Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5578 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Protein kinase C alpha |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PRKCA |
SynonymsGene synonyms aliases
|
AAG6, PKC-alpha, PKCA, PKCI+/-, PKCalpha, PRKACA |
ChromosomeChromosome number
|
17 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
17q24.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved |
SNPsSNP information provided by dbSNP.
|
SNP ID |
Visualize variation |
Clinical significance |
Consequence |
rs16960228 |
G>A |
Drug-response |
Intron variant, genic downstream transcript variant |
|
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
RARA |
Activation |
11525643 |
TFAP2A |
Activation |
12269829 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001525 |
Process |
Angiogenesis |
IEA |
|
GO:0001938 |
Process |
Positive regulation of endothelial cell proliferation |
IMP |
11909826 |
GO:0002159 |
Process |
Desmosome assembly |
IMP |
18474624 |
GO:0004672 |
Function |
Protein kinase activity |
IDA |
10770950 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
EXP |
7520444, 7539802, 12391145, 17392515 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IBA |
21873635 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
TAS |
|
GO:0004697 |
Function |
Protein kinase C activity |
ISS |
|
GO:0004698 |
Function |
Calcium-dependent protein kinase C activity |
IEA |
|
GO:0005178 |
Function |
Integrin binding |
ISS |
|
GO:0005515 |
Function |
Protein binding |
IPI |
12571249, 12893243, 16810323, 17244820, 18566587, 21703451, 21952047, 24658140, 30017192, 31980649, 32814053 |
GO:0005524 |
Function |
ATP binding |
IEA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IDA |
15632189, 23990668 |
GO:0005739 |
Component |
Mitochondrion |
HDA |
20833797 |
GO:0005783 |
Component |
Endoplasmic reticulum |
IDA |
18556656 |
GO:0005829 |
Component |
Cytosol |
IDA |
17983652 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005886 |
Component |
Plasma membrane |
IDA |
15632189, 23990668 |
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0006468 |
Process |
Protein phosphorylation |
IDA |
10770950 |
GO:0007077 |
Process |
Mitotic nuclear envelope disassembly |
TAS |
|
GO:0007155 |
Process |
Cell adhesion |
IEA |
|
GO:0007411 |
Process |
Axon guidance |
TAS |
|
GO:0008270 |
Function |
Zinc ion binding |
IEA |
|
GO:0010595 |
Process |
Positive regulation of endothelial cell migration |
IMP |
11909826 |
GO:0010613 |
Process |
Positive regulation of cardiac muscle hypertrophy |
ISS |
|
GO:0018105 |
Process |
Peptidyl-serine phosphorylation |
IBA |
21873635 |
GO:0018105 |
Process |
Peptidyl-serine phosphorylation |
TAS |
26078884 |
GO:0018107 |
Process |
Peptidyl-threonine phosphorylation |
ISS |
16717194 |
GO:0019899 |
Function |
Enzyme binding |
IDA |
18556656 |
GO:0030168 |
Process |
Platelet activation |
TAS |
|
GO:0030335 |
Process |
Positive regulation of cell migration |
IMP |
23990668 |
GO:0031666 |
Process |
Positive regulation of lipopolysaccharide-mediated signaling pathway |
IMP |
9830023 |
GO:0031966 |
Component |
Mitochondrial membrane |
IEA |
|
GO:0034351 |
Process |
Negative regulation of glial cell apoptotic process |
IMP |
9927633 |
GO:0035403 |
Function |
Histone kinase activity (H3-T6 specific) |
IDA |
20228790 |
GO:0035408 |
Process |
Histone H3-T6 phosphorylation |
IDA |
20228790 |
GO:0035556 |
Process |
Intracellular signal transduction |
IBA |
21873635 |
GO:0035866 |
Component |
Alphav-beta3 integrin-PKCalpha complex |
ISS |
|
GO:0038128 |
Process |
ERBB2 signaling pathway |
TAS |
|
GO:0043488 |
Process |
Regulation of mRNA stability |
TAS |
|
GO:0043536 |
Process |
Positive regulation of blood vessel endothelial cell migration |
IDA |
20011604 |
GO:0045651 |
Process |
Positive regulation of macrophage differentiation |
ISS |
|
GO:0045766 |
Process |
Positive regulation of angiogenesis |
IMP |
11909826 |
GO:0045780 |
Process |
Positive regulation of bone resorption |
ISS |
|
GO:0045785 |
Process |
Positive regulation of cell adhesion |
IMP |
11909826 |
GO:0045931 |
Process |
Positive regulation of mitotic cell cycle |
IMP |
10848585 |
GO:0048471 |
Component |
Perinuclear region of cytoplasm |
ISS |
|
GO:0050796 |
Process |
Regulation of insulin secretion |
TAS |
|
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19056867 |
GO:0070374 |
Process |
Positive regulation of ERK1 and ERK2 cascade |
ISS |
|
GO:0070555 |
Process |
Response to interleukin-1 |
IMP |
19281832 |
GO:0090330 |
Process |
Regulation of platelet aggregation |
IDA |
12724315 |
GO:0097190 |
Process |
Apoptotic signaling pathway |
TAS |
10825394 |
GO:0106071 |
Process |
Positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway |
ISS |
|
GO:2000707 |
Process |
Positive regulation of dense core granule biogenesis |
ISS |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P17252 |
Protein name |
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) |
Protein function |
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, ca |
PDB |
2ELI
,
3IW4
,
4DNL
,
4RA4
,
8U37
,
8UAK
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00130 |
C1_1 |
37 → 89 |
Phorbol esters/diacylglycerol binding domain (C1 domain) |
Domain |
PF00130 |
C1_1 |
102 → 154 |
Phorbol esters/diacylglycerol binding domain (C1 domain) |
Domain |
PF00168 |
C2 |
171 → 277 |
C2 domain |
Domain |
PF00069 |
Pkinase |
339 → 597 |
Protein kinase domain |
Domain |
PF00433 |
Pkinase_C |
623 → 658 |
Protein kinase C terminal domain |
Family |
|
Sequence |
|
Sequence length |
672 |
Interactions |
View interactions |