PTPRB (protein tyrosine phosphatase receptor type B)

Gene

• Entrez ID: 5787
• Gene name: Protein tyrosine phosphatase receptor type B
• Gene symbol: PTPRB
• Synonyms: HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP
• Chromosome: 12
• Chromosome location: 12q15
• Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022308	hsa-miR-124-3p	Microarray	18668037
MIRT053404	hsa-miR-629-5p	Microarray	23807165
MIRT457963	hsa-miR-627-5p	PAR-CLIP	23592263
MIRT457964	hsa-miR-19b-3p	PAR-CLIP	23592263
MIRT457965	hsa-miR-19a-3p	PAR-CLIP	23592263
MIRT457966	hsa-miR-924	PAR-CLIP	23592263
MIRT457967	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT457968	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT457969	hsa-miR-455-5p	PAR-CLIP	23592263
MIRT457970	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT457972	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT641046	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT641047	hsa-miR-4279	HITS-CLIP	23824327
MIRT641048	hsa-miR-561-5p	HITS-CLIP	23824327
MIRT641049	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT641050	hsa-miR-6830-5p	HITS-CLIP	23824327
MIRT641051	hsa-miR-513b-3p	HITS-CLIP	23824327
MIRT641052	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT641053	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT641054	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT641055	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT641056	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT737004	hsa-miR-1283	PAR-CLIP	26701625
MIRT747260	hsa-miR-4699-3p	PAR-CLIP	26701625
MIRT750923	hsa-miR-5580-3p	PAR-CLIP	26701625
MIRT765383	hsa-miR-3190-5p	PAR-CLIP	27292025
MIRT766686	hsa-miR-3675-3p	PAR-CLIP	27292025
MIRT767727	hsa-miR-3926	PAR-CLIP	27292025
MIRT771016	hsa-miR-4684-5p	PAR-CLIP	27292025
MIRT774056	hsa-miR-548ac	PAR-CLIP	27292025
MIRT774074	hsa-miR-548ae-3p	PAR-CLIP	27292025
MIRT774094	hsa-miR-548ah-3p	PAR-CLIP	27292025
MIRT774121	hsa-miR-548aj-3p	PAR-CLIP	27292025
MIRT774144	hsa-miR-548am-3p	PAR-CLIP	27292025
MIRT774181	hsa-miR-548aq-3p	PAR-CLIP	27292025
MIRT774286	hsa-miR-548bb-3p	PAR-CLIP	27292025
MIRT774364	hsa-miR-548d-3p	PAR-CLIP	27292025
MIRT774405	hsa-miR-548h-3p	PAR-CLIP	27292025
MIRT774428	hsa-miR-548j-3p	PAR-CLIP	27292025
MIRT774520	hsa-miR-548s	PAR-CLIP	27292025
MIRT774566	hsa-miR-548x-3p	PAR-CLIP	27292025
MIRT774586	hsa-miR-548z	PAR-CLIP	27292025
MIRT778648	hsa-miR-6771-3p	PAR-CLIP	27292025
MIRT780327	hsa-miR-6849-3p	PAR-CLIP	27292025

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IBA	21873635
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	TAS	2170109
GO:0005515	Function	Protein binding	IPI	12840032, 12907755, 16101282, 19167335, 19451274, 28065597, 31980649
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	2170109
GO:0006470	Process	Protein dephosphorylation	TAS	2170109
GO:0006796	Process	Phosphate-containing compound metabolic process	TAS	2170109
GO:0016311	Process	Dephosphorylation	IDA	19116766, 19136612
GO:0035579	Component	Specific granule membrane	TAS
GO:0043235	Component	Receptor complex	IBA	21873635
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045296	Function	Cadherin binding	IBA	21873635
GO:0045296	Function	Cadherin binding	IPI	28926625
GO:0070821	Component	Tertiary granule membrane	TAS
GO:1990264	Process	Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IBA	21873635

Other IDs

• MIM: 176882
• HGNC: 9665
• e!Ensembl: ENSG00000127329

Protein

• UniProt ID: P23467
• Protein name: Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
• Protein function: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
• PDB: 2AHS, 2H02, 2H03, 2H04, 2HC1, 2HC2, 2I3R, 2I3U, 2I4E, 2I4G, 2I4H, 2I5X
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00041	fn3	24 → 103	Fibronectin type III domain	Domain
  PF00041	fn3	112 → 194	Fibronectin type III domain	Domain
  PF00041	fn3	290 → 368	Fibronectin type III domain	Domain
  PF00041	fn3	378 → 460	Fibronectin type III domain	Domain
  PF00041	fn3	468 → 547	Fibronectin type III domain	Domain
  PF00041	fn3	555 → 633	Fibronectin type III domain	Domain
  PF00041	fn3	644 → 725	Fibronectin type III domain	Domain
  PF00041	fn3	732 → 812	Fibronectin type III domain	Domain
  PF00041	fn3	819 → 899	Fibronectin type III domain	Domain
  PF00041	fn3	908 → 986	Fibronectin type III domain	Domain
  PF00041	fn3	996 → 1077	Fibronectin type III domain	Domain
  PF00041	fn3	1086 → 1165	Fibronectin type III domain	Domain
  PF00041	fn3	1174 → 1252	Fibronectin type III domain	Domain
  PF00041	fn3	1262 → 1344	Fibronectin type III domain	Domain
  PF00041	fn3	1356 → 1435	Fibronectin type III domain	Domain
  PF18861	PTP_tm	1473 → 1643	Transmembrane domain of protein tyrosine phosphatase, receptor type J	Family
  PF00102	Y_phosphatase	1727 → 1962	Protein-tyrosine phosphatase	Domain

• Sequence:

  MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSS
  DTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSK
  EKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYN
  IAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKG
  ILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTND
  GSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSC
  VSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLL
  NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANE
  TSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG
  DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNES
  ISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYL
  SVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYE
  NHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPK
  SENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWS
  GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAF
  IEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFE
  HTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAA
  GVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTE
  GRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFS
  FQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGD
  FDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTA
  PSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY
  GLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDS
  DFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDS
  TITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDE
  LKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCD
  PTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAI
  EGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTS
  CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYD
  ATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVM
  VTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLI
  RHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRI
  LQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPI
  YENVNPEYHRDPVYSRH

• Sequence length: 1997