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PRKCB (protein kinase C beta)

Gene

5579

Protein kinase C beta

PRKCB

PKC-beta, PKCB, PKCI(2), PKCbeta, PRKCB1, PRKCB2

16p12.2-p12.1

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in d

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1131692056	G>T	Pathogenic	Coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022275	hsa-miR-124-3p	Microarray	18668037
MIRT718805	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT654742	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT718804	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT718803	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT718802	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT654756	hsa-miR-488-5p	HITS-CLIP	23824327
MIRT654755	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT654754	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT654753	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT654751	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT654752	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT654750	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT654749	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654747	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654748	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT654746	hsa-miR-6074	HITS-CLIP	23824327
MIRT654745	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT654744	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT654743	hsa-miR-1248	HITS-CLIP	23824327
MIRT654742	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT654741	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT608983	hsa-miR-3609	HITS-CLIP	24906430
MIRT608982	hsa-miR-548ah-5p	HITS-CLIP	24906430
MIRT608981	hsa-miR-106a-5p	HITS-CLIP	24906430
MIRT608980	hsa-miR-106b-5p	HITS-CLIP	24906430
MIRT608979	hsa-miR-17-5p	HITS-CLIP	24906430
MIRT608978	hsa-miR-20a-5p	HITS-CLIP	24906430
MIRT608977	hsa-miR-20b-5p	HITS-CLIP	24906430
MIRT608976	hsa-miR-519d-3p	HITS-CLIP	24906430
MIRT608975	hsa-miR-526b-3p	HITS-CLIP	24906430
MIRT608974	hsa-miR-93-5p	HITS-CLIP	24906430
MIRT395213	hsa-miR-4796-3p	HITS-CLIP	24906430
MIRT395211	hsa-miR-142-5p	HITS-CLIP	24906430
MIRT395214	hsa-miR-5590-3p	HITS-CLIP	24906430
MIRT608973	hsa-miR-4742-3p	HITS-CLIP	24906430
MIRT608972	hsa-miR-1537-5p	HITS-CLIP	24906430
MIRT608971	hsa-miR-4718	HITS-CLIP	24906430
MIRT608970	hsa-miR-4999-5p	HITS-CLIP	24906430
MIRT395212	hsa-miR-3650	HITS-CLIP	24906430
MIRT395216	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608969	hsa-miR-4455	HITS-CLIP	24906430
MIRT608968	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT442227	hsa-miR-890	PAR-CLIP	22100165
MIRT442226	hsa-miR-300	PAR-CLIP	22100165
MIRT442225	hsa-miR-381-3p	PAR-CLIP	22100165
MIRT442224	hsa-miR-3614-5p	PAR-CLIP	22100165
MIRT442223	hsa-miR-1261	PAR-CLIP	22100165
MIRT608981	hsa-miR-106a-5p	HITS-CLIP	27418678
MIRT608981	hsa-miR-106a-5p	HITS-CLIP	27418678
MIRT608980	hsa-miR-106b-5p	HITS-CLIP	27418678
MIRT608980	hsa-miR-106b-5p	HITS-CLIP	27418678
MIRT395211	hsa-miR-142-5p	HITS-CLIP	27418678
MIRT395211	hsa-miR-142-5p	HITS-CLIP	27418678
MIRT608972	hsa-miR-1537-5p	HITS-CLIP	27418678
MIRT608972	hsa-miR-1537-5p	HITS-CLIP	27418678
MIRT608979	hsa-miR-17-5p	HITS-CLIP	27418678
MIRT608979	hsa-miR-17-5p	HITS-CLIP	27418678
MIRT608978	hsa-miR-20a-5p	HITS-CLIP	27418678
MIRT608978	hsa-miR-20a-5p	HITS-CLIP	27418678
