Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5787 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Protein tyrosine phosphatase receptor type B |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PTPRB |
SynonymsGene synonyms aliases
|
HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP |
ChromosomeChromosome number
|
12 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
12q15 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P23467 |
Protein name |
Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) |
Protein function |
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and |
PDB |
2AHS
,
2H02
,
2H03
,
2H04
,
2HC1
,
2HC2
,
2I3R
,
2I3U
,
2I4E
,
2I4G
,
2I4H
,
2I5X
,
8JBN
,
8JBY
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00041 |
fn3 |
24 → 103 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
112 → 194 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
290 → 368 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
378 → 460 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
468 → 547 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
555 → 633 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
644 → 725 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
732 → 812 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
819 → 899 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
908 → 986 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
996 → 1077 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
1086 → 1165 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
1174 → 1252 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
1262 → 1344 |
Fibronectin type III domain |
Domain |
PF00041 |
fn3 |
1356 → 1435 |
Fibronectin type III domain |
Domain |
PF18861 |
PTP_tm |
1473 → 1643 |
Transmembrane domain of protein tyrosine phosphatase, receptor type J |
Family |
PF00102 |
Y_phosphatase |
1727 → 1962 |
Protein-tyrosine phosphatase |
Domain |
|
Sequence |
|
Sequence length |
1997 |
Interactions |
View interactions |