PRKCG (protein kinase C gamma)

Gene

• Entrez ID: 5582
• Gene name: Protein kinase C gamma
• Gene symbol: PRKCG
• Synonyms: PKC-gamma, PKCC, PKCG, PKCI(3), PKCgamma, SCA14
• Chromosome: 19
• Chromosome location: 19q13.42
• Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in d

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs78437096	T>A,C,G	Benign, pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs121918511	C>T	Pathogenic	Coding sequence variant, missense variant
rs121918512	T>C	Pathogenic	Coding sequence variant, missense variant
rs121918513	G>A	Pathogenic	Coding sequence variant, missense variant
rs121918514	G>A	Pathogenic	Coding sequence variant, missense variant
rs121918515	A>G	Pathogenic	Coding sequence variant, missense variant
rs121918516	T>C	Pathogenic	Coding sequence variant, missense variant
rs121918517	A>C,G	Pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs121918518	C>G	Pathogenic	Coding sequence variant, missense variant
rs386134157	A>G	Pathogenic	Missense variant, coding sequence variant
rs386134158	G>C	Pathogenic	Missense variant, coding sequence variant
rs386134159	G>T	Pathogenic	Missense variant, coding sequence variant
rs386134160	T>A,C	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs386134161	ACACAA>-	Pathogenic	Coding sequence variant, inframe deletion
rs386134162	G>A	Pathogenic	Missense variant, coding sequence variant
rs386134163	C>T	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs386134164	G>A,C	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs386134165	G>A	Pathogenic	Missense variant, coding sequence variant
rs386134166	T>A,C	Pathogenic	Missense variant, coding sequence variant
rs386134167	G>A	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs386134168	T>A,C	Pathogenic	Missense variant, coding sequence variant
rs386134169	C>A	Pathogenic	Missense variant, coding sequence variant
rs386134170	GC>TT	Pathogenic	Missense variant, coding sequence variant
rs386134171	G>A	Pathogenic	Missense variant, coding sequence variant
rs387906679	G>T	Pathogenic	Coding sequence variant, missense variant
rs797045900	T>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1303074743	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1406338491	G>A,T	Likely-pathogenic	Splice donor variant
rs1555806333	G>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1555808841	GTAATCTCACCCGCCGCCACTAGGTGTCCCCAACGTCCCCTCCGCCGTGCCGGCGGCAGCCCCACTTCACCCCCAACTTCACCACCCCCTGTCCCATTCTAG>-	Pathogenic	Stop lost, terminator codon variant, splice donor variant, inframe indel, intron variant, 3 prime UTR variant, splice acceptor variant
rs1599938631	G>A	Uncertain-significance, likely-pathogenic	Coding sequence variant, missense variant
rs1599943097	C>A	Likely-pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017708	hsa-miR-335-5p	Microarray	18185580
MIRT1263248	hsa-miR-3150b-3p	CLIP-seq
MIRT1263249	hsa-miR-4779	CLIP-seq
MIRT1263250	hsa-miR-4784	CLIP-seq
MIRT1263251	hsa-miR-765	CLIP-seq
MIRT1552563	hsa-miR-1243	CLIP-seq
MIRT1552564	hsa-miR-1281	CLIP-seq
MIRT1552565	hsa-miR-3654	CLIP-seq
MIRT1263249	hsa-miR-4779	CLIP-seq
MIRT1263251	hsa-miR-765	CLIP-seq
MIRT1552563	hsa-miR-1243	CLIP-seq
MIRT1552564	hsa-miR-1281	CLIP-seq
MIRT2077475	hsa-miR-1324	CLIP-seq
MIRT1552565	hsa-miR-3654	CLIP-seq
MIRT2077476	hsa-miR-4475	CLIP-seq
MIRT1263249	hsa-miR-4779	CLIP-seq
MIRT2077477	hsa-miR-615-3p	CLIP-seq
MIRT1263251	hsa-miR-765	CLIP-seq
MIRT1263248	hsa-miR-3150b-3p	CLIP-seq
MIRT2457162	hsa-miR-4693-3p	CLIP-seq
MIRT1263250	hsa-miR-4784	CLIP-seq
MIRT1263251	hsa-miR-765	CLIP-seq
MIRT1263248	hsa-miR-3150b-3p	CLIP-seq
MIRT2457162	hsa-miR-4693-3p	CLIP-seq
MIRT1263250	hsa-miR-4784	CLIP-seq
MIRT1263251	hsa-miR-765	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004672	Function	Protein kinase activity	IDA	15808853
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004697	Function	Protein kinase C activity	TAS	3755548
GO:0004698	Function	Calcium-dependent protein kinase C activity	IEA
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IDA	22797923
GO:0005515	Function	Protein binding	IPI	22939624, 31980649, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	ISS
GO:0005911	Component	Cell-cell junction	IEA
GO:0006468	Process	Protein phosphorylation	TAS	3755548
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007611	Process	Learning or memory	IEA
GO:0007635	Process	Chemosensory behavior	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0016310	Process	Phosphorylation	IDA	15808853
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0030168	Process	Platelet activation	TAS
GO:0030425	Component	Dendrite	ISS
GO:0031397	Process	Negative regulation of protein ubiquitination	IDA	15808853
GO:0032095	Process	Regulation of response to food	ISS
GO:0032425	Process	Positive regulation of mismatch repair	IDA	15808853
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0042177	Process	Negative regulation of protein catabolic process	IDA	15808853
GO:0042752	Process	Regulation of circadian rhythm	ISS
GO:0043278	Process	Response to morphine	ISS
GO:0043524	Process	Negative regulation of neuron apoptotic process	ISS
GO:0044305	Component	Calyx of Held	IEA
GO:0046777	Process	Protein autophosphorylation	IEA
GO:0048265	Process	Response to pain	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	ISS
GO:0048511	Process	Rhythmic process	IEA
GO:0050764	Process	Regulation of phagocytosis	IEA
GO:0060384	Process	Innervation	IEA
GO:0097060	Component	Synaptic membrane	IEA
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA
GO:0099523	Component	Presynaptic cytosol	IEA
GO:0099524	Component	Postsynaptic cytosol	IEA
GO:1901799	Process	Negative regulation of proteasomal protein catabolic process	ISS
GO:1990911	Process	Response to psychosocial stress	IEA
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IEA

Other IDs

• MIM: 176980
• HGNC: 9402
• e!Ensembl: ENSG00000126583

Protein

• UniProt ID: P05129
• Protein name: Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13)
• Protein function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation
• PDB: 2E73, 2UZP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00130	C1_1	36 → 88	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
  PF00130	C1_1	101 → 153	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
  PF00168	C2	171 → 277	C2 domain	Domain
  PF00069	Pkinase	351 → 613	Protein kinase domain	Domain
  PF00433	Pkinase_C	639 → 675	Protein kinase C terminal domain	Family

• Sequence:

  MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIG
  KQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSL
  LYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEA
  RNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRL
  SVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQ
  KFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKG
  SFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQL
  HSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRD
  LKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWS
  FGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGS
  GPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRL
  VLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM

• Sequence length: 697