PSMD13 (proteasome 26S subunit, non-ATPase 13)

Gene

• Entrez ID: 5719
• Gene name: Proteasome 26S subunit, non-ATPase 13
• Gene symbol: PSMD13
• Synonyms: HSPC027, Rpn9, S11, p40.5
• Chromosome: 11
• Chromosome location: 11p15.5
• Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047716	hsa-miR-10a-5p	CLASH	23622248
MIRT047503	hsa-miR-10b-5p	CLASH	23622248
MIRT047134	hsa-miR-183-5p	CLASH	23622248
MIRT045260	hsa-miR-186-5p	CLASH	23622248
MIRT040064	hsa-miR-615-3p	CLASH	23622248
MIRT038884	hsa-miR-93-3p	CLASH	23622248
MIRT1270458	hsa-miR-604	CLIP-seq
MIRT1270459	hsa-miR-647	CLIP-seq
MIRT2603050	hsa-miR-1184	CLIP-seq
MIRT2603051	hsa-miR-1205	CLIP-seq
MIRT2603052	hsa-miR-125a-5p	CLIP-seq
MIRT2603053	hsa-miR-125b	CLIP-seq
MIRT2603054	hsa-miR-1286	CLIP-seq
MIRT2603055	hsa-miR-1303	CLIP-seq
MIRT2603056	hsa-miR-132	CLIP-seq
MIRT2603057	hsa-miR-1324	CLIP-seq
MIRT2603058	hsa-miR-149	CLIP-seq
MIRT2603059	hsa-miR-185	CLIP-seq
MIRT2603060	hsa-miR-1910	CLIP-seq
MIRT2603061	hsa-miR-212	CLIP-seq
MIRT2603062	hsa-miR-2278	CLIP-seq
MIRT2603063	hsa-miR-3158-5p	CLIP-seq
MIRT2603064	hsa-miR-339-5p	CLIP-seq
MIRT2603065	hsa-miR-3667-5p	CLIP-seq
MIRT2603066	hsa-miR-4270	CLIP-seq
MIRT2603067	hsa-miR-4303	CLIP-seq
MIRT2603068	hsa-miR-4306	CLIP-seq
MIRT2603069	hsa-miR-4319	CLIP-seq
MIRT2603070	hsa-miR-4324	CLIP-seq
MIRT2603071	hsa-miR-4329	CLIP-seq
MIRT2603072	hsa-miR-4441	CLIP-seq
MIRT2603073	hsa-miR-4468	CLIP-seq
MIRT2603074	hsa-miR-451b	CLIP-seq
MIRT2603075	hsa-miR-4644	CLIP-seq
MIRT2603076	hsa-miR-4661-3p	CLIP-seq
MIRT2603077	hsa-miR-4722-5p	CLIP-seq
MIRT2603078	hsa-miR-4725-5p	CLIP-seq
MIRT2603079	hsa-miR-4733-5p	CLIP-seq
MIRT2603080	hsa-miR-4768-3p	CLIP-seq
MIRT2603081	hsa-miR-4768-5p	CLIP-seq
MIRT2603082	hsa-miR-4773	CLIP-seq
MIRT2603083	hsa-miR-4786-5p	CLIP-seq
MIRT2603084	hsa-miR-504	CLIP-seq
MIRT2603085	hsa-miR-564	CLIP-seq
MIRT2603086	hsa-miR-622	CLIP-seq
MIRT2603087	hsa-miR-663b	CLIP-seq
MIRT2603088	hsa-miR-769-5p	CLIP-seq
MIRT2603050	hsa-miR-1184	CLIP-seq
MIRT2603051	hsa-miR-1205	CLIP-seq
MIRT2603052	hsa-miR-125a-5p	CLIP-seq
MIRT2603053	hsa-miR-125b	CLIP-seq
MIRT2603054	hsa-miR-1286	CLIP-seq
MIRT2603055	hsa-miR-1303	CLIP-seq
MIRT2603056	hsa-miR-132	CLIP-seq
MIRT2603057	hsa-miR-1324	CLIP-seq
MIRT2603058	hsa-miR-149	CLIP-seq
MIRT2603059	hsa-miR-185	CLIP-seq
MIRT2603060	hsa-miR-1910	CLIP-seq
MIRT2603061	hsa-miR-212	CLIP-seq
MIRT2603062	hsa-miR-2278	CLIP-seq
MIRT2603063	hsa-miR-3158-5p	CLIP-seq
MIRT2603064	hsa-miR-339-5p	CLIP-seq
MIRT2603065	hsa-miR-3667-5p	CLIP-seq
MIRT2603066	hsa-miR-4270	CLIP-seq
MIRT2603068	hsa-miR-4306	CLIP-seq
MIRT2603069	hsa-miR-4319	CLIP-seq
MIRT2603070	hsa-miR-4324	CLIP-seq
MIRT2603071	hsa-miR-4329	CLIP-seq
MIRT2603072	hsa-miR-4441	CLIP-seq
MIRT2603074	hsa-miR-451b	CLIP-seq
MIRT2603075	hsa-miR-4644	CLIP-seq
MIRT2603076	hsa-miR-4661-3p	CLIP-seq
MIRT2603077	hsa-miR-4722-5p	CLIP-seq
MIRT2603078	hsa-miR-4725-5p	CLIP-seq
MIRT2603079	hsa-miR-4733-5p	CLIP-seq
MIRT2603080	hsa-miR-4768-3p	CLIP-seq
MIRT2603081	hsa-miR-4768-5p	CLIP-seq
MIRT2603082	hsa-miR-4773	CLIP-seq
MIRT2603083	hsa-miR-4786-5p	CLIP-seq
MIRT2603084	hsa-miR-504	CLIP-seq
MIRT2603085	hsa-miR-564	CLIP-seq
MIRT2603086	hsa-miR-622	CLIP-seq