MIRT608977	hsa-miR-20b-5p	HITS-CLIP	27418678
MIRT608977	hsa-miR-20b-5p	HITS-CLIP	27418678
MIRT608983	hsa-miR-3609	HITS-CLIP	27418678
MIRT608983	hsa-miR-3609	HITS-CLIP	27418678
MIRT395212	hsa-miR-3650	HITS-CLIP	27418678
MIRT395212	hsa-miR-3650	HITS-CLIP	27418678
MIRT608969	hsa-miR-4455	HITS-CLIP	27418678
MIRT608969	hsa-miR-4455	HITS-CLIP	27418678
MIRT608971	hsa-miR-4718	HITS-CLIP	27418678
MIRT608971	hsa-miR-4718	HITS-CLIP	27418678
MIRT608973	hsa-miR-4742-3p	HITS-CLIP	27418678
MIRT395213	hsa-miR-4796-3p	HITS-CLIP	27418678
MIRT395213	hsa-miR-4796-3p	HITS-CLIP	27418678
MIRT608970	hsa-miR-4999-5p	HITS-CLIP	27418678
MIRT608970	hsa-miR-4999-5p	HITS-CLIP	27418678
MIRT608976	hsa-miR-519d-3p	HITS-CLIP	27418678
MIRT608976	hsa-miR-519d-3p	HITS-CLIP	27418678
MIRT608975	hsa-miR-526b-3p	HITS-CLIP	27418678
MIRT608975	hsa-miR-526b-3p	HITS-CLIP	27418678
MIRT608982	hsa-miR-548ah-5p	HITS-CLIP	27418678
MIRT608982	hsa-miR-548ah-5p	HITS-CLIP	27418678
MIRT395214	hsa-miR-5590-3p	HITS-CLIP	27418678
MIRT395214	hsa-miR-5590-3p	HITS-CLIP	27418678
MIRT576416	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT576416	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT576416	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT576416	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT395216	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT395216	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT395216	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT395216	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608974	hsa-miR-93-5p	HITS-CLIP	27418678
MIRT608974	hsa-miR-93-5p	HITS-CLIP	27418678
MIRT733514	hsa-miR-1200	Microarray	34164896
MIRT733514	hsa-miR-1200	Microarray	34164896
MIRT718805	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT654742	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT718804	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT718803	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT718802	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT654756	hsa-miR-488-5p	HITS-CLIP	23824327
MIRT654755	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT654754	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT654753	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT654751	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT654752	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT654750	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT654749	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654747	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654748	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT654746	hsa-miR-6074	HITS-CLIP	23824327
MIRT654745	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT654744	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT654743	hsa-miR-1248	HITS-CLIP	23824327
MIRT654742	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT654741	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT442227	hsa-miR-890	PAR-CLIP	22100165
MIRT442226	hsa-miR-300	PAR-CLIP	22100165
MIRT442225	hsa-miR-381-3p	PAR-CLIP	22100165
MIRT442224	hsa-miR-3614-5p	PAR-CLIP	22100165
MIRT442223	hsa-miR-1261	PAR-CLIP	22100165
MIRT1262987	hsa-miR-106a	CLIP-seq
MIRT1262988	hsa-miR-106b	CLIP-seq
MIRT1262989	hsa-miR-1237	CLIP-seq
MIRT1262990	hsa-miR-1238	CLIP-seq
MIRT1262991	hsa-miR-1297	CLIP-seq
MIRT1262992	hsa-miR-1324	CLIP-seq
MIRT1262993	hsa-miR-141	CLIP-seq
MIRT1262994	hsa-miR-17	CLIP-seq
