PRPS2 (phosphoribosyl pyrophosphate synthetase 2)

Gene

• Entrez ID: 5634
• Gene name: Phosphoribosyl pyrophosphate synthetase 2
• Gene symbol: PRPS2
• Synonyms: PRSII
• Chromosome: X
• Chromosome location: Xp22.2
• Summary: This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024389	hsa-miR-215-5p	Microarray	19074876
MIRT026537	hsa-miR-192-5p	Microarray	19074876
MIRT029585	hsa-miR-26b-5p	Microarray	19088304

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0002189	Component	Ribose phosphate diphosphokinase complex	IBA	21873635
GO:0004749	Function	Ribose phosphate diphosphokinase activity	IBA	21873635
GO:0004749	Function	Ribose phosphate diphosphokinase activity	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 26496610, 31515488, 32814053
GO:0005524	Function	ATP binding	IBA	21873635
GO:0005524	Function	ATP binding	ISS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006015	Process	5-phosphoribose 1-diphosphate biosynthetic process	IBA	21873635
GO:0006015	Process	5-phosphoribose 1-diphosphate biosynthetic process	IEA
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	2538352
GO:0006164	Process	Purine nucleotide biosynthetic process	IBA	21873635
GO:0006167	Process	AMP biosynthetic process	IEA
GO:0009116	Process	Nucleoside metabolic process	IEA
GO:0016208	Function	AMP binding	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016310	Process	Phosphorylation	IEA
GO:0019003	Function	GDP binding	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0031100	Process	Animal organ regeneration	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0043531	Function	ADP binding	IEA

Other IDs

• MIM: 311860
• HGNC: 9465
• e!Ensembl: ENSG00000101911

Protein

• UniProt ID: P11908
• Protein name: Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II)
• Protein function: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13793	Pribosyltran_N	4 → 120	N-terminal domain of ribose phosphate pyrophosphokinase	Domain
  PF14572	Pribosyl_synth	200 → 314	Phosphoribosyl synthetase-associated domain	Domain

• Sequence:

  MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGC
  GEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG
  ADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTS
  IADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG
  ATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAI
  RRTHNGESVSYLFSHVPL

• Sequence length: 318