PSMD7 (proteasome 26S subunit, non-ATPase 7)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5713 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Proteasome 26S subunit, non-ATPase 7 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PSMD7 |
SynonymsGene synonyms aliases
|
MOV34, P40, Rpn8, S12 |
ChromosomeChromosome number
|
16 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
16q23.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a |
miRNAmiRNA information provided by mirtarbase database.
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|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000165 |
Process |
MAPK cascade |
TAS |
|
GO:0000209 |
Process |
Protein polyubiquitination |
TAS |
|
GO:0000502 |
Component |
Proteasome complex |
IBA |
21873635 |
GO:0000502 |
Component |
Proteasome complex |
IDA |
17323924 |
GO:0002223 |
Process |
Stimulatory C-type lectin receptor signaling pathway |
TAS |
|
GO:0002479 |
Process |
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
TAS |
|
GO:0005515 |
Function |
Protein binding |
IPI |
19615732, 22078707, 25416956, 25959826, 26496610, 28514442, 32296183, 32814053 |
GO:0005576 |
Component |
Extracellular region |
TAS |
|
GO:0005634 |
Component |
Nucleus |
HDA |
21630459 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005838 |
Component |
Proteasome regulatory particle |
IEA |
|
GO:0006521 |
Process |
Regulation of cellular amino acid metabolic process |
TAS |
|
GO:0008237 |
Function |
Metallopeptidase activity |
IKR |
17559875 |
GO:0010972 |
Process |
Negative regulation of G2/M transition of mitotic cell cycle |
TAS |
|
GO:0016020 |
Component |
Membrane |
HDA |
19946888 |
GO:0016579 |
Process |
Protein deubiquitination |
TAS |
|
GO:0031145 |
Process |
Anaphase-promoting complex-dependent catabolic process |
TAS |
|
GO:0031146 |
Process |
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
TAS |
|
GO:0033209 |
Process |
Tumor necrosis factor-mediated signaling pathway |
TAS |
|
GO:0034774 |
Component |
Secretory granule lumen |
TAS |
|
GO:0038061 |
Process |
NIK/NF-kappaB signaling |
TAS |
|
GO:0038095 |
Process |
Fc-epsilon receptor signaling pathway |
TAS |
|
GO:0042803 |
Function |
Protein homodimerization activity |
IDA |
17559875 |
GO:0043161 |
Process |
Proteasome-mediated ubiquitin-dependent protein catabolic process |
IBA |
21873635 |
GO:0043161 |
Process |
Proteasome-mediated ubiquitin-dependent protein catabolic process |
TAS |
|
GO:0043312 |
Process |
Neutrophil degranulation |
TAS |
|
GO:0043488 |
Process |
Regulation of mRNA stability |
TAS |
|
GO:0043687 |
Process |
Post-translational protein modification |
TAS |
|
GO:0050852 |
Process |
T cell receptor signaling pathway |
TAS |
|
GO:0055085 |
Process |
Transmembrane transport |
TAS |
|
GO:0060071 |
Process |
Wnt signaling pathway, planar cell polarity pathway |
TAS |
|
GO:0061418 |
Process |
Regulation of transcription from RNA polymerase II promoter in response to hypoxia |
TAS |
|
GO:0070062 |
Component |
Extracellular exosome |
HDA |
20458337 |
GO:0070122 |
Function |
Isopeptidase activity |
IEA |
|
GO:0070498 |
Process |
Interleukin-1-mediated signaling pathway |
TAS |
|
GO:0090090 |
Process |
Negative regulation of canonical Wnt signaling pathway |
TAS |
|
GO:0090263 |
Process |
Positive regulation of canonical Wnt signaling pathway |
TAS |
|
GO:1901990 |
Process |
Regulation of mitotic cell cycle phase transition |
TAS |
|
GO:1902036 |
Process |
Regulation of hematopoietic stem cell differentiation |
TAS |
|
GO:1904813 |
Component |
Ficolin-1-rich granule lumen |
TAS |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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|
Protein
|
UniProt ID |
P51665 |
Protein name |
26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Mov34 protein homolog) (Proteasome subunit p40) |
Protein function |
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which |
PDB |
2O95
,
2O96
,
5GJQ
,
5GJR
,
5L4K
,
5LN3
,
5M32
,
5T0C
,
5T0G
,
5T0H
,
5T0I
,
5T0J
,
5VFP
,
5VFQ
,
5VFR
,
5VFS
,
5VFT
,
5VFU
,
5VGZ
,
5VHF
,
5VHH
,
5VHI
,
5VHS
,
6MSB
,
6MSD
,
6MSG
,
6MSH
,
6MSJ
,
6MSK
,
6WJD
,
6WJN
,
7QXN
,
7QXP
,
7QXU
,
7QXW
,
7QXX
,
7QY7
,
7QYA
,
7QYB
,
7W37
,
7W38
,
7W39
,
7W3A
,
7W3B
,
7W3C
,
7W3F
,
7W3G
,
7W3H
,
7W3I
,
7W3J
,
7W3K
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01398 |
JAB |
4 → 118 |
JAB1/Mov34/MPN/PAD-1 ubiquitin protease |
Family |
PF13012 |
MitMem_reg |
166 → 277 |
Maintenance of mitochondrial structure and function |
Family |
|
Sequence |
|
Sequence length |
324 |
Interactions |
View interactions |
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