MIRT1262995	hsa-miR-197	CLIP-seq
MIRT1262996	hsa-miR-200a	CLIP-seq
MIRT1262997	hsa-miR-20a	CLIP-seq
MIRT1262998	hsa-miR-20b	CLIP-seq
MIRT1262999	hsa-miR-26a	CLIP-seq
MIRT1263000	hsa-miR-26b	CLIP-seq
MIRT1263001	hsa-miR-3124-3p	CLIP-seq
MIRT1263002	hsa-miR-3165	CLIP-seq
MIRT1263003	hsa-miR-3183	CLIP-seq
MIRT1263004	hsa-miR-361-5p	CLIP-seq
MIRT1263005	hsa-miR-3617	CLIP-seq
MIRT1263006	hsa-miR-3646	CLIP-seq
MIRT1263007	hsa-miR-3690	CLIP-seq
MIRT1263008	hsa-miR-3942-3p	CLIP-seq
MIRT1263009	hsa-miR-3977	CLIP-seq
MIRT1263010	hsa-miR-4254	CLIP-seq
MIRT1263011	hsa-miR-4263	CLIP-seq
MIRT1263012	hsa-miR-4302	CLIP-seq
MIRT1263013	hsa-miR-431	CLIP-seq
MIRT1263014	hsa-miR-4330	CLIP-seq
MIRT1263015	hsa-miR-4434	CLIP-seq
MIRT1263016	hsa-miR-4436a	CLIP-seq
MIRT1263017	hsa-miR-4465	CLIP-seq
MIRT1263018	hsa-miR-4491	CLIP-seq
MIRT1263019	hsa-miR-4516	CLIP-seq
MIRT1263020	hsa-miR-4529-5p	CLIP-seq
MIRT1263021	hsa-miR-4531	CLIP-seq
MIRT1263022	hsa-miR-4657	CLIP-seq
MIRT1263023	hsa-miR-4717-5p	CLIP-seq
MIRT1263024	hsa-miR-4723-3p	CLIP-seq
MIRT1263025	hsa-miR-500a	CLIP-seq
MIRT1263026	hsa-miR-508-5p	CLIP-seq
MIRT1263027	hsa-miR-511	CLIP-seq
MIRT1263028	hsa-miR-519d	CLIP-seq
MIRT1263029	hsa-miR-539	CLIP-seq
MIRT1263030	hsa-miR-548a-5p	CLIP-seq
MIRT1263031	hsa-miR-548aa	CLIP-seq
MIRT1263032	hsa-miR-548ab	CLIP-seq
MIRT1263033	hsa-miR-548ah	CLIP-seq
MIRT1263034	hsa-miR-548ak	CLIP-seq
MIRT1263035	hsa-miR-548b-5p	CLIP-seq
MIRT1263036	hsa-miR-548c-5p	CLIP-seq
MIRT1263037	hsa-miR-548d-5p	CLIP-seq
MIRT1263038	hsa-miR-548h	CLIP-seq
MIRT1263039	hsa-miR-548i	CLIP-seq
MIRT1263040	hsa-miR-548j	CLIP-seq
MIRT1263041	hsa-miR-548k	CLIP-seq
MIRT1263042	hsa-miR-548l	CLIP-seq
MIRT1263043	hsa-miR-548w	CLIP-seq
MIRT1263044	hsa-miR-548y	CLIP-seq
MIRT1263045	hsa-miR-559	CLIP-seq
MIRT1263046	hsa-miR-576-5p	CLIP-seq
MIRT1263047	hsa-miR-587	CLIP-seq
MIRT1263048	hsa-miR-610	CLIP-seq
MIRT1263049	hsa-miR-640	CLIP-seq
MIRT1263050	hsa-miR-641	CLIP-seq
MIRT1263051	hsa-miR-665	CLIP-seq
MIRT1263052	hsa-miR-93	CLIP-seq
MIRT1263053	hsa-miR-939	CLIP-seq
MIRT2303967	hsa-miR-1914	CLIP-seq
MIRT2303968	hsa-miR-2355-3p	CLIP-seq
MIRT2303969	hsa-miR-4265	CLIP-seq
MIRT2303970	hsa-miR-4296	CLIP-seq
MIRT2303971	hsa-miR-4322	CLIP-seq
MIRT2303972	hsa-miR-4417	CLIP-seq
MIRT2303973	hsa-miR-4646-3p	CLIP-seq
MIRT2303974	hsa-miR-561	CLIP-seq
MIRT2303975	hsa-miR-676	CLIP-seq
MIRT1263012	hsa-miR-4302	CLIP-seq
MIRT1263016	hsa-miR-4436a	CLIP-seq
MIRT1263026	hsa-miR-508-5p	CLIP-seq
MIRT1263048	hsa-miR-610	CLIP-seq
MIRT1263051	hsa-miR-665	CLIP-seq
MIRT1262990	hsa-miR-1238	CLIP-seq
MIRT1262995	hsa-miR-197	CLIP-seq
MIRT1263001	hsa-miR-3124-3p	CLIP-seq
MIRT2600903	hsa-miR-361-3p	CLIP-seq
MIRT2600904	hsa-miR-3682-5p	CLIP-seq
MIRT1263012	hsa-miR-4302	CLIP-seq
MIRT1263016	hsa-miR-4436a	CLIP-seq
MIRT2600905	hsa-miR-493	CLIP-seq
MIRT1263026	hsa-miR-508-5p	CLIP-seq
MIRT1263027	hsa-miR-511	CLIP-seq
MIRT2600906	hsa-miR-550b	CLIP-seq
MIRT1263048	hsa-miR-610	CLIP-seq
MIRT1263051	hsa-miR-665	CLIP-seq
MIRT1262990	hsa-miR-1238	CLIP-seq
MIRT1262995	hsa-miR-197	CLIP-seq
MIRT1263001	hsa-miR-3124-3p	CLIP-seq
MIRT2600904	hsa-miR-3682-5p	CLIP-seq
MIRT1263012	hsa-miR-4302	CLIP-seq
MIRT1263016	hsa-miR-4436a	CLIP-seq
MIRT1263026	hsa-miR-508-5p	CLIP-seq
MIRT1263027	hsa-miR-511	CLIP-seq
MIRT2600906	hsa-miR-550b	CLIP-seq
MIRT1263048	hsa-miR-610	CLIP-seq
MIRT1263051	hsa-miR-665	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
MITF	Unknown	16411896

