Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5716 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Proteasome 26S subunit, non-ATPase 10 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PSMD10 |
SynonymsGene synonyms aliases
|
dJ889N15.2, p28, p28(GANK) |
ChromosomeChromosome number
|
X |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
Xq22.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011] |
miRNAmiRNA information provided by mirtarbase database.
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|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000122 |
Process |
Negative regulation of transcription by RNA polymerase II |
IDA |
16023600 |
GO:0000165 |
Process |
MAPK cascade |
TAS |
|
GO:0000209 |
Process |
Protein polyubiquitination |
TAS |
|
GO:0000502 |
Component |
Proteasome complex |
IDA |
17323924 |
GO:0002223 |
Process |
Stimulatory C-type lectin receptor signaling pathway |
TAS |
|
GO:0002479 |
Process |
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
TAS |
|
GO:0005515 |
Function |
Protein binding |
IPI |
10613832, 11900540, 12525503, 16023600, 16189514, 17003112, 19490896, 21988832, 24338975, 25416956, 26972000, 32296183 |
GO:0005634 |
Component |
Nucleus |
IDA |
18040287 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IDA |
18040287 |
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006521 |
Process |
Regulation of cellular amino acid metabolic process |
TAS |
|
GO:0006915 |
Process |
Apoptotic process |
IEA |
|
GO:0007253 |
Process |
Cytoplasmic sequestering of NF-kappaB |
IDA |
18040287 |
GO:0008134 |
Function |
Transcription factor binding |
IPI |
18040287 |
GO:0008540 |
Component |
Proteasome regulatory particle, base subcomplex |
IDA |
19490896 |
GO:0010972 |
Process |
Negative regulation of G2/M transition of mitotic cell cycle |
TAS |
|
GO:0016579 |
Process |
Protein deubiquitination |
TAS |
|
GO:0030307 |
Process |
Positive regulation of cell growth |
IDA |
10613832 |
GO:0031145 |
Process |
Anaphase-promoting complex-dependent catabolic process |
TAS |
|
GO:0031146 |
Process |
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
TAS |
|
GO:0031398 |
Process |
Positive regulation of protein ubiquitination |
IMP |
16023600 |
GO:0032088 |
Process |
Negative regulation of NF-kappaB transcription factor activity |
IDA |
18040287 |
GO:0032436 |
Process |
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
IDA |
16023600 |
GO:0032436 |
Process |
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
TAS |
10613832 |
GO:0033209 |
Process |
Tumor necrosis factor-mediated signaling pathway |
TAS |
|
GO:0038061 |
Process |
NIK/NF-kappaB signaling |
TAS |
|
GO:0038095 |
Process |
Fc-epsilon receptor signaling pathway |
TAS |
|
GO:0043066 |
Process |
Negative regulation of apoptotic process |
IDA |
16023600 |
GO:0043066 |
Process |
Negative regulation of apoptotic process |
IMP |
19729910 |
GO:0043161 |
Process |
Proteasome-mediated ubiquitin-dependent protein catabolic process |
TAS |
|
GO:0043409 |
Process |
Negative regulation of MAPK cascade |
IMP |
19729910 |
GO:0043488 |
Process |
Regulation of mRNA stability |
TAS |
|
GO:0043518 |
Process |
Negative regulation of DNA damage response, signal transduction by p53 class mediator |
IDA |
16023600 |
GO:0043687 |
Process |
Post-translational protein modification |
TAS |
|
GO:0045111 |
Component |
Intermediate filament cytoskeleton |
IDA |
|
GO:0045737 |
Process |
Positive regulation of cyclin-dependent protein serine/threonine kinase activity |
IDA |
11900540 |
GO:0050852 |
Process |
T cell receptor signaling pathway |
TAS |
|
GO:0055085 |
Process |
Transmembrane transport |
TAS |
|
GO:0060071 |
Process |
Wnt signaling pathway, planar cell polarity pathway |
TAS |
|
GO:0061418 |
Process |
Regulation of transcription from RNA polymerase II promoter in response to hypoxia |
TAS |
|
GO:0070498 |
Process |
Interleukin-1-mediated signaling pathway |
TAS |
|
GO:0070682 |
Process |
Proteasome regulatory particle assembly |
IMP |
19490896 |
GO:0090090 |
Process |
Negative regulation of canonical Wnt signaling pathway |
TAS |
|
GO:0090201 |
Process |
Negative regulation of release of cytochrome c from mitochondria |
IMP |
19729910 |
GO:0090263 |
Process |
Positive regulation of canonical Wnt signaling pathway |
TAS |
|
GO:1901990 |
Process |
Regulation of mitotic cell cycle phase transition |
TAS |
|
GO:1902036 |
Process |
Regulation of hematopoietic stem cell differentiation |
TAS |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
O75832 |
Protein name |
26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) |
Protein function |
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.; Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export. |
PDB |
1QYM
,
1TR4
,
1UOH
,
4NIK
,
5VHF
,
5VHH
,
5VHI
,
5VHJ
,
5VHM
,
5VHN
,
5VHO
,
5VHP
,
5VHQ
,
5VHR
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF12796 |
Ank_2 |
8 → 103 |
Ankyrin repeats (3 copies) |
Repeat |
PF13637 |
Ank_4 |
40 → 93 |
|
Repeat |
PF13637 |
Ank_4 |
73 → 126 |
|
Repeat |
PF13637 |
Ank_4 |
139 → 184 |
|
Repeat |
|
Sequence |
|
Sequence length |
226 |
Interactions |
View interactions |