PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1)

Gene

• Entrez ID: 221823
• Gene name: Phosphoribosyl pyrophosphate synthetase 1 like 1
• Gene symbol: PRPS1L1
• Synonyms: PRPS1, PRPS3, PRPSL, PRS-III
• Chromosome: 7
• Chromosome location: 7p21.1
• Summary: This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. These enzymes convert pyrimidine, purine or pyridine bases to the corresponding ribonucleoside monophosphates. In vitro transcription/translation and site-directed mutagenesis studies indicate that translation of this mRNA initiates exclusively at a non-AUG (ACG) codon. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT443296	hsa-miR-559	PAR-CLIP	22100165
MIRT443297	hsa-miR-548y	PAR-CLIP	22100165
MIRT443298	hsa-miR-548w	PAR-CLIP	22100165
MIRT443299	hsa-miR-548o-5p	PAR-CLIP	22100165
MIRT443300	hsa-miR-548j-5p	PAR-CLIP	22100165
MIRT443301	hsa-miR-548i	PAR-CLIP	22100165
MIRT443302	hsa-miR-548h-5p	PAR-CLIP	22100165
MIRT443303	hsa-miR-548d-5p	PAR-CLIP	22100165
MIRT443304	hsa-miR-548c-5p	PAR-CLIP	22100165
MIRT443305	hsa-miR-548bb-5p	PAR-CLIP	22100165
MIRT443306	hsa-miR-548b-5p	PAR-CLIP	22100165
MIRT443307	hsa-miR-548ay-5p	PAR-CLIP	22100165
MIRT443308	hsa-miR-548au-5p	PAR-CLIP	22100165
MIRT443309	hsa-miR-548as-5p	PAR-CLIP	22100165
MIRT443310	hsa-miR-548ar-5p	PAR-CLIP	22100165
MIRT443311	hsa-miR-548aq-5p	PAR-CLIP	22100165
MIRT443312	hsa-miR-548ap-5p	PAR-CLIP	22100165
MIRT443313	hsa-miR-548am-5p	PAR-CLIP	22100165
MIRT443314	hsa-miR-548ak	PAR-CLIP	22100165
MIRT443315	hsa-miR-548ae-5p	PAR-CLIP	22100165
MIRT443316	hsa-miR-548ad-5p	PAR-CLIP	22100165
MIRT443317	hsa-miR-548ab	PAR-CLIP	22100165
MIRT443318	hsa-miR-548a-5p	PAR-CLIP	22100165
MIRT521623	hsa-miR-6516-5p	PAR-CLIP	23446348
MIRT521625	hsa-miR-455-3p	PAR-CLIP	23446348
MIRT521626	hsa-miR-4497	PAR-CLIP	23446348
MIRT521627	hsa-miR-25-5p	PAR-CLIP	23446348
MIRT521628	hsa-miR-6086	PAR-CLIP	23446348
MIRT521629	hsa-miR-658	PAR-CLIP	23446348
MIRT521630	hsa-miR-377-5p	PAR-CLIP	23446348
MIRT521631	hsa-miR-4459	PAR-CLIP	23446348
MIRT521632	hsa-miR-6087	PAR-CLIP	23446348
MIRT573870	hsa-miR-222-3p	PAR-CLIP	20371350
MIRT573871	hsa-miR-221-3p	PAR-CLIP	20371350
MIRT573872	hsa-miR-8082	PAR-CLIP	20371350
MIRT573873	hsa-miR-3134	PAR-CLIP	20371350
MIRT573874	hsa-miR-4534	PAR-CLIP	20371350
MIRT573875	hsa-miR-4772-5p	PAR-CLIP	20371350
MIRT573876	hsa-miR-484	PAR-CLIP	20371350
MIRT573877	hsa-miR-3155b	PAR-CLIP	20371350
MIRT573878	hsa-miR-3155a	PAR-CLIP	20371350
MIRT573879	hsa-miR-376c-3p	PAR-CLIP	20371350

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0002189	Component	Ribose phosphate diphosphokinase complex	IBA	21873635
GO:0004749	Function	Ribose phosphate diphosphokinase activity	IBA	21873635
GO:0004749	Function	Ribose phosphate diphosphokinase activity	ISS
GO:0004749	Function	Ribose phosphate diphosphokinase activity	NAS	2168892
GO:0005524	Function	ATP binding	IBA	21873635
GO:0005524	Function	ATP binding	ISS
GO:0005575	Component	Cellular_component	ND
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006015	Process	5-phosphoribose 1-diphosphate biosynthetic process	IBA	21873635
GO:0006015	Process	5-phosphoribose 1-diphosphate biosynthetic process	IEA
GO:0006164	Process	Purine nucleotide biosynthetic process	IBA	21873635
GO:0008584	Process	Male gonad development	IEA
GO:0009116	Process	Nucleoside metabolic process	IEA
GO:0009156	Process	Ribonucleoside monophosphate biosynthetic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016310	Process	Phosphorylation	IEA
GO:0042803	Function	Protein homodimerization activity	ISS

Other IDs

• MIM: 611566
• HGNC: 9463
• e!Ensembl: ENSG00000229937

Protein

• UniProt ID: P21108
• Protein name: Ribose-phosphate pyrophosphokinase 3 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 1-like 1) (PRPS1-like 1) (Phosphoribosyl pyrophosphate synthase III) (PRS-III)
• Protein function: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13793	Pribosyltran_N	4 → 120	N-terminal domain of ribose phosphate pyrophosphokinase	Domain
  PF14572	Pribosyl_synth	199 → 314	Phosphoribosyl synthetase-associated domain	Domain

• Sequence:

  MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIDESVRGEDVYIVQSGC
  GEINDSLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRSPISAKLVANMLSIAG
  ADHIITMDLHASQIQGFFDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKRVTS
  IADQLNVDFALIHKERKKANEVDCIVLVGDVNDRVAILVDDMADTCVTICLAADKLLSAG
  ATRVYAILTHGIFSGPAISRINTACFEAVVVTNTIPQDEKMKHCSKIRVIDISMILAEAI
  RRTHNGESVSYLFSHVPL

• Sequence length: 318