Show/Hide all(55)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0003682	Function	Chromatin binding	IDA	20228790
GO:0004674	Function	Protein serine/threonine kinase activity	EXP	12391145
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0004697	Function	Protein kinase C activity	IDA	25982116
GO:0004698	Function	Calcium-dependent protein kinase C activity	IEA
GO:0005080	Function	Protein kinase C binding	IPI	20228790
GO:0005246	Function	Calcium channel regulator activity	IEA
GO:0005515	Function	Protein binding	IPI	20228790, 21044950, 25852190
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	20228790
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	15632189
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	15632189
GO:0005886	Component	Plasma membrane	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IMP	20228790
GO:0006468	Process	Protein phosphorylation	TAS	3755548
GO:0006816	Process	Calcium ion transport	IEA
GO:0006874	Process	Cellular calcium ion homeostasis	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0007077	Process	Mitotic nuclear envelope disassembly	TAS
GO:0007165	Process	Signal transduction	NAS	3755548
GO:0008091	Component	Spectrin	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010827	Process	Regulation of glucose transmembrane transport	IDA	25982116
GO:0010829	Process	Negative regulation of glucose transmembrane transport	ISS
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0030168	Process	Platelet activation	TAS
GO:0030374	Function	Nuclear receptor coactivator activity	IMP	20228790
GO:0030949	Process	Positive regulation of vascular endothelial growth factor receptor signaling pathway	ISS
GO:0035403	Function	Histone kinase activity (H3-T6 specific)	IDA	20228790
GO:0035408	Process	Histone H3-T6 phosphorylation	IDA	20228790
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0042113	Process	B cell activation	ISS
GO:0042393	Function	Histone binding	IDA	20228790
GO:0042953	Process	Lipoprotein transport	TAS	18981301
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	ISS
GO:0044305	Component	Calyx of Held	IEA
GO:0045637	Process	Regulation of myeloid cell differentiation	TAS
GO:0045766	Process	Positive regulation of angiogenesis	ISS
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IEA
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	ISS
GO:0050681	Function	Androgen receptor binding	IDA	20228790
GO:0050853	Process	B cell receptor signaling pathway	ISS
GO:0050861	Process	Positive regulation of B cell receptor signaling pathway	ISS
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	ISS
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071322	Process	Cellular response to carbohydrate stimulus	IEA
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA
GO:0099523	Component	Presynaptic cytosol	IEA
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IEA

MIM	HGNC	e!Ensembl
176970	9395	ENSG00000166501

Protein

UniProt ID

P05771

Protein name

Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)

Protein function

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen

PDB

2I0E , 8SG2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00130	C1_1	37 → 89	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00130	C1_1	102 → 154	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00168	C2	171 → 277	C2 domain	Domain
PF00069	Pkinase	342 → 600	Protein kinase domain	Domain
PF00433	Pkinase_C	622 → 662	Protein kinase C terminal domain	Family

Sequence

MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV

Sequence length

671

Interactions

View interactions

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