PSMD3 (proteasome 26S subunit, non-ATPase 3)

Gene

• Entrez ID: 5709
• Gene name: Proteasome 26S subunit, non-ATPase 3
• Gene symbol: PSMD3
• Synonyms: P58, RPN3, S3, TSTA2
• Chromosome: 17
• Chromosome location: 17q21.1
• Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049247	hsa-miR-92a-3p	CLASH	23622248
MIRT045113	hsa-miR-186-5p	CLASH	23622248
MIRT044009	hsa-miR-378a-5p	CLASH	23622248
MIRT040625	hsa-miR-92b-3p	CLASH	23622248
MIRT039148	hsa-miR-769-5p	CLASH	23622248
MIRT036722	hsa-miR-760	CLASH	23622248
MIRT490810	hsa-miR-1276	PAR-CLIP	23592263
MIRT490809	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT490808	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT490807	hsa-miR-6814-5p	PAR-CLIP	23592263
MIRT490805	hsa-miR-4292	PAR-CLIP	23592263
MIRT490806	hsa-miR-6791-5p	PAR-CLIP	23592263
MIRT490804	hsa-miR-939-3p	PAR-CLIP	23592263
MIRT490803	hsa-miR-1285-3p	PAR-CLIP	23592263
MIRT490802	hsa-miR-3187-5p	PAR-CLIP	23592263
MIRT490801	hsa-miR-5189-5p	PAR-CLIP	23592263
MIRT490799	hsa-miR-612	PAR-CLIP	23592263
MIRT490800	hsa-miR-6860	PAR-CLIP	23592263
MIRT490798	hsa-miR-6859-3p	PAR-CLIP	23592263
MIRT490797	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT490796	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT490795	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT490794	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT490793	hsa-miR-3153	PAR-CLIP	23592263
MIRT490792	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT490791	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT490790	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT490789	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT490788	hsa-miR-224-5p	PAR-CLIP	23592263
MIRT490787	hsa-miR-181d-3p	PAR-CLIP	23592263
MIRT490786	hsa-miR-4667-5p	PAR-CLIP	23592263
MIRT490784	hsa-miR-4700-5p	PAR-CLIP	23592263
MIRT490785	hsa-miR-8089	PAR-CLIP	23592263
MIRT490783	hsa-miR-4731-5p	PAR-CLIP	23592263
MIRT490782	hsa-miR-765	PAR-CLIP	23592263
MIRT490781	hsa-miR-4505	PAR-CLIP	23592263
MIRT490780	hsa-miR-5787	PAR-CLIP	23592263
MIRT490779	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT490778	hsa-miR-3175	PAR-CLIP	23592263
MIRT490777	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT490776	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT490774	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT490775	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT490773	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT490810	hsa-miR-1276	PAR-CLIP	23592263
MIRT490809	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT490808	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT490807	hsa-miR-6814-5p	PAR-CLIP	23592263
MIRT490805	hsa-miR-4292	PAR-CLIP	23592263
MIRT490806	hsa-miR-6791-5p	PAR-CLIP	23592263
MIRT490804	hsa-miR-939-3p	PAR-CLIP	23592263
MIRT490803	hsa-miR-1285-3p	PAR-CLIP	23592263
MIRT490802	hsa-miR-3187-5p	PAR-CLIP	23592263
MIRT490801	hsa-miR-5189-5p	PAR-CLIP	23592263
MIRT490799	hsa-miR-612	PAR-CLIP	23592263
MIRT490800	hsa-miR-6860	PAR-CLIP	23592263
MIRT490798	hsa-miR-6859-3p	PAR-CLIP	23592263
MIRT490797	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT490796	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT490795	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT490794	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT490793	hsa-miR-3153	PAR-CLIP	23592263
MIRT490792	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT490791	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT490790	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT490789	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT490788	hsa-miR-224-5p	PAR-CLIP	23592263
MIRT490787	hsa-miR-181d-3p	PAR-CLIP	23592263
MIRT490786	hsa-miR-4667-5p	PAR-CLIP	23592263
MIRT490784	hsa-miR-4700-5p	PAR-CLIP	23592263
MIRT490785	hsa-miR-8089	PAR-CLIP	23592263
MIRT490783	hsa-miR-4731-5p	PAR-CLIP	23592263
MIRT490782	hsa-miR-765	PAR-CLIP	23592263
MIRT490781	hsa-miR-4505	PAR-CLIP	23592263
MIRT490780	hsa-miR-5787	PAR-CLIP	23592263
