155 |
Process |
Regulation of cell adhesion |
IMP |
12370829 |
GO:0030183 |
Process |
B cell differentiation |
ISS |
|
GO:0030308 |
Process |
Negative regulation of cell growth |
IDA |
14709717 |
GO:0030336 |
Process |
Negative regulation of cell migration |
IDA |
16682945 |
GO:0032587 |
Component |
Ruffle membrane |
IEA |
|
GO:0032760 |
Process |
Positive regulation of tumor necrosis factor production |
ISS |
|
GO:0035335 |
Process |
Peptidyl-tyrosine dephosphorylation |
IDA |
9531590, 10821867, 12913111, 18348712, 18936167, 19332538 |
GO:0035335 |
Process |
Peptidyl-tyrosine dephosphorylation |
IMP |
9780142, 12475979 |
GO:0035579 |
Component |
Specific granule membrane |
TAS |
|
GO:0035584 |
Process |
Calcium-mediated signaling using intracellular calcium source |
ISS |
|
GO:0042059 |
Process |
Negative regulation of epidermal growth factor receptor signaling pathway |
IMP |
19836242 |
GO:0043116 |
Process |
Negative regulation of vascular permeability |
IDA |
19332538 |
GO:0043312 |
Process |
Neutrophil degranulation |
TAS |
|
GO:0043407 |
Process |
Negative regulation of MAP kinase activity |
IBA |
21873635 |
GO:0043407 |
Process |
Negative regulation of MAP kinase activity |
IDA |
19494114 |
GO:0043410 |
Process |
Positive regulation of MAPK cascade |
ISS |
|
GO:0045295 |
Function |
Gamma-catenin binding |
IPI |
12370829 |
GO:0045296 |
Function |
Cadherin binding |
IPI |
28926625 |
GO:0045785 |
Process |
Positive regulation of cell adhesion |
IMP |
21091576 |
GO:0048008 |
Process |
Platelet-derived growth factor receptor signaling pathway |
IMP |
21091576 |
GO:0050731 |
Process |
Positive regulation of peptidyl-tyrosine phosphorylation |
ISS |
|
GO:0050852 |
Process |
T cell receptor signaling pathway |
TAS |
|
GO:0050860 |
Process |
Negative regulation of T cell receptor signaling pathway |
IDA |
12913111 |
GO:0050860 |
Process |
Negative regulation of T cell receptor signaling pathway |
IMP |
9780142, 11259588 |
GO:0050918 |
Process |
Positive chemotaxis |
IDA |
14709717 |
GO:0051019 |
Function |
Mitogen-activated protein kinase binding |
IPI |
19494114 |
GO:0051894 |
Process |
Positive regulation of focal adhesion assembly |
IMP |
21091576 |
GO:0051897 |
Process |
Positive regulation of protein kinase B signaling |
IMP |
18936167 |
GO:0051898 |
Process |
Negative regulation of protein kinase B signaling |
IMP |
19922411 |
GO:0060242 |
Process |
Contact inhibition |
NAS |
7937872 |
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19056867, 23533145 |
GO:0070097 |
Function |
Delta-catenin binding |
IPI |
12370829, 19332538 |
GO:1905451 |
Process |
Positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis |
ISS |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q12913 |
Protein name |
Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) |
Protein function |
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:1247597 |
PDB |
2CFV
,
2DLE
,
2NZ6
,
7U01
,
7U08
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00041 |
fn3 |
120 → 199 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
368 → 445 |
Fibronectin type III domain |
Domain |
PF18861 |
PTP_tm |
835 → 1000 |
Transmembrane domain of protein tyrosine phosphatase, receptor type J |
Family |
PF00102 |
Y_phosphatase |
1065 → 1297 |
Protein-tyrosine phosphatase |
Domain |
|
Sequence |
|
Sequence length |
1337 |
Interactions |
View interactions |