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PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2)

Gene

51422

Protein kinase AMP-activated non-catalytic subunit gamma 2

PRKAG2

AAKG, AAKG2, CMH6, H91620p, WPWS

7q36.1

AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMP

Show/Hide all(27)

SNP ID	Visualize variation	Clinical significance	Consequence
rs28938173	G>T	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs61746358	G>A,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity, likely-benign	Genic upstream transcript variant, 5 prime UTR variant, missense variant, synonymous variant, coding sequence variant
rs116541276	T>C	Likely-benign, benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs121908987	C>A,G,T	Uncertain-significance, pathogenic	Missense variant, coding sequence variant
rs121908988	T>C	Uncertain-significance, pathogenic	Missense variant, coding sequence variant
rs121908989	T>A,C	Pathogenic	Missense variant, coding sequence variant
rs121908990	G>A,C	Pathogenic	Missense variant, coding sequence variant
rs121908991	C>A,T	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs139579816	A>C	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant, genic upstream transcript variant, 5 prime UTR variant
rs144857453	C>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Genic upstream transcript variant, 5 prime UTR variant, coding sequence variant, missense variant
rs193922697	G>A,T	Likely-pathogenic, pathogenic	Synonymous variant, missense variant, coding sequence variant
rs201240745	G>C	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Intron variant, 5 prime UTR variant, missense variant, coding sequence variant, genic upstream transcript variant, upstream transcript variant
rs201878539	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign	Missense variant, coding sequence variant
rs201953758	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	5 prime UTR variant, missense variant, coding sequence variant, genic upstream transcript variant
rs267606976	A>G	Likely-pathogenic, pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs267606977	T>C	Pathogenic	Missense variant, coding sequence variant
rs267606978	C>G	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs267606979	A>G	Pathogenic	Missense variant, coding sequence variant
rs376173303	T>C	Conflicting-interpretations-of-pathogenicity, likely-benign	Intron variant
rs397517278	G>T	Conflicting-interpretations-of-pathogenicity	5 prime UTR variant, upstream transcript variant, genic upstream transcript variant, intron variant
rs397517283	A>C,T	Likely-pathogenic	Missense variant, coding sequence variant
rs587776643	->TAA	Pathogenic	Coding sequence variant, inframe insertion
rs727504392	G>A	Uncertain-significance, likely-pathogenic	Coding sequence variant, missense variant
rs730880982	T>G	Likely-pathogenic	Coding sequence variant, missense variant
rs730882148	C>G	Pathogenic	Coding sequence variant, missense variant
rs1131692281	C>G,T	Pathogenic	Genic upstream transcript variant, 5 prime UTR variant, coding sequence variant, missense variant
rs1563161306	A>G	Likely-pathogenic	Coding sequence variant, missense variant

Show/Hide all(78)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1262410	hsa-miR-132	CLIP-seq
MIRT1262411	hsa-miR-1324	CLIP-seq
MIRT1262412	hsa-miR-155	CLIP-seq
MIRT1262413	hsa-miR-205	CLIP-seq
MIRT1262414	hsa-miR-212	CLIP-seq
MIRT1262415	hsa-miR-3121-3p	CLIP-seq
MIRT1262416	hsa-miR-3140-5p	CLIP-seq
MIRT1262417	hsa-miR-3614-5p	CLIP-seq
MIRT1262418	hsa-miR-4258	CLIP-seq
MIRT1262419	hsa-miR-4293	CLIP-seq
MIRT1262420	hsa-miR-4766-5p	CLIP-seq
MIRT1262421	hsa-miR-500a	CLIP-seq
MIRT1262422	hsa-miR-548al	CLIP-seq
MIRT1262423	hsa-miR-570	CLIP-seq
MIRT1262424	hsa-miR-1183	CLIP-seq
MIRT1262425	hsa-miR-1305	CLIP-seq
MIRT1262426	hsa-miR-181a	CLIP-seq
MIRT1262427	hsa-miR-181b	CLIP-seq
MIRT1262428	hsa-miR-181c	CLIP-seq
MIRT1262429	hsa-miR-181d	CLIP-seq
MIRT1262430	hsa-miR-200b	CLIP-seq
MIRT1262431	hsa-miR-200c	CLIP-seq
MIRT1262432	hsa-miR-2053	CLIP-seq
MIRT1262433	hsa-miR-320a	CLIP-seq
MIRT1262434	hsa-miR-320b	CLIP-seq
MIRT1262435	hsa-miR-320c	CLIP-seq
MIRT1262436	hsa-miR-320d	CLIP-seq
MIRT1262437	hsa-miR-3613-5p	CLIP-seq
MIRT1262438	hsa-miR-3692	CLIP-seq
MIRT1262439	hsa-miR-423-3p	CLIP-seq
MIRT1262440	hsa-miR-425	CLIP-seq
MIRT1262441	hsa-miR-4262	CLIP-seq
MIRT1262442	hsa-miR-429	CLIP-seq
MIRT1262443	hsa-miR-4422	CLIP-seq
MIRT1262444	hsa-miR-4429	CLIP-seq
MIRT1262445	hsa-miR-4661-3p	CLIP-seq
MIRT1262446	hsa-miR-4775	CLIP-seq
MIRT1262447	hsa-miR-498	CLIP-seq
MIRT1262448	hsa-miR-548u	CLIP-seq
MIRT1262449	hsa-miR-590-3p	CLIP-seq
MIRT1262450	hsa-miR-617	CLIP-seq
MIRT1262451	hsa-miR-7	CLIP-seq
MIRT1262426	hsa-miR-181a	CLIP-seq
MIRT1262427	hsa-miR-181b	CLIP-seq
MIRT1262428	hsa-miR-181c	CLIP-seq
MIRT1262429	hsa-miR-181d	CLIP-seq
MIRT1262416	hsa-miR-3140-5p	CLIP-seq
MIRT2077365	hsa-miR-3163	CLIP-seq
MIRT1262441	hsa-miR-4262	CLIP-seq
MIRT2077366	hsa-miR-4668-3p	CLIP-seq
MIRT1262447	hsa-miR-498	CLIP-seq
MIRT2077367	hsa-miR-499-3p	CLIP-seq
MIRT2077368	hsa-miR-499a-3p	CLIP-seq
MIRT2303862	hsa-miR-1301	CLIP-seq
MIRT1262426	hsa-miR-181a	CLIP-seq
MIRT1262427	hsa-miR-181b	CLIP-seq
MIRT1262428	hsa-miR-181c	CLIP-seq
MIRT1262429	hsa-miR-181d	CLIP-seq
MIRT1262441	hsa-miR-4262	CLIP-seq
MIRT2303863	hsa-miR-4676-5p	CLIP-seq
MIRT2077367	hsa-miR-499-3p	CLIP-seq
MIRT2077368	hsa-miR-499a-3p	CLIP-seq
MIRT2303864	hsa-miR-5047	CLIP-seq
MIRT2303865	hsa-miR-575	CLIP-seq
MIRT2303866	hsa-miR-323-3p	CLIP-seq
MIRT2303867	hsa-miR-4496	CLIP-seq
MIRT2392977	hsa-miR-214	CLIP-seq
MIRT1262417	hsa-miR-3614-5p	CLIP-seq
MIRT2392978	hsa-miR-3619-5p	CLIP-seq
MIRT1262418	hsa-miR-4258	CLIP-seq
MIRT2392979	hsa-miR-4274	CLIP-seq
MIRT2392980	hsa-miR-4291	CLIP-seq
MIRT2392981	hsa-miR-4462	CLIP-seq
MIRT2392982	hsa-miR-4711-5p	CLIP-seq
MIRT2392983	hsa-miR-495	CLIP-seq
MIRT1262422	hsa-miR-548al	CLIP-seq
MIRT2392984	hsa-miR-761	CLIP-seq
MIRT2392985	hsa-miR-922	CLIP-seq