MIRT490779	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT490778	hsa-miR-3175	PAR-CLIP	23592263
MIRT490777	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT490776	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT490774	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT490775	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT490773	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT1270515	hsa-miR-101	CLIP-seq
MIRT1270516	hsa-miR-103a	CLIP-seq
MIRT1270517	hsa-miR-107	CLIP-seq
MIRT1270518	hsa-miR-1233	CLIP-seq
MIRT1270519	hsa-miR-1275	CLIP-seq
MIRT1270520	hsa-miR-144	CLIP-seq
MIRT1270521	hsa-miR-224	CLIP-seq
MIRT1270522	hsa-miR-3065-3p	CLIP-seq
MIRT1270523	hsa-miR-3160-3p	CLIP-seq
MIRT1270524	hsa-miR-370	CLIP-seq
MIRT1270525	hsa-miR-4487	CLIP-seq
MIRT1270526	hsa-miR-4525	CLIP-seq
MIRT1270527	hsa-miR-4640-3p	CLIP-seq
MIRT1270528	hsa-miR-4665-5p	CLIP-seq
MIRT1270529	hsa-miR-4718	CLIP-seq
MIRT1270530	hsa-miR-4723-5p	CLIP-seq
MIRT1270531	hsa-miR-4763-5p	CLIP-seq
MIRT1270532	hsa-miR-556-5p	CLIP-seq
MIRT1270533	hsa-miR-558	CLIP-seq
MIRT1270534	hsa-miR-625	CLIP-seq
MIRT1270535	hsa-miR-637	CLIP-seq
MIRT1270536	hsa-miR-939	CLIP-seq
MIRT2079495	hsa-miR-147	CLIP-seq
MIRT1270522	hsa-miR-3065-3p	CLIP-seq
MIRT2079496	hsa-miR-3144-5p	CLIP-seq
MIRT1270523	hsa-miR-3160-3p	CLIP-seq
MIRT2079497	hsa-miR-3191	CLIP-seq
MIRT2079498	hsa-miR-3911	CLIP-seq
MIRT1270525	hsa-miR-4487	CLIP-seq
MIRT1270527	hsa-miR-4640-3p	CLIP-seq
MIRT2079499	hsa-miR-4648	CLIP-seq
MIRT2079500	hsa-miR-4652-5p	CLIP-seq
MIRT2079501	hsa-miR-4654	CLIP-seq
MIRT2079502	hsa-miR-4668-5p	CLIP-seq
MIRT2079503	hsa-miR-4769-5p	CLIP-seq
MIRT1270533	hsa-miR-558	CLIP-seq
MIRT2079504	hsa-miR-644	CLIP-seq
MIRT1270515	hsa-miR-101	CLIP-seq
MIRT1270516	hsa-miR-103a	CLIP-seq
MIRT1270517	hsa-miR-107	CLIP-seq
MIRT1270518	hsa-miR-1233	CLIP-seq
MIRT1270519	hsa-miR-1275	CLIP-seq
MIRT2305788	hsa-miR-1285	CLIP-seq
MIRT1270520	hsa-miR-144	CLIP-seq
MIRT2305789	hsa-miR-149	CLIP-seq
MIRT2305790	hsa-miR-188-3p	CLIP-seq
MIRT2305791	hsa-miR-1909	CLIP-seq
MIRT2305792	hsa-miR-1976	CLIP-seq
MIRT2305793	hsa-miR-2114	CLIP-seq
MIRT1270521	hsa-miR-224	CLIP-seq
MIRT2305794	hsa-miR-300	CLIP-seq
MIRT1270522	hsa-miR-3065-3p	CLIP-seq
MIRT2079496	hsa-miR-3144-5p	CLIP-seq
MIRT1270523	hsa-miR-3160-3p	CLIP-seq
MIRT2305795	hsa-miR-3168	CLIP-seq
MIRT2305796	hsa-miR-3613-3p	CLIP-seq
MIRT2305797	hsa-miR-361-3p	CLIP-seq
MIRT2305798	hsa-miR-3617	CLIP-seq
MIRT2305799	hsa-miR-362-5p	CLIP-seq
MIRT2305800	hsa-miR-3652	CLIP-seq
MIRT2305801	hsa-miR-3667-3p	CLIP-seq
MIRT1270524	hsa-miR-370	CLIP-seq
MIRT2305802	hsa-miR-381	CLIP-seq
MIRT2305803	hsa-miR-4277	CLIP-seq
MIRT2305804	hsa-miR-4286	CLIP-seq
MIRT2305805	hsa-miR-4423-5p	CLIP-seq
MIRT2305806	hsa-miR-4430	CLIP-seq
MIRT2305807	hsa-miR-4435	CLIP-seq
MIRT1270525	hsa-miR-4487	CLIP-seq
MIRT2305808	hsa-miR-4509	CLIP-seq
MIRT1270526	hsa-miR-4525	CLIP-seq
MIRT2305809	hsa-miR-4532	CLIP-seq
MIRT1270527	hsa-miR-4640-3p	CLIP-seq
MIRT1270528	hsa-miR-4665-5p	CLIP-seq
MIRT2305810	hsa-miR-4667-3p	CLIP-seq
MIRT2305811	hsa-miR-4672	CLIP-seq
MIRT1270529	hsa-miR-4718	CLIP-seq
MIRT2305812	hsa-miR-4722-3p	CLIP-seq
MIRT1270530	hsa-miR-4723-5p	CLIP-seq
MIRT2305813	hsa-miR-4725-5p	CLIP-seq
MIRT1270531	hsa-miR-4763-5p	CLIP-seq
MIRT2305814	hsa-miR-500b	CLIP-seq
MIRT2305815	hsa-miR-501-5p	CLIP-seq
MIRT2305816	hsa-miR-504	CLIP-seq
MIRT2305817	hsa-miR-532-3p	CLIP-seq
MIRT2305818	hsa-miR-548c-3p	CLIP-seq
MIRT2305819	hsa-miR-554	CLIP-seq
MIRT1270532	hsa-miR-556-5p	CLIP-seq
MIRT1270533	hsa-miR-558	CLIP-seq
MIRT1270534	hsa-miR-625	CLIP-seq
MIRT1270535	hsa-miR-637	CLIP-seq
MIRT2305820	hsa-miR-641	CLIP-seq
MIRT1270536	hsa-miR-939	CLIP-seq
MIRT1270518	hsa-miR-1233	CLIP-seq
MIRT1270534	hsa-miR-625	CLIP-seq
MIRT1270535	hsa-miR-637	CLIP-seq
MIRT1270536	hsa-miR-939	CLIP-seq
MIRT2457362	hsa-miR-2355-5p	CLIP-seq
MIRT2457363	hsa-miR-3162-3p	CLIP-seq
MIRT2457364	hsa-miR-3679-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
BRCA2	Unknown	17563742

