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PRKCA (protein kinase C alpha)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5578
Gene nameGene Name - the full gene name approved by the HGNC.
Protein kinase C alpha
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PRKCA
SynonymsGene synonyms aliases
AAG6, PKC-alpha, PKCA, PKCI+/-, PKCalpha, PRKACA
ChromosomeChromosome number
17
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q24.2
SummarySummary of gene provided in NCBI Entrez Gene.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs16960228 G>A Drug-response Intron variant, genic downstream transcript variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006882 mmu-miR-24-2-5p Luciferase reporter assay, qRT-PCR, Western blot 22911661
MIRT020045 hsa-miR-375 Microarray 20215506
MIRT050756 hsa-miR-17-3p CLASH 23622248
MIRT049636 hsa-miR-92a-3p CLASH 23622248
MIRT041382 hsa-miR-193b-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
RARA Activation 11525643
TFAP2A Activation 12269829
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001938 Process Positive regulation of endothelial cell proliferation IMP 11909826
GO:0002159 Process Desmosome assembly IMP 18474624
GO:0004672 Function Protein kinase activity IDA 10770950
GO:0004674 Function Protein serine/threonine kinase activity EXP 7520444, 7539802, 12391145, 17392515
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P17252
Protein name Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Protein function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, ca
PDB 2ELI , 3IW4 , 4DNL , 4RA4 , 8U37 , 8UAK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00130 C1_1
37 89
Phorbol esters/diacylglycerol binding domain (C1 domain)
Domain
PF00130 C1_1
102 154
Phorbol esters/diacylglycerol binding domain (C1 domain)
Domain
PF00168 C2
171 277
C2 domain
Domain
PF00069 Pkinase
339 597
Protein kinase domain
Domain
PF00433 Pkinase_C
623 658
Protein kinase C terminal domain
Family
Sequence
Sequence length 672
Interactions View interactions

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