Show/Hide all(41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004862	Function	CAMP-dependent protein kinase inhibitor activity	IDA	17255938
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005524	Function	ATP binding	IDA	15877279
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005977	Process	Glycogen metabolic process	IMP	11827995, 15877279
GO:0006110	Process	Regulation of glycolytic process	IMP	15877279
GO:0006468	Process	Protein phosphorylation	IBA	21873635
GO:0006469	Process	Negative regulation of protein kinase activity	IDA	17255938
GO:0006633	Process	Fatty acid biosynthetic process	IEA
GO:0006754	Process	ATP biosynthetic process	TAS	11371514
GO:0006853	Process	Carnitine shuttle	TAS
GO:0007050	Process	Cell cycle arrest	TAS
GO:0008603	Function	CAMP-dependent protein kinase regulator activity	IMP	15877279
GO:0008607	Function	Phosphorylase kinase regulator activity	IMP	15877279
GO:0010800	Process	Positive regulation of peptidyl-threonine phosphorylation	IMP	15877279
GO:0016126	Process	Sterol biosynthetic process	TAS	9208914
GO:0016208	Function	AMP binding	IBA	21873635
GO:0016236	Process	Macroautophagy	TAS
GO:0016241	Process	Regulation of macroautophagy	TAS
GO:0019217	Process	Regulation of fatty acid metabolic process	IMP	15877279
GO:0019887	Function	Protein kinase regulator activity	IBA	21873635
GO:0019901	Function	Protein kinase binding	IBA	21873635
GO:0019901	Function	Protein kinase binding	IDA	10698692
GO:0030295	Function	Protein kinase activator activity	IMP	15877279
GO:0031588	Component	Nucleotide-activated protein kinase complex	IBA	21873635
GO:0031588	Component	Nucleotide-activated protein kinase complex	IDA	15877279
GO:0032147	Process	Activation of protein kinase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IMP	15877279
GO:0042149	Process	Cellular response to glucose starvation	IBA	21873635
GO:0042304	Process	Regulation of fatty acid biosynthetic process	TAS
GO:0043531	Function	ADP binding	IDA	15877279
GO:0045860	Process	Positive regulation of protein kinase activity	IMP	15877279
GO:0046320	Process	Regulation of fatty acid oxidation	TAS	9208914
GO:0046324	Process	Regulation of glucose import	TAS	11827995
GO:0050790	Process	Regulation of catalytic activity	IBA	21873635
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS
GO:2000480	Process	Negative regulation of cAMP-dependent protein kinase activity	IEA

MIM	HGNC	e!Ensembl
602743	9386	ENSG00000106617

Protein

UniProt ID

Q9UGJ0

Protein name

5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p)

Protein function

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP leve

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00571	CBS	355 → 410	CBS domain	Domain
PF00571	CBS	429 → 484	CBS domain	Domain
PF00571	CBS	502 → 556	CBS domain	Domain

Sequence

MGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSS
RKVDSPFGPGSPSKGFFSRGPQPRPSSPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRR
MSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFPLESY
KHEPERLENRIYASSSPPDTGQRFCPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEA
GMLEKLEFEDEAVEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANG
VRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKIETWRELYLQETFKP
LVNISPDASLFDAVYSLIKNKIHRLPVIDPISGNALYILTHKRILKFLQLFMSDMPKPAF
MKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVIN
LAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS
IVGIISLSDILQALILTPAGAKQKETETE

Sequence length

569

Interactions

View interactions

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