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0000502	Component	Proteasome complex	IDA	17323924
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002479	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS
GO:0005515	Function	Protein binding	IPI	15147878, 25416956, 25814554, 25910212, 26030138, 31515488, 32296183, 32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0006521	Process	Regulation of cellular amino acid metabolic process	TAS
GO:0008541	Component	Proteasome regulatory particle, lid subcomplex	IBA	21873635
GO:0010972	Process	Negative regulation of G2/M transition of mitotic cell cycle	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016579	Process	Protein deubiquitination	TAS
GO:0022624	Component	Proteasome accessory complex	ISS
GO:0030234	Function	Enzyme regulator activity	IEA
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	TAS
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	TAS
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	TAS
GO:0034774	Component	Secretory granule lumen	TAS
GO:0038061	Process	NIK/NF-kappaB signaling	TAS
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0042176	Process	Regulation of protein catabolic process	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043488	Process	Regulation of mRNA stability	TAS
GO:0043687	Process	Post-translational protein modification	TAS
GO:0050790	Process	Regulation of catalytic activity	IEA
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0055085	Process	Transmembrane transport	TAS
GO:0060071	Process	Wnt signaling pathway, planar cell polarity pathway	TAS
GO:0061418	Process	Regulation of transcription from RNA polymerase II promoter in response to hypoxia	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	TAS
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	TAS
GO:1901990	Process	Regulation of mitotic cell cycle phase transition	TAS
GO:1902036	Process	Regulation of hematopoietic stem cell differentiation	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 617676
• HGNC: 9560
• e!Ensembl: ENSG00000108344

Protein

• UniProt ID: O43242
• Protein name: 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)
• Protein function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which
• PDB: 5GJQ, 5GJR, 5L4K, 5LN3, 5M32, 5T0C, 5T0G, 5T0H, 5T0I, 5T0J, 5VFP, 5VFQ, 5VFR, 5VFS, 5VFT, 5VFU, 5VGZ, 5VHF, 5VHH, 5VHI, 5VHS, 6MSB, 6MSD, 6MSE, 6MSG, 6MSH, 6MSJ, 6MSK, 6WJD, 6WJN, 7QXN, 7QXP, 7QXU, 7QXW, 7QXX, 7QY7, 7QYA, 7QYB, 7W37, 7W38, 7W39, 7W3A, 7W3B, 7W3C, 7W3F, 7W3G, 7W3H, 7W3I, 7W3J, 7W3K, 7W3M
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01399	PCI	358 → 462	PCI domain	Domain
  PF08375	Rpn3_C	465 → 532	Proteasome regulatory subunit C-terminal	Family

• Sequence:

  MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAA
  EHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGF
  FTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKR
  YKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATL
  RHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQL
  EYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPY
  FLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLA
  DIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRI
  SFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP

• Sequence length: 534