GediPNet logo

PRKCE (protein kinase C epsilon)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5581
Gene nameGene Name - the full gene name approved by the HGNC.
Protein kinase C epsilon
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PRKCE
SynonymsGene synonyms aliases
PKCE, nPKC-epsilon
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p21
SummarySummary of gene provided in NCBI Entrez Gene.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003667 hsa-miR-205-5p immunoblot, qRT-PCR 19244118
MIRT007205 hsa-miR-1-3p Luciferase reporter assay 23226300
MIRT007286 hsa-miR-31-5p Luciferase reporter assay 23364795
MIRT027937 hsa-miR-96-5p Sequencing 20371350
MIRT030913 hsa-miR-21-5p Microarray 18591254
Transcription factors
Transcription factor Regulation Reference
PAX5 Unknown 9190940
SP1 Repression 24825907
STAT1 Repression 24825907
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002281 Process Macrophage activation involved in immune response IEA
GO:0003785 Function Actin monomer binding ISS
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 15695813
GO:0004697 Function Protein kinase C activity IDA 18556656
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q02156
Protein name Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon)
Protein function Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, m
PDB 2WH0 , 5LIH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00168 C2
6 119
C2 domain
Domain
PF00130 C1_1
170 223
Phorbol esters/diacylglycerol binding domain (C1 domain)
Domain
PF00130 C1_1
243 295
Phorbol esters/diacylglycerol binding domain (C1 domain)
Domain
PF00069 Pkinase
408 668
Protein kinase domain
Domain
PF00433 Pkinase_C
689 730
Protein kinase C terminal domain
Family
Sequence
Sequence length 737
Interactions View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412