MIRT2603087	hsa-miR-663b	CLIP-seq
MIRT2603088	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0000502	Component	Proteasome complex	IDA	17323924
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002479	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS
GO:0005198	Function	Structural molecule activity	IBA	21873635
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005838	Component	Proteasome regulatory particle	TAS	9714768
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0006521	Process	Regulation of cellular amino acid metabolic process	TAS
GO:0007127	Process	Meiosis I	IEA
GO:0008541	Component	Proteasome regulatory particle, lid subcomplex	IBA	21873635
GO:0010972	Process	Negative regulation of G2/M transition of mitotic cell cycle	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016579	Process	Protein deubiquitination	TAS
GO:0022624	Component	Proteasome accessory complex	ISS
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	TAS
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	TAS
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	TAS
GO:0034774	Component	Secretory granule lumen	TAS
GO:0038061	Process	NIK/NF-kappaB signaling	TAS
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	TAS
GO:0043248	Process	Proteasome assembly	IBA	21873635
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043488	Process	Regulation of mRNA stability	TAS
GO:0043687	Process	Post-translational protein modification	TAS
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0055085	Process	Transmembrane transport	TAS
GO:0060071	Process	Wnt signaling pathway, planar cell polarity pathway	TAS
GO:0061418	Process	Regulation of transcription from RNA polymerase II promoter in response to hypoxia	TAS
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	TAS
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	TAS
GO:1901990	Process	Regulation of mitotic cell cycle phase transition	TAS
GO:1902036	Process	Regulation of hematopoietic stem cell differentiation	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 603481
• HGNC: 9558
• e!Ensembl: ENSG00000185627

Protein

• UniProt ID: Q9UNM6
• Protein name: 26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5)
• Protein function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which
• PDB: 5GJQ, 5GJR, 5L4K, 5LN3, 5M32, 5T0C, 5T0G, 5T0H, 5T0I, 5T0J, 5VFP, 5VFQ, 5VFR, 5VFS, 5VFT, 5VFU, 5VGZ, 5VHF, 5VHH, 5VHI, 5VHS, 6MSB, 6MSD, 6MSE, 6MSG, 6MSH, 6MSJ, 6MSK, 6WJD, 6WJN, 7QXN, 7QXP, 7QXU, 7QXW, 7QXX, 7QY7, 7QYA, 7QYB, 7W37, 7W38, 7W39, 7W3A, 7W3B, 7W3C, 7W3F, 7W3G, 7W3H, 7W3I, 7W3J, 7W3K, 7W3M
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01399	PCI	231 → 335	PCI domain	Domain

• Sequence:

  MKDVPGFLQQSQNSGPGQPAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLY
  ENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKSSDEAVILCKTAIGA
  LKLNIGDLQVTKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFL
  GCVDIKDLPVSEQQERAFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAF
  NSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIAKSA
  KITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDV
  KSMEMLVEHQAHDILT

• Sequence length: 376